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Patent # Description
2017/0267681 ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES
Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in...
2017/0267680 Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
The present invention relates to compounds having the general formula (Ia) or (Ib), optionally in the form of a pharmaceutically acceptable salt, solvate,...
2017/0267679 TRICYCLIC FUSED PYRIMIDINE COMPOUNDS AS INHIBITORS OF p97 COMPLEX
Tricyclic fused pyrimidine compounds having an arylalkyl amine substituent at the P4 position and a substituted 1H-indol-1-yl, 1H-indol-3-yl, indanyl,...
2017/0267678 Tetrahydro-Pyrido-Pyrimidine Derivatives
The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), ##STR00001## wherein Y, R.sup.1, R.sup.2 and m are as defined...
2017/0267677 SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS
The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein...
2017/0267676 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE COMPOUNDS
The present invention relates to compounds of the formula I or II: (I) (II) processes for their preparation and their use as pharmaceutical agents or...
2017/0267675 INDAZOLES
The invention provides novel substituted indazole compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative...
2017/0267674 FUSED AMINO PYRIDINE AS HSP90 INHIBITORS
The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of...
2017/0267673 CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general...
2017/0267672 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers,...
2017/0267671 NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS
The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in...
2017/0267670 PIPERAZINE DERIVATIVES FOR TREATING DISORDERS
Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of...
2017/0267669 Process for the Preparation of Rivaroxaban
The present invention relates to an environmentally friendly process for preparing rivaroxaban. The present invention provides a process for preparing...
2017/0267668 PHARMACEUTICAL COMPOUND
Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the...
2017/0267667 ALKENYLDIARYLMETHANES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR ANTI-HIV-1 CHEMOTHERAPY
The invention disclosed herein pertains to compounds of alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for the...
2017/0267666 DIHYDROPYRIDINONE MGAT2 INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the...
2017/0267665 PRODRUG OF 1,1'-(1,6-DIOXO-1,6-HEXANEDIYL)BIS-D-PROLINE
The present invention relates to the compound (2R,2'R)-bis(((((tetrahydro-2H-pyran-4-yl)oxy)carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate),...
2017/0267664 Quinazolin-THF-Amines as PDE1 Inhibitors
The present invention provides Quinazolin-THF-amines as PDE I inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
2017/0267663 QUINAZOLINE DERIVATIVES, COMPOSITIONS THEREOF, AND USE AS PHARMACEUTICALS
Disclosed herein are protein kinase inhibitors, more particularly novel quinazoline derivatives and pharmaceutical compositions thereof, and method of use...
2017/0267662 INDOLE COMPOUNDS AND PHARMACEUTICAL USE THEREOF
The invention provides a compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: ##STR00001## ...
2017/0267661 INHIBITORS OF RET
Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using...
2017/0267660 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Disclosed are compounds of Formula I(b): ##STR00001## or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof,...
2017/0267659 METHOD FOR PRODUCING 2-PYRIDONE COMPOUND
To provide a method for producing a compound represented by the formula (1) which is a 2-pyridone compound useful as a pharmaceutical or an intermediate for a...
2017/0267658 PROCESSES FOR THE PREPARATION OF ISOTOPOLOGUES OF ...
Provided are processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,- 6-dione, or a...
2017/0267657 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
This document discloses molecules having the following formula ("Formula One"): ##STR00001## and processes related thereto.
2017/0267656 PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS
There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases,...
2017/0267655 PROCESS FOR PREPARING BENZOFURAN-2-CARBOXAMIDE DERIVATIVES
Provided herein are novel, commercially viable and industrially advantageous processes for the preparation of benzofuran-2-carboxamide derivatives and their...
2017/0267654 METHODS OF PRODUCING ALKYLFURANS
Provided herein are methods of producing dialkylfurans, such as 2,5-dimethylfuran, and other alkyl furans, such as 2-methylfuran. For example,...
2017/0267653 BCL-3 INHIBITORS
The present application relates to compounds of any one of Formulae I, Ia, Ib, Ic, Id, Ie, and If. Compounds of Formula (I) have the structure: ##STR00001## ...
2017/0267652 PROCESS FOR THE PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS
A process for the purification of diaminophenothiazinium compounds, and particularly of methylene blue, is described. The process provides for simple and...
2017/0267651 TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing...
2017/0267650 SODIUM CHANNEL BLOCKERS
The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium...
2017/0267649 STABLE SODIUM CHANNEL BLOCKERS
A very stable, selective and renally safe sodium channel blocker represented by the formula: ##STR00001## The invention also includes a variety of compositions,...
2017/0267648 SUBSTITUTED URACILS AS CHYMASE INHIBITORS
The present application relates to novel substituted uracil derivatives, to a method for the production thereof, to the use thereof either alone or in...
2017/0267647 SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF...
Provided herein are Diaminopyrimidine Compounds having the following structures: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are as ...
2017/0267646 PREPARATION METHOD FOR REVAPRAZAN HYDROCHLORIDE
Provided is a preparation method for revaprazan hydrochloride, the method comprising: (1) the preparation of ...
2017/0267645 ENZALUTAMIDE POLYMORPHIC FORMS AND ITS PREPARATION
The present application relates to crystalline and amorphous forms of Enzalutamide. The present application further relates to amorphous solid dispersions of...
2017/0267644 Electrically Conducting Oligo(pyrazoles)
An electrically conducting organic oligomer comprising 4-nitro-1H-pyrazole-3-yl-amine, 4-trifluoromethyl-1H-pyrazol-3-yl-amine, ...
2017/0267643 PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
The invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.o-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic...
2017/0267642 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein...
2017/0267641 Enhanced Erythropoiesis and Iron Metabolism
The present invention relates to methods and compounds for regulating or enhancing ethropoiesis and iron metabolism, and for treating or preventing iron...
2017/0267640 Process for Preparing Synthetic Intermediates for Preparing Tetrahydroquinoline Derivatives
The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline...
2017/0267639 Process for Synthesizing Oxidized Lactam Compounds
The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I: ##STR00001##
2017/0267638 COMPOUNDS, COMPOSITIONS AND METHODS
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of...
2017/0267637 Modified Amino Acids
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of...
2017/0267636 A PROCESS FOR SYNTHESIS OF PIPERIDINE ALKALOIDS
The present invention discloses a process for synthesis of piperidine alkaloids selected from fagomine, 4-epi-fagomine and nojirimycin from ...
2017/0267635 Anticancer Miliusane Lactams
The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to new anticancer miliusane...
2017/0267634 COMPOUNDS AS CRTH2 ANTAGONIST AND USES THEREOF
The compounds of Formula (I) which can be used as CRTH2 receptor antagonists are provided. The compounds of Formula (I) can be used in the treatment and...
2017/0267632 METHIONINE ANALOGS AND METHODS OF USING SAME
Provided are methionine analogs which may be useful for inhibiting protein synthesis, inhibiting microbial growth and/or treating infectious diseases. In some...
2017/0267631 IONIZABLE CATIONIC LIPID FOR RNA DELIVERY
What is described is a compound of formula I ##STR00001## wherein R.sub.1 is a linear alkyl, alkenyl, or alkynyl of 2 to 12 carbons, or a branched alkyl with...
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