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Patent # Description
2017/0189534 SYSTEMS COMPRISING A COMPOSITE BACKING AND METHODS FOR LONG TERM TRANSDERMAL ADMINISTRATION
Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.
2017/0189533 Compositions Containing a Bitter Tastant and at Least One Sophorolipid, and Methods of Reducing Bitter Taste...
A composition comprising a bitter tastant and at least one sophorolipid and optionally a carrier; wherein the composition is edible and wherein the bitter...
2017/0189532 PHOSPHOLIPID DEPOT
The present invention is directed to compositions and methods of preparation of phospholipid depots that are injectable through a fine needle.
2017/0189531 COMPOSITION AND METHODS FOR TETHERING BIOACTIVE PEPTIDES TO METAL OXIDE SURFACES
In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and...
2017/0189530 PHOTOACTIVATED MOLECULES FOR LIGHT INDUCED MODULATION OF THE ACTIVITY OF ELECTRICALLY EXCITABLE CELLS AND...
Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to...
2017/0189529 ANTIBODIES USEFUL IN PASSIVE INFLUENZA IMMUNIZATION, AND COMPOSITIONS, COMBINATIONS AND METHODS FOR USE THEREOF
Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that...
2017/0189528 STABLE AQUEOUS ADALIMUMAB FORMULATION
The present invention provides a stable aqueous adalimumab formulation by incorporating a histidine buffer solution and a phosphate buffer solution in...
2017/0189527 LIQUID PHARMACEUTICAL COMPOSITION
The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an histidine...
2017/0189526 Suppression of Myeloid Derived Suppressor Cells and Immune Checkpoint Blockade
Impressive responses have been observed in patients treated with checkpoint inhibitory anti-PD-1 or anti-CTLA-4 antibodies. However, immunotherapy against...
2017/0189525 Methods for Inhibiting Fibrosis in a Subject in Need Thereof
In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of...
2017/0189524 HUMAN-DERIVED ANTI-HUMAN IL-20 ANTIBODIES AND ASSAY FOR THE IDENTIFICATION OF ANTI-CYTOKINE ANTIBODIES
Provided are novel interleukin-20 (IL-20) binding molecules of human origin, particularly human-derived anti-human IL-20 antibodies as well as IL-20 binding...
2017/0189523 METHODS FOR PROVIDING ADJUVANTED VIROSOMES AND ADJUVANTED VIROSOMES OBTAINABLE THEREBY
The invention relates to the fields of immunology and vaccinology. Provided is a method for preparing adjuvanted virosomes, comprising the steps of: (i)...
2017/0189522 PHARMACEUTICAL COMBINATIONS FOR IMMUNOTHERAPY
The present invention relates generally to a method for regulating immune reactions and test substances useful for same. Specifically, the method of the...
2017/0189521 LIPIDATED IMMUNE RESPONSE MODIFIER COMPOUND COMPOSITIONS, FORMULATIONS, AND METHODS
The compound N-(4-{[4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl]oxy}butyl) octadecanamide is a useful drug compound for enhancing immune response and...
2017/0189520 GENETICALLY STABLE LIVE ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINE AND ITS PRODUCTION
Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses...
2017/0189519 INFLUENZA VIRUS VACCINES AND USES THEREOF
Provided herein are multimeric influenza hemagglutinin stem domain polypeptides, methods for providing hemagglutinin stem domain polypeptides, compositions...
2017/0189518 NUCLEIC ACID MOLECULES ENCODING FERRITIN-HEMAGGLUTININ FUSION PROTEINS
Novel vaccines are provided that elicit broadly neutralizing anti-influenza antibodies. Some vaccines comprise nanoparticles that display hemagglutinin trimers...
2017/0189517 ANTIGENIC EPITOPES FROM EBV gp350/220 AND USES THEREOF
The present invention relates to a peptide comprising (A) (i) a first domain comprising an amino acid sequence having at least 60% sequence similarity with the...
2017/0189516 COMPOSITIONS AND METHODS FOR ENTEROHEMORRHAGIC ESCHERICHIA COLI (EHEC) VACCINATION
Certain embodiments are directed to compositions comprising EHEC-specific antigens. In certain aspects EHEC O157:H7-specific antigen(s) are used as components...
2017/0189515 PEPTIDE MIXTURE
There is disclosed a peptide mixture suitable for eliciting an immune response. It comprises a first and a second peptide, each corresponding to a fragment of...
