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Patent # Description
2017/0204160 USE OF HDL-RELATED MOLECULES TO TREAT AND PREVENT PROINFLAMMATORY CONDITIONS
Molecules and compositions are described for use in the treatment and prevention of proinflammatory conditions. HDL-related molecules, including ApoA-I, bovine...
2017/0204159 GLYCOPROTEIN HORMONE RECEPTOR MUTATIONS
A mutant thyroid stimulating hormone receptor (TSHR) or fragment thereof comprises one or more mutations, wherein the mutant TSHR has increased thermostability...
2017/0204158 IL-33 Antagonists and Uses Thereof
The present invention provides interleukin-33 (IL-33) antagonists comprising one or more IL-33-binding domains and one or more multimerizing domains and...
2017/0204157 HUMAN FGFR2C EXTRACELLULAR PROTEIN AS WELL AS CODING GENE AND APPLICATION THEREOF
The present invention provides an isolated FGFR2c extracellular protein. The extracellular protein comprises a wild type or S252W mutant human FGFR2c...
2017/0204156 THERAPEUTIC USE OF P75NTR NEUROTROPHIN BINDING PROTEIN
The present invention relates to a new therapeutic use of a p75NTR neurotrophin binding protein and related molecules in the treatment of osteoarthritis.
2017/0204155 PEPTIDE ANTAGONISTS OF THE CALCITONIN CGRP FAMILY OF PEPTIDE HORMONES AND THEIR USE
The embodiments provide a modified calcitonin gene-related peptide antagonist including an N-terminal fragment of modified calcitonin gene-related peptide or...
2017/0204154 MOLECULES THAT SELECTIVELY ACTIVATE REGULATORY T CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
This invention provides for a fusion protein between an IL2.alpha..beta..gamma. Selective Agonist protein (IL2 Selective Agonist) and a IgG Fc protein using a...
2017/0204153 METHOD OF DESIGNING A PEPTIDE AND/OR PEPTIDE DERIVATIVE FOR MODULATING GAMMA-C-CYTOKINE ACTIVITY
The .gamma.c-family cytokines, Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-7 (IL-7), Interleukin-9 (IL-9), Interleukin-15 (IL-15), and...
2017/0204152 CHIMERIC POLYNUCLEOTIDES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules, which allow for...
2017/0204151 Mesenchymal Stem Cells Expressing Biomarkers that Predict the Effectiveness of Mesenchymal Stem Cells for...
Isolated mesenchymal stem cells, which produce mRNA encoding TSG-6 protein or a biologically active fragment, derivative, or analogue thereof in an amount of...
2017/0204150 POLYPEPTIDES TARGETING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND PROSTATE SPECIFIC MEMBRANE ANTIGEN
Polypeptides comprising a VEGF scaffold modified to bind to PSMA are provided, and bifunctional derivatives thereof that also bind to VEGFR. The polypeptides...
2017/0204149 HSA-GDF-15 FUSION POLYPEPTIDE AND USE THEREOF
The disclosure relates to fusion polypeptides comprising serum albumin or a functional variant thereof and GDF15 protein or a functional variant thereof and to...
2017/0204148 PEPTIDE-BASED STAT INHIBITOR
A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or...
2017/0204147 Bioactive Protein, Use Thereof and Method for its Production
The present invention according to a firrst aspect relates to a Trichoderma longibrachiatum strain comprising an autologous nucleotide sequence coding for a...
2017/0204146 Novel Antimicrobial Peptides
The present invention provides novel antimicrobial peptides and nucleic acids encoding them, the peptides having an inhibitory or bactericidal/bacteriostatic...
2017/0204145 ANTI-INFLAMMATORY PROPERTIES OF A SURFACE PROTEIN OF PROPIONIBACTERIUM FREUDENREICHII
Disclosed is a polypeptide including or consisting of the amino acid sequence SEQ id n.sup.o:1, for use in the treatment or prevention of an inflammatory...
2017/0204144 SELECTIVE RECOVERY
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
2017/0204143 Constrained proteins and uses therefor
A fusion protein comprising an N-terminal portion and a C-terminal portion, wherein the N-terminal portion is a heterologous protein of interest which includes...
2017/0204142 POLYPEPTIDES FOR GENERATING ANTI-INFLUENZA ANTIBODIES AND USES THEREOF
The present disclosure relates to a polypeptide comprising hemagglutinin stem domain fragments that can elicit broadly cross-reactive anti-influenza antibodies...
2017/0204141 ANTAGONISTS OF NEUROKININ B IN FISH REPRODUCTION
Provided are Peptide-based neurokinin antagonists of fish reproduction. Compositions including antagonists of fish neurokinin and methods of inhibiting or...
2017/0204140 ANTAGONISTIC PEPTIDES
The present invention relates to a compositions and methods for treating and/or preventing neurologic disorders such as Alzheimer's disease and disorders...
2017/0204139 MATRIPTASE AND U-PLASMINOGEN ACTIVATOR SUBSTRATES AND OTHER CLEAVABLE MOIETIES AND METHODS OF USE THEREOF
The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one protease selected from matriptase and...
2017/0204138 ANTIBACTERIAL AGENTS
The invention concerns agents with antibacterial activity, their production and use in the treatment of bacterial infections in animals, including man. The...
2017/0204137 POLYETHYLENE GLYCOL BASED PRODRUG OF ADRENOMEDULLIN AND USE THEREOF
The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for...
2017/0204136 PROCESS FOR EXTRACTION OF FISH COLLAGEN AND FORMULATIONS OF 3D MATRICES OF COLLAGEN FOR BIOMEDICAL AND...
Polyelectrolyte based bioactive super-absorbent material ionotropically crosslinked/neutralized involving polyvalent carboxylic acids, citrate, Kojic Acid,...
