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Patent # Description
2017/0258804 METHODS FOR TREATING CANCERS
Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective...
2017/0258803 SALTS AND SOLID FORMS OF (S)-3-(4-((4-(MORPHOLINOMETHYL)BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDIN- ...
Salts and solid forms of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,- 6-dione, or a stereoisomer thereof, are disclosed....
2017/0258802 METHOD OF TREATING POLYCYSTIC KIDNEY DISEASES WITH CERAMIDE DERIVATIVES
A method of treating polycystic kidney disease in a subject comprises administering to the subject an effective amount of a compound represented by Structural...
2017/0258800 SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND...
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor ...
2017/0258799 CAFFEINATED GUMMIES
Described herein are gummy compositions and products. In one aspect the gummy compositions include: (I) one or more gelating agents; (II) at least one fruit...
2017/0258798 INJECTION PREPARATION AND METHOD FOR PRODUCING SAME
Provided are an injection preparation which include: an aqueous composition containing pemetrexed or a salt thereof, at least one antioxidant agent which is...
2017/0258797 TREATMENTS FOR AUTOIMMUNE DISEASE
The invention relates to a novel approach to the treatment of autoimmune diseases, particularly multiple sclerosis. In a further embodiment of the invention...
2017/0258796 Methods And Compositions To Reduce Oxidative Stress
The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention...
2017/0258795 FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX
Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position...
2017/0258794 PRODRUGS OF AMINO QUINAZOLINE KINASE INHIBITOR
Disclosed are compounds having the formula: ##STR00001## wherein X is as defined herein, and methods of making and using the same.
2017/0258793 METHOD FOR TREATING PROSTATE CANCER
The invention provides a method for treating prostate cancer in a subject comprising administering to the subject an effective amount of a selective inhibitor...
2017/0258792 LIGANDS THAT TARGET PLASMODIUM SPOROZOITE BINDING SITES ON CD81 AND THERAPEUTIC METHODS USING THEM
The invention pertains to ligands that bind to CD81 and that inhibit or block Plasmodium attachment to CD81, compositions and methods for preventing,...
2017/0258791 PHARMACEUTICAL COMPOSITION FORMED BY COMBINING PYRIDOXAMINE COMPOUND AND THIAMINE COMPOUND
Vitamin B1 deficiency caused when a pyridoxamine compound is administered in a large amount is prevented and/or treated. A pharmaceutical composition formed by...
2017/0258790 Methods Of Treating Depression Using Orexin-2 Receptor Antagonists
The present disclosure is directed to, inter alia, methods of treating a subject suffering from or diagnosed with depression, comprising administering to a...
2017/0258789 DNA-PK INHIBITORS
The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said...
2017/0258788 CARBOSTYRIL DERIVATIVES AND SEROTONIN REUPTAKE INHIBITORS FOR TREATMENT OF MOOD DISORDERS
The pharmaceutical composition of the present invention comprises (1) a carbostyril derivative and (2) a serotonin reuptake inhibitor in a pharmaceutically...
2017/0258787 PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS ASSOCIATED WITH...
The present invention relates to a prophylactic and/or therapeutic agent for behavioral and psychological symptoms associated with neurodegenerative disease or...
2017/0258786 RBP4 ANTAGONISTS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in a mammal afflicted therewith, comprising administering to...
2017/0258785 COMPOSITE NANOPARTICLES AND USES THEREOF
Provided herein are composite nanoparticles, methods of making composite nanoparticles and methods of using composite nanoparticles to treat or ameliorate...
2017/0258784 USE OF PYRROLOQUINOLINE COMPOUNDS TO KILL CLINICALLY LATENT MICROORGANISMS
There is provided the use of compounds of formula I ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and X have meanings given in the description, for the...
2017/0258783 PFKFB3 INHIBIT AND METHODS OF USE AS AN ANTI-CANCER THERAPEUTIC
A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one- , is provided herein. ...
2017/0258782 ALKYL LINKED QUINOLINYL MODULATORS OF ROR.gamma.t
The present invention comprises compounds of Formula I. ##STR00001## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and...
2017/0258781 ATRIAL SPECIFIC ANTIARRHYTHMICS FOR USE IN TREATING OR PREVENTING ATRIAL FIBRILLATION
The invention relates to methods and compositions for treating or preventing atrial fibrillation.
2017/0258780 TREATMENT OF LUPUS NEPHRITIS USING LAQUINIMOD
This invention provides a method of treating a subject afflicted with active lupus nephritis comprising periodically administering to the subject an amount of...
