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Patent # Description
2017/0260231 Substrates and Inhibitors of Prolyl Oligopeptidase and Methods of Use Thereof
Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to...
2017/0260230 COMPUNDS FOR ENZYME INHIBITION
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile...
2017/0260229 REACTION PROCESS WITH MEMBRANE SEPARATION
Provided herein are processes for carrying out a chemical reaction of a substrate in a diluted reaction mixture. The processes include conducting the reaction...
2017/0260228 SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF EYE DISEASE
The present invention relates to a terpenoid derivative that has the ability to activate the Keap1/Nrf2/ARE signaling pathway and is excellent in...
2017/0260227 C17-ALKANEDIYL AND ALKENEDIYL DERIVATIVES OF OLEANOLIC ACID AND METHODS OF USE THEREOF
Disclosed herein are novel C17-alkanediyl and alkenediyl derivatives of oleanolic acid, including those of the formula: ##STR00001## wherein the variables are...
2017/0260226 3-NITROGEN OR SULPHUR SUBSTITUTED OESTRA-1,3,5(10),16-TETRAENE AKR1C3 INHIBITORS
The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of...
2017/0260225 3-DESOXY DERIVATIVE AND PHARMACEUTICAL COMPOSITIONS THEREOF
The present application provides Compound 1: ##STR00001## or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to...
2017/0260224 NANOPARTICLES, PROCESS FOR PREPARATION AND USE THEREOF AS CARRIER FOR AMPHIPATIC AND HYDROPHOBIC MOLECULES IN...
The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja...
2017/0260223 ENANTIOMERS OF THE 1',6'-ISOMER OF NEPLANOCIN A
Enantiomers of 1',6'-isoneplanocin, including derivatives of the enantiomers of 1',6'-isoneplanocin, are disclosed along with novel synthetic methods. In...
2017/0260222 CRYSTALLINE FORMS OF FERRIC MALTOL
There is provided polymorphs of ferric maltol. Such forms may be useful in the treatment of iron deficiency with or without anaemia, such as iron deficiency...
2017/0260221 Ruthenium-Based Photolinkers and Methods of Use
The present invention provides ruthenium-based photolinker compounds, caged molecules comprising the ruthenium-based photolinker compounds, and methods of use....
2017/0260220 Metathesis Catalyst
The current invention describes new metathesis catalysts, a method for their preparation and their use in metathesis reactions.
2017/0260219 PHOSPHONATE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2017/0260218 NANOCRYSTAL AND PREPARATION METHOD THEREOF
A nanocrystal represented by the following Formula 1 and a preparation method thereof: AMX.sub.3L Formula 1 wherein A is cesium (Cs), rubidium (Rb), or an ...
2017/0260217 METHODS FOR SYNTHESIZING METAL MESOPORPHYRINS
Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin...
2017/0260216 HYDROSILYLATION IRON CATALYST
A hydrosilylation iron catalyst prepared from a two-electron ligand (L) and a mononuclear, binuclear, or trinuclear complex of iron indicated by formula (1),...
2017/0260215 HYDROSILYLATION REACTION CATALYST
A hydrosilylation reaction catalyst prepared from: a catalyst precursor comprising a transition metal compound, excluding platinum, belonging to group 8-10 of...
2017/0260213 NEW METAL N-AMINOGUANIDINATE COMPLEXES FOR USE IN THIN FILM FABRICATION AND CATALYSIS
The present patent application relates to new metal complexes having at least one N-aminoguanidinate ligand. The patent application further relates to the...
2017/0260212 METAL COMPLEX AND COLOR CONVERSION FILM COMPRISING SAME
The present disclosure relates to a novel compound, a color conversion film, a backlight unit and a display device comprising the same.
2017/0260211 HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER
Disclosed herein are heterocyclic compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of...
2017/0260210 METHOD FOR PREPARING MARMYCIN A AND ANALOGUES THEREOF, AND ALSO USES THEREOF
The present invention relates to a method for preparing marmycin A and analogues thereof, to novel marmycin A analogues, and also to the use of these compounds...
