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Patent # Description
2017/0143852 LIBRARY OF PH RESPONSIVE POLYMERS AND NANOPROBES THEREOF
The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a...
2017/0143851 IMAGING AGENTS FOR IMAGING PROTEASE ACTIVITY AND USES THEREOF
Disclosed are imaging agents having the following Formula I: ##STR00001## wherein F is a near infrared fluorophore, S is an enzymatically cleavable oligopeptide,...
2017/0143850 APPLICATION OF GPR45 GENE
The present invention relates to the field of biotechnology, in particular to application of a GPR45 gene. The present invention discloses, for the first time,...
2017/0143849 NON-DIFFUSIVE BOTULINUM TOXIN CAUSING LOCAL MUSCLE PARALYSIS, AND PURIFICATION METHOD THEREOF
The present invention relates to a method for purifying a non-spreading botulinum toxin that causes local muscle paralysis and a non-spreading botulinum toxin...
2017/0143848 MRNA THERAPY FOR THE TREATMENT OF OCULAR DISEASES
The present invention provides, among other things, a method of ocular delivery of messenger RNA (mRNA), comprising administering into an eye of a subject in...
2017/0143847 MODIFIED HUMAN U1SNRNA MOLECULE, A GENE ENCODING FOR THE MODIFIED HUMAN U1SNRNA MOLECULE, AN EXPRESSION VECTOR...
The invention provides a modified human U1snRNA molecule, capable of correcting the skipping of an exon caused by a mutation localized in the sequence...
2017/0143846 TARGETED PYRROLOBENZODIAZAPINE CONJUGATES
Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
2017/0143845 ACETYLENEDICARBOXYL LINKERS AND THEIR USES IN SPECIFIC CONJUGATION OF A CELL-BINDING MOLECULE
Cell binding agent-drug conjugates comprising bridge linkers, and methods of using such linkers and conjugates are provided.
2017/0143844 Composition and Methods of Use of Nano Anti-Radical Therapeutics To Inhibit Cancer
This invention relates to the compositions and methods of use of macromolecular nitroxide as a nano anti-radical therapy (NanoART) to compliment current...
2017/0143843 ANTI-FACTOR D ANTIBODY VARIANT CONJUGATES AND USES THEREOF
The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation...
2017/0143842 COMPOUNDS FOR TREATING BIOFILM INFECTION
In some aspects, pegylated aminoglycoside compounds are provided. In some embodiments, m-PEG-tobramycin compounds may be used to treat a biofilm infection or...
2017/0143841 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS
The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such...
2017/0143840 BIO-ORTHOGONAL DRUG ACTIVATION
The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal...
2017/0143839 Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydromorphone, Prodrugs,...
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone ...
2017/0143838 CHARACTERIZATION OF THE COCRYSTAL PRODUCTS FORMED BY METOPROLOL AND DABIGATRAN BASES WITH L-THEANINE
Cocrystal compositions of metoprolol and dabigatran bases with enantiomers of theanine.
2017/0143837 COMPOSITION FOR SKIN PENETRATION, CONTAINING CATIONIC MOLECULE TRANSPORTER AND ANIONIC BIOACTIVE MATERIAL
The present invention relates to a composition for skin penetration, wherein the composition contains an ion conjugate in which a cationic compound is...
2017/0143836 UNIQUE DUAL-ACTION THERAPEUTICS
A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate...
2017/0143835 SUBSTITUTED ANIONIC COMPOUNDS CONSISTING OF A BACKBONE MADE UP OF A DISCRETE NUMBER OF SACCHARIDE UNITS
The invention relates to substituted anionic compounds consisting of a backbone made up of a discrete number u of between 1 and 8 (1.ltoreq.u.ltoreq.8) of...
2017/0143834 FORMULATION FOR HGH AND RHIGF-1 COMBINATION
Pharmaceutical compositions, in particular, compositions comprising growth hormone (GH) and insulin-like growth factor (IGF-1) which are stable at a desirable...
2017/0143833 PRODUCTION OF THERMOREVERSIBLE HYDROGELS FOR THERAPEUTIC APPLICATIONS
A method is disclosed for production of a sterile thermoreversible hydrogel characterized by a known temperature T.sub.min at which the viscosity reaches at...
2017/0143832 SEMIFLUORINATED ALKANE COMPOSITIONS
The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be...
2017/0143831 IN VIVO LIVE 3D PRINTING OF REGENERATIVE BONE HEALING SCAFFOLDS FOR RAPID FRACTURE HEALING
Bio-Inks and methods of using compositions comprising the bio-Inks are disclosed. 3-D tissue repair and regeneration through precise and specific formation of...
2017/0143830 Cellular Micromotors and Uses Thereof
Living cells, such as red blood cells (RBCs) modified with functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide...
