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Patent # Description
2016/0221992 DENDRITIC COMPOUNDS INCLUDING A CHELATING, FLUOROCHROME OR RECOGNITION AGENT, COMPOSITIONS INCLUDING SAME AND...
The invention relates to dendritic compounds comprising a chelating, fluorochrome or recognition agent of formula (I), to compositions comprising same, and to...
2016/0221991 NOVEL TRIAZINE DERIVATIVE
To provide a novel triazine derivative represented by the following formula (I): A triazine derivative represented by the following formula (I): ...
2016/0221990 NOVEL CYTOCHROME P450 INHIBITORS AND THEIR METHOD OF USE
Embodiments of the present invention relate to novel cytochrome P450 inhibitors and pharmaceutical compositions thereof having a disease-modifying action in...
2016/0221989 N-Acylpyrrolidine Ether Tropomyosin-Related Kinase Inhibitors
The present invention relates to compounds of Formula I ##STR00001## described herein and their pharmaceutically acceptable salts, and their use in medicine, in...
2016/0221988 CRYSTALLINE C21H22Cl2N4O2 MALONATE
The present invention provides a malonate salt of a compound of formula (I): ##STR00001## which is a crystalline salt. Also provided are pharmaceutical ...
2016/0221987 CRYSTALLINE FORMS OF C21H22Cl2N4O2
The present invention provides crystalline forms of a compound of formula (I): ##STR00001## Also provided are pharmaceutical compositions that include the...
2016/0221986 METHODS FOR THE SYNTHESIS OF TIOTROPIUM BROMIDE
Present invention relates to methods for preparing (1.alpha., 2.beta., 4.beta., 5.alpha., ...
2016/0221985 METHOD FOR THE PREPARATION OF THIADIAZOLES
The present invention relates to processes for preparing protected glyceraldehydes, such as (hydroxy)methanesulfonates. In addition, the invention relates to...
2016/0221984 MIGRASTATINS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2016/0221983 AFLATOXIN TEMPLATES, MOLECULARLY IMPRINTED POLYMERS, AND METHODS OF MAKING AND USING THE SAME
Molecularly imprinted polymers (MIPs) are materials exhibiting molecular recognition of a target molecule. MIPs are synthesized in the presence of an aflatoxin...
2016/0221982 Catalytic Enantioselective Synthesis of 2-Aryl Chromenes and Related Phosphoramidite Ligands and Catalyst Compounds
Methods to access 2-aryl chromene compounds via an asymmetric catalytic process.
2016/0221981 Processes for Preparing Medicaments for the Treatment of Cardiovascular Diseases and Intermediates for Use Therein
The present invention provides a compound of formula N wherein: X is CH.sub.2, oxygen or sulphur; R.sub.1, R.sub.2 and R.sub.3 are the same or different and...
2016/0221980 FURAN-2,5-DICARBOXYLIC ACID PURGE PROCESS
Disclosed is an oxidation process to produce a crude carboxylic acid product carboxylic acid product. The process comprises oxidizing a feed stream comprising...
2016/0221979 2,5-FURAN DICARBOXYLIC ACID PRODUCTION METHOD
The present invention relates to a process for producing 2,5-furan dicarboxylic acid by subjecting 5-hydroxymethylfurfural to oxidation reaction in the...
2016/0221978 ESTER NITRATES DERIVATIVES OF AROMATIC ALDEHYDES WITH MULTIPLE PHARMALOGIC PROPERTIES TO TREAT SICKLE CELL...
The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing...
2016/0221977 ANTIBACTERIAL BETA-LACTONES, AND METHODS OF IDENTIFICATION, MANUFACTURE AND USE
An antibacterial therapeutic ##STR00001## wherein R.sub.1 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl,...
2016/0221976 RADIOMITIGATING PHARMACEUTICAL FORMULATIONS
The present disclosure relates to compounds of Formula (I) and (II), compositions containing the compounds (alone or in combination with other agents), and...
2016/0221975 NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF
Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the...
2016/0221974 SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN AND DIABETES
Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I': ##STR00001## In...
2016/0221973 3-ARYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present invention relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with...
2016/0221972 3-ALKYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS
The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an...
2016/0221971 DI-MACROCYCLES
The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
2016/0221970 NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments,...
2016/0221969 Compounds, compositions and methods of using same for modulating uric acid levels
Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of making and using them. In some...
2016/0221968 SUBSTITUTED TRIAZOLES AND METHODS RELATING THERETO
Substituted 1,2,3-triazole compounds are disclosed which have utility in the treatment of a variety of neurological disorders. The compounds provided herein...
