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Patent # Description
2017/0183391 Stabilized Receptor Polypeptides and Uses Thereof
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A,...
2017/0183390 MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF
Described herein are modified integrin .alpha. and/or .beta. headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified...
2017/0183389 METHOD FOR IMPROVING PROTEIN EXPRESSION, AND COMPOSITION FOR PROTEIN EXPRESSION
The present invention provides a method for improving protein expression and a composition for protein expression. The composition is a composition for use in...
2017/0183388 METHODS, COMPOSITIONS, DIAGNOSTICS AND ASSAYS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
The invention provides compounds for the treatment of Alzheimer's disease, methods for the use of such compounds, assays for the identification of such...
2017/0183387 METHODS AND COMPOSITIONS FOR SUPPRESSING RETROVIRUSES
The disclosure provides methods and compositions for suppressing retroviruses, including novel methods for treating a retroviral infection in a human in need...
2017/0183386 PEPTIDES, AND USES THEREOF
A composition comprising a plurality of bioactive peptides including SEQUENCE ID NO's 555 and 701 is described. The composition may be a powder that is...
2017/0183384 FACTOR H BINDING PROTEIN VARIANTS AND METHODS OF USE THEREOF
Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising...
2017/0183383 OXYNTOMODULIN ANALOGUE
Provided is an oxyntomodulin analogue. The analogue comprises GCGR and GLP-1R dual agonist activity, improved enzymolysis stability and biological activity,...
2017/0183382 Process for the Preparation of Cyclic Depsipeptides
Processes for preparing compounds of Formula (1) and Formula (2) are described, wherein X, Y, Z, R.sub.1-R.sub.7, L and n are defined herein. Intermediates...
2017/0183381 NOVEL PEPTIDES FOR PREVENTING OR TREATING BONE DISEASES AND USE THEREOF
The present disclosure relates to a novel peptide for preventing or treating bone diseases. Further, the present disclosure relates to a polynucleotide...
2017/0183380 CANCER TARGETING BY ANTI-EGFR PEPTIDES AND APPLICATIONS THEREOF
A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth...
2017/0183379 Drug Delivery Enhancement Agents
A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions,...
2017/0183378 TRAPPING REAGENTS FOR REACTIVE METABOLITES SCREENING
The present invention provides compounds of Formula (I) and (II): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.4, R.sup.5, R.sup.6, X and n are as defined...
2017/0183377 Continuous System and Process for Treating a Low-Water Biomass Stream with Liquefied-Gas Solvent to Separate...
A method and system for the treatment of a biomass stream to separate organic extracts/biomolecules (such as proteins, lipids and/or carotenoids) from the...
2017/0183376 METHODS OF PURIFYING ANTIBODIES
Methods of purifying an antibody (Ab) from a mixture comprising impurities are disclosed. One method comprises: (a) purifying the Ab using an affinity resin;...
2017/0183375 USE OF A TETRAPHENYLBORATE (TPB) SALT FOR THE SEPARATION OF BIOMOLECULES
Process for the separation of a biomolecule containing at least one cationic group from a liquid medium containing said biomolecule, which comprises the use of...
2017/0183374 Methods of Constructing and Screening Libraries of Peptide Structures
The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming...
2017/0183373 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYERMASE
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds...
2017/0183371 METHOD FOR PRODUCING SUCROSE FATTY ACID ESTER
The present invention provides a method for producing a sucrose fatty acid ester having high monoester selectivity, the method for producing a sucrose fatty...
2017/0183370 TRANSITION METAL COMPOUND HAVING HETEROATOM, CATALYST COMPOSITION INCLUDING THE SAME AND PREPARATION METHOD OF...
The present invention discloses a transition metal compound including a heteroatom and having a novel structure, a catalyst composition including the same, and...
2017/0183369 CATALYSTS AND METHODS FOR POLYMER SYNTHESIS
The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are...
2017/0183368 Organometallic Complex, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device
A novel light-emitting material is provided. A novel orgnometallic complex is provided. An orgnometallic complex having a high carrier-transport property is...
2017/0183367 Metal Complexes, Comprising Carbene Ligands Having an O-Substituted Non-Cyclometalated Aryl Group and Their Use...
Cyclometallated Ir complex comprising three N,N diaryl substituted carbene ligands, bearing substituents in the 2 position of the non-cyclometallated aryl...
