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Patent # Description
2017/0226195 IMMUNOGLOBULINS AND VARIANTS DIRECTED AGAINST PATHOGENIC MICROBES
Anti-SpA murine, chimeric and humanized monoclonal antibodies, and variant antibodies having a heavy chain with at least one amino acid substitution are...
2017/0226194 POLY-N-ACETYL GLUCOSAMINE (PNAG/DPNAG)-BINDING PEPTIDES AND METHODS OF USE THEREOF
The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as...
2017/0226193 ANTI-OSPA ANTIBODIES AND METHODS OF USE
The invention provides anti-OspA antibodies and methods of using the same.
2017/0226192 METHODS OF MODULATING AN IMMUNE RESPONSE
The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to a filovirus (e.g., Marburg virus (MARV)),...
2017/0226191 INTRADERMAL ADMINISTRATION OF IMMUNOGLOBULIN G PREPARATION
A method for administration of an IgG preparation by an intradermal (ID) route to a subject includes loading with a volume of the IgG preparation an ID...
2017/0226190 Metallothionein-Derived Peptide Fragments
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT),...
2017/0226189 IMMUNOGLOBULIN CHIMERIC MONOMER-DIMER HYBRIDS
The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide...
2017/0226188 VIRAL VECTORS ENCODING RECOMBINANT FVIII VARIANTS WITH INCREASED EXPRESSION FOR GENE THERAPY OF HEMOPHILIA A
The present disclosure provides, among other aspects, codon-altered polynucleotides encoding Factor VIII variants for expression in mammalian cells. In some...
2017/0226187 NUCLEIC ACID SEQUENCE ENCODING A FUSION PROTEIN
The present invention relates to fusion proteins for the expression of G-protein coupled receptor proteins (GPCR) with the fusion partners, as inserted...
2017/0226186 METHOD OF EXPRESSING A G-PROTEIN COUPLED RECEPTOR PROTEIN
The present invention relates to fusion proteins for the expression of G-protein coupled receptor proteins (GPCR) with the fusion partners, as inserted...
2017/0226185 Human IL1-R1 Derived Inhibitor of IL-1b
A therapeutic composition is described that can be used for treating or prevention of diseases association with modulation of activity of human IL-1.beta.. In...
2017/0226184 SOLUBLE HYBRID FCGAMMA RECEPTORS AND RELATED METHODS
Disclosed are soluble hybrid Fc.gamma. receptor (Fc.gamma.R) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and...
2017/0226183 ROR1 SPECIFIC MULTI-CHAIN CHIMERIC ANTIGEN RECEPTOR
The present invention relates to a new generation of chimeric antigen receptors (CAR) referred to as multi-chain CARs, which are made specific to the antigen...
2017/0226182 PD-1 MODULATION AND USES THEREOF FOR MODULATING HIV REPLICATION
Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the...
2017/0226181 SOLUBLE CD80 AS A THERAPEUTIC TO REVERSE IMMUNE SUPPRESSION IN CANCER PATIENTS
The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions...
2017/0226180 Peptide Inhibitors of Sodium Channels
The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium...
2017/0226179 POLYPEPTIDES, RELATED NUCLEIC ACIDS, AND THEIR USES FOR CELL MODULATION AND TREATMENTS
Disclosed herein are inventive polypeptides (e.g., comprising a thermal sensitive ion channel or variant thereof and a domain 5 of kininogen 1 or variant or...
2017/0226178 THERAPEUTIC USES OF MODIFIED RELAXIN POLYPEPTIDES
Modified relaxin polypeptides and their uses thereof are provided. Exemplary embodiments provide relaxin polypeptides which include one or more amino acid...
2017/0226177 PEPTIDOMIMETIC MACROCYCLES
The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment...
2017/0226176 METHODS AND COMPOSITIONS FOR TREATING CANCER
A nucleic acid sequence is provided that encodes a chimeric protein comprising a ligand that comprises a naturally occurring or modified follicle stimulating...
2017/0226175 INSULINOTROPIC PEPTIDE DERIVATIVE WITH MODIFIED N-TERMINAL CHARGE
The present invention relates to an insulinotropic peptide derivative with a modified N-terminal charge and a pharmaceutical composition including the same....
2017/0226174 HETERODIMERS OF IL-15 AND IL-15R ALPHA TO INCREASE THYMIC OUTPUT AND TO TREAT LYMPHOPENIA
The present invention provides method for promoting the maturation and export of T cells from thymic tissue by contacting the thymic tissue with ...
2017/0226173 GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are...
2017/0226172 FGF23 FUSION PROTEINS
Disclosed herein are FGF23 c-tail fusion proteins, pharmaceutical compositions comprising the FGF23 c-tail fusion proteins, and methods of treatment using the...
2017/0226171 ADENOCARCINOMA ANTIGENIC DETERMINANTS AND METHODS
Adenocarcinoma antigenic determinants, methods for their production and use, and broadly-specific human monoclonal antibodies reactive to the epitopes. These...
2017/0226170 THERAPEUTIC PROTEINS FOR TREATING CANCERS AND METHODS FOR USING SUCH PROTEINS
Therapeutic proteins for inducing apoptosis in cells and method for using such proteins are described. The protein, e.g., a chimeric protein, has a host...
