A system and method for cluster-sensitive sticky load balancing of server workload may include a load balancer receiving an initial request from a client. A session may be initiated in response to receiving the request. The load balancer may relay the initial request to a selected node, where the selected node may be part of a cluster of multiple nodes. Upon receiving a subsequent request pertaining to the session initiated by the initial request, the load balancer may determine if the selected node is active. If the selected node is active, the load balancer may relay the subsequent request to the selected node. If the selected node is not active, the load balancer may determine for which cluster the selected node was a member, and relay the subsequent request to another node in that same cluster.