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Patent # Description
2017/0267732 COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O.sub.2 delivery. The engineered H-NOX proteins...
2017/0267731 DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF
Disintegrin variants that bind specifically to one or more of .alpha.5.beta.1 and .alpha.v integrins, such as .alpha.v.beta.1, .alpha.v.beta.3,...
2017/0267730 Synthetic Multiphase Systems
A synthetic multiphase product comprising BsIA is presented. Methods of producing a synthetic multiphase product comprising BsIA, and applications of BsIA in...
2017/0267729 VACCINE ANTIGENS THAT DIRECT IMMUNITY TO CONSERVED EPITOPES
A method of identification and elimination of immunodominant epitopes to elicit a response to secondary epitopes, especially conserved structures, is...
2017/0267728 POLYPEPTIDE-BASED SHUTTLE AGENTS FOR IMPROVING THE TRANSDUCTION EFFICIENCY OF POLYPEPTIDE CARGOS TO THE CYTOSOL...
The present description relates to synthetic peptides useful for increasing the transduction efficiency of polypeptide cargos to the cytosol of target...
2017/0267727 Conjugates of pH Low Insertion Peptide and Monomethyl Auristatins in the Treatment of Solid Tumors
Constructs comprising pH low insertion peptide and variants thereof conjugated to monomethyl auristatins and analogs thereof are described. These constructs...
2017/0267726 NON-IMMUNOSUPPRESSIVE CYCLOSPORIN DERIVATIVES AS ANTIVIRAL AGENTS
A cyclosporin derivative which is a compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of a viral...
2017/0267725 Peptidomimetics for Treating HER2-Overexpressed Cancer
Novel peptidomimetic compounds are disclosed, compounds that inhibit protein-protein interactions (PPI) of epidermal growth factor receptors (EGFR), also...
2017/0267724 Non-Cleavable Substance P Conjugates and Methods of Use Thereof
Described herein are methods for treating disorders that relate to neurons that express the neurokinin-1 receptor (NK-1R) in a subject which comprises...
2017/0267723 NOVEL PEPTIDES FOR PREVENTING OR TREATING BONE DISEASES AND USE THEREOF
The present disclosure relates to a novel peptide for preventing or treating bone diseases. Further, the present disclosure relates to a polynucleotide...
2017/0267722 INHIBITORY PEPTIDES OF VIRAL INFECTION
Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of...
2017/0267720 OPIOID PEPTIDE
The present invention relates to an opioid peptide represented by general formula TyrGlyGly-X1-X2-X3-X4, wherein: X1 is represented by Thr or Glu; X1 is...
2017/0267719 METHOD FOR REGRESSING PANCREATIC TUMOR BY A LIPOSOMAL FORMULATION ALONG WITH DNA VACCINES
The present invention discloses a Plectin-1 receptor targeting novel cationic KTLLPTPK-lipopeptide. The present invention further discloses a liposomal...
2017/0267718 TRIPEPTIDE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Provided are a tripeptide compound, a preparation method therefor, and an application thereof. The structure of the related compound is represented by formula...
2017/0267717 Novel method for the production of 18F-labeled active esters and their application exemplified by the...
Novel efficient, time-saving and reliable radiofluorination procedures for the production of .sup.18F-labelled active esters via nucleophilic substitution of...
2017/0267716 PRECIPITATION OF POLYPEPTIDES BY APTAMER-POLYMER CONJUGATES
Provided herein are aptamer-polymer conjugates which are responsive to environmental stimuli and are useful in selective purification of untagged target...
2017/0267715 Moisture Displacement and Simultaneous Migration of Surface-Functionalized Algae from Water to an Extraction...
This invention is in the field of micro-organism and algal cell processing. The invention relates to a method of maximizing migration of micro-organism and/or...
2017/0267714 NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast,...
2017/0267713 PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present...
2017/0267712 MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA
Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor .gamma. (ROR.gamma.) activity. This modulation has numerous effects,...
2017/0267711 COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS
Compounds and methods of synthesizing oxysterols are provided. The compounds and methods provided allow the oxysterol to be safely produced at a high yield....
2017/0267710 MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF
Compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the...
2017/0267709 B-VITAMIN AND AMINO ACID CONJUGATES OFNICOTINOYL RIBOSIDES AND REDUCED NICOTINOYL RIBOSIDES, DERIVATIVES...
The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): ##STR00001## wherein X.sup.-, Z.sup.1, Z.sup.2, n,...
