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Patent # Description
2017/0226145 METHODS OF EXTRACTION AND PURIFICATION FROM STEVIA REBAUDIANA OF COMPOSITIONS WITH ENHANCED REBAUDIOSIDE-M...
A method for purifying Reb M includes preparing a crude mother liquor/Stevia rebaudiana primary extract, passing a solution of this primary extract through a...
2017/0226144 METHOD FOR SEPARATING HYDROLYZED PRODUCT OF BIOMASS
A method for separating hydrolysis product of biomass is provided. The method includes providing a mixture solution containing a hydrolysis product of biomass...
2017/0226143 Platinum (IV) Complex with Increased Anti-tumor Efficacy
The invention relates to a new platinum (IV) complex with substantially increased antitumor efficacy. The invention further discloses a process for preparing...
2017/0226142 Factor D Inhibitors Useful for Treating Inflammatory Disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2017/0226141 PRODRUGS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITOR
Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.
2017/0226140 2' FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
Provided are methods for treating Orthomyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: ...
2017/0226139 CRYSTALLINE SALTS OF (Z)-O-OCTADEC-9-EN-1-YL O,O-DIHYDROGEN PHOSPHOROTHIOATE
Here provided are a salt of Z)--O-octadec-9-en-1-yl O,O-dihydrogen phosphorothioate with an L-lysine addition in crystalline form and methods of making and...
2017/0226138 METHOD FOR PREPARING TRIS(TRIALKYLSILYL)PHOSPHINE
The present invention relates to a method for preparing a tris(trialkylsilyl)phosphine in high yield and high purity with safety and no risk of fire or explosion.
2017/0226137 SUBSTITUTED PIPERIDINE COMPOUND AND USE THEREOF
Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): ##STR00001## wherein...
2017/0226136 ORGANOSILICON COMPOUND, METHOD FOR PRODUCING SAME AND METAL SURFACE TREATMENT AGENT USING SAME
An organosilicon compound represented by general formula (1). The present invention is able to provide an organosilicon compound which has excellent adhesion...
2017/0226135 BETA-LACTAMASE INHIBITORS
Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit...
2017/0226134 High Performance Organic Electrodes for Secondary Batteries
The present disclosure relates to a compound of general Formula (1) which can be used as an electrode material, an electrode comprising said compound, and a...
2017/0226133 Gold (I)-Phosphine Compounds as Anti-Bacterial Agents
A compound of formula (I): for use in the prevention or treatment of a bacterial infection wherein: A is either S or Se; RA is selected from: wherein: each of...
2017/0226132 TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
2017/0226131 Inhibitors of PI3K-Delta and Methods of Their Use and Manufacture
The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof as well as methods of making and using the...
2017/0226130 Ataxia Telengiectasia And Rad3-Related (ATR) Protein Kinase Inhibitors
Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided, ##STR00001## wherein R.sup.1, R.sup.2,...
2017/0226129 HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit...
2017/0226128 POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY
The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory...
2017/0226127 COMPOUNDS, COMPOSITIONS AND METHODS
The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
2017/0226126 INTERMEDIATES IN THE SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
Described herein are crystalline forms of a compound of formula (III.sup.-), including toluene solvates off A TD-CLE, as well as processes for the preparation...
2017/0226125 INDOLIZINE-BASED DYES FOR DYE-SENSITIZED SOLAR CELL
Compounds for use as sensitizer dyes in dye-sensitized solar cells.
2017/0226124 PHTHALAZINONE DERIVATIVES
Compounds of the formula (I): ##STR00001## wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NR.sup.X or...
2017/0226122 ARTEMISININ DERIVATIVES, METHODS FOR THEIR PREPARATION AND THEIR USE AS ANTIMALARIAL AGENTS
Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in...
2017/0226121 MODULATORS OF VIRUS ASSEMBLY AS ANTIVIRAL AGENTS
In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle...
2017/0226120 INHIBITORS OF HIF PROLYL HYDROXYLASE
The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for...
