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Patent # Description
2017/0145064 Fusion Protein Suitable for Measurement of Autophagy, Nucleic Acid Encoding Said Fusion Protein, and Use of These
A fusion protein including a LC3 protein which includes a first tag and a protein which includes a second tag.
2017/0145063 MODIFIED BIOTIN, STREPTAVIDIN MUTANT, AND USAGE OF THEM
An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which...
2017/0145062 SERUM HALF-LIFE EXTENSION USING IGBD
The present invention relates to complexes comprising (i) an immunoglobulin (Ig) binding moiety and (ii) a pharmaceutically active moiety, wherein the Ig...
2017/0145061 ENGINEERED BACTEROIDES OUTER MEMBRANE VESICLES
The present disclosure provides, in some aspects, versatile intestinal protein delivery systems deploying engineered human gut commensals of the Bacteroides...
2017/0145060 MEANS AND METHODS FOR BREAKING NONCOVALENT BINDING INTERACTIONS BETWEEN MOLECULES
Described are multimeric proteinaceous molecules comprising at least two members that bind each other via a region of noncovalent interaction, wherein a first...
2017/0145059 Novel Amylin And Calcitonin Receptor Agonist
The present invention relates to peptides comprising an amino acid sequence SEQ ID NO: 1 (EASELSTAALGRLSAELHELATLPRTETGPESP), analogues and derivatives thereof...
2017/0145058 METHOD FOR TARGETED CONJUGATION OF PEPTIDES AND PROTEINS BY PAIRED C2 BRIDGING OF CYSTEINE AMINO ACIDS
The present application relates to a novel process for the targeted conjugation of peptides and proteins which is characterized by the pairwise C2-bridging of...
2017/0145057 ANTIMICROBIAL PEPTIDES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Disclosed herein are novel antimicrobial peptides, pharmaceutical compositions containing the peptides, and methods of use of the peptides to inhibit the...
2017/0145056 Melanocortin-1 Receptor-Specific Linear Peptides
Melanocortin receptor-specific linear peptides of the formula Z-Xaa.sup.1-Xaa.sup.2-Xaa.sup.3-Xaa.sup.4-Xaa.sup.5-Xaa.sup.6-Y (VI) or a pharmaceutically...
2017/0145055 PEPTIDE INHIBITORS OF CASPASE 2 ACTIVATION
The present invention relates to compositions, including membrane permeable complexes, comprising a Caspase 2 activation inhibitory peptide having the amino...
2017/0145054 PROCESS FOR THE PRODUCTION OF A DIPEPTIDE DERIVATIVE
The present invention is related to a novel and improved process for the manufacture of compounds of formula (I) or salts thereof herein designated as...
2017/0145053 CHROMATOGRAPHY MEMBRANES, DEVICES CONTAINING THEM, AND METHODS OF USE THEREOF
Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite...
2017/0145052 PROTEIN RECOVERY
There is provided a process for producing proteins from the by-product streams arising from distillation processes, in particular the by-product stream known...
2017/0145051 CARRIER FOR AFFINITY CHROMATOGRAPHY
Provided is an affinity chromatography carrier that suppresses nonspecific adsorption of impurities, suppresses a decrease in dynamic binding capacity due to...
2017/0145050 CATION-EXCHANGE CHROMATOGRAPHIC SUPPORT AND METHOD FOR USING SAME
The present invention provides a cation-exchange chromatographic support, comprising a membrane matrix and a copolymer immobilized on the surface of the...
2017/0145049 REFOLDING PROTEINS USING A CHEMICALLY CONTROLLED REDOX STATE
A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying...
2017/0145048 ATOM TRANSFER RADICAL POLYMERIZATION UNDER BIOLOGICALLY COMPATIBLE CONDITIONS
Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The...
2017/0145047 DIARYLSULFIDE BACKBONE CONTAINING PHOTOLABILE PROTECTING GROUPS
The present disclosure relates to photoactivable protecting groups containing a diarylsulfide chromophore, a method for the synthesis thereof and their use as...
2017/0145046 6-ETHER/THIOETHER-PURINES AS TOPOISOMERASE II CATALYTIC INHIBITORS AND THEIR USE IN THERAPY
The present invention relates to certain purines of the following formulae, which act as topoisomerase II catalytic inhibitors: wherein: J is independently:...
2017/0145045 URACYL SPIROOXETANE NUCLEOSIDES
The present invention relates to compounds of the formula I: ##STR00001## including any possible stereoisomers thereof, wherein R.sup.9 has the meaning as...
2017/0145044 Prodrugs of a JAK Inhibitor Compound for Treatment of Gastrointestinal Inflammatory Disease
The invention provides compounds which are prodrugs of a JAK inhibitor agent for the targeted delivery of the JAK inhibitor to the gastrointestinal tract of a...