2017/0267708 C-4" POSITION SUBSTITUTED MACROLIDE DERIVATIVE
A useful novel compound that shows superior antibacterial activity also against erythromycin resistant bacteria, for example, resistant pneumococci,...
2017/0267707 Methods and Compositions for Substituted Alpha-Aminophosphonate Analogues
Provided herein are .alpha.-aminophosphonates and methods for making same. Also provided are N-heterocyclic phosphines (NHPs) useful in metal-free...
2017/0267706 METHOD FOR THE SYNTHESIS OF HETEROCYCLIC HYDROGEN PHOSPHINE OXIDE
A method for the synthesis of a heterocyclic hydrogen phosphine oxide, having the general formula: ##STR00001## wherein: R is a aliphatic or aromatic divalent...
2017/0267705 DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
The invention provides compounds of the formula: ##STR00001## R.sup.1 is OR.sup.11, or NR.sup.5R.sup.5'; R.sup.2 is H or F; R.sup.5 is H, OH, C.sub.1-C.sub.6...
2017/0267704 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF
The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a...
2017/0267703 METHOD FOR PREPARING A POLYORGANOSILOXANE AND A POLYORGANOSILOXANE
A polyorganosiloxane resin represented by the following general formula (5): (R.sub.3SiO.sub.1/2).sub.l'(R.sub.2SiO.sub.2/2).sub.m'(RSiO.sub.3/2)- ...
2017/0267702 Method for Making Alkylhalosilanes
Disclosed is a method for making alkylhalosilanes from an alkyl halide and silicon in the presence of the catalyst package comprising metallic aluminum...
2017/0267701 Method for Producing Tetraalkoxysilane
An object of the present invention is to provide a method for producing tetraalkoxysilane while saving energy at a high yield. Tetraalkoxysilane can be...
2017/0267700 Precursors for Electron Beam-Induced Deposition of Gold and Silver
Precursors are prepared and employed in electron beam induced decomposition (EBID). The EBID precursors are complexes of the formula: X-M-Y, where M is Au or...
2017/0267699 NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS
The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a...
2017/0267698 NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS
The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a...
2017/0267697 3-(1H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINE AND THERAPEUTIC USES THEREOF
Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an azaindazole...
2017/0267696 CERTAIN PROTEIN KINASE INHIBITORS
Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof. ##STR00001##
2017/0267695 ERK INHIBITORS
The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The...
2017/0267694 CRYSTALLINE FORMS OF AN ANTIVIRAL COMPOUND
Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1- ...
2017/0267693 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a...
2017/0267692 BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES
The present invention relates to methods and compositions for inhibiting the activity of skin proteases, especially human kallikrein 7 (KLK7), human kallikrein...
2017/0267691 ERK INHIBITORS
The present invention provides thieno[2,3-c]pyrrol-4-one compounds that inhibit activity of extracellular-signal-regulated kinase (ERK) and may be useful in...
2017/0267690 SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF
The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the...
2017/0267689 STIMULI-SWITCHABLE MOIETIES, MONOMERS AND POLYMERS INCORPORATING STIMULI-SWITCHABLE MOIETIES, AND METHODS OF...
Stimuli-switchable moieties, monomers incorporating stimuli-switchable moieties, and polymers incorporating such stimuli-switchable moieties are provided. The...
2017/0267688 ALDOSTERONE SYNTHASE INHIBITORS
The present invention relates to compounds of the formulas (IA) and (IB) and pharmaceutically acceptable salts thereof, wherein A and R.sup.1-R.sup.6, are as...
2017/0267687 Dihydroetorphines and Their Preparation
The present invention provides a process for the preparation of a compound of formula (VI), or a salt or derivative thereof, ##STR00001## wherein R.sup.1 and...
2017/0267686 Compositions and Methods For Making Alkaloid Morphinans
Methods that may be used for the manufacture of a class of chemical compounds known as morphinans, including neopine, are provided. Compositions useful for the...
2017/0267685 HETEROARYL COMPOUNDS AND USES THEREOF
The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention...
2017/0267684 A DEUTERATED TRIAZOLOPYRIDAZINE AS A KINASE MODULATOR
The invention is directed to a triazolopyridazine compound of formula (I), N-oxides, pharmaceutically acceptable salts and solvates thereof, wherein D...
2017/0267683 CRYSTALLINE FORMS OF PARP INHIBITORS
The present disclosure relates to crystalline forms of 4,5,6,7-tetrahydro-11-methoxy-2-[(4-methyl-1-piperazinyl)methyl]-1H-cyclo- ...
2017/0267682 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
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