2017/0226119 SOLID SALT FORM OF ALPHA-6-MPEG6-O-HYDROXYCODONE AS OPIOID AGONISTS AND USES THEREOF
Solid forms of certain opioid agonists are provided herein. Methods of preparing the solid forms, methods of using the solid forms, and pharmaceutical...
2017/0226118 Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydrocodone, Prodrugs,...
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, ...
2017/0226117 ORGANIC COMPOUNDS
The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), useful for the treatment of diseases or disorders characterized by disruption of or...
2017/0226116 NEW DIHYDROQUINOLINE PYRAZOLYL COMPOUNDS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, ...
2017/0226115 SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR
The compounds of the invention are antagonists of CAR, with specificity for CAR over other proteins including PXR. The disclosed compounds are useful in...
2017/0226114 SOLID STATE FORMS OF IBRUTINIB
The present invention encompasses solid state forms of Ibrutinib, including forms G, J and K, and pharmaceutical compositions thereof.
2017/0226113 PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF
The present invention relates to pyridine, pyrimidine, and pyrazene compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
2017/0226112 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2017/0226111 MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS
Inhibitors of HCV replication of formula (I) ##STR00001## and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double...
2017/0226110 INHIBITORS OF ERK AND METHODS OF USE
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases...
2017/0226109 PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS
Compounds of formula (I) defined herein are phosphoinositide 3-kinases (PI3K) inhibitors and are useful for the treatment of disorders associated with PI3K...
2017/0226108 IBRUTINIB SOLID FORMS AND PRODUCTION PROCESS THEREFOR
Provided are ibrutinib polymorphs, e.g., crystalline ibrutinib Forms III, IV, V, VI, VII, VIII and Form IX and processes for producing these crystalline forms,...
2017/0226107 Heterocyclic Compounds as Pesticides
The present application relates to novel heterocyclic compounds of the formula (I) ##STR00001## in which G, R.sup.1, R.sup.2, Q and V have the meanings given in...
2017/0226106 CXCR4 Receptor Antagonists
The compounds of formula (I) are antagonists of the CXCR4 receptor ##STR00001## Wherein R.sup.1, X, Y and R.sup.2 are as defined in the claims.
2017/0226105 TIED-BACK BENZAMIDE DERIVATIVES AS POTENT ROCK INHIBITORS
The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables...
2017/0226104 STABLE SNS-595 COMPOSITIONS AND METHODS OF PREPARATION
Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially...
2017/0226103 DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS
The present application relates to certain difluoropyrrolidine compounds, pharmaceutical compositions containing them, and methods of using them, including...
2017/0226102 INDOLES FOR USE IN INFLUENZA VIRUS INFECTION
The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
2017/0226101 CRYSTAL FORMS OF GLUTAMINASE INHIBITORS
The invention relates to crystalline salts of a heterocyclic compound, methods of their preparation, and related pharmaceutical preparations thereof. The...
2017/0226100 AMINOTHIAZOLE COMPOUNDS
Aminothiazole compounds of Formula (I) shown herein and pharmaceutical compositions containing one of such compounds.
2017/0226099 QUINAZOLINE DERIVATIVE
Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of...
2017/0226098 NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE
The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable...
2017/0226097 PYRIDINYLOXY- AND PHENYLOXY-PYRAZOLYL COMPOUNDS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2 and n are as described herein, compositions including...
2017/0226096 BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE
Novel benzamide derivatives of formula (I) ##STR00001## wherein W.sup.1, W.sup.2, R.sup.1 to R.sup.10 and X have the meaning according to the claims, are...
2017/0226095 COMPOUNDS FOR PREVENTING, INHIBITING, OR TREATING CANCER, AIDS AND/OR PREMATURE AGING
The manufacture and use of compounds of formula (Ia) or a pharmaceutically acceptable salt thereof for preventing, inhibiting or treating cancer, AIDS and/or...
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