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Patent # Description
2017/0240574 ALKENYL (PERFLUOROALKYL) PHOSPHINIC ACIDS
The invention relates to alkenyl(perfluoroalkyl)phosphinic acids, to the preparation and intermediates thereof, to the use thereof as monomers for the...
2017/0240573 ORGANOSILICON COMPOUND AND CURABLE COMPOSITION
A cyclic organosilicon compound having a (meth)acrylic group and a urea structure on a silicon atom cures into a product having improved flexibility, surface...
2017/0240572 METHOD OF PREPARING SILYLATIVE-REDUCED N-HETEROCYCLIC COMPOUND USING ORGANOBORON CATALYST
Provided is a method of preparing a silylative-reduced N-heterocyclic compound by reducing an N-heteroaromatic compound including a sp.sup.2 hybridized...
2017/0240571 STABLE SILYLATING REAGENTS
The present invention is directed to compositions for silylating organic substrates containing C--H or O--H bonds, especially heteroaromatic substrates. The...
2017/0240570 NOVEL SMALL MOLECULE ANTICANCER AGENTS
The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell...
2017/0240569 METAL COMPLEXES BASED ON A BIS(2-PYRIDYLMETHYL)AMINE-BASED SCAFFOLD AND METHODS OF MAKING THE SAME
A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound...
2017/0240568 METHOD FOR SELECTIVE DETECTION AND ESTIMATION OF HISTIDINE AND CYSTEIN
The Invention relates to a novel receptor molecule for estimation of amino acids based on florescence enhancements. Particularly, the invention relates to a...
2017/0240567 ETHYL N-BOC PIPERIDINYL PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS
The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as...
2017/0240566 AMINO-SUBSTITUTED ANNULATED PYRIMIDINES AND USE THEREOF
The present application relates to novel amino-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the...
2017/0240565 MACROCYCLIC LRRK2 KINASE INHIBITORS
The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in...
2017/0240563 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION
The present invention encompasses the use of compounds for a novel approach to treat and prevent diseases, conditions, and disorders such as diabetes and...
2017/0240562 PYRIDINE COMPOUNDS
The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory...
2017/0240561 PROCESS FOR THE PREPARATION OF MACROCYCLIC KETONE ANALOGS OF HALICHONDRIN B OR PHARMACEUTICALLY ACCEPTABLE...
The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts...
2017/0240560 STEREOCHEMICALLY DEFINED POLYPROPIONATES AND METHODS FOR MAKING AND USING THE SAME
The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined...
2017/0240559 Method for Producing Anhydrosugar Alcohol by High-Pressure Reaction
The present invention relates to a method of producing anhydrosugar alcohol by dehydrating sugar alcohol at high pressure in the presence of a catalyst which...
2017/0240558 SANGUINARINE ANALOG PP2C INHIBITORS FOR CANCER TREATMENT
Sanguinarine analogs as PP2C inhibitors are disclosed for the treatment of various cancers, as well as methods of synthesizing such analogs.
2017/0240557 COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE
The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl...
2017/0240556 BIFLUORODIOXALANE-AMINO-BENZIMIDAZOLE KINASE INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNEINFLAMMATION AND...
The invention relates to a compound of the general formula (I) or a physiologically functional derivative, solvate or salt thereof, ##STR00001## wherein A is a...
2017/0240555 INHIBITORS OF HIF PROLYL HYDROXYLASE
The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for...
2017/0240554 PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers,...
2017/0240553 SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE DISEASES
Disclosed are novel compounds useful in the treatment of multiple sclerosis and other autoimmune diseases. The present invention describes compounds of formula...
2017/0240552 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES
A compound compound having the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound...
2017/0240551 SUBSTITUTED [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS
Novel compounds of Formula I ##STR00001## and their use in therapeutic treatments.
2017/0240550 WNT PATHWAY MODULATORS
The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making...
2017/0240549 TETRAHYDROPYRIDO[3',2':4,5]PYRROLO[1,2-a]PYRAZINE-2-CARBOXAMIDE DERIVATIVES USEFUL AS RSK INHIBITORS
Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the...
