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Patent # Description
2017/0204423 Methods of Transforming a Listeria
Site-specific Listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a...
2017/0204422 CIRCULAR POLYNUCLEOTIDES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
2017/0204420 METHODS OF PRODUCING 7-CARBON CHEMICALS VIA C1 CARBON CHAIN ELONGATION ASSOCIATED WITH COENZYME B SYNTHESIS
This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or ...
2017/0204419 MRGPRX2/MRGPRB2 EXPRESSING CELL BASED ASSAY TO DETECT PSEUDO-ALLERGIC DRUG REACTIONS AND TO IDENTIFY BLOCKERS...
The present invention relates to cells and methods for detecting compounds that induce a pseudo-allergic-type reaction and methods for reducing the severity of...
2017/0204418 POLYNUCLEOTIDE AGENTS TARGETING AMINOLEVULINIC ACID SYNTHASE-1 (ALAS1) AND USES THEREOF
The invention relates to polynucleotide agents, e.g., antisense polunucleotide agents, targeting the ALAS1 gene, and methods of using such agents to alter...
2017/0204417 dsRNA For Treating Viral Infection
The invention relates to double-stranded ribonucleic acids (dsRNAs) targeting gene expression of phosphatidylinositol 4-kinase (PI4K), in particular human...
2017/0204416 METHOD FOR CONTROLLING OBESITY USING MINIMALLY INVASIVE MEANS
Methods for controlling obesity using minimally-invasive procedures including introducing embolic crystal particles that are naturally occurring and mostly...
2017/0204415 Compositions of Matter that Reduce Pain, Shock, and Inflammation by Blocking Linoleic Acid Metabolites and Uses...
A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a...
2017/0204414 OLIGONUCLEOTIDE COMPRISING AN INOSINE FOR TREATING DMD
The invention provides an oligonucleotide comprising an inosine, and/or a nucleotide containing a base able to form a wobble base pair or a functional...
2017/0204413 OLIGOMERS
Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be...
2017/0204412 Modifications for Antisense Compounds
The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from...
2017/0204411 METHODS AND COMPOSITIONS FOR TREATING INSECTS
Provided herein are methods and compositions for modulating gene expression in insects by administering a composition comprising an RNA effector molecule and a...
2017/0204410 ANTISENSE NUCLEIC ACIDS
Provided is a drug that allows highly-efficient skipping of exon. The present invention provides an antisense oligomer wherein two or more unit oligomers...
2017/0204409 METHOD FOR CONTROLLING OBESITY USING MINIMALLY INVASIVE MEANS
Methods for controlling obesity using minimally-invasive procedures including introducing embolic crystal particles that are naturally occurring and mostly...
2017/0204408 Compositions for Targeted Delivery of siRNA
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi...
2017/0204407 CRISPR/CAS TRANSCRIPTIONAL MODULATION
Methods, compositions, and kits are provided for CRISPR/Cas mediated transcriptional modulation.
2017/0204406 METHOD FOR COUNTING NUMBER OF NUCLEIC ACID MOLECULES
The object of the invention is to provide a method for counting the number of nucleic acid molecules in a mixture of a plurality of nucleic acid molecules more...
2017/0204405 METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING BIO-MOLECULES USING MODELS OF MULTIPLICATIVE FORM
The present invention provides methods for identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from...
2017/0204404 METHODS FOR THE PRODUCTION OF LIBRARIES FOR DIRECTED EVOLUTION
Disclosed herein is an efficient method of generating a library of variants of a sequence of interest, such as may be used in directed evolution, in one...
2017/0204403 PROCESS FOR PRODUCING BACTERIAL MUTANTS
Disclosed is a process for producing a mutant bacterium which exhibits improved survival and/or growth under a selected growth condition, the process...
2017/0204402 In Vivo Detection of Proteins Interaction based on Adenylate Cyclase Hybrid System
The present invention relates to a method to detect the interaction between a target ligand and a moiety of interest using an adenylate cyclase enzyme (AC) and...
2017/0204401 REDUCING HORIZONTAL GENE TRANSFER OF FUNCTIONAL PROTEINS
Disclosed are methods and compositions for reducing horizontal gene transfer of functional proteins. In some embodiments, the risk of horizontal gene transfer...
2017/0204400 BIOSYNTHESIS AND ENGINEERING OF LANTHIPEPTIDES
Platforms, systems and methods are provided for identifying engineered lanthipeptide display peptides expressed in vivo from biological organisms.
2017/0204399 GENOMICALLY-ENCODED MEMORY IN LIVE CELLS
Aspects of the present disclosure provide synthetic-biology platforms for in vivo genome editing, which enable the use of live cell genomes as "tape recorders"...
2017/0204398 NUCLEIC ACID PREPARATION METHOD
A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least...
2017/0204397 NUCLEIC ACID PURIFICATION
Methods and composition for nucleic acid isolation are provided. In one embodiment, a method is provided for nucleic acid purification from biological samples,...
