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Patent # Description
2017/0190745 FACTOR INVOLVED IN LATENT INFECTION WITH HERPES VIRUS, AND USE THEREOF
Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in...
2017/0190744 DALBAVANCIN COMPOSITIONS FOR TREATMENT OF BACTERIAL
The invention provides methods for drying dalbavancin. The method includes providing wet dalbavancin that includes dalbavancin, water, and a solvent. The wet...
2017/0190743 CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF
Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and...
2017/0190742 COMPOSITION OF CYCLIC PEPTIDE COMPOUND, PREPARATION METHOD FOR SAME, AND USES THEREOF
Disclosed is a composition of a cyclic peptide compound having a water content of 3%-20%, represented by formula I is the structural formula of the cyclic...
2017/0190741 COMPSTATIN ANALOGS WITH IMPROVED ACTIVITY
Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. These compounds display...
2017/0190740 BETA SHEET TAPES RIBBONS IN TISSUE ENGINEERING
There is described a material comprising tapes, ribbons, fibrils or fibres characterized in that each of the ribbons, fibrils or fibres have an antiparallel...
2017/0190739 METHOD FOR PREPARING AMG 416
A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist...
2017/0190738 CYCLIC TETRAPEPTIDE STEREOISOMERS
Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical...
2017/0190737 MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
Provided are compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are...
2017/0190736 Antibody Drug Conjugates
There is disclosed a Dolastatin derivative, conjugated to an antibody, comprising a Dolastatin derivative moiety of Formula IV.
2017/0190735 DERIVATIVES OF DOLAPROINE-DOLAISOLEUINE PEPTIDES
Provided are peptide analogs, pharmaceutical compositions comprising such compounds, and methods of treating cancer with such compounds.
2017/0190734 MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
Provided are compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided...
2017/0190733 CYCLOPENTANOPERHYDROPHENANTHRENE FRAMEWORK COMPOUNDS AND PREPARATION METHOD THEREFOR
The present invention pertains to the field of pharmaceutical chemistry, and relates to compounds having cyclopentanoperhydrophenanthrene skeletons and...
2017/0190732 NEUROACTIVE 19-ALKOXY-17-SUBSTITUTED STEROIDS, PRODRUGS THEREOF, AND METHODS OF TREATMENT USING SAME
The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts...
2017/0190731 CHOLANE DERIVATIVES FOR USE IN THE TREATMENT AND/OR PREVENTION OF FXR AND TGR5/GPBAR1 MEDIATED DISEASES
The present invention relates to compounds having cholane scaffolds of formula (I), said compounds for use in the treatment and/or prevention of FXR and...
2017/0190730 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide...
2017/0190729 POLYENE MACROLIDE DERIVATIVE
The present invention is the following Amphotericin B derivative: ##STR00001## wherein each symbol is defined in description. The compound of the present...
2017/0190728 HIGH-PURITY STEVIOL GLYCOSIDES
Methods of preparing highly purified steviol glycosides, particularly Rebaudioside D, are described. The methods include purification from the extraction stage...
2017/0190727 NOVEL MATERIAL MIXTURE CONTAINING RUBUSOSIDE OR ALPHA GLYCOSYLRUBUSOSIDE, FOR ENHANCING SWEET TASTE
The invention relates to novel substance mixtures which can be used as aroma compositions to enhance the sweet taste of oral preparations.
2017/0190726 PRODRUG FOR RELEASE OF CISPLATIN AND CYCLOOXYGENASE INHIBITOR
Pt(IV) prodrugs include one or more conjugated cyclooxygenase inhibitor. Reduction of Pt(IV) to Pt(II) can result cisplatin and a cyclooxygenase inhibitor. For...
2017/0190725 PHOSPHAZENE COMPOUND, A PREPREG AND A COMPOSITE METAL LAMINATE
The present invention relates to a phosphazene compound and a prepreg and a composite metal laminate. The phosphazene compound has a structure as shown in...
2017/0190724 METHOD FOR PREPARING RACEMIC OR OPTICALLY ACTIVE D- OR L-A-GLYCEROPHOSPHORYL CHOLINE SOLIDS
The present invention is characterized in that racemic or optically active D- or L-.alpha.-glycerophosphoryl choline solids are prepared from liquid type...