2017/0145043 DEPOLYMERIZATION OF LIGNIN USING METAL INCORPORATED MESOPOROUS SILICATE CATALYSTS
Provided is a process for depolymerizing lignin, the process comprising exposing a liquid feed comprising lignin and a solvent to a metal-incorporated solid...
2017/0145042 CYSTEINE-MODIFYING SUBSTRATE ANALOGUE INHIBITORS OF RIBOSE 5-PHOSPHATE ISOMERASE FOR PARASITIC DISEASES, ALONG...
Compounds are generally provided, along with pharmaceutical compositions including such compounds. Methods are also generally provided for inhibiting ribose...
2017/0145041 METHOD FOR THE SYNTHESIS OF SOLID HETEROGENEOUS CHIRAL CATALYSTS AND THEIR USE IN STEREOSELECTIVE REACTIONS
This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be...
2017/0145040 METHOD OF SELECTIVELY RELEASING NITRIC OXIDE DEPENDING ON CHANGE IN PH USING CALCIUM PHOSPHATE
Provided is a method of controlling release of nitric oxide, and more particularly, to a method of selectively releasing nitric oxide depending on a change in...
2017/0145039 FLUORINE-CONTAINING SILANE COMPOUND
A novel fluorine-containing silane compound is provided. The fluorine-containing silane compound is capable of providing excellent water repellency and oil...
2017/0145038 SUBSTITUTED ASYMMETRIC UREAS AND MEDICAL USES THEREOF
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin...
2017/0145037 ORALLY BIOAVAILABLE BETA-LACTAMASE INHIBITORS
Described herein are compounds and compositions that modulate the activity of beta-lactamases and methods thereof. In some embodiments, the compounds described...
2017/0145036 Metalloboranes for High Density Hydrogen Storage
Provided herein are the metalloborane compounds, MOF-metalloborane compositions, and hydrogen storage system used for high density hydrogen storage. The...
2017/0145035 SYNTHESIS AND COMPOSITION OF PHOTODYNAMIC THERAPEUTIC AGENTS FOR THE TARGETED TREATMENT OF CANCER
The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to...
2017/0145034 ALKYNYL ALCOHOLS AND METHODS OF USE
The invention relates to compounds of Formula (0): ##STR00001## wherein Q, A.sup.1-A.sup.8, R.sup.4 and R.sup.5 and each has the meaning as described herein....
2017/0145033 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a...
2017/0145032 HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE
The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT.sub.2) receptor. More particularly the invention...
2017/0145031 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. ...
2017/0145030 POLYMER COMPOUND AND ORGANIC SEMICONDUCTOR DEVICE USING THE SAME
A polymer compound comprising a structural unit represented by the formula (1): ##STR00001## wherein a ring A and a ring B represent a heterocyclic ring....
2017/0145029 CYCLIC THIENOURACIL-CARBOXAMIDES AND USE THEREOF
The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives ("thienouracil"-carboxamides), to...
2017/0145028 ACC INHIBITORS AND USES THEREOF
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
2017/0145027 ANTIVIRAL COMPOUNDS
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
2017/0145026 EIF4A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer,...
2017/0145025 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I'), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2017/0145024 PROCESS FOR OBTAINING OPTICALLY ACTIVE PIRLINDOLE ENANTIOMERS AND SALTS THEREOF
The present invention provides a new process for obtaining optically active pirlindole enantiomers, in the form of a free base or in the form of...
2017/0145023 DIAZEPANE DERIVATIVES AND USES THEREOF
The present disclosure provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) have been found to bind...
2017/0145022 Imidazopyridazine Compounds
The present invention is directed to compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the substituents R.sup.1,...
2017/0145021 NOVEL COMPOUNDS
Benzodiazepine compounds of formula (I) ##STR00001## and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
2017/0145020 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF
Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
2017/0145019 2-(2-AMINOCYCLOHEXYL)AMINO-PYRIMIDINE-5-CARBOXAMIDES AS SPLEEN TYROSINE KINASE(SYK) INHIBITORS
The present invention relates to compounds of formula (Ia), (Ib) or (Ic): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable...
2017/0145018 COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK
This invention relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants.
2017/0145017 PROCESS FOR PREPARING IBRUTINIB AND ITS INTERMEDIATES
The present invention provides efficient, economical, and improved methods for synthesizing ibrutinib and intermediates thereof. The invention involves a...
2017/0145016 NOVEL TRIAZOLOPYRIMIDINONE OR TRIAZOLOPYRIDINONE DERIVATIVES, AND USE THEREOF
The present invention relates to a novel triazolopyrimidinone or triazolopyridinone derivative, a tautomer thereof, a stereoisomer thereof and their mixture,...
2017/0145015 (R)-PIRLINDOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
(R)-pirlindole or its pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising the same for use in the therapeutic treatment and...
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