Hypericum perforatum L. Oleoresin, procedure for obtaining it and uses of it. A Hypericum perforatum L Oleoresin is describes that is stable over time on its Hyperforin and Hypericine content without adding preservatives; a procedure for obtaining the Oleoresin by extraction with low-polarity solvents, followed by purification; also its use as a regulator of the components of the extracellular matrix is described and its use for the manufacture of hydrosoluble gels containing Hypericum perforatum L Oleoresin.