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Patent # Description
2017/0202965 TREATMENT OF CANCER WITH A COMBINATION OF RADIATION, CERIUM OXIDE NANOPARTICLES, AND A CHEMOTHERAPEUTIC AGENT
The present invention is directed to methods for the treatment of cancer with a combination of radiation, cerium oxide nanoparticles and at least one...
2017/0202964 NITROBENZALDEHYDE PROTON RELEASE FOR MANIPULATION OF CELLULAR ACIDOSIS
Certain embodiments are directed to photo-activated compounds for the manipulation of pH in a cell. In certain aspects the photo-activated compound is...
2017/0202963 Methods of Preventing Platelet Alloimmunization and Alloimmune Platelet Refractoriness and Induction of...
Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. Methods are provided to modify donor...
2017/0202962 COMBINATION OF LENALIDOMIDE AND POLYPEPTIDE CONSTRUCT, AND USES THEREOF
Methods for cancer treatment include administering to a cancer patient an anti-CD38 antibody-attenuated human IFN alpha-2b construct and lenalidomide or...
2017/0202960 CATIONIC OIL-IN-WATER EMULSIONS
This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The...
2017/0202959 ADJUVANT COMPOSITIONS AND RELATED METHODS
The present disclosure provides for an adjuvant composition that is suited for injectable as well as transdermal administration. The adjuvant composition...
2017/0202958 VACCINE DELIVERY METHOD
The present invention includes a composition including as one component a slurry matrix that is a liquid at room temperature and a gel at physiological pH,...
2017/0202957 COMPOSITION COMPRISING A COMPLEXED (m)RNA AND A NAKED mRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY...
The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA,...
2017/0202956 Methods and Compositions for Inhibiting Akt3
Compounds and compositions for selectively inhibiting Akt3 are provided. Methods of using the compounds are also provided. Because Akt3 modulates the...
2017/0202955 Adjuvanted Influenza Vaccines for Pediatric Use
An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared...
2017/0202954 Stabilization of Aqueous Compositions of Proteins With Displacement Buffers
An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b....
2017/0202953 HBV EPITOPE REACTIVE EXOGENOUS T CELL RECEPTOR (TCR) AND USES THEREOF
There is provided at least one isolated cell comprising at least one HBV epitope-reactive exogenous T cell receptor and/or fragment thereof, and methods for...
2017/0202952 RECOMBINANT HERPES SIMPLEX VIRUS 2 (HSV-2) VACCINE VECTORS
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each...
2017/0202951 Novel Vaccine Compositions for Porcine Epidemic Diarrhea Virus and Porcine Deltacoronavirus
The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The...
2017/0202950 HIGHLY IMMUNOGENIC HIV P24 SEQUENCES
The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides...
2017/0202948 VACCINE COMPOSITIONS HAVING IMPROVED STABILITY AND IMMUNOGENICITY
Disclosed herein are nanoparticles suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a...
2017/0202947 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR INFLUENZA
The development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates is...
2017/0202946 STABILIZED INFLUENZA HEMAGGLUTININ STEM REGION TRIMERS AND USES THEREOF
Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their...
2017/0202945 VACCINES AND METHODS FOR CREATING A VACCINE FOR INDUCING IMMUNITY TO ALL DENGUE VIRUS SEROTYPES
Described here is a method to produce a chimeric protein having portions of yellow fever virus and dengue virus. A small portion of the yellow fever virus 17D...
2017/0202944 Prevention of Pertussis Using Adenylate Cyclase Deficient Bordetella Strains
A CyaA-deficient B. pertussis mutant was constructed and used in a vaccine. The pertussis-specific antibody profile and Th17 response induced by vaccination...
2017/0202943 TREATMENT OF MICROBIAL INFECTIONS
The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in...
2017/0202942 ANTI-MYCOPLASMA SPP. SUBUNIT VACCINE
Provided in the present invention are anti-Mycoplasma spp. subunit vaccines, especially proteins suitable for being used as the active ingredient of the...
2017/0202941 OMPA AND ASP14 IN VACCINE COMPOSITIONS AND AS DIAGNOSTIC TARGETS
Anaplasma phagocytophilum surface proteins Asp14 and OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for...
2017/0202940 TRANSGENIC ALGAE FOR DELIVERING ANTIGENS TO AN ANIMAL
Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an...
2017/0202939 PERSONALIZED CANCER VACCINES AND METHODS THEREFOR
Methods of cane r treatment based, on personalized vaccines are disclosed. Individual amino acid substitutions from tumors are revealed using whole genome...
2017/0202938 Cancer Vaccines
The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an...
2017/0202937 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS, SUCH AS LUNG CANCER, INCLUDING NSCLC
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2017/0202936 Identification, Optimization And Use Of Cryptic HLA-B7 Epitopes For Immunotherapy
The invention provides methods for identifying a HLA-B*0702-restricted cryptic epitope in an antigen, as well as methods for increasing the immunogenicity of...