2016/0221967 Catalysis of Diketopiperazine Synthesis
Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of .epsilon.-amino...
2016/0221966 HETEROARYL COMPOUNDS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2016/0221965 DISUBSTITUTED TRIFLUOROMETHYL PYRIMIDINONES AND THEIR USE
The present application relates to novel 2,5-disubstituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use...
2016/0221964 FUNGICIDAL PYRIMIDINE COMPOUNDS
The present invention relates to fungicidal pyrimidine compounds I, to their use and to methods for combating phytopathogenic fungi. The present invention also...
2016/0221963 PYRIDAZINONE COMPOUNDS AND USES THEREOF
Disclosed herein are pyridazinone compounds, pharmaceutical compositions that include one or more pyridazinone compounds, and methods of synthesizing the same....
2016/0221962 COMPOUNDS FOR AFFINITY CHROMATOGRAPHY AND FOR EXTENDING THE HALF-LIFE OF A THERAPEUTIC AGENT
Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum...
2016/0221961 LOW 4-METHYLIMIDAZOLE (4-MeI) CARAMEL COLOR CLASS IV PRODUCTION
The application pertains to a process comprising a) acidifying a carbohydrate to a pH below 2; b) heating the mixture from step a) to a temperature from about...
2016/0221960 Hydrazinyl Lipidoids and Uses Thereof
The present disclosure is directed to hydrazinyl lipidoids, formulations thereof further comprising at least one active agent, as well as methods of delivering...
2016/0221959 ANTIBACTERIAL 2H-INDAZOLE DERIVATIVES
The invention relates to antibacterial compounds of formula I ##STR00001## wherein R.sup.1 is H or halogen; R.sup.2 is alkynyloxy or the group M; R.sup.3 is H or...
2016/0221958 SUBSTITUTED PYRAZOLES AS HEAT SHOCK TRANSCRIPTION FACTOR ACTIVATORS
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically...
2016/0221957 PROCESS FOR PREPARING 5-FLUORO-1-ALKYL-3-FLUOROALKYL-1H-PYRAZOLE-4-CARBALDEHYDE
New method for the preparation of N-methyl-3-difluormethyl-5-fluorpyrazol aldehyde starting from N-methyl-3-haloalkyl-5-chlororpyrazol aldehyde comprising...
2016/0221956 Liver X Receptor (LXR) Modulators
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of LXR-associated diseases, disorders or...
2016/0221955 Method for synthesizing cationic bleach activators via a single-bath reaction
The present invention provides a method for synthesizing cationic bleach activators via a single-bath reaction, comprising steps of: separately dissolving...
2016/0221954 PHENYL-DIHYDROPYRIDINE DERIVATIVES AS INHIBITORS OF ALDOSTERONE SYNTHASE
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, ...
2016/0221953 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
2016/0221952 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
This invention relates to a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R is COOH or CH.sub.2OH.
2016/0221951 METHODS OF MAKING 2-HALONICOTINONITRILES
A method of making a 2-halonicotinonitrile comprises reacting an alkylidene nitrile with a C1-compound in an organic solvent and a dehydrating agent. The...
2016/0221950 CARBOXAMIDE DERIVATIVES AS PESTICIDAL COMPOUNDS
Disclosed are compounds of formula (I) which possess pesticidal, especially nematicidal properties wherein in the structural elements have the meaning as...
2016/0221949 ELECTROCHROMIC TWO-CORE VIOLOGEN DERIVATIVES AND OPTICAL ARTICLES CONTAINING THEM
The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials having two-core viologens...
2016/0221948 NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND
The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: ##STR00001## [wherein, R.sup.1...
2016/0221947 TRIPLE REUPTAKE INHIBITORS AND METHODS OF THEIR USE
Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or...
2016/0221946 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME
Disclosed are a sulfonylindole derivative useful for the prevention or treatment of pepetic ulcer, gastritis or reflux esophagitis, a method of preparing the...
2016/0221945 SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS
The invention is concerned with the compounds of formula I or II: ##STR00001## and salts thereof. In addition, the present invention relates to methods of...
2016/0221944 PYRROLIDINE DERIVATIVES AS OXYTOCIN/VASOPRESSIN V1a RECEPTORS ANTAGONISTS
The present invention relates to a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrro- lidin-3-one...
2016/0221943 PROCESS FOR THE RECOVERY OF EPSILON-CAPROLACTAM FROM EXTRACT WATER
A process for the recovery of .epsilon.-caprolactam from extract water of polycaprolactam obtained by hydrolytic polymerization, wherein the extract water is...
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