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Patent # Description
2017/0240625 Antagonist Antibodies Directed Against Calcitonin Gene- Related Peptide
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
2017/0240624 Antagonist Antibodies Directed Against Calcitonin Gene- Related Peptide
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
2017/0240623 Antagonist Antibodies Directed Against Calcitonin Gene- Related Peptide
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
2017/0240622 Antagonist Antibodies Directed Against Calcitonin Gene- Related Peptide
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
2017/0240621 Humanized Antibodies That Recognize Alpha-Synuclein
The present application discloses humanized 9E4 antibodies. The antibodies bind to human alpha synuclein and can be used for immunotherapy of Lewy body disease.
2017/0240620 ANTI-POLYUBIQUITIN ANTIBODIES AND METHODS OF USE
The invention provides anti-polyubiquitin antibodies and methods of using the same.
2017/0240619 MODIFIED VARIABLE DOMAIN MOLECULES AND METHODS FOR PRODUCING THEM
The present disclosure provides an isolated, engineered or non-naturally occurring protein comprising an antibody light chain variable domain (V.sub.L) which...
2017/0240618 MONOCLONAL ANTIBODIES FOR TREATMENT OF MICROBIAL INFECTIONS
Described are a therapeutic monoclonal antibody specific for the Type Six Secretion System (T6SS) needle protein of Acinetobacter baumannii (A. baumannii) and...
2017/0240617 FORMULATIONS OF ANTIBODY MOLECULES TO INFLUENZA VIRUS
This disclosure relates to formulations of peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza...
2017/0240616 COMPOSITION WITH REDUCED IMMUNOGENICITY
The present invention relates to polyclonal antibodies directed against at least one non-human biological pathogen, or against at least one molecule derived...
2017/0240615 COMPOSITIONS OF, AND METHODS FOR, ALPHA-1 ANTITRYPSIN Fc FUSION MOLECULES
A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for...
2017/0240614 BLOOD GLUCOSE LOWERING COMPOUND
The present invention relates to the field of medicine and the treatment of diabetes or hyperglycemia within that field. More particularly, the invention...
2017/0240613 COMPOSITIONS AND METHODS FOR MODULATING T-CELL MEDIATED IMMUNE RESPONSE
The present disclosure relates to compositions and methods for modulating T-cell mediated immune response in a subject in need thereof. The method includes...
2017/0240611 Modulation of the VPS10p-Domain Receptor Family for the Treatment of Mental and Behavioural Disorders
The present invention relates to methods for modulating the activity of one or more Vps10p-domain receptors selected from the group consisting of Sortilin,...
2017/0240610 PEPTIDE FOR TREATMENT OF TYPE 2 DIABETES MELLITUS AND ITS COMPLICATIONS
The invention relates to biotechnology. The exenatide analogue with the formula H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-As-Leu-Ser-Lys-Gln-Glu-Glu-Glu-- ...
2017/0240609 GIP AGONIST COMPOUNDS AND METHODS
The present invention relates to acylated GIP analogues which have GIP agonist activity, and their use in the treatment of metabolic disorders.
2017/0240608 PROPROTEINS AND METHODS OF USE THEREOF
The present disclosure provides for proprotein and activatable proprotein compositions. A proprotein contains a functional protein (i.e. a full length protein...
2017/0240607 MODULATING GAMMA-C-CYTOKINE ACTIVITY
Peptide antagonists of .gamma.c-family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases,...
2017/0240606 Compositions and Methods for Inhibiting Tumor Cells by Inhibiting the Transcription Factor ATF5
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the...
2017/0240605 COMPOSITIONS AND METHODS FOR INHIBITING TUMOR CELLS BY INHIBITING THE TRANSCRIPTION FACTOR ATF5
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the...
2017/0240604 RAS INHIBITORY PEPTIDES AND USES THEREOF
The present invention provides peptides comprising a sequence of X-.sub.6X-.sub.5X-.sub.4X-.sub.3X-.sub.2X-.sub.1X.sub.1PX.sub.3X.sub.4PX.- ...
2017/0240603 INSECTICIDAL POLYPEPTIDES HAVING BROAD SPECTRUM ACTIVITY AND USES THEREOF
The disclosure provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having...
2017/0240602 PULMONARY ADMINISTRATION OF PYOCINS FOR TREATING BACTERIAL RESPIRATORY INFECTIONS
The invention relates to the treatment of bacterial respiratory infections using the bacterially-originating antibiotics known as pyocins. In particular, the...
2017/0240601 VACCINE
The invention provides a recombinant polypeptide comprising the EDIII domain of each of Dengue virus serotype DENV-1, DENV-2, DENV-3, and DENV-4 linked to the...