2017/0143829 METAL-ASSISTED AND MICROWAVE-ACCELERATED DECRYSTALLIZATION
In this study, we demonstrated a unique application of our Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD) technique for the ...
2017/0143828 PROTEIN FORMULATIONS AND METHODS OF MAKING SAME
The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a...
2017/0143827 COMPOSITIONS COMPRISING A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND ANOTHER ANTIBODY
This provides pharmaceutical compositions that comprise a combination of an anti-cancer agent which is an first antibody and a second antibody. In some...
2017/0143826 ANTI-ANGIOGENESIS THERAPY FOR THE TREATMENT OF OVARIAN CANCER
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the...
2017/0143825 METHODS OF TREATING CANCER USING TIGIT INHIBITORS AND ANTI-CANCER AGENTS
The present disclosure provides methods comprising administering to the individual an effective amount of an agent that decreases or inhibits TIGIT expression...
2017/0143824 RITUXIMAB INDUCTION THERAPY FOLLOWED BY GLATIRAMER ACETATE THERAPY
The present invention provides a method of treating a subject afflicted with a form of multiple sclerosis or presenting a clinically isolated syndrome...
2017/0143823 NOVEL MUCOSAL ADJUVANTS AND DELIVERY SYSTEMS
Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of...
2017/0143822 ANTIGEN-LOADED CHITOSAN NANOPARTICLES FOR IMMUNOTHERAPY
The present invention is directed to nanoparticles comprising chitosan and an antigen, whereby the chitosan has a degree of deacetylation of about 90% and a...
2017/0143821 MULTIVALENT GLYCOCONJUGATE VACCINES
The present invention refers to new conjugate antigens expressing built-in multiple epitopes and to polyvalent glycoconjugate vaccines and formulations...
2017/0143820 IMMUNOGENIC COMBINATIONS
Immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic...
2017/0143819 FMDV and E2 Fusion Proteins and Uses Thereof
The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The...
2017/0143818 INTRADERMAL HPV PEPTIDE VACCINATION
The invention relates to the use of a peptide derived from HPV-E2, -E6 and/or E7 protein for the manufacture of a medicament for the treatment or prevention of...
2017/0143817 DENGUE VIRUS VACCINE
Recombinant fusion proteins including a dengue virus EIII and an E2 subunit derived from a thermophilic bacterium are described. Also described are expression...
2017/0143816 MUTANT STAPHYLOCOCCAL ANTIGENS
Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fc.gamma. portion of human IgG is provided.
2017/0143815 IMMUNOMODULATORY MINICELLS AND METHODS OF USE
The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
2017/0143814 IMMUNOTHERAPY USING CELL-TARGETING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT EFFECTORS AND CD8+ T-CELL EPITOPES
The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of the cell. The...
2017/0143813 METHODS AND MATERIALS FOR TREATING CANCER
This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that...
2017/0143812 EXOSOME MEDIATED INNATE AND ADAPTIVE IMMUNE STIMULATION FOR TREATMENT OF CANCER
Disclosed are means of stimulating innate and/or adaptive immunity to cancer by administration of exosomes. Stimulation of innate immunity involves modifying...
2017/0143811 METHOD OF TREATING MELANOMA
The present invention relates to a method of treating or preventing melanoma using vaccination or immunisation, wherein said vaccination or immunisation...
2017/0143810 IMMUNOGENIC GLYCOPEPTIDES, COMPOSITION COMPRISING THE GLYCOPEPTIDES AND USE THEREOF
Disclosed herein are an immunogenic glycopeptide for inducing immune response to treat cancer. Other aspects of the present disclosure are pharmaceutical...
2017/0143809 CMV VECTORS COMPRISING MICRORNA RECOGNITION ELEMENTS
Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the...
2017/0143808 BOTULINUM TOXIN FOR USE IN THE TREATMENT OF PARATONIA
The present invention relates to botulinum toxins for use in the treatment of paratonia. In particular, the present invention relates to the treatment of...
2017/0143807 Botulinum Toxin and the Treatment of Primary Disorders of Mood and Affect
The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and CNS disorders...
2017/0143806 Anti-Inflammatory Peptides and Composition Comprising the Same
A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned...
2017/0143805 METHOD OF PURIFYING THERAPEUTIC PROTEINS
The present invention relates generally to a method of reducing the level of at least one protein selected from the group consisting of plasminogen, tissue...
2017/0143804 Use of Ultrarapid Acting Insulin
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial...
2017/0143803 MODIFICATION OF PHARMACEUTICAL PREPARATIONS TO MAKE THEM MORE CONDUCIVE TO ULTRASONIC TRANSDERMAL DELIVERY
A method for improving the ultrasonic transdermal delivery of an drug by modifying the excipient solution to which an active ingredient is intermixed in a drug...
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