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Patent # Description
2017/0266208 TREATING AND PREVENTING DISEASE WITH TMA AND TMAO LOWERING AGENTS
Provided herein are compositions, systems, and methods for treating a disease, such as kidney and/or cardiovascular disease, with an agent that reduces the...
2017/0266207 COMPOSITION, FORMULATIONS AND METHODS OF MAKING AND USING BOTANICALS AND NATURAL COMPOUNDS FOR THE PROMOTION OF...
The present disclosure provides compositions and formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults,...
2017/0266206 POLYMERIC BILE ACID DERIVATIVES INHIBIT HEPATITIS B AND D VIRUS AND NTCP TRANSPORT
The invention provides for treating HBV or HDV infection or inhibiting human sodium taurocholate co-transporting polypeptide (hNTCP) with a polymeric bile acid...
2017/0266205 INDUCING LACTATION IN NURSING FEMALES
A topical cream applied to a nipple of a lactating female induces lactation. The cream comprises a base cream having from about 0.5% to about 10%, by volume,...
2017/0266204 ONAPRISTONE METABOLITE COMPOSITIONS AND METHODS
Methods and pharmaceutical compositions for inhibiting the activity of the progesterone receptor with methyl onapristone. Aspects include methods of...
2017/0266203 FULVESTRANT COMPOSITIONS AND METHOD OF USE
Provided are inclusion complexes comprising fulvestrant and a cyclodextrin. The complexes may be useful for treating various conditions, such as cancer and...
2017/0266202 DOSAGE FORMS CONTAINING FLUTICASONE PROPIONATE FOR THE TREATMENT OF INFLAMMATORY CONDITIONS OF THE ESOPHAGUS
The present invention describes novel and improved dosage forms containing fluticasone propionate for the treatment of conditions associated with inflammation...
2017/0266201 Oil-in-Oil emulsified polymeric implants containing a hypotensive lipid and related methods
Biocompatible intraocular implants, such as microparticles, include a prostamide component and a biodegradable polymer that is effective in facilitating...
2017/0266200 COMPOSITIONS AND METHODS FOR DELIVERING A BIO-ACTIVE AGENT OR BIO-ACTIVE AGENTS
In some embodiments, the present invention is a composition, including: a bulking agent, where the bulking agent is a kaolin, an absorbent material, where the...
2017/0266199 HETEROCYCLIC AMIDES AS RIP1 KINASE INHIBITORS AS MEDICAMENTS
Disclosed is a method of treating a RIP1 kinase-mediated disease or disorder which comprises administering a therapeutically effective amount of a compound...
2017/0266198 MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE
Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the...
2017/0266197 METHODS AND COMPOSITIONS FOR TREATING HEPATITIS B VIRUS INFECTIONS
Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful...
2017/0266196 PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2-(1-HYDROXY-ALKYL)-CHROMEN-4-ONE...
The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the...
2017/0266195 METHOD OF TREATMENT OF ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD)
The invention comprises a method for treatment of ADHD or ADHD-related disorders by a pharmaceutical agent exhibiting combined serotonergic or noradrenergic...
2017/0266194 PLEUROMUTILIN DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY MICROBES
A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R.sub.3 are in vicinal position (if m=0 then R.sub.3 is...
2017/0266193 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are compounds useful for treating cancer and methods of treating cancer, for example an advanced solid tumor, such as a glioma, or angioimmunoblastic...
2017/0266192 METHODS FOR IMPROVING DIAPHRAGM FUNCTION
Provided are compositions and methods for improving diaphragm function in a patient. In some embodiments, the methods comprise administering to a patient or...
2017/0266191 Therapeutic Combination of PI3K Inhibitor and a BTK Inhibitor
In some embodiments, the invention includes a therapeutic combination of a phosphoinositide 3-kinase (PI3K) inhibitor, including PI3K inhibitors selective for...
2017/0266190 DRUG COMBINATION
The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is ...
2017/0266189 Pyrimido[4,5-b]quinoline-4,5(3H,10H)-diones
The invention relates to compound of the formula (I); or a salt thereof, wherein the substituents are as defined in the specification; to its preparation, to...
2017/0266188 Methods For the Treatment of Cancer
The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use...
2017/0266187 Pemetrexed Polymeric Nanoparticles And Methods Of Making And Using Same
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of pemetrexed; and about 10 to about 99 weight percent of...
2017/0266186 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)
Methods are provided for treating a hematologic cancer comprising administering an anticancer agent to a subject identified as having an increased mobilization...
