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Patent # Description
2017/0189433 NICOTINAMIDE RIBOSIDE ANALOGS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
Provided herein are stereoisomerically pure ester and carbonate analogues of nicotinamide riboside and nicotinamide riboside hydride, and pharmaceutical...
2017/0189432 PHARMACEUTICAL COMPOSITION AND METHOD FOR REGENERATING MYOFIBERS IN THE TREATMENT OF MUSCLE INJURIES
A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages or injuries caused by an ischemic...
2017/0189431 ANTICANCER AGENTS OF THE ANTHRACYCLIN FAMILY
Anthracyclin compounds of the general structure: ##STR00001## are disclosed. In these compounds R.sup.1 is methyl, acetyl or hydroxyacetyl; R.sup.2-R.sup.5 and...
2017/0189430 ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS
The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and...
2017/0189429 Treating Arrhythmia with Mitochondrial-Targeted Antioxidants
This invention relates to reducing the risk of arrhythmias as a result of an acute cardiovascular disorder or injury such as a myocardial infarction by using...
2017/0189428 Dialkyl-phosphinoyl-alkane (Dapa) compounds and compositions for treatment of lower gastrointestinal tract...
Heat abstraction from the body's surfaces causes sensations of cold from the skin, orbit, nose, mouth, throat, upper esophagus, airways, and anogenital...
2017/0189427 Topical Minocycline Compositions and Methods of Using the Same
Topical minocycline compositions with reduced fluorescence are provided. In some instances, the compositions include an amount of a minocycline active agent...
2017/0189426 PHARMACEUTICAL DOSAGE FORM FOR ORAL ADMINISTRATION OF A BCL-2 FAMILY INHIBITOR
The invention relates to a pharmaceutical dosage form which comprises a solid dispersion product comprising ...
2017/0189425 Cancer Drug and Uses
A pharmaceutical composition comprising a cancer therapeutic that is capable of inhibiting and/or reducing the ability of a cancer cell to take up and utilize...
2017/0189424 FLUTICASONE FUROATE IN THE TREATMENT OF COPD
The present invention relates to pharmaceutical products comprising fluticasone furoate for use in the treatment of COPD patients, particularly a subgroup of...
2017/0189423 Medicinal Aerosol Formulations
The present invention provides a medical aerosol suspension formulation of MDI administration, comprising: a) micronized pa-agonist; b) micronized...
2017/0189422 STABLE FIXED DOSE PHARMACEUTICAL COMPOSITION COMPRISING MOMETASONE AND OLOPATADINE
The present invention relates to a stable fixed dose aqueous pharmaceutical composition (e.g., contained in a container) for nasal administration to a human,...
2017/0189421 Compositions and Methods for Suppressing Endometrial Proliferation
The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention...
2017/0189420 OXYSTEROLS AND HEDGEHOG SIGNALING
Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit Hedgehog signaling. Also described herein are methods...
2017/0189419 PHARMACEUTICAL COMPOSITION FOR TREATING PROSTATE CANCER
The present invention provides a pharmaceutical composition for treating prostate cancer in a subject in need thereof, which comprises a first agent comprising...
2017/0189418 PHARMACEUTICAL COMPOSITION FOR TREATING LUNG CANCER
The present invention provides a pharmaceutical composition for treating lung cancer in a subject in need thereof, which comprises a first agent comprising at...
2017/0189417 PHARMACEUTICAL COMPOSITION FOR TREATING COLORECTAL CANCER
The present invention provides a pharmaceutical composition for treating colorectal cancer in a subject in need thereof, which comprises a first agent...
2017/0189416 PHARMACEUTICAL COMPOSITION FOR TREATING BREAST CANCER
The present invention provides a pharmaceutical composition for treating breast cancer in a subject in need thereof, which comprises a first agent comprising...
2017/0189415 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING...
The present invention relates to the use of an oxytocin receptor antagonist in females undergoing embryo transfer as part of an assisted reproductive...
2017/0189414 CONTROLLED RELEASE DELIVERY SYSTEM FOR NASAL APPLICATIONS AND METHOD OF TREATMENT
This invention relates to a gel formulation for nasal administration of a controlled release formulation of hormones to the systemic circulation and/or to the...
2017/0189413 COMPOSITIONS AND TREATMENT FOR EYE DISEASES AND DISORDERS
The invention relates to compositions and methods for treating eye diseases and disorders. More specifically, the invention provides compositions comprising...
2017/0189412 ANDROGEN COMPOSITION FOR TREATING AN OPTHALMIC CONDITION
The disclosure provides compositions for treating an ocular condition. The composition comprises a physiologically effective amount of an androgen, wherein the...
2017/0189411 Compounds That Modulate Oxidative Stress
The present invention provides methods of identifying compounds that selectively induce an oxidative stress response in a biological sample. The present...
