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Patent # Description
2017/0143751 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a...
2017/0143750 Treatment Regimen Tiacumicin Compound
A tiacumicin compound, a stereo-isomer thereof, a polymorph thereof or a pharmaceutically acceptable solvate thereof, and a pharmaceutical composition,...
2017/0143749 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such...
2017/0143748 ANTI-TUMOR PHARMACEUTICAL APPLICATION OF PENTACYCLIC TRITERPENE SAPONIN COMPOUNDS OF SZECHUAN MELANDIUM ROOT
The invention provides compounds of structural formula I or a salt thereof, and total saponins comprising such compounds in the preparation of anti-tumor...
2017/0143747 COMPOSITIONS FOR ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING LOW BACK PAIN
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid in an acid or a salt form, can be used to treat or alleviate pain or related conditions,...
2017/0143746 PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Compounds of formula (I): ##STR00001## wherein X, Y, A.sub.1, A.sub.2, R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.3, R.sub.4, T and R.sub.5 are as defined in the...
2017/0143745 INHIBITION OF HIV INFECTION THROUGH CHEMOPROPHYLAXIS
A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by...
2017/0143744 STABLE LIQUID FORMULATIONS OF CYCLOPHOSPHAMIDE AND PROCESSES TO PREPARE THE SAME
The present invention relates to stable liquid pharmaceutical formulations of cyclophosphamide comprising cyclophosphamide and at least one pharmaceutically...
2017/0143743 FORMULATION FOR ORAL ADMINISTRATION CONTAINING MESALAZINE
The present invention relates to a formulation containing Mesalazine in a stable form, obtained by coating the starting core with a first membrane in...
2017/0143742 BERBERINE-URSODEOXYCHOLIC ACID CONJUGATE FOR TREATING THE LIVER
The present invention is a method and compound for treating specific cancerous cell lines. The invention treats liver cancer by directing a cancer-fighting...
2017/0143741 Controlled Release and Taste Masking Oral Pharmaceutical Compositions
The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least...
2017/0143740 ANESTHETIC FORMULATION
The present invention relates to compositions and methods for pain reduction, including but not limited to, peripheral nerve blocks.
2017/0143739 PHARMACEUTICAL COMPOSITION OR GROUP OF COMPOSITIONS FOR INHIBITING AUTOCRINE HCG PRODUCTION IN ADULT HUMAN CELLS
A pharmaceutical composition for use as medicament that inhibits autocrine Human Chorionic Gonadotropin (HCG) production and thus carcinogenesis in adult human...
2017/0143738 SOLID FORMULATION AND METHOD FOR STABILIZING THE SAME
The present invention relates to stabilization of a certain benzothia(dia)zepine derivative in a solid formulation containing the same. In the present...
2017/0143737 COMBINATION THERAPY OF TETRACYCLIC QUINOLONE ANALOGS FOR TREATING CANCER
The present invention provides methods, compositions, and combinations for treating cancer via combined use of a compound of formula I or a pharmaceutically...
2017/0143736 METHODS OF TREATMENT OF PARTIAL ONSET SEIZURES USING ESLICARBAZEPINE ACETATE.
The present disclosure relates to the treatment of various diseases and conditions with eslicarbazepine acetate. The present disclosure also relates to the use...
2017/0143735 METHODS FOR TREATING, DIAGNOSING AND PROGNOSING A HAEMATOLOGICAL MALIGNANCY
The invention relates to a serotonin receptor (5-HTR) inhibitor selected from the group consisting of a type 1 5-HTR inhibitor and a type 2 5-HTR inhibitor for...
2017/0143734 PRODRUGS OF METOPIMAZINE
Provided herein are methods, compounds, compositions, and kits for the treatment of an enteric nervous system disorder. Such methods may comprise administering...
2017/0143733 COMPOUNDS AND METHODS FOR SKIN REPAIR
The disclosure provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one mixed...
2017/0143732 SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
Provided are immediate or prolonged administration of certain salts of K.sub.ATP channel openers such as diazoxide to a subject to achieve novel ...
2017/0143731 NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
2017/0143730 Imidazopyridine Compounds and Uses Thereof
This invention generally relates to substituted imidazopyridine compounds, particularly substituted 4-(imidazo[1,2-a]pyridin-2-yl)benzamide compounds and salts...
2017/0143729 SALT FORM OF A HUMAN HISTONE METHYLTRANSFERASE EZH2 INHIBITOR
Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl (tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-bip- ...
2017/0143728 METHOD OF TREATING CONDITIONS WITH KINASE INHIBITORS
The present invention relates to a method of treating ophthalmic diseases and conditions, e.g. diabetic retinopathy, age-related macular degeneration,...
2017/0143727 USE OF CINNABARINIC ACID AS A MODULATOR OF IMMUNE RESPONSE IN AUTOIMMUNE DISORDERS
The present invention provides compounds and methods for preventing and treating an immune disorder in a subject.
2017/0143726 ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS TO MODULATE T CELL RESPONSES
Described are uses of A.sub.2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A.sub.2a receptor antagonists...
