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| Patent # | Description |
|---|---|
| 2017/0233481 |
ANTI-CD25 ANTIBODIES AND THEIR USES The present disclosure relates to antibodies directed to CD25 and uses of such antibodies, for example to suppress organ transplant rejection or to treat... |
| 2017/0233480 |
ANTI-VEGFR ANTIBODY AND USES THEREOF The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The... |
| 2017/0233479 |
ANTI-VISTA ANTIBODIES AND FRAGMENTS, USES THEREOF, AND METHODS OF
IDENTIFYING SAME The present invention relates to antibodies and fragments that bind to a V-domain Ig Suppressor of T cell Activation (VISTA), and methods of eliciting certain... |
| 2017/0233478 |
Antibodies Directed Against ICOS and Uses Thereof The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation... |
| 2017/0233477 |
CELL LINE 3M The present invention provides, inter alia, an isolated cell line, 3M as well as methods for making such a cell line and methods of using such a cell line,... |
| 2017/0233476 |
Antibody Therapeutics That Bind CTLA4 There is disclosed compositions and methods relating to or derived from anti-CTLA4 antibodies. More specifically, there is disclosed fully human antibodies... |
| 2017/0233475 |
ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON One aspect as reported herein is using a method comprising the step of immunizing an experimental animal, three times with primary cynomolgus PBLs, whereby the... |
| 2017/0233474 |
BINDING-TRIGGERED TRANSCRIPTIONAL SWITCHES AND METHODS OF USE THEREOF The present disclosure provides binding-triggered transcriptional switch polypeptides, nucleic acids comprising nucleotide sequences encoding the ... |
| 2017/0233473 |
C10RF32 ANTIBODIES, AND USES THEREOF FOR TREATMENT OF CANCER This invention relates to C1ORF32-specific antibodies, antibody fragments, alternative scaffolds, conjugates and compositions comprising same, for treatment of... |
| 2017/0233472 |
ROR1-Binding Molecules, and Methods of Use Thereof The present invention is directed to optimized ROR1-binding molecules having enhanced affinity and superior ability to mediate redirected cytotoxicity of tumor... |
| 2017/0233471 |
ANTI-LGR5 ANTIBODIES AND USES THEREOF The invention provides anti-LgR5 antibodies and methods of using the same. |
| 2017/0233470 |
ANTI-NEUROTENSIN ANTIBODIES AND USES THEREOF The present invention relates to a neutralising antibody which is capable of binding to neurotensin with high affinity. The antibody of the present invention... |
| 2017/0233469 |
PROPHYLAXIS OF COLORECTAL AND GASTROINTESTINAL CANCER The present disclosure provides methods and compositions useful for preventing gastrointestinal and/or colorectal cancer in animals, including humans, having... |
| 2017/0233468 |
IL-17 ANTAGONIST ANTIBODIES The disclosure relates to antibodies against human IL-17 which act as antagonists of IL-17, and their use in the diagnosis or treatment of IL-17 mediated... |
| 2017/0233467 |
Antibodies Directed to Angiopoietin-1 and Angiopoietin-2 for Ocular
Therapies The present disclosure provides methods of treating ocular disorders using anti-angiogenic antibodies and pharmaceutical formulations. |
| 2017/0233466 |
Methods for Treating or Preventing Atherosclerosis by Administering an
Inhibitor of ANGPTL3 The present invention provides methods and compositions for treating or preventing atherosclerosis in a subject. The methods of the present invention comprise... |
| 2017/0233465 |
TREATMENT OF MYOCARDIAL INFARCTION USING TGF BETA ANTAGONISTS Disclosed herein is a method of treating a patient suffering a myocardial infarction, particularly an acute myocardial infarction, or of reducing an adverse... |
| 2017/0233464 |
Use of TGF-Beta Antagonists to Treat Infants at Risk of Developing
Bronchopulmonary Dysplasia The disclosure relates to methods of treating an infant at risk of developing bronchopulmonary dysplasia, including premature infants, by administering a... |
| 2017/0233463 |
Anti-Alpha Synuclein Binding Molecules Provided are anti-human .alpha.-synuclein-specific binding molecules, e.g., antibodies or antiben-binding fragments, variants or derivatives thereof, as... |
| 2017/0233462 |
Antibody Against Secreted N-Terminal Peptide of GPC3 Present in Blood or
C-Terminal Peptide of GPC3 Disclosed is an antibody against a secreted form of GPC3 capable of detecting a secreted form of glypican 3 (GPC3) in a test sample. It is possible to... |
| 2017/0233461 |
COMPOSITIONS AND METHODS FOR PHAGOCYTE DELIVERY OF ANTI-STAPHYLOCOCCAL
AGENTS The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding... |
| 2017/0233460 |
Anti-Dengue Virus NS1 Protein Monoclonal Antibodies The present invention provides matched antibody pairs for the specific detection of one or more of the four dengue virus serotypes in a biological sample that... |
| 2017/0233459 |
Systems and Methods for the Production of Human Polyclonal Antibodies Disclosed herein is a method for producing human antibodies against a pathogen comprising injecting a non-human animal with a pathogen-derived DNA vaccine in... |
| 2017/0233458 |