2017/0189410 Amino Compounds for Treatment of Complement Mediated Disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2017/0189409 MEDICAL USE
The present invention provides a compound, which is an inhibitor of phosphoinositide 3-kinase delta or a pharmaceutically acceptable salt and/or solvate...
2017/0189408 NOVEL PHARMACEUTICAL COMPOSITION
Disclosed are novel pharmaceutical formulations containing N-{3-p-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-tri- ...
2017/0189407 Modulators of Androgen Synthesis
The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses...
2017/0189406 DEUTERATED BARICITINIB
The present invention in one embodiment provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the variables shown...
2017/0189405 ARF6 INHIBITORS AND METHODS OF SYNTHESIS AND USE THEREOF
Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are...
2017/0189404 BRUTON'S TYROSINE KINASE AS ANTI-CANCER DRUG TARGET
Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that...
2017/0189403 TREATMENT OR PREVENTION OF NON-INFLAMMATORY NEURONAL DAMAGE FROM BRAIN TRAUMA AND STROKES USING MENTHOL,...
Compositions tor prevention or treatment of non-inflammatory neuronal damage from brain trauma and strokes are provided, and the compositions contain a...
2017/0189402 SOLID DOSAGE FORMS
The present invention features solid dosage forms comprising two or more different active ingredients. In one embodiment, the present invention features a...
2017/0189401 2,3-DISUBSTITUTED 1 -ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS
The present invention relates to novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy.
2017/0189400 SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to...
2017/0189399 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula I: ##STR00001## where R.sup.1, R.sup.2a, R.sup.2b, and R.sup.3-R.sup.6 are as defined in the...
2017/0189398 METHODS AND COMPOSITIONS FOR SLEEP DISORDERS AND OTHER DISORDERS
Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment...
2017/0189397 HEADACHE PRE-EMPTION BY DIHYDROERGOTAMINE TREATMENT DURING HEADACHE PRECURSOR EVENTS
Disclosed are methods that address providing a subject experiencing, or who has experienced, a headache precursor event and administering dihydroergotamine, or...
2017/0189396 METHODS AND COMPOSITIONS FOR TREATING DRY EYE DISEASE AND OTHER EYE DISORDERS
The present invention relates to a method for treating a dry eye syndrome using an alpha 2 adrenergic agonist, pharmaceutically acceptable salt thereof or a...
2017/0189395 DIKETOPIPERAZINE MICROPARTICLES WITH DEFINED SPECIFIC SURFACE AREAS
Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m.sup.2/g. The diketopiperazine microparticle can be...
2017/0189394 NOVEL POLYMORPHIC FORMS OF VORTIOXETINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
The present invention provides polymorphic forms of Vortioxetine of and its pharmaceutically acceptable salts. Specifically the present invention relates to...
2017/0189393 COMPOSITIONS AND METHODS FOR MINIMIZING OR REVERSING AGONIST-INDUCED DESENSITIZATION
Methods and compositions are provided for preventing or reversing loss of the therapeutic effect of a drug, where the loss is associated with the repeated...
2017/0189392 LIPOSOME OF IRINOTECAN OR IRINOTECAN HYDROCHLORIDE AND PREPARATION METHOD THEREOF
A liposome of irinotecan or irinotecan hydrochloride and its preparation method are disclosed. The liposome contains irinotecan or irinotecan hydrochloride,...
2017/0189391 Protein kinase C inhibitor for treating triple-negative breast cancer
Protein kinase C plays important roles in TNBC development and could be a specific target. The in vitro anti-proliferative activity of PKC inhibitor...
2017/0189389 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters...
2017/0189388 NICOTINE REPLACEMENT THERAPY PRODUCTS COMPRISING SYNTHETIC NICOTINE
A composition suitable for use in nicotine replacement therapy products includes a nicotine product that includes a synthetic nicotine that is substantially...
2017/0189387 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE
The present disclosure relates to HIF-1.alpha. prolyl hydroxylase inhibitors, compositions which comprise the HIF-1.alpha. prolyl hydroxylase inhibitors...
2017/0189386 TETRAHYDROCARBOLINE DERIVATIVE
An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as...
2017/0189385 PHARMACEUTICAL COMPOSITIONS COMPRISING RIFAXIMIN AND AMINO ACIDS, PREPARATION METHODS AND USE THEREOF
The present invention relates to rifaximin compositions comprising amino acids, characterized in that they increase rifaximin solubility in aqueous solutions...
2017/0189384 REVERSING INTESTINAL INFLAMMATION BY INHIBITING RETINOIC ACID METABOLISM
An agent that increases local concentration of retinoic acid (RA) in the intestine through modifying enzymatic pathways involved in RA metabolism is...
2017/0189383 PPAR COMPOUNDS FOR USE IN THE TREATMENT OF FIBROTIC DISEASES
The invention relates to the use of a pan-PPAR agonist, or of a pharmaceutical composition containing said agonist, for the treatment of a fibrotic condition.
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