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Patent # Description
2017/0190695 PARASITE- AND HYGIENIC PEST-CONTROLLING AGENT
There is provided a novel agent for controlling harmful arthropods or nematodes that are parasites and hygienic pests for animals. An ecto- or ...
2017/0190694 PYRIDINE DERIVATIVE
Provided is a pyridine derivative represented by formula (I), a prodrug thereof, a pharmaceutically acceptable salt of the pyridine derivative or the prodrug,...
2017/0190693 SUBSTITUTED CHROMANES AND METHOD OF USE
The invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, X, Y, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11,...
2017/0190692 ATRASENTAN MANDELATE SALTS
The present disclosure relates to: (a) mandelate salts of atrasentan, (b) pharmaceutical compositions comprising an atrasentan mandelate salt, and, optionally,...
2017/0190691 NOVEL 5-ACYLSULFANYL-HISTIDINE COMPOUNDS AS PRECURSORS OF THE CORRESPONDING 5-SULFANYLHISTIDINES AND THEIR...
The invention relates to a compound of the 5-acylsulfanyl-histidine type and the derivatives thereof, of general formula (I), wherein R1 to R3=H, alkyl,...
2017/0190690 Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene
A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I) as described herein and further reactions with this compound.
2017/0190689 PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS
The present disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide...
2017/0190688 CRYSTALLINE SALTS OF (S)-6-((1-ACETYLPIPERIDIN-4-YL)AMINO)-N-(3-(3,4-DIHYDROISOQUINOLIN-2(1H)-- ...
Disclosed are novel crystalline salts of (S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-- yl)-2-hydroxypropyl)pyrimidine-4-carboxamide...
2017/0190687 IMIDAZOL- OR 1,2,4-TRIAZOL-DERIVATIVES AND THEIR USE
The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use. ##STR00001##
2017/0190686 OPTICAL RESOLUTION METHOD OF LENALIDOMIDE
The problem addressed by the present invention is to provide a novel method for separating and purifying pure enantiomer of lenalidomide. Pure enantiomer of...
2017/0190685 SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix...
2017/0190684 PREPARATION METHOD FOR CHIRAL INTERMEDIATE FOR USE IN STATINS
The present invention relates to a preparation method for a chiral intermediate for use in statins, acquired with chloroacetic acid and benzyl alcohol as...
2017/0190683 HIGHLY PURIFID PHARMACEUTICAL GRADE TASIMELTEON
A process for preparing a batch of highly purified, pharmaceutical grade tasimelteon comprises analyzing a batch of tasimelteon synthesized under GMP...
2017/0190682 PROCESSES AND APPARATUS FOR PRODUCING FURFURAL, LEVULINIC ACID, AND OTHER SUGAR-DERIVED PRODUCTS FROM BIOMASS
In some variations, the invention provides a process for producing furfural, 5-hydroxymethylfurfural, and/or levulinic acid from cellulosic biomass,...
2017/0190681 1-(CYCLOPENT-2-EN-1-YL)-3-(2-HYDROXY-3-(ARYLSULFONYL)PHENYL)UREA DERIVATIVES AS CXCR2 INHIBITORS
The invention relates to 1-(3-sulfonylphenyl)-3-(cyclopent-2-en-1-yl)urea derivatives, and their use in treating or preventing diseases and conditions mediated...
2017/0190680 CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS
The present disclosure relates to cyclopropyl compounds of general formula (I), wherein R.sup.1, and R.sup.2 are as defined in the specification. The present...
2017/0190679 METHOD FOR PRODUCING POLYMERIZABLE COMPOUND
Provided is a method for producing a polymerizable compound represented by a formula (I) comprising: a step (1) that reacts a compound represented by a formula...
2017/0190678 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND...
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having...
2017/0190677 ALPHA-AMINO ESTERS OF HYDROXYPROPYLTHIAZOLIDINE CARBOXAMIDE DERIVATIVE AND SALT FORM, CRYSTAL POLYMORPH THEREOF
The invention provides .alpha.-amino esters of a hydroxypropylthiazolidine carboxamide derivative, ...
2017/0190676 Isoxazole Carboxamide Compounds
The present disclosure provides substituted isoxazole carboxamide compounds having Formula (I) and the pharmaceutically acceptable salts and solvates thereof,...
2017/0190675 CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE
Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of...
2017/0190674 Unique Self-Assembled Poly-Amidoamine Polymers and Their Electrochemical Reactivity
Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and...
2017/0190673 OXOPIPERAZINE HELIX MIMETICS FOR CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION
The present invention relates to oxopiperazines that mimic helix .alpha.B of the C-terminal transactivation domain of HIF1.alpha.. Also disclosed are...
2017/0190672 METHODS FOR PREPARATION OF QUINAZOLINE DERIVATIVES
Methods for preparing compounds having the following structure (I): ##STR00001## or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, ...