METHOD OF MANUFACTURING INTRAVENOUS IMMUNOGLOBULIN FROM FRACTION III The present subject matter is directed to a method of manufacturing purified IVIG from Fraction III of plasma, comprising re-constituting a Fraction III paste... |
| 2017/0233457 |
Immunoglobulin Variable Region Libraries Antigen-specific immunoglobulin V-regions are identified from a library of nucleic acids amplified using polymerase chain reaction using leader ... |
| 2017/0233456 |
AN IMPROVED EXPRESSION CASSETTE FOR PACKAGING AND EXPRESSION OF VARIANT
FACTOR VIII FOR THE TREATMENT OF... Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over... |
| 2017/0233455 |
VIRAL VECTORS ENCODING RECOMBINANT FVIII VARIANTS WITH INCREASED
EXPRESSION FOR GENE THERAPY OF HEMOPHILIA A The present disclosure provides, among other aspects, codon-altered polynucleotides encoding Factor VIII variants for expression in mammalian cells. In some... |
| 2017/0233454 |
CHIMERIC ANTIGEN RECEPTOR CONTAINING A TOLL-LIKE RECEPTOR INTRACELLULAR
DOMAIN The present invention relates to a chimeric antigen receptor, a nucleic acid encoding the same and a cell expressing the same, and their use in manufacturing... |
| 2017/0233453 |
METHODS OF USE OF SOLUBLE CD24 FOR THERAPY OF RHEUMATOID ARTHRITIS Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian... |
| 2017/0233452 |
CHIMERIC ANTIGEN RECEPTORS SPECIFIC TO AVB6 INTEGRIN AND METHODS OF USE
THEREOF TO TREAT CANCER Disclosed are chimeric antigen receptors (CAR) specific to .alpha.v.beta.6 integrin which is uniquely expressed in a wide variety of cancers. Also disclosed... |
| 2017/0233451 |
HIGH AFFINITY PD-1 AGENTS AND METHODS OF USE High affinity PD-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type PD-1 protein; and (ii) have an... |
| 2017/0233450 |
VIRUS LIKE PARTICLE COMPRISING PD-1 ANTIGEN OR PD-1 LIGAND ANTIGEN The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a... |
| 2017/0233449 |
FUSIONS OF ANTIBODIES TO CD38 AND ATTENUATED INTERFERON ALPHA The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion... |
| 2017/0233448 |
INTERLEUKIN-2/INTERLEUKIN-2 RECEPTOR ALPHA FUSION PROTEINS AND METHODS OF
USE Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a... |
| 2017/0233447 |
PROTEIN AND PROTEIN CONJUGATE FOR DIABETES TREATMENT, AND APPLICATIONS
THEREOF The present invention relates to the field of biopharmaceuticals, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use... |
| 2017/0233446 |
METHODS AND COMPOSITIONS USING KLOTHO-FGF FUSION POLYPEPTIDES The present invention is directed to methods, kits and compositions for preventing or treating age-related conditions or metabolic disorders. The Klotho fusion... |
| 2017/0233445 |
ANTI-MICROBIAL PEPTIDE AND METHOD FOR TREATING MICROBIAL INFECTION The present invention provides an antimicrobial peptide, wherein the antimicrobial peptide comprises SEQ ID NO: 4. |
| 2017/0233444 |
RTEF-1 VARIANTS AND USES THEREOF Disclosed are variant RTEF-1 polypeptides having an RTEF-1 amino acid sequence with one or more internal deletions, wherein the polypeptides reduce VEGF... |
| 2017/0233443 |
CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or... |
| 2017/0233442 |
PEPTIDYLYIC INHIBITOR TARGETING CAG-REPEAT RNA TOXICITY IN POLYGLUTAMINE
DISEASES The present invention provides for a novel peptide and method for treating polyglutamine (polyQ) diseases. Also disclosed are related compositions and kits for... |
| 2017/0233441 |
RECOMBINANT HIV-1 ENVELOPE PROTEINS AND THEIR USE HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several... |
| 2017/0233440 |
INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal... |
| 2017/0233439 |
INSECTICIDAL POLYPEPTIDES HAVING BROAD SPECTRUM ACTIVITY AND USES THEREOF The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having... |
| 2017/0233438 |
ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that... |
| 2017/0233437 |
PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII The present invention provides compounds of formula (I) ##STR00001## wherein X.sup.1 to X.sup.8 and R.sup.1 to R.sup.8 are as described herein, as well as... |
| 2017/0233436 |
BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING Benzodiazepine dimers having a structure represented by ##STR00001## wherein R.sup.1 is ##STR00002## wherein the variables in formulae (I), (Ia), and (Ib) are as... |
| 2017/0233435 |
A METHOD FOR MOLECULAR EXTRACTION IN LIVE CELLS A method of extracting biomolecules from live cells comprising: introducing a plurality of magnetized carbon nanotubes (MCNTs) into a live cell, wherein the... |
| 2017/0233433 |
COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein, R.sup.1, R.sup.2a, R.sup.2b, R.sup.3 and... |
| 2017/0233432 |
19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): ##STR00001## and pharmaceutical compositions thereof. Such compounds... |
| 2017/0233431 |
BILE ACID DERIVATIVES AND METHODS FOR SYNTHESIS AND USE Provided herein, inter alia, are methods for the preparation of modulators of farnesoid X receptor (FXR), and compositions and uses of the modulators of FXR. |
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