2017/0189514 IDENTIFICATION OF MUTATIONS IN HERPES SIMPLEX VIRUS ENVELOPE GLYCOPROTEINS THAT ENABLE OR ENHANCE VECTOR...
In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a...
2017/0189513 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189512 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189511 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189510 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189509 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189508 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189507 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189506 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189505 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189504 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0189503 PCSK9 VACCINE AND METHODS OF USING THE SAME
A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood...
2017/0189502 IMMUNIZATION PROTOCOL FOR DIRECTED EXPANSION AND MATURATION
A first antigen is administered to a subject to select progenitor B cells that are suitable for subsequent production of a desirable affinity-matured antibody,...
2017/0189501 METHOD OF TREATMENT OF SCHIZOPHRENIFORM DISORDER
Described herein are compositions which include digestive enzymes and which are formulated to reduce one or more symptoms of a neuropsychiatric disorder. Also...
2017/0189500 USE OF RECOMBINANT CLOSTRIDIAL NEUROTOXINS FOR THE TREATMENT OF PATIENTS HAVING CERTAIN MUSCLE-RELATED DISORDERS
This invention relates to novel uses of recombinant clostridial neurotoxins exhibiting decreased duration of effect, in particular uses for the treatment of...
2017/0189499 HEMOSTATIC COMPOSITIONS
The invention relates to a hemostatic composition in powder form comprising collagen of the fibrillar type comprising a content of fibrous collagen and/or...
2017/0189498 MITRECIN A POLYPEPTIDE WITH ANTIMICROBIAL ACTIVITY
The present invention provides a Mitrecin A polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or...
2017/0189497 Augmented Acid Alpha-Glucosidase For The Treatment Of Pompe Disease
A method for treating Pompe disease including administration of recombinant human acid .alpha.-glucosidase having optimal glycosylation with...
2017/0189496 USE OF PHOSPHORYLATION PATHWAY-RELATED FACTOR IN REGULATING FUNCTION OF REGULATORY T CELL
A method for the treatment and/or the prevention of a disease or a symptom related to dysfunction of regulatory T cell immunomodulation includes administering...
2017/0189495 USE OF MICROPEROXIDASES FOR THE TREATMENT OF CARBOXYHEMOGLOBINEMIA
It is disclosed herein that microperoxidases are capable of binding carbon monoxide (CO) with high affinity and displacing CO from hemoglobin, thereby acting...
2017/0189494 PROTECTING COMPOSITIONS FOR RECOMBINANTLY PRODUCED FACTOR VIII
A histidine-free composition comprising: a high purity factor VIII (r-factor VIII); arginine and/or sucrose; a surface-active agent to prevent or at least...
2017/0189493 METHOD OF DRUG DELIVERY FOR PTH, PTHrP AND RELATED PEPTIDES
The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly...
2017/0189492 Use of Ultrarapid Acting Insulin
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial...
2017/0189491 COMPOSITION CONTAINING NEUROPEPTIDE Y FOR INHIBITING SIDE EFFECTS OF ANTICANCER AGENTS
Provided is a composition containing neuropeptide Y for inhibiting side effects of anticancer agents. The neuropeptide Y of the present invention exhibits an...
2017/0189489 CARDIAC MUSCLE FUNCTION AND MANIPULATION
A method of causing cardiomyocyte growth and/or differentiation, the method comprising exposing a cardiomyocyte to neuregulin (NRG) thereby activating the MAP...
2017/0189488 CODON-OPTIMIZED RECOMBINANT PLASMID, METHOD OF STIMULATING PERIPHERAL NERVE REGENERATION, AND METHOD OF...
Provided is a method for treating a peripheral nervous system damage or injury, or for regenerating peripheral nervous system tissue that involves...
2017/0189487 LYOPHILIZED FORMULATION OF HGF
An object of the present invention is to provide a lyophilized formulation having improved storage stability of hepatic growth factor compared to conventional...
2017/0189486 MODIFIED FGF-21 POLYPEPTIDES AND USES THEREOF
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides...
2017/0189485 MODULATION OF ESTROGEN RECEPTOR-RELATED RECEPTOR GAMMA (ERR GAMMA) AND USES THEREFOR
This application provides methods of increasing vascularization, muscle performance, muscle rehabilitation, and/or mitochondrial activity in subjects in need...
2017/0189484 CEACAM5 PEPTIDES FOR CROHN'S DISEASE
The present invention relates to small peptides, derived from the N-terminal domain of CEACAM5 (carcinoembryonic antigen family member 5), with the ability to...
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