2017/0226169 BIPARTITE MOLECULES AND USES THEREOF IN TREATING DISEASES ASSOCIATED WITH ABNORMAL PROTEIN AGGREGATES
Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate...
2017/0226168 CELL-PERMEABLE (ICP)-SOCS3 RECOMBINANT PROTEIN AND USES THEREOF
The present invention relates to providing improved cell-permeable (iCP)-SOCS3 recombinant protein and uses thereof. Preferably, the iCP-SOCS3 recombinant...
2017/0226167 MODIFIED PEPTIDES AND THEIR USE FOR TREATING AUTOIMMUNE DISEASES
The present invention relates to a peptide, or a salt thereof, comprising or consisting of the amino acid sequence IHMVYSKRSGKPRGYAFIEY, comprising one or more...
2017/0226166 Mu-Conotoxin Peptides And Use Thereof As A Local Anesthetic
The present invention relates to novel mu-conotoxin peptides, biologically active fragments thereof, combinations thereof and /or variants thereof. The...
2017/0226165 SYSTEM AND METHOD FOR ISOLATION OF PROTEIN AS A CO-PRODUCT OF BIOFUEL AND/OR BIOCHEMICAL PRODUCTION
A method for protein isolation as a co-product of alcohol production is disclosed. The method includes receiving grain product at a holding receptacle, the...
2017/0226164 INSECTICIDAL POLYPEPTIDES HAVING IMPROVED ACTIVITY SPECTRUM AND USES THEREOF
The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having...
2017/0226163 Insect Inhibitory Toxin Family Active Against Hemipteran and/or Lepidopteran Insects
The present invention discloses a genus of insect inhibitory proteins that exhibit properties directed to controlling Lepidopteran and/or Hemipteran crop...
2017/0226162 ENHANCED PRODUCTION OF IMMUNOGLOBULINS
The present invention provides methods and compositions for generating transgenic animals, including transgenic mammals, as well as plasma cells that allow for...
2017/0226161 MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
The inventors have identified residues within variant 2 and variant 3 of meningococcal fHbp which can be modified to enhance their properties.
2017/0226160 ASSEMBLY ACTIVATING PROTEIN (AAP) AND ITS USE FOR THE MANUFACTURE OF PARVOVIRUS PARTICLES ESSENTIALLY...
The present invention relates to nucleic acids encoding the novel parvoviral protein "assembly activating protein" S(AAP), the encoded polypeptides, methods of...
2017/0226159 METHOD FOR PRODUCING HYDROPHOBIC PEPTIDE
A method for producing a purified peptide from a supported crude peptide having a support and a first peptide chain bonded to the support at the C-terminus....
2017/0226158 INTRACELLULAR ANTIGEN BINDING
The disclosure generally provides a Designed Ankyrin Repeat Protein (DARPin) that specifically binds to an antigen, the DARPin having an N-terminal cap...
2017/0226157 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR DISEASES
Use of a polypeptide comprising a chemokine binding peptide as set forth in SEQ ID NO: 1 attached to an Fc domain or a fragment thereof is provided. The...
2017/0226156 METHODS FOR INHIBITING IMMUNE COMPLEX FORMATION IN A SUBJECT
Polypeptides and other compounds that can bind specifically to the C.sub.H2-C.sub.H3 cleft of an immunoglobulin molecule, and methods for using such...
2017/0226155 Smart Pro-Drugs of Serine Protease Inhibitors
The present invention relates to prodrugs of protease inhibitors, such as inhibitors of the proteosome, DPP IV, FAP.alpha. and the like. These"pro-inhibitors"...
2017/0226154 PPAR AGONISTS AND METHODS OF USE THEREOF
Provided herein are deuterated compounds and compositions useful in increasing PPAR.delta. activity. The compounds and compositions provided herein are useful...
2017/0226153 Method for Separation of Biopolymer Molecules and a Carrier for Application of this Method
The invention relates to a method for separation of biopolymer molecules, particularly biopolymer molecules from the group consisting of mono- a ...
2017/0226152 SOLID PHASE PEPTIDE SYNTHESIS
An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and...
2017/0226151 CHEMICAL COMPOUNDS AND USE THEREOF FOR IMPROVING MUSCULAR QUALITY
Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular...
2017/0226150 TRITERPENOID COMPOSITION OF ANTRODIA CINNAMOMEA, PREPARATION AND ANALYSIS METHOD THEREOF
Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia...
2017/0226149 Preparation and Uses of Obeticholic Acid
The present invention relates to obeticholic acid: ##STR00001## or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid...
2017/0226148 3-(4'-SUBSTITUTED)-BENZYL-ETHER DERIVATIVES OF PREGNENOLONE
The invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt thereof: wherein R1 is C1-8 alkyl, C1-8 alkoxy, CN, NO.sub.2, amino,...
2017/0226147 METHODS OF SEPARATING GEMCITABINE-PHOSPHATE DIASTEREOISOMERS
This application relates to a method of separating the phosphate diastereoisomers of gemcitabine[phenyl-benzoxy-L-alaninyl)]-phosphate (NUC-1031) using...
2017/0226146 PROCESS FOR MAKING CHLORO-SUBSTITUTED NUCLEOSIDE PHOSPHORAMIDATE COMPOUNDS
The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): ##STR00001## which are useful...
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