2017/0190671 BIS(ARYL)CATECHOL DERIVATIVES AS HERBICIDES
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein A, R.sup.1 R.sup.5 and R.sup.6 are as...
2017/0190670 IMPROVED PROCESS FOR THE PREPARATION OF ENZALUTAMIDE
The present application relates to an improved process for preparation of Enzalutamide (I). ##STR00001## The present application also relates to an improved...
2017/0190669 PYRAZOLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
2017/0190668 ASYMMETRIC CATALYTIC REDUCTION OF OXCARBAZEPINE
A process for preparing (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide or ...
2017/0190667 CRYSTALLINE FORMS OF A PROLYL HYDROXYLASE INHIBITOR
The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of...
2017/0190666 METHOD FOR PREPARING DABIGATRAN ETEXILATE INTERMEDIATE, AND INTERMEDIATE COMPOUND
Disclosed are a method for preparing a dabigatran etexilate intermediate, and an intermediate compound. The method for preparing a dabigatran etexilate...
2017/0190665 Sugar Derivatives Comprising Sulfur-Containing Moieties And Methods Of Making Same And Methods Of Using The...
Described herein are modified sugar, iminosugar and azasugar compounds and methods of making same. One or more of these modified compounds contain sulfates,...
2017/0190664 Tetrahydrocarbazole Inhibitors Of SIRT1 Receptors
Described are deuterium-substituted tetrahydrocarbazole compounds of Formulae I, II, or III which are inhibitors of sirtuin 1 (SIRT1). Also described are...
2017/0190663 SALT FORMS OF [R-(R*,R*)]-2-(4-FLUOROPHENYL)-BETA,DELTA-DIHYDROXY-5-(1-METHYLETHYL)-3-P- ...
Novel salt forms of [R--(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl- )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid ...
2017/0190662 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R.sup.A, R.sup.AA,...
2017/0190661 Aromatic Ionizable Cationic Lipid
What is described is a compound of formula I ##STR00001## wherein X is an ethene, or an unsubstituted or substituted arene or heteroarene; Y is a bond, an...
2017/0190660 Small Molecules That Covalently Modify Transthyretin
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more...
2017/0190659 BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE
The invention provides benzenesulfonamido and related compounds, pharmaceutical compositions, methods of promoting ROR.gamma. activity, increasing the amount...
2017/0190658 IMAGING AGENTS
Provided herein is technology relating to imaging agents and particularly, but not exclusively, to methods of manufacturing fluorine-18-labeled...
2017/0190657 ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (.+-.)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof,...
2017/0190656 A Substituted Acethydrazide Derivative, Preparation Method and Use Thereof
The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use...
2017/0190655 NITRONE COMPOUNDS AND THEIR USE IN PERSONAL CARE
Provided are compounds and compositions thereof that are useful as antioxidants in personal care formulations. The compounds are of the Formula I: ...
2017/0190654 METHODS OF MANUFACTURING BENZOQUINOLINE COMPOUNDS
The present invention relates to new methods of manufacturing benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), and intermediates...
2017/0190653 Ketamine Derivatives
The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising...
2017/0190652 A Continuous Flow Process For The Preparation Of Ingenol-3-Mebutate
Disclosed is a continuous process for the preparation of ingenol-3-mebutate by reaction, in solution, of ingenol or ingenol anion and angelic anhydride or an...
2017/0190651 PROCESS TO PREPARE LEVULINIC ACID
The invention describes processes to prepare levulinic acid, formic acid and/or hydroxymethyl furfural from various biomass materials.
2017/0190650 PROCESS FOR ACETIC ACID RECOVERY FROM AQUEOUS STREAMS
A process for removing acetic acid from an aqueous stream containing yellow oil. According to the process, yellow oil is removed from the aqueous stream prior...
2017/0190649 PROCESS
A method of operating a heavy ends column in an acetic acid production unit, said production unit comprising at least a reaction section, a light ends recovery...
2017/0190648 3,6-DICHLOROSALICYLIC ACID COMPOUNDS AND RELATED SYNTHETIC PROCESSES
The present disclosure relates, in general, to 5-halo-3,6-dichlorosalicylic acid compounds, 5-halo-3,6-dichlorosalicy-aldehyde compounds, processes for...
2017/0190647 PLASMA ARC FURNACE AND APPLICATIONS
A Plasma Arc Reformer for creating a useful fuel, such as Methanol, using any of Methane, Municipal Solid Waste, farm or forest waste, coal orchar rock from...
2017/0190646 Manufacture of Methylolalkanes with Augmented Heat Transfer and Improved Temperature Control
A multistage tubular reaction system and method for preparing methylol derivatives of an aldehyde includes a tubular reaction system with a plurality of...
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