2017/0190723 Tin-Containing Dopant Compositions, Systems and Methods For Use in ION Implantation Systems
A novel method and system for using certain tin compounds as dopant sources for ion implantation are provided. A suitable tin-containing dopant source material...
2017/0190722 DIALKYL COBALT CATALYSTS AND THEIR USE FOR HYDROSILYLATION AND DEHYDROGENATIVE SILYLATION
Disclosed herein are dialkyl cobalt complexes containing pyridine di-imine ligands and their use as catalysts for hydrosilylation, dehydrogenative silylation,...
2017/0190721 ALKOXYSILYL-VINYLENE GROUP-CONTAINING SILICON COMPOUND
Provided is an alkoxysilyl-vinylene group-containing silicon compound represented by the following general formula (1): ##STR00001## wherein each of R.sup.1 and...
2017/0190720 ALKYLAMINO-SUBSTITUTED CARBOSILANE PRECURSORS
Disclosed are Si-containing film forming compositions comprising alkylamino-substituted carbosilane precursors, methods of synthesizing the same, and their use...
2017/0190719 PREPARATION OF A SOLID FORM OF GADOBENATE DIMEGLUMINE
The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of...
2017/0190718 NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVE
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
2017/0190717 Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase
Compounds and compositions, and methods of use thereof, are provided and have utility in inhibiting hedgehog signaling and/or phosphodiesterase-4 activity.
2017/0190716 FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the...
2017/0190715 PYRIDINE DERIVATIVE
The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically a pharmaceutically...
2017/0190714 PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their...
2017/0190713 FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the...
2017/0190712 BENZIMIDAZOLE RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR MODULATORS AND USES THEREOF
Provided herein are compounds of the formulas (I) and (II): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
2017/0190711 UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF
Provided are compounds represented by the formula: ##STR00001## In which: Y is an unbranched, saturated or unsaturated hydrocarbon chain with 2-5 hydrocarbon...
2017/0190710 PHARMACEUTICAL COMPOSITIONS COMPRISING PERILLYL ALCOHOL DERIVATIVES
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated...
2017/0190709 NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME
The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method...
2017/0190708 PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT
The invention provides compounds of Formula I or Formula II: ##STR00001## or a pharmaceutically acceptable salt or ester, thereof, as described herein. The...
2017/0190707 CRYSTALLINE FORMS OF 3-(IMIDAZO[1,2-B] PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-BENZAMIDE AND ITS MONO HYDROCHLORIDE ...
Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin- -1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free...
2017/0190706 CRYSTALLINE FORMS OF SODIUM 4--2-METHOXYBENZOATE
The present invention is directed to a compound of formula (I): ##STR00001## or a crystalline form thereof, or a solvate thereof; to a solid pharmaceutical...
2017/0190705 Compositions and Methods for Inhibiting BMP
The present invention provides small molecules inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and...
2017/0190704 COMPOSITIONS AND METHODS USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE
The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable salts thereof, for the treatment and/or prevention of...
2017/0190703 ORGANIC COMPOUNDS
The invention provides novel compounds, composition comprising said compounds and methods for inhibiting CK1 as well as methods of treating CK1 related...
2017/0190702 SPIROCYCLIC MORPHINANS AND USE THEREOF
In one aspect, the invention provides compounds of Formula I: (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2,...
2017/0190701 FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS
The present invention relates to Fused Tricyclic Heterocyclic Compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, wherein...
2017/0190700 Emetine Derivatives, Prodrugs Containing Same, And Methods Of Treating Conditions Using Same
Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific...
2017/0190699 SUBSTITUTED TROPANE DERIVATIVES
Provided is a compound which is useful as a prophylactic or therapeutic agent for various diseases in which T-type calcium channels are involved, such as...
2017/0190698 ENZYME INTERACTING AGENTS
The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact...
2017/0190697 NOVEL PYRROLIDINE COMPOUND AND APPLICATION AS MELANOCORTIN RECEPTOR AGONIST
The present invention relates to a novel pyrrolidine compound having melanocortin receptor agonist activity or a pharmaceutically acceptable salt thereof, and...
2017/0190696 DIARYL-AZOLE COMPOUND
Provided is a diaryl-azole compound represented by formula (1) ##STR00001## wherein R.sup.1-3 are C.sub.1-6 chain hydrocarbon, etc.; p=0-3; q=0-4; n=0-2; X is N,...
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