2017/0143725 COMBINATION COMPRISING AN ATP ANALOG AND AN ADENOSINE RECEPTOR ANTAGONIST OR A NUCLEOBASE NUCLEOSIDE ANALOG FOR...
A method for treating an ATP analog-induced side effect in a subject comprises administering an effective amount of an adenosine receptor antagonist to the...
2017/0143724 THEOBROMINE OR ITS DERIVATIVES FOR THE TREATMENT OR PREVENTION OF RENAL LITHIASIS
The present invention refers to the use of theobromine or its derivatives as an inhibitor of the crystallisation of uric acid to avoid the formation of uric...
2017/0143723 PHARMACEUTICAL COMBINATIONS
The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely ...
2017/0143722 SUBSTITUTED PYRROLIDINES AS ROS TYROSINE KINASE INHIBITORS
The main purpose of the invention is to provide a novel aromatic heterocyclic derivative or a pharmaceutically acceptable salt thereof. Examples of the...
2017/0143721 COMPOSITIONS AND METHODS INVOLVING POLYMER, SOLVENT, AND HIGH VISCOSITY LIQUID CARRIER MATERIAL
Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent....
2017/0143720 CALCIUM FOLATE (CAFOLATE) AND THERAPEUTIC METHODS BASED THEREON
Disclosed herein are methods for the treatment of cancer and inflammatory-based diseases and disorders, such as hepatitis B virus infection, tuberculosis and...
2017/0143719 STABLE FORMULATION OF PHENOBARBITAL SODIUM INJECTION
Stable phenobarbital sodium solutions for injection that do not generate impurities during extended storage. These solutions include phenobarbital sodium in an...
2017/0143718 PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH...
Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic...
2017/0143717 ANTI-TUMOR USE OF ANAGRELIDE AND DERIVATIVES THEREOF
The present invention provides an anti-tumor use of Anagrelide and derivatives thereof and, more specifically, the present invention provides the use of...
2017/0143716 METHOD OF TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY BCR-ABL, C-KIT, DDR1,...
The present invention relates to a regimen for the administration of a pyrimidyl-aminobenzamide of formula 1 as defined herein for the treatment of...
2017/0143715 PHARMACEUTICAL COMPOSITIONS
The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the...
2017/0143714 Pharmaceutical composition for preventing or treating of cirrhosis of liver comprising G protein coupled...
Provided is a pharmaceutical composition for preventing or treating liver fibrosis, comprising a GPR119 ligand as an active ingredient. The composition...
2017/0143713 MACROCYCLIC PYRIDAZINONE DERIVATIVES
A compound of formula (I) is provided: ##STR00001## wherein R1, R2, R3, R4, L and Z have the meaning given in the claims. Further provided is the prophylaxis and...
2017/0143712 Methods of Treating Cancers, Immune and Autoimmune Diseases, and Inflammatory Diseases Based on BTK Occupancy...
In an embodiment, therapeutic methods and uses of Bruton's Tyrosine Kinase (BTK) inhibitors for treatment of cancer, inflammation, immune disorders, and...
2017/0143711 NOVEL USES
This invention relates to the new use of the compound (I) or pharmaceutically acceptable salts thereof and pharmaceutical compositions containing it for the...
2017/0143710 PHARMACEUTICALLY ACCEPTABLE SALTS OF PIRLINDOLE ENANTIOMERS FOR USE IN MEDICINE
The present invention provides pharmaceutically acceptable salts of enantiomerically pure (R)-pirlindole and (S)-pirlindole compounds having an increased...
2017/0143709 (S)-PIRLINDOLE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR USE IN MEDICINE
(S)-pirlindole or its pharmaceutically acceptable salts, as well as pharmaceutical compositions comprising the same for use in the therapeutic treatment and...
2017/0143708 COMPOUNDS, COMPOSITIONS AND METHODS OF AGELASTATIN ALKALOIDS
The present invention, among other things, provides compounds, compositions and methods for treatment of cancer. In some embodiments, the present invention...
2017/0143707 SYNERGISTIC CLOFAZIMINE/METRONIDAZOLE COMBINATION FOR TREATING CLOSTRIDIUM DIFFICILE
Methods for treating a subject infected with Clostridium difficile comprises administering to the subject a synergistic combination of clofazimine and...
2017/0143706 SELECTIVE KINASE INHIBITORS
The present disclosure relates to methods of modulating (for example, inhibiting) activity of JAK3, comprising contacting the JAK3 with a compound of Formula I...
2017/0143705 PYRAZINE DERIVATIVES AS ENAC BLOCKERS
Compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6,...
2017/0143704 CANNABINOID RECEPTOR MODULATORS
Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that...
2017/0143703 TOXIC RNA INHIBITORS SELF-ASSEMBLED IN SITU
Potent modulators of RNA function can be assembled in cellulo by using the cell as a reaction vessel and a disease-causing RNA as a catalyst. When designing...
2017/0143702 Treatment of Motor Neuronopathies
The invention relates to a calcium channel blocker selected from the group of the calcium channel blockers of the phenylalkylamine family, the calcium channel...
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