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Patent # Description
2017/0239249 QUINAZOLINE-BASED KINASE INHIBITORS
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
2017/0239248 PATHOGENIC CONTROL OF APOPTOSIS
The present invention relates to methods and compositions for modulating the control of apoptosis, specifically for modulating the interaction between hnRNP-K...
2017/0239247 Solid Forms of Nilotinib Hydrochloride
A solid form of Nilotinib hydrochloride, which exists as a co-crystal of nilotinib hydrochloride and levulinic acid having a molar ratio of nilotinib...
2017/0239246 BIHETEROARYL COMPOUNDS AND USES THEREOF
The present invention provides for compounds of Formula I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases)....
2017/0239245 PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such...
2017/0239244 Dry Eye Treatments
Described herein are methods and pharmaceutical formulations for treating dry eye disease.
2017/0239243 METHOD OF INCREASING BIOAVAILABILITY AND/OR PROLONGING OPHTHALMIC ACTION OF A DRUG
The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling...
2017/0239241 NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are...
2017/0239240 Sustained Release Buprenorphine Microshperes (SRBM) and Methods of Use Thereof
The present invention is directed to a sustained release buprenorphine microsphere (SRBM) formulation capable of delivering buprenorphine, a metabolite, or a...
2017/0239239 Method for Inducing a Sustained Immune Response
A method for inducing a sustained immune response in humans or animal patient suffering from human immunodeficiency virus (HIV) acquired immune deficiency...
2017/0239238 Method for Inducing a Sustained Immune Response
A method for inducing a sustained immune response in humans or animal patient suffering from human immunodeficiency virus (HIV) acquired immune deficiency...
2017/0239237 PYRROLOQUINOLINE DERIVATIVES AS 5-HT6 ANTAGONISTS, PREPARATION METHOD AND USE THEREOF
This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel...
2017/0239236 CGRP Receptor Antagonists
The disclosures herein relate to novel compounds of formula ##STR00001## wherein Ar.sup.1 and R.sub.1 are as defined herein, and their use in treating,...
2017/0239235 SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INIHIBITORS
Provided herein are compounds that are urea transporter-A inhibitors that are useful for producing a strong diuretic response and may be used for treating...
2017/0239234 TREATMENT OF BDNF-RELATED DISORDERS USING LAQUINIMOD
This application provides for a method of increasing brain-derived neurotrophic factor (BDNF) serum level in a human subject comprising periodically...
2017/0239233 PHARMACEUTICAL TABLET FOR USE IN ADMINISTERING NICOTINE
The invention relates to a chewable tablet including a polymer system, tobacco powder, flavor and sweetener, at least about 70% by weight of the polymer system...
2017/0239232 ARIMOCLOMOL FORMULATION
The present invention relates to a pharmaceutical formulation which provides for extended release of an active pharmaceutical ingredient selected from ...
2017/0239231 METHOD FOR TREATING MOVEMENT DISORDERS WITH BEFIRADOL
The present invention relates to a method of treatment of movement disorders, comprising administering to a patient in need thereof an effective amount of...
2017/0239230 SUBLINGUAL FENTANYL SPRAY
The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable sale thereof, or derivative thereof, suitable...
2017/0239229 ABUSE RESISTANT FORMULA
There is provided a sustained-release pharmaceutical composition comprising a solid, continuous network comprising an excipient with a high mechanical...
2017/0239228 COMPOSITIONS OF TOLPERISONE
The present disclosure relates to tolperisone, or a pharmaceutically acceptable salt or hydrate thereof, with 10 ppm 2-methyl-1-(4-methylphenyl)-propenone...
2017/0239227 COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS
The present invention provides compounds of formula I: ##STR00001## or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the...
2017/0239226 N-Substituted-5-Substituted Phthalamic Acids as Sortilin Inhibitors
The present invention is directed to N-substituted-5-substituted phthalamic acids which of formula (A). ##STR00001## The compounds are considered useful for the...
2017/0239225 COMBINATION THERAPIES FOR TREATMENT OF SPINAL MUSCULAR ATROPHY
Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase...
2017/0239224 METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING AUTOIMMUNE CONDITIONS AND DELAYING...
Dopamine reuptake inhibitors, and their analogs, are disclosed for treating and delaying the progression of autoimmune diseases.
2017/0239223 TRIAZOLONE COMPOUNDS AND USES THEREOF
The invention disclosed herein is directed to compounds of Formula I ##STR00001## and pharmaceutically acceptable salts thereof, which are useful in the ...
2017/0239222 MOLECULAR GENETIC APPROACH TO TREATMENT AND DIAGNOSIS OF ALCOHOL AND DRUG DEPENDENCE
Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol...
2017/0239221 PREVENTION OR TREATMENT OF SLEEP DISORDERS USING DEXMEDETOMIDINE FORMULATION
There is provided a composition suitable for oral transmucosal administration (sublingual) comprising dexmedetomidine. The composition is useful for the...