2017/0258779 COMBINATION THERAPY FOR BIPOLAR DISORDER
The present invention relates to a method of decreasing cholesterol or low density lipid protein in a subject in need thereof comprising: administering to said...
2017/0258778 SOLID FORMS COMPRISING 4-AMINO-2-(2,6-DIOXOPIPERIDINE-3-YL)ISOINDOLINE-1,3-DIONE AND A COFORMER, ...
Provided herein are solid forms comprising (a) 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione and (b) a coformer. Pharmaceutical compositions...
2017/0258777 Selective NR2B Antagonists
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds...
2017/0258776 Methods for Treating Disorders or Diseases Associated with Hyperlipidemia and Hypercholesterolemia While...
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an...
2017/0258775 MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS
There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or...
2017/0258774 NOVEL OXIMES FOR REACTIVATING BUTYRYLCHOLINESTERASE
Oxime molecules for reactivating butyrylcholinesterase (BChE) and methods for protection against and therapeutic treatment of the toxic effects of ...
2017/0258773 SOLID FORMS OF ACETIC ACID, COMPOSITIONS, AND USES THEREOF
Provided herein are solid forms comprising {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions comprising the solid forms,...
2017/0258772 COMPOSITIONS AND METHODS FOR PROMOTING INTESTINAL STEM CELL AND/OR NON-STEM PROGENITOR CELL FUNCTION
Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful...
2017/0258771 Compositions and Methods of Treating Cardiac Fibrosis with Ifetroban
The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by...
2017/0258770 Method for Topically Treating Actinic Keratosis on the Full Face or 250 cm2 on the Chest with Ingenol...
The invention relates to the treatment of actinic keratosis on the full face or 250 cm.sup.2 on the chest with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).
2017/0258769 A Method for Topically Treating Actinic Keratosis on the Trunk (except chest) and Extremities with Ingenol ...
The invention relates to the treatment of actinic keratosis on the trunk (except chest) and extremities with ingenol 3-(3,5-diethylisoxazole-4-carboxylate).
2017/0258768 ONDANSETRON EXTENDED RELEASE SOLID DOSAGE FORMS FOR TREATING EITHER NAUSEA, VOMITING OR DIARRHEA SYMPTOMS
A method of treating a patient comprises orally administering a solid oral dosage form comprising a core comprising a non-ionic polymer matrix, a first amount...
2017/0258767 METHODS FOR THE TREATMENT OF OVERACTIVE BLADDER
Disclosed herein are methods of treating overactive bladder in a patient, the method comprising identifying a patient in need thereof; and administering to the...
2017/0258766 ANGIOTENSIN IN TREATING BRAIN CONDITIONS
The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include...
2017/0258765 Priming of Pancreatic Tumor Cells and Cancer Stem Cells to TRAIL-Induced Apoptosis
This invention relates generally to compositions and methods for treatment of pancreatic cancer. The present invention relates more particularly to use of JNK...
2017/0258764 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the...
2017/0258763 RAPID DISPERSE DOSAGE FORM
A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of water soluble drug in a porous matrix that disperses in water...
2017/0258762 FORMULATION COMPRISING GLYCOPYRROLATE, METHOD AND APPARATUS
A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising co-jet milling glycopyrrolate and magnesium stearate,...
2017/0258761 Pharmaceutical Compositions Comprising Canagliflozin
The present invention belongs to the field of pharmaceutical industry and relates to a dry pharmaceutical composition comprising Canagliflozin, as well as to a...
2017/0258760 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8 (TRPM8) ANTAGONISTS AND METHODS OF USE
The invention provides methods of treating or preventing an ocular disease or disorder in a subject, methods of treating or preventing ocular pain or...
2017/0258759 METHOD OF IMPROVING VISUAL PROCESSING, VISUAL ACUITY, OR BOTH BY ADMINISTERING COMPOSITIONS COMPRISING...
Methods for improving the visual processing of a healthy infant by administering a composition comprising RRR-alpha-tocopherol and a carotenoid to the infant...
2017/0258758 METHODS FOR TREATING BRAIN METASTASIS
The present invention relates to methods for treating brain metastasis by inhibiting gap junction functionality. It is based, at least in part, on the...
2017/0258757 ANTI-CANCER AGENT DELIVERY VEHICLES CAPABLE OF IMPROVED LOADING
There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric...
2017/0258755 METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT ON STATIN THERAPY
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in...
2017/0258754 METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT ON STATIN THERAPY
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in...
2017/0258753 METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT ON STATIN THERAPY
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in...
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