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Patent # Description
2017/0260180 DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA
Provided are novel compounds of Formula (I): ##STR00001## pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in...
2017/0260179 2-(1H-INDAZOL-3-YL)-1H-IMIDAZO[4,5-C]PYRIDINE AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
2017/0260178 ANTIBACTERIAL COMPOUNDS
The present invention provides a compound of the following formula, salts, racemates, diastereomers, enantiomers, esters, carbamates, phosphates, sulfates,...
2017/0260177 METHYL OXAZOLE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to methyl oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
2017/0260176 GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS
The present disclosure provides .gamma.-diketones or analogs thereof, that activate Wnt/.beta.-catenin signaling and thus treat or prevent diseases related to...
2017/0260175 ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE
The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K.gamma.. The invention also provides pharmaceutically acceptable...
2017/0260174 Benzene, Pyridine, and Pyridazine Derivatives
Disclosed are compounds and pharmaceutically acceptable salts of Formula I ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7,...
2017/0260173 DIFLUOROLACTAM COMPOSITIONS FOR EP4-MEDIATED OSTEO RELATED DISEASES AND CONDTIONS
Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds...
2017/0260171 ALPHA-HYDROXY-BETA-AZIDO-TETRAZOLES
Alpha-hydroxy-beta-azido tetrazole compounds of formula (I): ##STR00001## a process for manufacturing alpha-hydroxy-beta-azido tetrazoles of formula (I), and...
2017/0260170 FLAVONOID DERIVATIVE COMPOUNDS AND METHOD FOR PREPARING SAME BY DEPOLYMERIZATION OF CONDENSED TANNINS
A compound of general formula (I) in which R.sub.1, R.sub.2, R.sub.3 and R.sub.5, identical or different, each represent a hydrogen atom or a hydroxyl group,...
2017/0260169 INHIBITORS FOR STEROID RESPONSE ELEMENTS AND RNA POLYMERASE II AND RELATED METHODS
The present invention relates to polyamides capable of inhibiting ARE-, GRE- and ERE-mediated gene regulation in cells. The present invention also relates to...
2017/0260168 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES
Provided herein are compounds of the general Formula I: ##STR00001## and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X,...
2017/0260167 SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3-YLVINYL)PYRIMIDINE
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of...
2017/0260166 QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS
Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I ##STR00001## including addition salts, and...
2017/0260165 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase
Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase.
2017/0260164 CD38 INHIBITORS AND METHODS OF TREATMENT
Compounds of Formula I and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are...
2017/0260163 THERAPEUTIC INHIBITORY COMPOUNDS
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma...
2017/0260162 POLYMORPHIC FORMS OF NILOTINIB HYDROCHLORIDE
Crystalline Forms R5, R5a, R5b and R6 of nilotinib hydrochloride and processes for their preparation.
2017/0260161 BI-BENZYL ISOQUINOLINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF IN HEPATOPATHY TREATMENT AND PREVENTION
The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically...
2017/0260160 INDOLE CARBOXAMIDE COMPOUNDS
Disclosed are compounds of Formula (I): ##STR00001## or a salt thereof, wherein: X is CR.sub.4 or N; R.sub.1, R.sub.2, R.sub.3, R.sub.4, and A are defined...
2017/0260159 TETRAZOLONE-SUBSTITUTED DIHYDROPYRIDINONE MGAT2 INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, a solvate...
2017/0260158 QUINOLINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE SEROTONIN 5-HT6 RECEPTOR
The present invention relates to quinoline compounds of formula I ##STR00001## wherein the variables are defined as in the claims and the description. The...
2017/0260157 PROCESS FOR PREPARATION AND PURIFICATION OF POMALIDOMIDE
Processes are disclosed for making pomalidomide which involve reducing 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione using a catalyst and at least...
2017/0260156 HYDROGENATION OF CATMINT OIL
Disclosed are methods for treating catmint oil. The treated catmint oil can be used for the production of hydrogenated catmint oil, which is enriched in the...
2017/0260155 Method for Preparing Isobenzofuran-1(3H)-One Compound
A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification. ...