2017/0183366 PHOSPHAZENE COMPOUND, AND A COMPOSITION, A PREPREG AND A WIRING BOARD COMPRISING THE SAME
The present invention relates to a phosphazene compound and a composite metal laminate. The phosphazene compound with a partial structure of carboxylic esters...
2017/0183365 MACROCYCLES
The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
2017/0183364 SYNTHETIC BLEND F-POSS COMPOSITIONS FORMED FROM MULTIPLE FEEDSTOCK MATERIALS
The present disclosure relates, in exemplary embodiments, to compositions of matter comprising synthetic blends of at least two feedstocks that produce a...
2017/0183363 Silanol Compound, Composition, and Method for Producing Silanol Compound
The purpose of the present invention is to provide silanol compounds that can be used as raw materials of siloxane compounds and the like, and a composition of...
2017/0183362 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS
Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2017/0183360 BICARBAZOLE COMPOUND, MATERIAL FOR ORGANIC LIGHT-EMITTING DEVICE INCLUDING BICARBAZOLE COMPOUND, AND ORGANIC...
A bicarbazole compound represented by Formula 1: [Ar.sub.1].sub.n1-(L.sub.1).sub.a1-[Ar.sub.2].sub.n2 Formula 1 wherein in Formula 1, a1, Ar.sub.1, Ar.sub.2,...
2017/0183359 COMPOUND HAVING AGONISTIC ACTIVITY ON SOMATOSTATIN RECEPTOR, AND USE THEREOF FOR MEDICAL PURPOSES
Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): ##STR00001## ...
2017/0183358 BICYCLIC PYRAZOLONE COMPOUNDS AND METHODS OF USE
The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases,...
2017/0183357 BIOACTIVE COMPOUNDS
The invention relates to novel bioactive polycyclic ether compounds comprising a spiro-linked five-membered cyclic imine. In particular, the invention relates...
2017/0183356 New Imaging Agents and Methods of Identifying Same
The present invention includes a novel method capable of identifying a compound as an imaging agent using a DAZAX-based scaffold or derivative thereof. The...
2017/0183355 INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers,...
2017/0183354 SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
The invention provides substituted pyrazolol1,5-alpyrimidine and related organic compounds, compositions containing such compounds, medical kits, and methods...
2017/0183353 N-HYDROXY BICYCLIC HYDANTOIN CARBAMATES AS TOOLS FOR INDETIFICATION OF SERINE HYDROLASE TARGETS
Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions...
2017/0183352 PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES
The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment...
2017/0183350 ORGANIC COMPOUNDS
The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or...
2017/0183349 BIISOQUINOLINE COMPOUNDS AND METHODS OF TREATMENT
The instant invention describes biisoquinoline compounds having therapeutic activity, and methods of treating dis-orders such as cancer, tumors and cell...
2017/0183348 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK
The present invention relates to compounds of formula I: ##STR00001## in which n, R.sub.1, R.sub.2, R.sub.3a, R.sub.4 and R.sub.5 are defined in the Summary of...
2017/0183347 NOVEL ANXIOLYTIC COMPOUNDS
The present invention relates to chemical compounds of general formula (I) ##STR00001## which may possess useful therapeutic activity in a range of central ...
2017/0183346 SYNTHETIC METHODS FOR PREPARATION OF ...
Provided herein are processes for the preparation of (S)-(2R,3R,11bR-3-isobuty-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrid- o[2,1-a]isoquinolin-2-yl...
2017/0183345 KINASE INHIBITORS
Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the...
2017/0183344 KINASE INHIBITORS
Compounds of formulae (I), (II), and (III), defined herein, are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia,...
2017/0183343 KINASE INHIBITORS
Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the...
2017/0183342 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine...
2017/0183341 Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione derivatives
The invention relates to compound of the formula (I) or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to...
2017/0183340 BIARYL KINASE INHIBITORS
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
2017/0183338 PIPERIDIN-1 -YL AND AZEPIN-1 -YL CARBOXYLATES AS MUSCARINIC M4 RECEPTOR AGONISTS
The present invention provides muscarinic M4 receptor agonists of formula (I) and pharmaceutically acceptable salts thereof, wherein m, n, p, q, R, R.sup.2 and...
2017/0183337 TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF
The disclosure relates to Compounds of Formula (I) ##STR00001## and pharmaceutically acceptable derivatives thereof, where R.sub.1, R.sub.4, R.sub.8, R.sub.9,...
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