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Patent # Description
2017/0182059 IBAT Inhibitors for the Treatment of Liver Disease
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions...
2017/0182058 TREATMENT OF RETT SYNDROME
Rett syndrome (RTT), a childhood neurological disorder that affects primarily females, may be treated by use of a galanthamine analog wherein the hydroxy group...
2017/0182057 THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS
A method for treating diseases mediated by a P2X.sub.3 and/or a P2X.sub.2/3 receptor with compounds of the formula I: ##STR00001## or a pharmaceutically...
2017/0182056 QUINOLINYL MODULATORS OF RORyt
The present invention comprises compounds of Formula I. ##STR00001## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9...
2017/0182055 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer...
2017/0182054 HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF
The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for...
2017/0182053 TETRAHYDROPYRANYL AMINO-PYRROLOPYRIMIDINONE AND METHODS OF USE THEREOF
The application relates to a compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite,...
2017/0182052 THERAPEUTIC THIOPHENE-, FURAN-, AND PYRIDINE-FUSED AZOLOPYRIMIDIN-5-(6H)-ONES
Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and...
2017/0182051 SMALL MOLECULE NF-kB INHIBITORS
The present invention provides, inter alia, compounds capable of inhibiting NF-.kappa.B. Pharmaceutical compositions containing and methods of using the...
2017/0182050 DIFLUOROMETHOXY COMPOUND WITH LOW BIOACTIVATION POTENTIAL FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION
The compound N2-(3-(difluoromethoxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fl- ...
2017/0182049 NOVEL THERAPEUTICS FOR BRAIN CANCER
Provided herein are novel compositions and methods to inhibit Olig2 activity. The Olig2 inhibitors and methods of using the same are useful, inter alia, for...
2017/0182047 Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof
Provided herein are methods and compounds for post-translational regulation of cytochrome P450 46A1 (CYP46A1) enzyme activity in the brain and retina. Also, a...
2017/0182046 THERAPEUTIC COMPOUNDS
The invention provides compounds of formulae I, II, III, and IV: ##STR00001## and salts thereof, as well as pharmaceutical compositions comprising such ...
2017/0182045 Novel Phtalazinone Derivatives and Manufacturing Process Thereof
The present invent ion relates to phthalazinone derivatives, including pharmaceutical compositions and for the preparation of phthalazinone derivatives. And...
2017/0182044 TREATMENT OF CANCER WITH DIHYDROPYRAZINO-PYRAZINES
Provided herein are methods for treating or preventing glioblastoma multiforme (GBM) characterized by O6-methylguanine-DNA methyltransferase (MGMT) expression...
2017/0182043 Anti-Neoplastic Combinations and Dosing Regimens using CDK4/6 Inhibitor Compounds to Treat RB-Positive Tumors
This invention directed to methods for treating select RB-positive cancers and other Rb-positive abnormal cellular proliferative disorders using CDK4/6...
2017/0182042 PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-- ...
Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-- 3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one,...
2017/0182041 COMPOSITION FOR REDUCING NERVOUS SYSTEM INJURY AND METHOD OF MAKING AND USE THEREOF
This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system...
2017/0182040 EPITHELIAL ION CHANNEL (ENAC) BLOCKERS TO TREAT PSORIASIS
Methods of treatment for psoriasis, and compositions for use in such methods are provided. An effective dose of an epithelial ion channel (ENAC) blocker is...
2017/0182039 INHIBITOR OF p38 MAP KINASE
A dry powder pharmaceutical formulation for inhalation including a compound of formula (I): ##STR00001## that is...
2017/0182038 AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS
The present invention provides a compound of Formula (I) or a salt thereof; ##STR00001## and therapeutic uses of these compounds. The present invention further ...
2017/0182037 POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE
The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine- ,...
2017/0182036 SOLUTION FOR ORAL ADMINISTRATION
Provided is a solution suitable for oral administration of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one (compound (I)) or a salt...
2017/0182035 OPHTHALMIC FORMULATIONS OF CETIRIZINE AND METHODS OF USE
The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in...
2017/0182034 Pharmaceutical Composition Of Vortioxetine Hydrobromide Comprising Vortioxetine Hydrobromide In A Polyethylene...
The present invention relates to a solid oral pharmaceutical composition comprising vortioxetine hydrobromide in a matrix formed from at least one polyethylene...
