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Patent # Description
2017/0145417 IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that...
2017/0145416 Complement Binding Aptamers and Anti-C5 Agents Useful in the Treatment of Ocular Disorders
Methods of treating complement-mediated ocular disorders by administering agents that inhibit a subject's complement component in an amount sufficient to treat...
2017/0145415 TRANSFERRIN/TRANSFERRIN RECEPTOR-MEDIATED siRNA DELIVERY
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in...
2017/0145414 TREATMENT OF FRATAXIN (FXN) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO FXN
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Frataxin (FXN), in particular, by targeting...
2017/0145413 CANCER TREATMENT
In certain embodiments, methods, compounds, and compositions for treating B-cell lymphoma or hepatocellular carcinoma by inhibiting expression of ST AT3 mRNA...
2017/0145412 COMPOSITIONS FOR INHIBITING NLRP3 GENE EXPRESSION AND USES THEREOF
The present invention is directed to compounds, compositions, and methods useful for modulating NLRP3 mRNA or protein expression using gene silencing compounds...
2017/0145411 TREATMENT OF NUCLEAR FACTOR (ERYTHROID-DERIVED 2)-LIKE 2 (NRF2) RELATED DISEASES BY INHIBITION OF NATURAL...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Nuclear factor (erythroid-derived 2)-like 2...
2017/0145410 PURIFICATION OF TRIPHOSPHORYLATED OLIGONUCLEOTIDES USING CAPTURE TAGS
The present invention relates to a method of preparing triphosphate-modified oligonucleotides using a capture tag. The method allows the synthesis and...
2017/0145409 BICYCLIC CARBOCYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
The present invention provides novel bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the bicyclic...
2017/0145408 METHOD FOR MAKING CHROMOSOME SUBSTITUTION LIBRARIES
The invention relates to a method for producing a chromosome substitution library, comprising: a) producing a population of DH lines from an at least partially...
2017/0145407 METHODS FOR INCREASING THE DIVERSITY OF MONOCLONAL ANTIBODIES PRODUCED AGAINST AN ANTIGEN
The present invention relates to methods for increasing the diversity of monoclonal antibodies produced against an antigen. The methods of the invention...
2017/0145406 EXTRACTING LOW CONCENTRATIONS OF BACTERIA FROM A SAMPLE
The invention generally relates to conducting an assay on a sample that isolates a bacterium from the sample, in which the assay isolates as low as about 1...
2017/0145405 CRISPR/CAS-MEDIATED GENOME EDITING TO TREAT EGFR-MUTANT LUNG CANCER
The invention relates to a clustered regularly interspaced short palindromic repeats (CRISPR)/Cas guide RNA (gRNA) comprising a targeting domain that is...
2017/0145404 PROCESSING BIOMASS
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed for use in the production of useful products, such as fuels. For...
2017/0145403 EXPRESSION OF POLYPEPTIDES INVOLVED IN LYSINE DECARBOXYLATION, AND METHODS AND APPLICATIONS THEREOF
The expression plasmid vectors comprise a polynucleotide sequence encoding Ldc2 polypeptide, a fragment, and/or a mutant. A backbone plasmid is capable of...
2017/0145402 MODIFIED BETA-LACTAMASES AND METHODS AND USES RELATED THERETO
The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and...
2017/0145401 Mutant with enhanced secretion of L-asparaginase and its application
The present invention provides a mutant with enhanced secretion of L-asparaginase and its application, which relates to the field of enzyme engineering. This...
2017/0145400 SUBTILASE VARIANTS AND POLYNUCLOETIDES ENCODING SAME
The present invention relates to novel subtilase variants exhibiting increased stability and preferably on par or improved wash performance. The variants of...
2017/0145399 NON-DIFFUSIVE BOTULINUM TOXIN CAUSING LOCAL MUSCLE PARALYSIS, AND PURIFICATION METHOD THEREOF
The present invention relates to a method for purifying a non-spreading botulinum toxin that causes local muscle paralysis and a non-spreading botulinum toxin...
2017/0145398 DEIMMUNIZED LYSOSTAPHIN AND METHODS OF USE
Compositions comprising deimmunized lysostaphin and methods of using the same, e.g., to treat microbial infection in or on a subject, are provided.
2017/0145397 Polypeptides Having Xylanase Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having xylanase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding...
2017/0145396 BETA-GLUCOSIDASE I VARIANTS WITH IMPROVED PROPERTIES
The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase...
2017/0145395 Polypeptides having Xylanase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
2017/0145394 TRACKING AND MANIPULATING CELLULAR RNA VIA NUCLEAR DELIVERY OF CRISPR/CAS9
Cas9 polypeptides which target RNA and methods of using them are provided.
2017/0145393 NPP1 FUSION PROTEINS
The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion...
2017/0145392 HBV Polymerase Mutants
The present invention relates to polymerase HBV mutant polypeptides comprising a mutated polymerase domain which is functionally disrupted for polymerase...
2017/0145391 TRUNCATED VARIANT OF THE MAMMALIAN TARGET FOR RAPAMYCIN (mTOR) PROTEIN
The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to...
2017/0145390 OMEGA-HYDROXYLASE-RELATED FUSION POLYPEPTIDES WITH IMPROVED PROPERTIES
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when...