2017/0204135 METHOD FOR PREPARING A COMPOSITION COMPRISING HIGHLY CONCENTRATED ANTIBODIES BY ULTRAFILTRATION
The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode...
2017/0204134 Cyclising Peptides
A method for preparing a cyclic peptide, derivative or analogue thereof is described. The method comprises contacting a peptide, derivative or analogue thereof...
2017/0204133 BETULINIC ACID DERIVATIVES WITH HIV MATURATION INHIBITORY ACTIVITY
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid...
2017/0204132 COMPOUNDS AND METHODS INVOLVING STEROLS
Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield....
2017/0204131 PREPARATION AND USE OF CRYSTALLINE BETA-D-NICOTINAMIDE RIBOSIDE
Provided herein are crystalline beta-D-nicotinamide riboside chloride compositions and methods of preparation and use thereof. Also provided are related...
2017/0204130 FLAME RETARDANTS, PREPARATION METHODS, AND THERMOPLASTIC COMPOSITIONS THEREOF
Disclosed are flame retardants comprising compounds of Formula 1, wherein the polyol is a disaccharide or a C.sub.12 sugar alcohol, which has at least one...
2017/0204129 NOVEL TRANSITION METAL COMPOUND, TRANSITION METAL CATALYST COMPOSITION FOR POLYMERIZING OLEFIN, CONTAINING...
Provided are a novel transition metal compound, a transition metal catalyst composition for preparing an ethylene homopolymer or a copolymer of ethylene and...
2017/0204128 METHOD FOR PREPARING TRANSITION METAL COMPLEX
The present invention relates to a method for preparing a transition metal complex for the preparation of an olefin copolymer, and more specifically, to a...
2017/0204127 COORDINATION COMPLEXES, PHARMACEUTICAL SOLUTIONS COMPRISING COORDINATION COMPLEXES, AND METHODS OF TREATING...
A coordination complex having a physiologically acceptable pK.sub.a includes a metal and a biologically active agent. The pK.sub.a of the coordination complex...
2017/0204126 MOLYBDENUM- AND TUNGSTEN-CONTAINING PRECURSORS FOR THIN FILM DEPOSITION
Electrochromic tungsten or molybdenum oxide and their doped derivative nanomaterials are prepared using sol-gel or vapor deposition methods from precursors...
2017/0204125 CRYSTAL FORM OF TENOFOVIR PRODRUG, PREPARATION METHOD THEREOF, AND METHOD OF USE THEREOF
A crystal form of 9-[(R)-2-[[(S)-[[[1-(isopropoxycarbonyl)-1-methyl]ethyl]amino]phenoxyphos- phinyl]methoxyl]propyl]adenine fumarate of formula (I) is provided....
2017/0204124 Ionic Complex, Electrolyte for Nonaqueous Electrolyte Battery, Nonaqueous Electrolyte Battery and Ionic Complex...
To provide a material suitable for a nonaqueous electrolyte battery having high-temperature durability. An ionic complex of the present invention is...
2017/0204123 Gold (I)-Phosphine Compounds as Anti-Bacterial Agents
A compound of formula (I) for use in the prevention or treatment of a bacterial infection wherein R.sup.P1 is either methyl, ethyl, isopropyl, cyclohexyl or...
2017/0204121 NOVEL POLYFLUOROALKYLATED ALKENES AND SILANE COMPOUNDS PREPARED THEREFROM
Novel polyfluoroalkylated alkenes and silane compounds prepared therefrom are described.
2017/0204120 Organoaminosilanes and Methods for Making Same
Organoaminosilanes, such as without limitation di-iso-propylaminosilane (DIPAS), are precursors for the deposition of silicon containing films such as...
2017/0204119 Aminosilyl-Substituted Diarylethene Compounds for Anionic Polymerisation
The invention related to novel compounds useful as modifying monomers and precursors for polymerization initiators. The invention further relates to a method...
2017/0204118 METAL ORGANIC FRAMEWORK WITH PERFLUORINATED LINKER
A metal organic framework includes metal-containing secondary building units and perfluorinated linkers (e.g., pefluorinated arene linkers, perfluorinated...
2017/0204117 PROCESS FOR PREPARING (4R,12aS)-N-(2,4-DIFLUOROBENZYL)-7-METHOXY-4-METHYL-6,8-DIOXO-3,4,6,8,12,- -...
The present invention relates to the preparation of carbamoylpyridone derivatives and intermediates.
2017/0204116 MACROCYCLIC KINASE INHIBITORS AND USES THEREOF
The present disclosure provides macrocyclic compounds of Formula (I). The provided compounds are able to bind protein kinases and may be useful in modulating...
2017/0204115 Method of Preparing Anhydrosugar Alcohol Using Additive for Prohibiting Polymerization by Dehydration
The present invention relates to a method for producing anhydrosugar alcohol using an organic additive having one hydroxyl group. The present invention makes...
2017/0204114 NOVEL PHARMACEUTICAL COMPOUND HAVING INHIBITORY ACTIVITY AGAINST CHOLESTEROL ACYLTRANSFERASE ISOZYME 2 (ACAT2)
This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity...
2017/0204113 7-BETA-ALKYL ANALOGS OF ORVINOLS
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.1a, R.sup.1b,...
2017/0204112 ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME
Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases...
2017/0204111 THERAPEUTIC ISOXAZOLE COMPOUNDS
The invention provides a compound of formula I: ##STR00001## wherein A.sup.1, A.sup.2, A.sup.3, R.sup.1, X, Y, and B have any of the values described herein, as...
2017/0204110 COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
The invention relates to a compound of Formula I or IA compositions comprising compounds of Formula I or IA, and methods of treating cystic fibrosis comprising...
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