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Patent # Description
2017/0266310 PRO-DRUG FORM (P2PDOX) OF THE HIGHLY POTENT 2-PYRROLINODOXORUBICIN CONJUGATED TO ANTIBODIES FOR TARGETED...
Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2-pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments...
2017/0266309 IMMUNOGLOBULIN CHIMERIC MONOMER-DIMER HYBRIDS
The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide...
2017/0266308 SMALL MOLECULE CONJUGATES SPECIFICALLY ACTIVATED IN TUMOR MICROENVIROMENT FOR TARGETING AND USE THEREOF
Provided is an anticancer compound including a cleavable linker specifically activated in a tumor microenvironment, and use thereof. The anticancer compound is...
2017/0266307 Methods Of Treating Cancer Using Compounds Containing A Vascular Disrupting Agent
The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage...
2017/0266306 TARGETED ANTIMICROBIAL MOIETIES
This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide...
2017/0266305 PHARMACEUTICAL COMPOSITION OF POLYETHYLENE GLYCOL-MODIFIED CAMPTOTHECIN DERIVATIVE AND PREPARATION METHOD THEREOF
A pharmaceutical composition of a polyethylene glycol-modified camptothecin derivative and a preparation method thereof. The pharmaceutical composition is...
2017/0266304 METAL COMPLEX FORMULATIONS
The present invention relates to a method of preparation of formulations of lanthanide metal complexes of macrocyclic chelators which further comprise a small...
2017/0266303 METHODS OF TREATING CANCER BY TARGETING TUMOR-ASSOCIATED MACROPHAGES
Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for...
2017/0266302 Hydrazinyl-Substituted Heteroaryl Compounds and Methods for Producing a Conjugate
The present disclosure provides conjugate structures and hydrazinyl-substituted heteroaryl compounds used to produce these conjugates. The disclosure also...
2017/0266301 PARTICLES COMPRISING SINGLE STRANDED RNA AND DOUBLE STRANDED RNA FOR IMMUNOMODULATION
The present invention relates to chimeric particles comprising single stranded RNA (ssRNA), double stranded RNA (dsRNA) and at least one cationic agent, a...
2017/0266300 Combined enteropathogen recombinant construct
The inventive subject matter relates to a construct comprising antigens derived from multiple enterobacteria including Campylobacter jejuni capsule...
2017/0266299 THERAPEUTIC APAC MOLECULE COMPRISING HEPARIN CONJUGATED TO A PLASMA PROTEIN
The invention relates to an anti-thrombotic molecule having both antiplatelet and anticoagulant (APAC) activity; its use as a medicament; its selective...
2017/0266298 NEBULISATION-BASED METHOD FOR MIXING SUBSTANCES
The invention relates to a method for producing a mixture containing a hydrated egg product and a substance of interest, wherein the mixing is carried out by...
2017/0266297 PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZOQUINOLIN(AMINES) AND DERIVATIVES THEREOF SUITABLE FOR LOCAL...
The present invention relates in general to the field of modulators of the innate immune system, particularly to pharmaceutical compositions comprising...
2017/0266296 DICLOFENAC TOPICAL FORMULATION
The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical...
2017/0266295 CONTROLLED DRUG RELEASE LIPOSOME COMPOSITIONS AND METHODS THEREOF
The present invention relates to pharmaceutical compositions comprising at least one liposome, at least one polyvalent counterion donor or a pharmaceutically...
2017/0266294 PHARMACEUTICAL FORMULATIONS THAT FORM GEL IN SITU
The present invention provides aqueous formulations containing an anti-infection agent, a biocompatible polysaccharide, an osmotic pressure regulator, a pH...
2017/0266293 METHODS OF TREATING CANCERS WITH THERAPEUTIC NANOPARTICLES
The present disclosure relates in part to methods of treating cholangiocarcinoma or tonsillar cancer in a patient in need thereof, comprising administering to...
2017/0266292 LIPIDIC COMPOUND-TELODENDRIMER HYBRID NANOPARTICLES AND METHODS OF MAKING AND USES THEREOF
Lipidic compound (lipidic molecule)-telodendrimer hybrid nanoparticles. For example, the lipidic compound-telodendrimer hybrid nanoparticles are ...
2017/0266291 A PH RESPONSIVE HYBRID HYDROGEL AND METHOD OF SYNTHESIS THEREOF
A pH-responsive hybrid hydrogel, namely poly(Methacrylic acid-grafted-Ethylene Glycol) P(MAA-g-EG) cross-linked with Styrene-Butadiene-Styrene (SBS) polymer...
2017/0266290 TIGECYCLINE COMPOSITIONS AND METHODS OF PREPARATION
The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these...
2017/0266289 TOPICAL FORMULATION
The invention described herein provides topical formulations that can be prepared at ambient temperature without the need for any heating step during...
2017/0266288 PHARMACEUTICAL FORMULATIONS CONTAINING CORTICOSTEROIDS FOR TOPICAL ADMINISTRATION
Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and...
2017/0266287 Compositions and Methods for Treating Chronic Inflammation and Inflammatory Diseases
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
2017/0266286 NOVEL PHARMACEUTICAL DOSAGE FORMS COMPRISING VALGANCICLOVIR HYDROCHLORIDE
The present invention provides novel solid pharmaceutical dosage forms for oral administration, after being constituted in water. The solid dosage forms...
2017/0266285 PHARMACEUTICAL COMPOSITION COMPRISING MODIFIED HEMOGLOBIN-BASED THERAPEUTIC AGENT FOR CANCER TARGETING...