2017/0204396 NOVEL METHOD FOR SECRETION OF EXTRACELLULAR VESICLES FROM CELLS AND TISSUES USING SHOCK WAVE
The present invention relates to a method for promoting the generation and secretion of extracellular vesicles from cells by using extracorporeal shockwave....
2017/0204395 ESTABLISHMENT OF CELL LINES WITH ALTERED MITOCHONDRIAL DNA COPY NUMBER
Reduced mitochondrial DNA copy number has been reported in numerous adverse clinical conditions, yet suitable tools for modulating mitochondrial DNA copy...
2017/0204393 Thermally Stable Enzymes, Compositions Thereof and Method of Using Same
Described herein are isolated recombinant proteins having lyase activity and nucleic acid sequences which code therefor; along with methods of expressing,...
2017/0204392 Polypeptides Having Protease Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having protease activity and isolated polynucleotides encoding the polypeptides. The invention also...
2017/0204391 METHOD FOR THE MANUFACTURING OF DI-CHAIN PROTEINS FOR USE IN HUMANS
This invention relates to a novel method for producing di-chain proteins for use in humans from single-chain precursors, including di-chain clostridial...
2017/0204390 DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN
Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic...
2017/0204389 B-GALACTOSIDASE MUTANT WITH HIGH TRANSGLYCOSIDASE ACTIVITY, AND PREPARATION METHOD THEREOF AND USES THEREOF
The present invention relates to the field of genetic engineering and hereditary engineering. The present invention discloses a .beta.-galactosidase...
2017/0204388 Engineered Nucleic-Acid Targeting Nucleic Acids
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the...
2017/0204387 RIBOTOXIN MOLECULES DERIVED FROM SARCIN AND OTHER RELATED FUNGAL RIBOTOXINS
The present application relates to modified T cell epitopes derived from fungal ribotoxins, including .alpha.-sarcin, clavin, gigantin, mitogillin, and...
2017/0204386 P97-IDS FUSION PROTEINS
Provided are fusion proteins between p97 (melanotransferrin) and iduronate-2-sulfatase (IDS), and related compositions and methods of use thereof, for...
2017/0204385 THERMUS SCOTODUCTUS NUCLEIC ACID POLYMERASES
The invention provides nucleic acids and polypeptides for a nucleic acid polymerase from a thermophilic organism, Thermus scotoductus. The invention also...
2017/0204384 THERMOPHILIC DNA POLYMERASE MUTANTS
This disclosure relates to thermophilic family B DNA polymerases comprising a neutral amino acid residue at a certain position near the C-terminus of the...
2017/0204383 C-RAF Mutants that Confer Resistance to RAF Inhibitors
Nucleic acids and proteins having a mutant C-RAF sequence, and methods of identifying patients having cancer who are likely to benefit from a combination...
2017/0204382 ISOLATED GDF TRAP POLYPEPTIDE
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
2017/0204381 PMST1 MUTANTS FOR CHEMOENZYMATIC SYNTHESIS OF SIALYL LEWIS X COMPOUNDS
The present invention provides mutants of PmST1 for the preparation of sialyl-Lewis.sup.x oligosaccharides, and other sialosides with decreased sialidase...
2017/0204380 GLYCOSYL TRANSFERASES AND THEIR USES
The present invention relates to novel glycosyl transferases from Vitis vinifera that are capable of catalyzing the formation of certain glycosides with high...
2017/0204379 LUCIFERASE SHOWING ORANGE LUMINESCENCE
A luciferase according to an embodiment comprises an amino acid sequence in which a mutation is introduced into an amino acid sequence of SEQ ID NO: 38. The...
2017/0204378 BIOCATALYSTS FOR EZETIMIBE SYNTHESIS
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods...
2017/0204377 MUTEIN, METHOD FOR PRODUCING SAID MUTEIN, GENE ENCODING SAID MUTEIN, RECOMBINANT VECTOR AND PLANT BEARING SAID...
Provided is a mutant protein obtained by mutating a specific amino acid residue of HMGR, a rate-limiting enzyme of isoprene monomer biosynthesis in the...
2017/0204376 ACTIVATION OF INNATE IMMUNITY FOR ENHANCED NUCLEAR REPROGRAMMING OF SOMATIC CELLS WITH mRNA
The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses...
2017/0204375 Inhibition of Serotonin Expression in Gut Enteroendocrine Cells Results in Conversion to Insulin-Positive Cells
Disclosed herein are methods involving the targeting of 5HT biosynthesis in gut insulin-negative cells to convert them into insulin-positive cells. Also...
2017/0204374 METHOD FOR EVALUATING QUALITY OF HUMAN MESENCHYMAL STEM CELL, AND MONOCLONAL ANTIBODY FOR USE IN SAID METHOD
The present invention aims to obtain a method for quality evaluation of human mesenchymal stem cells, a method for isolation, selection and culture of human...
2017/0204373 PERIVASCULAR MESENCHYMAL PRECURSOR CELLS
Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor...
2017/0204372 ENGINEERED CELLS FOR ADOPTIVE CELL THERAPY
Provided are engineered cells for adoptive therapy, including NK cells and T cells. Also provided are compositions for engineering and producing the cells,...
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