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Patent # Description
2017/0190797 GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain...
2017/0190796 GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain...
2017/0190795 GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain...
2017/0190794 GENETIC ENGINEERING OF NON-HUMAN ANIMALS FOR THE PRODUCTION OF CHIMERIC ANTIBODIES
The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain...
2017/0190793 CARRIER IMMUNOGLOBULINS
Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions...
2017/0190792 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2017/0190790 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2017/0190789 Methods and Compositions for the Treatment of Ocular Diseases and Disorders
Compositions and methods for the treatment of an ocular disease or disorder are disclosed.
2017/0190788 USES OF ANTI-HER3 ANTIBODIES FOR TREATING CANCER
Provided herein are methods of treating cancer comprising administering antibodies and antigen-binding fragments thereof that bind the extracellular domain of...
2017/0190787 ANTI- EGFR CONFORMATIONAL SINGLE DOMAIN ANTIBODIES AND USES THEREOF
The present invention relates to anti-Epidermal Growth Factor Receptor (EGFR) conformational single domain antibodies and uses thereof in particular in the...
2017/0190786 ANTI-ErbB2 ANTIBODIES
Anti-ErbB2 antibodies are described which bind to an epitope in Domain 1 of ErbB2 and induce cell death via apoptosis. Various uses for these antibodies are...
2017/0190785 HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 ANTIBODIES
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high...
2017/0190784 ACTIVIN-ACTRIIA ANTAGONISTS AND USES FOR TREATING MULTIPLE MYELOMA
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment...
2017/0190783 BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In...
2017/0190782 ANTI-PSGL-1 ANTIBODIES
Immunoglobulin chains or antibodies having light or heavy chain complementarity determining regions of antibodies that bind to P-Selectin Glycoprotein...
2017/0190781 ANTI-DEATH RECEPTOR 3 (DR3) ANTAGONISTIC ANTIBODIES WITH REDUCED AGONISTIC ACTIVITY
According to the present invention, anti-death receptor 3 (DR3) antagonistic IgG antibodies and antibody fragments thereof, wherein the antibodies and the...
2017/0190780 USE OF IL-31RA MONOCLONAL ANTIBODIES FOR TREATING NEURONAL INFLAMMATION
Use of antagonists to IL-31Ra and OSMRb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing...
2017/0190779 METHOD FOR THE TREATMENT OF MULTIPLE SCLEROSIS
A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple...
2017/0190778 INHIBITORS OF FIBROPROLIFERATIVE DISORDERS AND CANCER
The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention...
2017/0190777 ANTIBODY MOLECULES TO TIM-3 AND USES THEREOF
Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune,...
2017/0190776 Methods for Manipulating Phagocytosis Mediated by CD47
Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, acute...
2017/0190775 ANTIBODIES THAT BIND AND BLOCK TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 (TREM-1)
The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes,...
2017/0190774 LIGANDS THAT POTENTIATE THE BIOACTIVITY OF GONADOTROPINS
The invention relates to antibodies directed against follicle-stimulating hormone (FSH) and capable of potentiating the bioactivity of gonadotropins.
2017/0190773 LIGANDS THAT POTENTIATE THE BIOACTIVITY OF GONADOTROPINS
The invention relates to antibodies directed against follicle-stimulating hormone (FSH) and capable of potentiating the bioactivity of gonadotropins.
2017/0190772 TREATMENT OF LYSOSOMAL DISORDERS (IL-1 ANTAGONISTS)
The invention relates to methods for treating a Lysosomal storage disease (LSD) in a patient. Kits for use in such methods are also provided.
2017/0190771 USE OF IL-31 MONOCLONAL ANTIBODIES FOR TREATING NEURONAL INFLAMMATION
Use of antagonists to IL-31 are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in...
2017/0190770 HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 8 (IL-8)
Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or...
2017/0190769 IMPROVED TNF BINDERS
The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha ("TNF" or "TNF-alpha"). In particular,...
2017/0190768 COMPOSITIONS FOR SELECTIVE REDUCTION OF CIRCULATING BIOACTIVE SOLUBLE TNF AND METHODS FOR TREATING TNF-MEDIATED...
An isolated or synthetic antibody or ligand is provided that specifically binds to an epitope of a dissociated monomer of human TNF. Such binding disrupts...
2017/0190767 COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth...
2017/0190766 ANTIBODIES AND CONJUGATES THEREOF
Provided herein are anti-VEGF-A antibodies and antibody conjugates thereof. Some embodiments of the antibodies can be conjugated to a moiety, such as a HEMA-PC...
