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Patent # Description
2017/0260282 GITR Antibodies, Methods, and Uses
Provided herein are antibodies that specifically bind to GITR. Also described are related polynucleotides capable of encoding the provided GITR-specific...
2017/0260281 ANTI-DR5 FAMILY ANTIBODIES, BISPECIFIC OR MULTIVALENT ANTI-DR5 FAMILY ANTIBODIES AND METHODS OF USE THEREOF
Anti-DR5 family member antibodies and bispecific antibodies comprising one or more anti-DR5 family member antibodies are disclosed. These antibodies can be...
2017/0260280 Antibodies that Bind to OX40 and Their Uses
The present invention relates to antagonist antibodies or fragments thereof that bind to human OX40. More specifically, the present invention relates to an...
2017/0260279 SYNERGISTIC COMBINATIONS OF OX40L ANTIBODIES FOR THE TREATMENT OF GVHD
The present invention relates to anti-human OX40L antibodies, new medical uses and methods.
2017/0260278 METHODS OF INHIBITING PATHOLOGICAL ANGIOGENESIS WITH DOPPEL-TARGETING MOLECULES
Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with...
2017/0260277 CD123-Specific Chimeric Antigen Receptor Redirected T Cells and Methods of Their Use
A family of chimeric antigen receptors (CARs) containing a CD123 specific scFv was developed to target different epitopes on CD123. In some embodiments, such a...
2017/0260276 TREATMENT FOR RHEUMATOID ARTHRITIS
Treatment of rheumatoid arthritis (RA) to provide clinical benefit in patients, including decrease in DAS28-CRP by more than 1.2 and/or improvement determined...
2017/0260275 MYOSTATIN OR ACTIVIN ANTAGONISTS FOR THE TREATMENT OF SARCOPENIA
The present invention relates to myostatin or activin antagonists, dose regimen and pharmaceutical compositions thereof, for the treatment of sarcopenia, in...
2017/0260274 CONSTRUCT FOR THE DELIVERY OF A MOLECULE INTO THE CYTOPLASM OF A CELL
Described is a construct comprising (a) a targeting moiety; (b) a fusogenic moiety consisting one or more fusogenic sequence(s) derived from dengue virus...
2017/0260273 ANTI-C-MET/ANTI-ANG2 BISPECIFIC ANTIBODY
An anti-c-Met/anti-Ang2 bispecific antibody, a composition including the anti-c-Met/anti-Ang2 bispecific antibody, and a method of preventing and/or treating a...
2017/0260272 LECTIN-LIKE OXIDIZED LDL RECEPTOR 1 ANTIBODIES AND METHODS OF USE
The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes...
2017/0260271 T Cell-Redirected Antigen-Binding Molecule For Cells Having Immunosuppression Function
It was discovered that antigen-binding molecules comprising (i) a domain that binds to a molecule expressed on the surface of cells having immune ...
2017/0260270 ANTI CD84 ANTIBODIES, COMPOSITIONS COMPRISING SAME AND USES THEREOF
An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal...
2017/0260269 SIGNALLING SYSTEM
The present invention provides a chimeric antigen receptor (CAR) signalling system comprising; (i) a receptor component comprising an antigen binding domain, a...
2017/0260268 TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY
The present invention provides compositions and methods for regulating the specificity and activity of immune effector cells for use in immunotherapy. In one...
2017/0260267 METHODS OF TREATING ATOPIC DERMATITIS WITH IL-31 MONOCLONAL ANTIBODIES
The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced...
2017/0260266 TSLP BINDING PROTEINS
The present disclosure relates to TSLP binding proteins that interact with particular residues of human full length TSLP, or contact particular regions of...
2017/0260265 BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES AND THEIR USE IN THE TREATMENT OF OCULAR VASCULAR DISEASES
The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of...
2017/0260264 ANTIBODIES AGAINST NERVE GROWTH FACTOR (NGF) WITH ENHANCED IN VIVO STABILITY
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation...
2017/0260263 PROTEIN-BASED THERAPY AND DIAGNOSIS OF TAU-MEDIATED PATHOLOGY IN ALZHEIMER'S DISEASE
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions...
2017/0260262 MONOCLONAL ANTIBODY AGAINST HUMAN TAU PROTEIN
The invention relates to the monoclonal antibody 1G2, the hybridoma cell line H-1 G2 characterized by DSM ACC3248, and the epitope TPP comprising the amino...
2017/0260261 Conditionally Active Chimeric Antigen Receptors for Modified T-Cells
This disclosure relates to a chimeric antigen receptor for binding with a target antigen. The chimeric antigen receptor comprises at least one antigen specific...
2017/0260259 MONOCLONAL ANTIBODY AGAINST MURAMYL PEPTIDES
Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog...
2017/0260258 ANTIBODY BINDING SPECIFICALLY TO PRE-S1 OF HEPATITIS B VIRUS AND USE OF THE ANTIBODY
Provided are: an antibody binding specifically to a surface antigen, pre-S1, of a hepatitis B virus (HBV); a polynucleotide coating the antibody; an expression...
