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Patent # Description
2017/0145114 BIOLOGICAL PRODUCTS
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also...
2017/0145113 ANTI-HtrA1 ANTIBODIES AND METHODS OF USE THEREOF
The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for...
2017/0145112 ANTI-FACTOR D ANTIBODIES AND CONJUGATES
The invention provides anti-Factor D antibodies and conjugates and methods of using the same.
2017/0145111 Antibody Substituting for Function of Blood Coagulation Factor VIII
The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F....
2017/0145110 ANTIBODY-ENDOSTATIN FUSION PROTEIN AND ITS VARIANTS
Methods of inhibiting the growth of tumors comprising administering chimeric fusion molecules comprising endostatin mutants and all or a portion of anti-Her2...
2017/0145109 Anti-MCAM Antibodies And Associated Methods Of Use
Described herein are anti-MCAM antibodies and antigen binding fragments thereof that are capable of inhibiting the interaction between MCAM and its ligand, a...
2017/0145108 CHIMERIC ANTIGEN RECEPTORS RECOGNIZING CANCER-SPECIFIC TN GLYCOPEPTIDE VARIANTS
Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope...
2017/0145107 EPITOPES OF EPIDERMAL GROWTH FACTOR RECEPTOR SURFACE ANTIGENAND USE THEREOF
Disclosed are epitopes of the epidermal growth factor receptor (EGFR) and the use thereof. The epitopes are highly preserved, and located in the domain closely...
2017/0145106 Chimeric antigen receptor hCD87-CAR and applications thereof
The present invention relates to a cellular immunotherapy for treatment of tumors, particularly to a peptide of a chimeric antigen receptor hCD87-CAR and the...
2017/0145105 VCAM-1 MEDIATED METHODS AND COMPOSITIONS FOR TREATING AGING-ASSOCIATED IMPAIRMENTS
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing cell surface VCAM-1 activity in...
2017/0145104 ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND USES THEREOF
Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these...
2017/0145103 PREDICTING RESPONSE TO CANCER TREATMENT WITH FGFR2 INHIBITORS
Provided herein are uses of fibroblast growth factor receptor 2 (FGFR2) inhibitors in cancer treatment, in some cases in combination with immune stimulating...
2017/0145102 FGFR2 INHIBITORS ALONE OR IN COMBINATION WITH IMMUNE STIMULATING AGENTS IN CANCER TREATMENT
Provided herein are uses of fibroblast growth factor receptor 2 (FGFR2) inhibitors in cancer treatment, in some cases in combination with immune stimulating...
2017/0145101 Fab FRAGMENT SPECIFICALLY BINDING TO EGFR
The present invention relates to a fragment antigen-binding (Fab) fragment specifically binding to epidermal growth factor receptor (EGFR), an expression...
2017/0145100 METHOD FOR PURIFYING ACTIVE POLYPEPTIDES OR IMMUNOCONJUGATES
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active...
2017/0145099 METHOD FOR REDUCING SIDE EFFECTS OF IMMUNE CHECKPOINT CONTROL AGENT
Disclosed is a means for reducing side effects of an immune checkpoint regulator that is used as an anticancer drug or the like. A side-effect reducing agent...
2017/0145098 ANTI-MGLUR2 CONFORMATIONAL SINGLE DOMAIN ANTIBODIES AND USES THEREOF
The present invention relates to anti-metabotropic glutamate receptor subtype 2 (mGluR2) conformational single do main antibodies and uses thereof in...
2017/0145097 HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR CD22
Disclosed herein are isolated human monoclonal antibodies that specifically bind human CD22 with a dissociation constant (K.sub.d) of 25 nM or less. Nucleic...
2017/0145096 METHODS FOR ACHIEVING THERAPEUTICALLY EFFECTIVE DOSES OF ANTI-CD47 AGENTS
Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically...
2017/0145095 CHIMERIC ANTIGEN RECEPTOR AND ITS USE
In a first aspect, the present invention relates to a recombinant polypeptide containing a domain comprising at least two antibody units whereby the first...
2017/0145094 CD33 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and...
2017/0145093 NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.
2017/0145092 Methods and Agents for the Diagnosis and Treatment of Hepatocellular Carcinoma
The present invention relates to methods of diagnosing and methods of treating hepatocellular carcinoma in a subject. The invention also relates to antagonists...
2017/0145091 COMPOUNDS AND METHODS TO MEASURE METABOLIC FUNCTION AND RESTORE NORMAL METABOLIC FUNCTION
The invention relates to treatment to restore normal metabolic function, including but not limited to normal glucose levels. The invention in one embodiment...