2017/0260154 OXIDATION PROCESS TO PRODUCE A PURIFIED CARBOXYLIC ACID PRODUCT VIA SOLVENT DISPLACEMENT AND POST OXIDATION
Disclosed is a process to produce a dry purified carboxylic acid product comprising furan-2,5-dicarboxylic acid (FDCA). The process comprises oxidizing at...
2017/0260153 Use of Reactants in the Production of 2,5-Furandicarboxylic Acid
Methods for providing effective, efficient and convenient ways of producing 2,5-furandicarboxylic acid are presented. In addition, compositions of...
2017/0260152 2-(2,3-EPOXYPROPYL)PHENOL COMPOSITION AND METHOD OF MAKING
Disclosed herein is a method of making a 2-(2,3-epoxypropyl)phenol by reacting a 2-allylphenol with an oxidant in the presence of a catalyst. A 3-chromanol can...
2017/0260151 Novel Selenazolidine and Thiazolidine Compounds for Treating Cancer and Other Diseases
The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of...
2017/0260150 POLYMERIZABLE COMPOUND, COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, LIQUID CRYSTAL DISPLAY ELEMENT, AND...
It is an object of the present invention to provide a polymerizable compound having a good liquid crystal property, a good alignment property, sufficient...
2017/0260149 A Process for Preparing Olodaterol and Intermediates Thereof
The present invention relates to a process for preparing olodaterol and intermediates thereof. The process comprises of forming compound of Formula 1 by...
2017/0260148 METHOD FOR PREPARING CALCOBUTROL
Disclosed is a novel method of preparing highly pure calcobutrol using an intermediate (butrol) of gadobutrol without using highly pure gadobutrol. This method...
2017/0260147 ANTIVIRAL COMPOUNDS AND METHODS
The invention relates to compounds having antiviral and methods utilizing the compounds to treat viral infections.
2017/0260146 A CONVERGENT APPROACH TO THE TOTAL SYNTHESIS OF TELMISARTAN VIA A SUZUKI CROSS-COUPLING REACTION
Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two...
2017/0260145 HETEROCYCLIC KINASE INHIBITORS
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
2017/0260144 METHODS FOR THE SAFE ADMINISTRATION OF IMIDAZOLE OR IMIDAZOLIUM COMPOUNDS
Methods for the safe administration of imidazole or imidazolium compounds such as zoledronic acid, and conditions that may be treated by these methods, are...
2017/0260143 NOVEL COMPOUNDS
There is provided a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of...
2017/0260142 SOLID FORMS OF FUNGICIDAL PYRAZOLES
Disclosed are solid forms of 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-py- razol-5-amine (Compound 1). Methods for the preparation...
2017/0260141 ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR
The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (KOR) antagonists. The...
2017/0260140 SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS
The present application relates to novel substituted N,2-diarylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof...
2017/0260139 NOVEL 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND THEIR USE
The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the...
2017/0260138 PROCESS FOR PRODUCING DIAMINE DERIVATIVE
The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula...
2017/0260137 MODIFIED AMINO ACIDS
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of...
2017/0260136 HETEROARYL OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
2017/0260135 PROCESS FOR LARGE SCALE PRODUCTION OF N-[4-(1-CYCLOBUTYL PIPERIDIN-4-YLOXY) PHENYL]-2-(MORPHOLIN-4-YL)...
The present, invention relates to a process for large scale production of N-[4-(1-Cyclobutyl piperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide...
2017/0260134 Ceramide Analogs
Ceramide analogs and methods of their use are provided.
2017/0260133 MALASSEZIN AND ANALOGS THEREOF AS SKIN BRIGHTENING AGENTS
The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention...
2017/0260132 OXIME SULFONATE DERIVATIVES
Oxime sulfonate compounds of the formula (I), wherein R.sub.1 is O(CO)R.sub.4, COOR.sub.5 or CONR.sub.6R.sub.7; n is 1 or 2; R.sub.2 for example is...
2017/0260131 PRODRUGS OF PHENOLIC TRPV1 AGONISTS
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate...
2017/0260130 Benzimidazole Inhibitors of the Sodium Channel
The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with...
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