2017/0145389 NOVEL FORMALDEHYDE DEHYDROGENASE AND METHOD FOR PREPARING FORMALDEHYDE USING SAME
This invention relates to a novel formaldehyde dehydrogenase expressed by a formaldehyde dehydrogenase gene and having independent reduction activity for...
2017/0145388 STABLE CELL LINES FOR RETROVIRAL PRODUCTION
The invention relates to retroviral producer cell comprising nucleic acid sequences encoding: gag and pol proteins; envelope protein or a functional substitute...
2017/0145387 DEVICE AND METHOD OF COLLECTION FOR RNA VIRUSES
The present disclosure generally relates to a method and device for inactivation and dry storage, under ambient conditions, of a biological sample containing...
2017/0145386 SELF-ASSEMBLING CELL AGGREGATES AND METHODS OF MAKING ENGINEERED TISSUE USING THE SAME
A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a...
2017/0145385 Mesenchymal Stem Cells Derived From Induced Pluripotent Stem Cells
A method of producing mesenchymal stem cells from induced pluripotent stem cells in which induced pluripotent stem cells are cultured in the presence of a...
2017/0145384 CARBON-NANOTUBE MODULATION OF MYOCYTE CELLS
Embodiments include compositions of carbon nanotubes complexed with myocyte cells. Embodiments also include methods for making compositions of carbon...
2017/0145383 EXPANDED NK CELLS
The present invention relates to expanded NK cells. The NK cells have been expanded ex vivo, are activated and have a cytotoxic phenotype. The cytotoxicity...
2017/0145382 METHOD FOR STEM CELL DIFFERENTIATION IN VIVO BY DELIVERY OF MORPHOGENES WITH MESOPOROUS SILICA AND...
A pharmaceutical active ingredient for cell differentiation to alleviate cell and cell-related deficiencies in mammals comprising porous silica containing a...
2017/0145381 METHOD OF GENERATING MULTILINEAGE POTENTIAL CELLS FROM LYMPHOCYTES
The present invention relates generally to a method of generating cells exhibiting multilineage potential and to cells generated thereby. More particularly,...
2017/0145380 CONDITIONED MEDIUM AND EXTRACELLULAR MATRIX COMPOSITIONS FROM CELLS CULTURED UNDER HYPOXIC CONDITIONS
The present invention is directed to a method of producing compositions including embryonic proteins. The method includes culturing cells under hypoxic...
2017/0145379 Lactic Acid Bacteria for Coeliac Disease
The present invention discloses strains of Lactobacillus and Streptococcus which have a capacity to degrade gliadin peptides involved in coeliac disease and...
2017/0145378 METHODS OF CULTURING MICROORGANISMS IN NON-AXENIC MIXOTROPHIC CONDITIONS
Methods of culturing microorganisms in non-axenic mixotrophic conditions are disclosed. A method of culturing microalgae mixotrophically and controlling...
2017/0145377 HYBRID SEPARATION
This disclosure describes techniques for using a single feedstock of barley to produce a fermented product and a method for filtering a large-particles stream...
2017/0145376 ULTRAHIGH-PRESSURE HOMOGENIZING INTEGRATED DEVICE AND CELL DISRUPTOR
Disclosed is an ultrahigh-pressure homogenizing integrated device and a cell disruptor. The ultrahigh-pressure homogenizing integrated device includes a long...
2017/0145375 Continuous Fermenter for Sequential Fermentation of Hexose-Pentose
Discloses is a continuous fermenter for sequential fermentation of hexose and pentose which includes (a) a hexose fermenter equipped with a saccharified...
2017/0145374 METHOD AND SYSTEM FOR CONTROLLING THE CONVERSION OF LIGNOCELLULOSIC MATERIALS
The invention provides a method and system for controlling the conversion of crystalline insoluble cellulose to an organic product in a bioreactor containing...
2017/0145373 AUTOMATED SYSTEM FOR CULTIVATING TRANSGENIC C. ELEGANS
The present invention provides a self-draining well plate cassette and an automated system for cultivating C. elegans comprising a housing, a well plate...
2017/0145372 Embryo Incubator Incorporating Temperature Control
The invention relates to an incubator having a chamber for cultivating embryos and a gas control system and a temperature control system for providing...
2017/0145371 APPARATUS AND METHOD FOR EXPANDING SKIN
An embodiment of the present invention provides an apparatus and method for expanding skin capable of expanding autologous skin to the maximum extent and...
2017/0145370 CELL CULTURE CONTAINER, CELL IMAGING METHOD, AND CELL CULTURE SYSTEM
A cell culture container includes a container that houses therein a liquid mixture including one or more cells and a culture solution, an irradiator that...
2017/0145369 PROCESS AND DEVICE FOR ISOLATING CELLS FROM BIOLOGICAL TISSUE
The invention is directed to a Perfusion device for biological tissues comprising a casing having two parts, a first part (1) and a second part (9), a holder...
2017/0145368 MEDIA MIXING CHAMBER
A mixing apparatus for reconstituting a powdered cell culture media. The apparatus includes at least one fluid chamber, an influent port at a lower portion of...
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