2017/0190765 Alpha-Synuclein Antibodies and Uses Thereof
The invention describes antibodies having a high affinity for aggregated forms of .alpha.-synuclein and a low affinity for monomeric forms of ...
2017/0190764 PEPTIDES MIMICKING HIV-1 VIRAL EPITOPES IN THE V2 LOOP FOR THE GP120 SURFACE ENVELOPE GLYCOPROTEIN
The present invention relates to an isolated immunogenic peptide comprising a V2 loop fragment from HIV surface envelope glycoprotein gp120. This peptide binds...
2017/0190763 HUMAN IMMUNODEFICIENCY VIRUS NEUTRALIZING ANTIBODIES
The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.
2017/0190762 ALPHA1 -ANTITRYPSIN COMPOSITIONS AND METHODS OF TREATING AUTOIMMUNE DISEASES
The specification provides compositions comprising chimeric proteins comprising AAT conjugated to an Fc region of an immunoglobulin. Methods for treating...
2017/0190761 TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS FOR TYROSINE KINASES RECEPTORS, INCLUDING IGF-IR
The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The...
2017/0190760 POLYPEPTIDES DERIVED FROM CALCITONIN RECEPTORS AND METHODS OF USE
The present invention is based, in part, on our discovery of compositions and methods that can be used to treat a patient who has a compromised bone (due, for...
2017/0190758 ENGINEERED RECEPTORS AND THEIR USE
Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein....
2017/0190757 Novel Glucagon Analogues
The present invention relates to novel peptide compounds which have a protracted profile of action and improved solubility and stability, to the use of the...
2017/0190756 RECOMBINANT NEL-LIKE (NELL) PROTEIN PRODUCTION
The present invention provides a method and system for producing a NELL protein. The method and system comprise a CELL encoding a NELL protein or peptide and a...
2017/0190755 IMMUNOMODULATORY COMPOSITIONS AND METHODS FOR TREATING DISEASE WITH MODIFIED HOST DEFENSE PEPTIDES
Compositions and methods are provided for modulating an immune response in a vertebrate subject. Compositions and methods can comprise administering a modified...
2017/0190754 CELL-PERMEABLE (ICP)-SOCS3 RECOMBINANT PROTEIN AND USES THEREOF
The present invention relates to providing improved cell-permeable (iCP)-SOCS3 recombinant protein and uses thereof. Preferably, the iCP-SOCS3 recombinant...
2017/0190753 RECOMBINANT PROTEINS HAVING FACTOR H ACTIVITY
The invention relates to a recombinant protein having factor H activity.
2017/0190752 E1-MINUS ADENOVIRUSES AND USE THEREOF
The present invention is related to a virus, preferably an adenovirus, characterised in that the virus comprises: a lacking functional wildtype E1 region,...
2017/0190751 MUTANT NGAL PROTEINS AND USES THEREOF
In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and...
2017/0190750 Peptide for Protection of Allergic Respiratory Disorders
A peptide (Peptide-1) based on the C-terminal of Equine CC10 has been discovered that can be used as a vaccine to protect horses from respiratory airway...
2017/0190749 GENETICALLY ENCODED PHOTOCLEAVABLE PROTEINS
Genetically encoded, photocleavable proteins are derived from a fluorescent protein. Upon illumination, the proteins photocleave and spontaneously dissociate...
2017/0190748 ANTI-INFLAMMATORY PROTEINS AND PEPTIDES AND METHODS OF PREPARATION AND USE THEREOF
The present disclose relates to anti-inflammatory proteins/peptides, their uses, methods of preparation and methods of their detection. In particular, the...
2017/0190747 SV82 POLYPEPTIDE, AND COSMETIC COMPOSITION FOR REDUCING SKIN WRINKLES AND MAINTAINING SKIN ELASTICITY...
A spider venom (SV) 82 polypeptide has an amino acid sequence of SEQ ID NO: 2. An SV82 polypeptide-encoding gene having a nucleotide sequence of SEQ ID NO: 1...
2017/0190746 RECOMBINANT POLYPEPTIDE FOR PROMOTING SCARLESS WOUND HEALING AND BIOADHESIVE MATERIAL INCLUDING THE SAME
Provided are a recombinant polypeptide in which a small leucine-rich proteoglycan mimetic sequence is attached to a terminal of a mussel adhesive protein, a...
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