2017/0260209 3-(3H-IMIDAZO[4,5-B]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2017/0260208 PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS
The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo...
2017/0260207 BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS
The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of...
2017/0260206 ANDROGEN RECEPTOR MODULATING COMPOUNDS
The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions...
2017/0260205 MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
Macrocyclic benzodiazepine dimers having a structure represented by formula I ##STR00001## where A and B are independently according to formulae Ia or Ib ...
2017/0260204 POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
2017/0260203 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a...
2017/0260202 QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS
This invention provides compounds of Formula 11: ##STR00001##
2017/0260201 5-HT3 RECEPTOR ANTAGONISTS
The present invention provides 5-HT3 receptor antagonists of Formula (I): ##STR00001## which are useful for the treatment of diseases treatable by inhibition of ...
2017/0260200 COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS
The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof and therapeutic uses of these compounds for treatment...
2017/0260199 OXAZEPINE COMPOUND AND AGRICULTURAL/HORTICULTURAL INSECTICIDE CONTAINING SAID COMPOUND AS ACTIVE INGREDIENT,...
An oxazepine compound, or salt thereof, has General Formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be identical or different,...
2017/0260198 SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
2017/0260197 THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS
The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R.sup.1, R.sup.2 and R.sup.3 are as defined in the...
2017/0260196 Pseudopolymorphic Forms of a HIV Protease Inhibitor
New pseudopolymorphic forms of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) ...
2017/0260195 SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS
The application relates to novel sulfoximine substituted quinazoline derivatives of formula (I) wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are as defined in the...
2017/0260194 CAMPTOTHECIN DERIVATIVES AND USES THEREOF
Provided herein are camptothecin derivatives and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment,...
2017/0260193 Crystalline Forms of Therapeutic Compounds and Uses Thereof
Described herein is certain crystalline forms of Compound 5, as well as pharmaceutical compositions employing the crystalline forms. Also provided are...
2017/0260192 COMPOUNDS AND METHODS FOR THE PREVENTION AND TREATMENT OF TUMOR METASTASIS AND TUMORIGENESIS
The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R.sup.1, R.sup.2,...
2017/0260191 KINASE INHIBITORS AND RELATED METHODS OF USE
The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can...
2017/0260190 SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE
This invention provides substituted pyrimidine compounds having the formula: ##STR00001## wherein X is absent, CH.sub.2, S, or O, and R is an alkyl group having ...
2017/0260189 METHOD OF PREPARING AZA-PYRIDONE COMPOUNDS
Disclosed herein are methods for obtaining aza-pyridone compounds, which can be useful for ameliorating and/or treating a disease and/or a condition, including...
2017/0260188 Tricyclic Compounds as Inhibitors of Immunosuppression Mediated By Tryptophan Metabolization
Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and...
2017/0260187 NEW AGENTS FOR TREATING NEUROGENIC INFLAMMATION AND NEUROPATHIC HYPERALGESIA RELATED DISORDERS
The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts...
2017/0260186 PROCESS OF PREPARING AMORPHOUS FORM OF IDELALISIB
A process for preparing an amorphous form of idelalisib comprises: (a) forming a first solution of idelalisib in a solvent; (b) adding the first solution...
2017/0260185 2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS...
The present invention provides compounds of formula (I) and in particular 2-[bis(4-fluorophenyl)methyl]-2,7-diazaspiro[4.5]decan-10-one derivatives and related...
2017/0260184 TOLL-LIKE RECEPTOR-7 AND -8 MODULATORY 1H IMIDAZOQUINOLINE DERIVED COMPOUNDS
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts...
2017/0260183 BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS
The present application relates to novel bicyclic compounds, to compositions comprising these compounds, to their use for controlling animal pests and to...
2017/0260182 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
##STR00001## Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, ...
2017/0260181 S-IMINO-S-OXO IMINOTHIAZINE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I): or a tautomer...
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