2017/0239220 Improvements to Nasal Compositions and Method of Use Thereof
A nasal composition is provided comprising or consisting of a first composition part in the form of a liquid for nasal application to a patient in use, and a...
2017/0239219 ESTROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF LOCALLY ADVANCED OR METASTATIC ESTROGEN RECEPTOR POSITIVE...
Described herein are methods of treating locally advanced or metastatic estrogen receptor positive breast cancer.
2017/0239218 ANTIPARASITIC ISOXAZOLINE COMPOUNDS, LONG-ACTING INJECTABLE FORMULATIONS COMPRISING THEM, METHODS AND USES THEREOF
This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid...
2017/0239217 ANHYDROUS LIQUID MELATONIN COMPOSITION
The present invention relates to a concentrated melatonin solution, wherein melatonin is present in a quantity of 10.0% or higher in a substantially water-free...
2017/0239216 SMALL MOLECULE INHIBITORS OF N-TERMINUS ACTIVATION OF THE ANDROGEN RECEPTOR
Compounds having a structure of Formula (A) are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as...
2017/0239215 PROLINE OR PROLINE DERIVATIVES FOR THE TREATMENT OF DEMENTIA
A pharmaceutical compositions including proline or proline derivatives is provided. A method for the treatment of dementia, Alzheimer's and neurodegenerative...
2017/0239214 COMPOSITION FOR PREVENTING OR TREATING OBESITY CONTAINING ALPHA-LIPOIC ACID AND N-ACETYLCYSTEINE AS ACTIVE...
The present invention provides a composition containing .alpha.-lipoic acid and N-acetylcysteine as active ingredients. The mixed composition of .alpha.-lipoic...
2017/0239213 METHODS OF TREATMENT OF FIBROSIS AND CANCERS
The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5-dimethyl-4-carboxydimethyl-methyloxyphenyl]- prop-2-en-1-one for treating...
2017/0239212 BRYOSTATIN ANALOGS AND USE THEREOF AS ANTIVIRAL AGENTS
Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of...
2017/0239211 USE OF CHROMONE DERIVATIVE AS PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF FIBROSIS USING EMT...
A pharmaceutical composition contains the chromone derivative of Chemical Formula 1 and a pharmaceutically acceptable salt as an active ingredient, thus...
2017/0239210 METHOD OF TREATMENT
Embodiments of the invention relate to the treatment of sleep disturbances in individuals with Smith-Magenis Syndrome (SMS).
2017/0239209 Intranasal Compositions For Treatment of Neurological And Neurodegenerative Diseases And Disorders
The present invention relates generally to intranasal pharmaceutical compositions. In particular, the present invention is directed to sustained, enhanced...
2017/0239208 USE OF SILVER(I) COMPLEXES AS ANTICANCER AGENTS
The present invention relates to the use of silver(I) monophosphine complexes as Active Pharmaceutical Ingredients (API's), including anticancer agents, for...
2017/0239207 Method for Treating Skin Cancer
A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the...
2017/0239206 CRYSTALLINE FORMS OF (N, N-DIETHYLCARBAMOYL)METHYL METHYL (2E)BUT-2-ENE-1,4-DIOATE, METHODS OF SYNTHESIS AND USE
Disclosed herein are crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, which is a prodrug of methyl hydrogen fumarate....
2017/0239205 GLYCOGEN OR POLYSACCHARIDE STORAGE DISEASE TREATMENT METHOD
A method for treating glycogen storage disease by administering an effective amount of a composition that includes ketogenic odd carbon fatty acids that...
2017/0239204 METHODS OF TREATING A POIKILOTHERMIC ORGANISM IN A DECREASING TEMPERATURE ENVIRONMENT
There is provided herein a method of treating a poikilothermic organism, such as marine bivalves, in a decreasing temperature environment which method...
2017/0239203 PREGABALIN SUSTAINED-RELEASE PREPARATION
Disclosed is a pregabalin sustained-release preparation, wherein the sustained-release tablet contains a pharmaceutically active ingredient containing...
2017/0239202 (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and Related Compounds as GABA...
Cyclopentene carboxylic acid-related compounds as GABA-AT inhibitors for treatment of various addictions, disorders and disease states.
2017/0239201 GLYCOLIC ACID ENHANCES SPERM MOBILITY
The present invention relates to glycolic acid or a pharmaceutically acceptable salt or ester thereof for use in the treatment or prevention of male...
2017/0239200 SMALL MOLECULE INHIBITORS OF RNA BINDING MOTIF (RBM) PROTEINS FOR THE TREATMENT OF ACUTE CELLULAR INJURY
A method of treating a cellular injury in a subject comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of...
2017/0239199 METHODS OF TREATMENT USING SUSTAINED RELEASE SOTALOL FORMULATIONS
Sustained release compositions of sotalol, or a pharmaceutically acceptable salt thereof, are provided. In certain examples, sotalol, or a pharmaceutically...
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