2017/0240600 TAGGED HEPADNAVIRUS E ANTIGEN AND ITS USE IN SCREENING ANTIVIRAL SUBSTANCES
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit...
2017/0240599 A PROCESS FOR THE PREPARATION OF LINACLOTIDE
The present invention relates to a process for the preparation of Linaclotide by oxidizing linear Linaclotide of formula (II) using combination of air and...
2017/0240598 ADVANCED MACROMOLECULE TRANSDUCTION DOMAIN (AMTD) SEQUENCES FOR IMPROVEMENT OF CELL-PERMEABILITY,...
The present invention is to execute macromolecule intracellular transduction technology (MITT) for delivering biologically active macromolecules into the...
2017/0240597 VIVO METHODS OF MONITORING BIODISTRIBUTION
Functional-lipid constructs of the structure F-S-L are disclosed, wherein F comprises a tyrosine or histidine residue, S is a spacer covalently linking F to L...
2017/0240596 PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) TARGETING PEPTIDES
Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel...
2017/0240595 Melanocortin Receptor Ligands
The present invention is directed to compounds according to formula, (R.sup.2R.sup.3)-A.sup.1-c(A.sup.2-A.sup.3-A.sup.4-A.sup.5-A.sup.6-A.sup- ...
2017/0240594 Therapeutic Use of Peptide Inhibitors of NADPH Oxidase; Aerosolization as a Delivery Mechanism
A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide...
2017/0240593 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron...
2017/0240592 GADD45BETA/MKK7 INHIBITOR FOR THE TREATMENT OF A RESISTANT HAEMATOLOGICAL MALIGNANCY
A Gadd45.beta./MKK7 inhibitor for use in a method of treating a resistant haematological malignancy, combinations of said inhibitor with a further anti-cancer...
2017/0240591 LIGAND FUNCTIONALIZED POLYMERS
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
2017/0240590 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising...
2017/0240589 COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein (II), A, R.sup.1, R.sup.2, R.sup.3a,...
2017/0240588 AMPHIPHILIC COMPOUNDS WITH NEUROPROTECTIVE PROPERTIES
Amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use in methods of treatment of...
2017/0240587 HETEROARYL CONTAINING BILE ACID ANALOGS AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
The present invention provides compounds of Formula I, ##STR00001## pharmaceutical compositions comprising these compounds and methods of using these compounds...
2017/0240586 Benzoic Acid Derivatives of Bile Acid as FXR/TGR5 Agonists and Methods of Use Thereof
The present invention provides compounds of Formula I: ##STR00001## pharmaceutical compositions comprising these compounds and methods of using these compounds...
2017/0240585 DEUTERATED BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
The present invention provides compounds of Formula (I) or Formula (II): ##STR00001## pharmaceutical compositions comprising these compounds and methods of using...
2017/0240584 NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES
The invention provides compounds of formula I, wherein R.sub.1, R.sub.2 and R.sub.3 have values defined in the specification and a pharmaceutically acceptable...
2017/0240583 Bola-amphiphilic compounds and their uses for biomedical applications
The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of ...
2017/0240582 1,4,7,10-TETRAZACYCLODODECANE BASED AGENTS TO TARGET BACTERIA AND ITS USE
The present invention relates to new compounds comprising a siderophore moiety as well as a core structure able to chelate a metal ion. Optionally, the...
2017/0240581 ANTI-CANCER AGENT AND CANCER CELL KILLING METHOD
[Object] An anticancer agent capable of continuously killing cancer cells in a plurality of phases is provided. [Solution] An anticancer agent contains a complex...
2017/0240580 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
Phosphorescent metal complexes comprising a pendant redox-active metallocene are disclosed. These complexes are useful as emitters for phosphorescent OLEDs.
2017/0240579 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
Novel phosphorescent tetradentate platinum compounds of Formula I are provided. The complexes contain a dibenzo moiety, which allows for the creation of OLED...
2017/0240578 STABILIZED ORGANOPHOSPHOROUS COMPOUNDS
A hydroformylation process wherein the hydrolyzable organophosphorous ligand component of the catalyst is supplied as a stabilized ligand composition...
2017/0240577 ANTIOXIDANT COMPOUND HAVING ANTI ATHEROSCLEROTIC EFFECT AND PREPARATION THEREOF
The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly...
2017/0240576 Phosphorylcholine Group-Containing Compound and Phosphorylcholine Complex
[Object] To provide a phosphorylcholine group-containing compound capable of producing a phosphorylcholine complex, and the phosphorylcholine complex, the...
2017/0240575 Chemical inhibitors of sebocyte function
The present discovery pertains to the discovery of certain amphiphilic compounds that may be useful for the management of sebum secretion in subjects with...
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