The present invention provides a pharmaceutical composition containing hemoglobin-based therapeutic agent for treating cancer. The hemoglobin moiety can target...
2017/0266284 PERSONALIZED METHODS FOR TREATING DISEASE BY RADIOSENSITIZATION
Methods are provided for treating cancer and neoplastic diseases where such methods include the administration of radiosensitizing agents.
2017/0266283 METHOD, DEVICE AND SYSTEM FOR TARGETTED CELL LYSIS
A method, device and system employs particles, such as nanoparticles, and an electric or electro-magnetic field, to cause cell death in target cells by...
2017/0266282 DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a...
2017/0266281 SUBCUTANEOUS ADMINISTRATION OF ANTI-CD74 ANTIBODY FOR SYSTEMIC LUPUS ERYTHEMATOSUS AND AUTOIMMUNE DISEASE
Disclosed are methods, compositions and uses of concentrated formulations of anti-CD74 antibody, of use for treating autoimmune diseases. In a specific...
2017/0266280 NOVEL APPROACH FOR TREATMENT OF CANCER USING IMMUNOMODULATION
The present invention discloses a method of treating, preventing or ameliorating tumor growth by administering a therapeutic agent that selectively inhibits...
2017/0266279 COMPOSITIONS INCLUDING BETA-GLUCANS AND METHOD OF USE
The invention generally relates to soluble beta-glucan compositions and method of using such compositions. In one aspect, an adjuvant for a pharmaceutical...
2017/0266278 FLAGELLIN-BASED AGENTS AND USES INCLUDING EFFECTIVE VACCINATION
The present invention relates to, in part, compositions comprising improved flagellin derived constructs and methods of using for vaccination, including...
2017/0266277 Naturally-Occurring CpG Oligonucleotide Compositions and Therapeutic Applications Thereof
The present invention relates to combination therapies for the treatment of a variety of disorders in mammals, including hepatic disorders and cancer. The...
2017/0266276 Combination Therapy For Treatment of Cancer
Described herein are combination therapies for the treatment of cancer and other diseases. In one aspect, the methods described herein for the treatment of...
2017/0266275 VACCINES AGAINST GENITAL HERPES SIMPLEX INFECTIONS
The present invention provides vaccines for treating or preventing a herpes simplex virus infection and methods of using and making the vaccine. Further...
2017/0266274 MUTANT PORCINE EPIZOOTIC DIARRHEA VIRUS FOR USE IN A VACCINE
The invention relates to a mutant Porcine Epizootic Diarrhea Virus (PEDVdN), to methods of producing said PEDVdN, and to compositions comprising the PEDVdN....
2017/0266273 RECOMBINANT ADENO-ASSOCIATED VIRUS VECTORS CARRYING THE MUTANT HPV- 16 E7 ANTIGEN GENE, CONSTRUCTION METHOD AND...
Provided are a recombinant adeno-associated virus (AAV) vector carrying human papillomavirus type 16 (HPV-16) mutation E7 antigen gene and a construction...
2017/0266272 TRANSGENIC VERO-CD4/CCR5 CELL LINE
The present relation relates to a transgenic Vero cell line expressing CD4 and CCR5. The present invention encompasses the preparation and purification of...
2017/0266271 PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST CANCERS
The present description relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present description...
2017/0266270 Combination Therapy for Treating Cancer with a Poxvirus Expressing a Tumor Antigen and an Antagonist and/or...
The invention relates to compositions, kits, and methods for cancer therapy using recombinant poxviruses encoding a tumor-associated antigen in combination...
2017/0266269 METHODS OF IDENTIFYING ANTIGENS FOR VACCINES
The methods, processes, and systems described herein include identifying an epitope of a peptide that may elicit an immune response in a subject. Often the...
2017/0266268 VACCINATION IN NEWBORNS AND INFANTS
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or...
2017/0266266 Functions of 55 Newfound Proteins and Their Medicinal Application in the Treatment and Prevention of Disease
The invention relates to 55 newly discovered proteins, which are present in isolated purified protein complexes, derived medicinal products, recombinant DNA,...
2017/0266265 NEURODEGENERATIVE DISORDERS
The invention relates to novel peptides, compositions, therapies and methods for treating neurodegenerative disorders, for example Alzheimer's disease.
2017/0266264 TRUNCATED LYSOSOMAL ACID LIPASE
Recombinant human lysosomal acid lipase (rhLAL) containing an N-terminal truncation, a composition of truncated recombinant human LAL (TLAL), an isolated...
2017/0266263 METHODS FOR INCREASING INTRACELLULAR ACTIVITY OF HSP70
The present invention relates to a bioactive agent capable of increasing the intracellular concentration and/or activity of Hsp70 for use in the treatment of a...
2017/0266262 FIBRINOGEN PREPARATIONS ENRICHED IN FIBRINOGEN WITH AN EXTENDED ALPHA CHAIN
The present invention relates to fibrinogen preparations enriched in .alpha.-extended fibrinogen. Compositions comprising such preparations show improved...
2017/0266261 PROTEIN THERAPY FOR TREATMENT OF RETINAL DISEASES
The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes...
2017/0266260 Fusion Proteins Containing Insulin-Like Growth Factor-1 and Epidermal Growth Factor and Variants Thereof and...
Fusion proteins comprising cytokines, particularly insulin-like growth factor-1 (IGF-1) and variants thereof, epidermal growth factor (EGF), and other ligands...
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