2017/0260257 ANTIBODY COMPOSITION FOR PREVENTION OR TREATMENT OF MUTANT HEPATITIS B VIRUS INFECTION
The present invention provides an antibody that binds to the surface antigen (HBsAg) of hepatitis B virus (HBV) to neutralize the hepatitis B virus. The...
2017/0260256 MODIFIED COLOSTRUM PROTEIN AND APPLICATION THEREOF
Disclosed is a modified colostrum protein having an amino acid sequence shown in SEQ ID NO.: 1, which is generated by replacing Ile at position 33, Glu at...
2017/0260255 FUSION PROTEIN AND PURIFYING METHOD
The invention relates to, inter alia, a fusion protein comprising a protein of interest and an affinity tag which binds lysozyme. Lysozyme can be used to...
2017/0260254 METHOD FOR PRODUCING VARIANTS HAVING AN FC WITH IMPROVED SIALYLATION
The present invention relates to a method for increasing the sialylation of an Fc fragment, including a mutation step of at least one amino acid selected from...
2017/0260253 CYSTEINE ENGINEERED ANTIBODIES AND CONJUGATES
Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of...
2017/0260252 PRODUCTION OF HETEROMULTIMERIC PROTEINS USING MAMMALIAN CELLS
Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as...
2017/0260251 ECOTIN VARIANTS
Ecotin variants and their use in treating viral hemorrhagic fever are described. Described herein are methods for treating systemic inflammatory response...
2017/0260250 MUTATIONS IN THE EXTRACELLULAR DOMAIN III OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE
The invention relates to new identified mutations in the epidermal growth factor receptor gene, leading to amino acidic changes which highly correlate with the...
2017/0260249 Uterine cancer treatments
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0260248 STABILIZED INSULINOTROPIC PEPTIDES AND METHODS OF USE
The present invention provides stably crosslinked insulinotropic polypeptides having superior and unexpected benefits in the treatment of conditions involving...
2017/0260247 Method For Synthesizing Degarelix
The present invention relates to the field of medicinal synthesis, and discloses a method for synthesizing degarelix. The method of the present invention as a...
2017/0260246 CARCINOMA HOMING PEPTIDE (CHP), ITS ANALOGS, AND METHODS OF USING
A mini-peptide and its analogs have been found to target gene products to tumors. The peptide, named Carcinoma Homing Peptide (CHP), increased the tumor...
2017/0260245 TUMOR NECROSIS FACTOR SUPERFAMILY AND TNF-LIKE LIGAND MUTEINS AND METHODS OF PREPARING AND USING THE SAME
The invention features homo-multimers, e.g., homo-trimers, of TNFSF or TNF-like ligand muteins in which each TNFSF ligand or TNF-like ligand mutein monomer...
2017/0260244 Endoplasmic Reticulum Localization Signals
The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or...
2017/0260243 CHLOROTOXIN POLYPEPTIDES AND CONJUGATES AND USES THEREOF
Reduced lysine chlorotoxin polypeptides that may be used to generate single species conjugates of chlorotoxin. Conjugates comprising such chlorotoxin...
2017/0260242 METHOD FOR MODIFYING RNA BINDING PROTIEN USING PPR MOTIF
The objects of the present invention are to identify the amino acids that play a principal role for the PPR motif to act as a RNA binding unit, as well as to...
2017/0260241 TREATMENT OF DIABETES, TOLL-LIKE RECEPTOR 4 MODULATORS AND METHODS FOR USING THE SAME
The present invention relates to treatment of diabetes, toll-like receptor 4 (TLR-4) modulators and methods for using the same. Particularly, the present...
2017/0260240 BROAD SPECTRUM CONJUGATE VACCINE TO PREVENT KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA INFECTIONS
The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked...
2017/0260239 MODIFIED VP1-CAPSID PROTEIN OF PARVOVIRUS B19
The inventions relates to a modified VP1-capsid protein of parvovirus B19 having reduced phospholipase A2-like enzyme activity as compared to the wild type...
2017/0260238 New Polypeptides
The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding...
2017/0260237 MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
2017/0260236 COMPOSITIONS FOR EXPANDING REGULATORY T CELLS (TREG), AND TREATING AUTOIMMUNE AND INFLAMMATORY DISEASES AND...
Provided are compositions, including isolated, synthetic or recombinant peptides for: expanding regulatory T cells (Treg) populations; for treating or...
2017/0260235 POLYPEPTIDE EXPRESSED IN THE STRATUM CORNEUM AND USE THEREOF
Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the...
2017/0260234 ALZHEIMER'S DISEASE TREATMENT METHOD
The invention relates to antibodies which are used in the preparation of a medicament for the treatment of Alzheimer's disease. More specifically, the...
2017/0260233 PEPTIDE HAVING OSTEOCLAST DIFFERENTIATION AND ACTIVATION INHIBITION, AND USE OF SAME
A peptide which is formed from an amino acid sequence selected from the group comprising amino acid sequences of SEQ ID NO: 1 to SEQ ID NO: 3, according to the...
2017/0260232 TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE
Tubulysin compounds of the formula (I) ##STR00001## where R.sup.1, R.sup.2 R.sup.3a, R.sup.3b, R.sup.4, R.sup.5, W, and n are as defined herein, are anti-mitotic...
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