2017/0266185 MNK INHIBITORS AND METHODS RELATED THERETO
The present invention relates to compounds according to Formula (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, ...
2017/0266184 NON ADDICTIVE MORPHINE PLUS BUSPIRONE COMBINATION FOR THE TREATMENT OF PAIN
The present invention is a development of a morphine plus buspirone combination (7.5 mg/kg morphine plus 1-2 mg/kg buspirone) used as a non-addictive treatment...
2017/0266183 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CUSHING'S SYNDROME USING 2S, 4R KETOCONAZOLE
Methods for treating Cushing's Syndrome and other conditions associated with excessive cortisol production such as Cushing's Disease, ectopic ...
2017/0266182 Treatment of IgG-Immune Complex-Mediated Organ Damage
Methods for treating IgG-immune complex-mediated organ damage, e.g., in lupus or Goodpasture syndrome, using Bcr-Abl tyrosine-kinase inhibitors, e.g., Bosutinib.
2017/0266181 NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER...
Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit...
2017/0266180 TREATMENT OF CROHN'S DISEASE WITH LAQUINIMOD
This application provides for a method of treating a subject suffering from Crohn's disease, the method comprising periodically administering to the subject an...
2017/0266179 Treatment of Glaucoma Using Laquinimod
The subject invention provides a method of treating a subject afflicted with glaucoma, suffering from retinal ganglion cell (RGC) loss or damage, or elevated...
2017/0266178 C-Met Modulator Pharmaceutical Compositions
Pharmaceutical compositions and unit dosage forms comprising Compound I are disclosed. ##STR00001##
2017/0266177 Methods for Increasing CFTR Activity
The present disclosure provides compounds effective in increasing mucociliary clearance in a subject. In one embodiment, the compounds are of the general...
2017/0266176 Pharmaceutical Compositions of (R)-1-(2,2-Difluorobenzo[D] ...
A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6- ...
2017/0266175 NOVEL PIPERIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein A.sup.1, A.sup.2 and R.sup.1 to R.sup.3 are defined as in the description and in the...
2017/0266174 Compositions and Methods for Extending Lifespan
In one embodiment, the present application discloses a method of reducing senescence in a mammal by reducing the concentration of non-ferritin iron within the...
2017/0266173 MAPK INHIBITORS
The present invention relates to certain novel substituted thiophene compounds and the finding that they display useful efficacy in the inhibition of the...
2017/0266172 Compositions and Uses of Amidine Derivatives
Use of a compound of formula (I): wherein A, X, Y, R.sub.1 and R.sub.2 as defined herein, in treating hereditary angioedema is disclosed. A composition...
2017/0266171 Durable Treatment with 4-Aminopyridine in Patients with Demyelination
Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a...
2017/0266170 PHARMACEUTICAL COMPOSITIONS FOR COMBINATION THERAPY
This invention relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a dopaminergic stabilizer known as...
2017/0266169 CYP2J2 ANTAGONISTS IN THE TREATMENT OF PAIN
The present invention pertains to novel treatments of neuropathic pain; in particular chemotherapy induced peripheral neuropathic pain (CIPNP). The invention...
2017/0266167 ERK INHIBITORS
The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The...
2017/0266166 Compositions and Methods to Inhibit Estrogen Receptor Beta for the Treatment of Renal Cell Carcinoma
The invention provides compositions and methods for treating and preventing cancer. The invention relates to compositions and methods for treating subjects...
2017/0266165 Soft Chewable Pharmaceutical Products
A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a ...
2017/0266164 NEW METHODS AND USES
This invention relates to a new use of compounds that are angiotensin II receptor agonists, specifically agonists of the angiotensin II type 2 receptor (the...
2017/0266163 METHODS FOR RESTORATION OF HISTAMINE BALANCE
Several embodiments provided herein relate to histamine dosing regimens are and uses of such regimens in the restoration of histamine balance in subjects...
2017/0266162 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the...
2017/0266161 COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME
The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are...
2017/0266160 METHODS FOR TREATING PULMONARY EMPHYSEMA USING SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID ...
This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 ##STR00001## and their use as inhibitors of...
2017/0266159 Enalapril Formulations
Provided herein are stable enalapril oral liquid formulations. Also provided herein are methods of using enalapril oral liquid formulations for the treatment...
2017/0266158 FORMULA COMPRISING A HYPOLIPIDEMIC AGENT
The present invention relates to the stable pharmaceutical composition of a suitable hypolipidemic agent. Preferably, the present invention discloses novel...
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