2017/0240548 TETRACYCLIC PYRIDONE COMPOUNDS AS ANTIVIRALS
The invention provides compounds of Formula (I) ##STR00001## as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions...
2017/0240547 IMIDAZO(4,5-B) PYRIDIN-2-YL AMIDES AS KV7 CHANNEL ACTIVATORS
Compounds represented by formula 1 can be potent and/or partially selective for the Kv7.2/7.3 heteromultimer. They may be useful in treating disorders related...
2017/0240546 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
2017/0240545 NOVEL INHIBITORS OF PROTEIN KINASES
Protein kinases are regulators of cellular signaling and their functional dysregulation is common in carcinogenesis and many other disease states or disorders....
2017/0240544 ISOQUINOLINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER
The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as a...
2017/0240543 CRYSTALLINE FORMS OF PALBOCICLIB
The present invention provides crystalline Form I, Form II, Form III, Form IV, Form V, Form V-A, Form VI, Form VII, and Form VIII of palbociclib, processes for...
2017/0240542 NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED-3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE...
The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions...
2017/0240541 PROCESS FOR PREPARING THIAZOLE DERIVATIVES
The present invention relates to a novel process for preparing thiazole derivatives.
2017/0240540 3-ALKYL-5-FLUORO-4-SUBSTITUTED-IMINO-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AS FUNGICIDES
This present disclosure is related to the field of 3-alkyl-5-fluoro-4-substituted-imino-3,4-5 dihydropyrimidin-2(1H)-ones and their derivatives and to the use...
2017/0240539 Preparation and Use of Cyclic Sulfonamide Derivatives as PAR-1 Receptor Antagonists
The present invention relates to cyclic sulfonamide derivatives of Formula (I) or a pharmaceutically acceptable salt thereof. ##STR00001##
2017/0240538 G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME
Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and...
2017/0240537 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2017/0240536 DIARYL ISOXAZOLINE COMPOUND
The present invention concerns compounds of formula (I) or an N-oxide or salt thereof and their use for controlling parasites in and on warm-blooded animals or...
2017/0240535 HDAC1/2 INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE AND/OR COGNITIVE DISORDERS
Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent diseases or...
2017/0240534 POLYCYCLIC INHIBITOR OF ANAPLASTIC LYMPHOMA KINASE
Disclosed is a polycyclic inhibitor of anaplastic lymphoma kinase as represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof....
2017/0240533 CRYSTALLINE FORM OF AFATINIB DIMALEATE
The present invention provides a crystalline Form I of afatinib dimaleate, its process for preparation and pharmaceutical composition thereof, and its use in...
2017/0240532 AZETIDINYLOXYPHENYLPYRROLIDINE COMPOUNDS
The invention provides certain azetidinyloxyphenylpyrrolidine compounds, particularly compounds of formula I, and pharmaceutical compositions thereof. The...
2017/0240531 AMINOMETHYLENE PYRAZOLONES WITH THERAPEUTIC ACTIVITY
A compound having the structure according to formula III ##STR00001## wherein: X is NH or S; R.sup.1 is H or (1C-4C)alkyl; R.sup.2 is (1C-4C)alkyl, phenyl or a...
2017/0240530 BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR AGONISTS
This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic...
2017/0240529 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted ...
2017/0240528 PROCESS FOR THE PREPARATION OF POLYMORPHIC FORMS OF NILOTINIB HYDROCHLORIDE
A process for preparing Nilotinib hydrochloride Form R5 and Form R6 comprises: step a) providing a solution of Nilotinib free base in acetic acid and...
2017/0240527 ACID-ADDITION SALT OF Trk-INHIBITING COMPOUND
In order to provide a prophylactic and/or therapeutic agent for Trk-related diseases, the present invention provides a compound which has a selective...
2017/0240526 SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND USES THEREOF
The present invention features compounds having soluble epoxide hydrolase inhibitory activity. The compounds of the invention, alone or in combination with...
2017/0240525 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to...
2017/0240524 Factor XIa Inhibitors
The present invention provides a compound of Formula (I) (Formula(I)) and pharmaceutical compositions comprising one or more said compounds, and methods for...
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