K and K Biosciences, Inc.

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K and K Biosciences, Inc. -
City: Chadds Ford State/Country: PA

K and K Biosciences, Inc. ( Chadds Ford, PA )

US20040073039 - Delta2-1,2,3-triazoline anticonvulsants and their active metabolite analogues, the aminoalkylpyridines, are excitatory amino acid antagonists and antiischemic agents, useful in the treatment of cerebral ischemia resulting from stroke - 04/15/2004

Pharmaceutical compositions comprise as the active ingredient, nonneurotixic antiischemic compounds that are highly effective by the intraperitoneal route, and that are excitatory amino acid and NMDA/sigma receptor antagonists and are selected from the group consisting of those of the formulae, 1 wherein R.sup.2 is 4-pyridyl, 3-pyridyl, or 2-oxo-1-pyrrolidino and R.sup.1 is 3,4- or 3,5-dichloro, p- or m-chloro, p- or m-bromo, p- or m-fluoro, p- or m-trifluoromethyl, p-methyl, p-methoxy, or hydrogen, and those of the formulae, 2 wherein R.sup.2 is 4-pyridyl or 3-pyridyl, R.sup.3 is hydrogen, methyl or ethyl and R.sup.1 is 3,4- or 3,5-dichloro, p- or m-chloro, p- or m-bromo, p- or m-fluoro, p- or m-trifluoromethyl, p-methyl, p-methoxy or hydrogen.

US6638954 - .DELTA.2-1,2,3-TRIAZOLINE ANTICONVULSANTS AND THEIR ACTIVE METABOLITE ANALOGUES, THE AMINOALKYLPYRIDINES, ARE EXCITATORY AMINO ACID ANTAGONISTS AND ANTIISCHEMIC AGENTS, USEFUL IN THE TREATMENT OF CEREBRAL ISCHEMIA RESULTING FROM STROKE - 10/28/2003

Pharmaceutical compositions comprise as the active ingredient, nonneurotixic antiischemic compounds that are highly effective by the intraperitoneal route, and that are excitatory amino acid and NMDA/sigma receptor antagonists and are selected from the group consisting of those of the formulae, ##STR1## wherein R.sup.2 is 4-pyridyl, 3-pyridyl, or 2-oxo-1-pyrrolidino and R.sup.1 is 3,4- or 3,5-dichloro, p- or m-chloro, p- or m-bromo, p- or m-fluoro, p- or m-trifluoromethyl, p-methyl, p-methoxy, or hydrogen, and those of the formulae, ##STR2## wherein R.sub.2 is 4-pyridyl or 3-pyridyl, R.sup.3 is hydrogen, methyl or ethyl and R.sup.1 is 3,4- or 3,5-dichloro, p- or m-chloro, p- or m-bromo, p- or m-fluoro, p- or m-trifluoromethyl, p-methyl, p-methoxy or hydrogen.