2017/0202935 METHODS OF TREATING OR PREVENTING PERIODONTITIS AND DISEASES ASSOCIATED WITH PERIODONTITIS
The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also...
2017/0202934 Methods and Compositions for the Prevention and Treatment of Influenza
This disclosure relates to the prevention and treatment of Influenza, and more particularly Influenza A Virus Subtype H1N1, with the use of a pharmaceutical...
2017/0202932 METHODS FOR INHIBITING NEURON APOPTOSIS AND NECROSIS
The present invention relates generally to methods for inhibiting neuron apoptosis and necrosis associated with excess glutamate release.
2017/0202931 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGIC DISEASE
Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic IDUA or IDS protein such as an enzyme into a cell, thereby...
2017/0202930 USE OF HYALURONIDASE FOR TREATMENT OF MUSCLE STIFFNESS
Provided are methods and kits for reducing the severity of muscle stiffness. The method comprises delivering to one or more specific locations in the deep...
2017/0202929 LIPOPROTEIN LIPASE FOR TREATMENT OF HYPERTRIGLYCERIDEMIC-RELATED CONDITIONS INCLUDING ACUTE PANCREATITIS
A lipoprotein lipase (LPL) protein for treating and/or preventing HTG and its associated diseases, including but not limited to acute pancreatitis (AP), and in...
2017/0202928 METHOD OF FEEDING ANIMALS PHYTASE PRODUCTS
Methods involve feeding livestock animals a milk replacer, where the milk replacer includes non-milk proteins and phytase. Prior to feeding the milk replacer,...
2017/0202927 PROCESS FOR CONCENTRATION OF A POLYPEPTIDE
The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for...
2017/0202926 Parenteral Glucagon Formulations
This invention relates to compositions of glucagon suitable for administration by manual injection or by an insulin pump or other injection device to treat...
2017/0202925 PHARMACEUTICAL COMPOSITIONS COMPRISING AGONISTS OF OREXIN-1 RECEPTOR OX1R FOR THE TREATMENT OF INFLAMMATORY...
The present invention relates to methods and pharmaceutical compositions for the treatment of inflammatory bowel diseases. The presents methods relates to a...
2017/0202924 IL-15 AND IL-15RALPHA HETERODIMER DOSE ESCALATION REGIMENS FOR TREATING CONDITIONS
Described herein are dose escalation regimens for the administration of complexes comprising interleukin-15 ("IL-15") covalently or noncovalently bound to...
2017/0202922 TARGETED CARGO PROTEIN COMBINATION THERAPY
The present invention combines a targeted cargo protein with an active agent for the treatment of a disease or condition.
2017/0202921 AN ISOLATED INTERLEUKIN-34 POLYPEPTIDE FOR USE IN PREVENTING TRANSPLANT REJECTION AND TREATING AUTOIMMUNE DISEASES
The invention relates to an isolated interleukin-34 (IL-34) polypeptide for use in preventing or treating graft rejection, autoimmune disease, unwanted immune...
2017/0202920 Compositions and Methods for Treating Rotator Cuff Injuries
The present invention provides compositions and methods for attaching tendon to bone. The present invention provides compositions and methods for treating...
2017/0202919 Methods for preventing or treating optic neuritis
The invention is directed to methods for preventing and/or treating optic neuritis. The invention is further directed to reducing inflammation associated with...
2017/0202918 METHODS AND COMPOSITIONS RELATING TO TREATMENT OF PULMONARY ARTERIAL HYPERTENSION
The technology described herein is directed to methods and compositions for the treatment of hypertension, e.g. pulmonary arterial hypertension, relating to...
2017/0202917 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING SKIN RASH
Provided is a method for preventing or treating skin rash comprising administering to a subject in need thereof epidermal growth factor as an active...
2017/0202916 METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT AND PREVENTION OF AGENT-INDUCED...
A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising...
2017/0202915 Lymphangiogenesis inhibitors for cancer and for graft survival
Compositions and methods are provided for treating and/or preventing lymphangiogenesis in a subject by using an inhibitor of a galectin-8 protein in an amount...
2017/0202914 USE OF ANNEXIN V AS A METHOD TO BLOCK TUMOR INDUCED IMMUNOSUPPRESSION OF THE INNATE IMMUNE RESPONSE
Methods are provided for treating a subject with cancer, with a therapeutic dose of annexin V to the subject.
2017/0202913 CTL INDUCER COMPOSITION
The present invention provides a CTL inducer composition which comprises one or more peptides selected from the group consisting of the peptides of SEQ ID NOS:...
2017/0202912 OPTOGENETIC CONTROL OF INPUTS TO THE VENTRAL TEGMENTAL AREA
The present disclosure provides a method of inducing or modulating reward- or aversive-related behaviors in animals using light-responsive opsins. The present...
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