2017/0182033 PHARMACEUTICAL COMPOSITIONS FOR EXTENDED RELEASE OF OXYCODONE AND ACETAMINOPHEN RESULTING IN A QUICK ONSET AND...
The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of...
2017/0182032 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIOIDS AND OTHER DRUGS
An abuse-deterrent pharmaceutical composition has been developed to reduce the likelihood of improper administration of drugs, especially drugs such as...
2017/0182031 REDUCING DRUG LIKING IN A SUBJECT
There is described a method of reducing drug liking a subject comprising the step of administering to the subject an oral pharmaceutical composition...
2017/0182030 COMPOUNDS AND ANTI-TUMOR NQO1 SUBSTRATES
Compositions comprising Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compositions are useful for the management,...
2017/0182029 NOVEL SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical...
2017/0182028 PHARMACEUTICAL COMPOSITIONS COMPRISING 7-(1H-IMIDAZOL-4-YLMETHYL)-5,6,7,8-TETRAHYDRO-QUINOLINE FOR TREATING...
The present invention relates to a method for treating skin diseases and skin conditions in a patient in need thereof which comprises of administering a...
2017/0182027 METHOD FOR TREATING TUMOUR, PHARMACEUTICAL COMPOSITION AND MEDICINAL KIT
The present invention provides 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinolin-7-yl]oxy]me- thyl]cyclopro-pylamine used for combating a tumor....
2017/0182026 Anti-Metastasis Treatment of Melanoma
The present invention provides medicaments and methods for the treatment of melanoma. Disclosed herein are methods and uses for preventing melanoma, reducing...
2017/0182025 BROMODOMAIN AND EXTRA-TERMINAL PROTEIN INHIBITOR COMBINATION THERAPY
The present disclosure relates generally to compositions and methods of treating cancers, such as glioblastoma and non-Hodgkin's lymphomas, or other cancers in...
2017/0182024 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PARKINSON'S DISEASE
Disclosed is a pharmaceutical composition comprising i) a dopamine agonist and ii) a L-DOPA derivative in combination in form of a liquid preparation. The...
2017/0182022 THIO COMPOUNDS
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: ##STR00001## wherein A, B and D are each oxygen or sulfur, provided...
2017/0182021 COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS
Provided herein is a combination therapy comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog. The combination therapy is...
2017/0182020 Remifentanil Injection Formulation Containing Colorant
A remifentanil injection formulation contains remitentanil and/or physiologically acceptable salts of said remifentanil and a colorant selected from among...
2017/0182019 Remifentanil Injection
A remifentanil injection solution formulation contains remifentanil and or physiologically acceptable salts thereof, water, and a stabilizer, the remifentanil...
2017/0182018 TREATMENT FOR DOPAMINERGIC DISORDERS
The present invention provides systems, compositions and methods for treatment of dopaminergic disorders (e.g., Parkinson's disease) using the combination of a...
2017/0182017 THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of...
2017/0182016 BIOMARKERS AND USE OF MET INHIBITOR FOR TREATMENT OF CANCER
The present invention relates to methods of therapeutic treatment of cancer using selective tyrosine kinase inhibitors and cancer biomarkers, such as MET...
2017/0182015 METHODS OF USING SNS-595 FOR TREATMENT OF CANCER SUBJECTS WITH REDUCED BRCA2 ACTIVITY
Methods of using SNS-595 for treatment of a subject having cancer with BRCA2 mutation are described. In certain embodiments, the methods comprise administering...
2017/0182014 AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE
The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in...
2017/0182013 METHODS FOR TREATING IRRITABLE BOWEL SYNDROME (IBS)
The present invention provides new methods and kits for treating IBS; treating IBS in females; treating IBS in older subjects; and treating IBS in non-white...
2017/0182012 METHOD FOR DIAGNOSIS OF ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION, DIAGNOSTIC AGENT,...
It has been revealed that, from a pre-onset stage of Alzheimer's disease, enhancement of phosphorylations of MARCKS and the like causes abnormal spine...
2017/0182011 HETEROCYCLYLALKYNE DERIVATIVES AND THEIR USE AS MODULATORS OF MGLUR5 RECEPTORS
This invention relates to compounds of formula I, ##STR00001## their use as allosteric modulators of mGluR5 receptor activity, pharmaceutical compositions...
2017/0182009 SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS
The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors...
2017/0182008 BENDAMUSTINE DERIVATIVES AND METHODS OF USING SAME
The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.
2017/0182007 Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably...
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