2017/0145090 Human Oncostatin M Antibodies and Methods of Use
Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin...
2017/0145089 ANTI-IL4-IL 13 BISPECIFIC ANTIBODIES
Disclosed herein are safe doses of dual-V-region antibody-like binding proteins or fragments thereof, as well as methods for assessing binding of dual-V-region...
2017/0145088 HUMANIZED ANTIBODIES
The invention relates to novel humanized antibodies derived from the conventional antibody repertoire of species in the family Camelidae.
2017/0145087 FORMULATION OF HUMAN ANTIBODIES FOR TREATING TNF-ALPHA ASSOCIATED DISORDERS
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.
2017/0145086 ANTIBODY MOLECULES TO APRIL AND USES THEREOF
Antibody molecules that specifically bind to APRIL are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as IgA...
2017/0145085 METHOD OF PROMOTING BONE GROWTH BY AN ANTI-ACTRIIA ANTIBODY
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
2017/0145084 ANTIBODY TO GDF8 AND USES THEREOF
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific...
2017/0145083 Phoenixin Peptides
Human phoenixin peptides, analogs and mimetics useful in production of anti-phoenixin antibodies, diagnostic screening and assays, and in modulating cellular...
2017/0145082 PROTEIN-BASED THERAPY AND DIAGNOSIS OF TAU-MEDIATED PATHOLOGY IN ALZHEIMER'S DISEASE
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions...
2017/0145081 EHD2 Antibody and Application Thereof in Preparation of Immunohistochemical Detection Reagent for Breast Cancer
An EHD2 antibody and an application thereof in the preparation of an immunohistochemical detection reagent for breast cancer. The antibody can be used for...
2017/0145080 LIGAND
The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or...
2017/0145079 E. COLI SPECIFIC ANTIBODY SEQUENCES
The invention refers to an isolated antibody that specifically binds to O25b antigen of E. coli strains comprising at least an antibody heavy chain variable...
2017/0145078 ENGINEERED HETERODIMERIC PROTEIN DOMAINS
The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a...
2017/0145077 AN IMPROVED FETAL HEMOGLOBIN FOR GENETIC CORRECTION OF SICKLE CELL DISEASE
Methods and compositions disclosed herein generally relates to methods of determining minimum hematopoietic stem cell (HSC) chimerism and gene dosage for...
2017/0145076 Peptide-Mediated Non-Covalent Delivery of Active Agents Across the Blood-Brain Barrier
The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or...
2017/0145075 MUTANT G-PROTEIN COUPLED RECEPTOR PROTEINS AND METHODS FOR PRODUCING THEM
A method for producing a mutant G-protein coupled receptor (GPCR) with increased stability relative to a parent GPCR, the method comprising making one or more...
2017/0145074 ACTIVIN-ACTRIIA ANTAGONISTS AND USES FOR TREATING OR PREVENTING BREAST CANCER
In certain aspects, the present invention provides compositions and methods for treating or preventing breast cancer in humans.
2017/0145073 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0145072 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0145071 CD80 EXTRACELLULAR DOMAIN POLYPEPTIDES AND THEIR USE IN CANCER TREATMENT
This application relates to CD80 (B7-1) extracellular domain (ECD) polypeptides and CD80-ECD fusion molecules and their use in treatment of cancer, both alone...
2017/0145070 ANTI-HUMAN PAPILLOMAVIRUS 16 E7 T CELL RECEPTORS
Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E7.sub.11-19....
2017/0145069 GLP-1 Derivatives
The invention relates to a derivative of a GLP-1 peptide, which peptide has two Lys residues, namely a first and a second Lys residue, and a maximum of eight...
2017/0145068 NOVEL IFN BETA PROTEIN ANALOGS
The present invention provides a composition comprising an interferon-beta (IFN-beta) protein of which at least 80% is deamidated, a deamidated IFN-beta 1a...
2017/0145067 COMPOSITIONS AND METHODS RELATED TO TAUOPATHY
Disclosed herein are isolated polypeptides, antibody preparations, treatment methods, diagnostic methods, and screening methods related to tauopathy....
2017/0145066 SPLICE VARIANTS OF GDNF AND USES THEREOF
The present invention relates to Glial Cell Line-Derived Neurotrophic Factor (GDNF) protein and gene and is, in particular, directed to a novel splice variant...
2017/0145065 NEW CATH2 DERIVATIVES
The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic...
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