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Patent # Description
2017/0275338 Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Dengue Virus Infection
Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHR) are significant global public health problems and understanding the overall immune response to infection...
2017/0275337 HIGH-TRANSDUCTION-EFFICIENCY RAAV VECTORS, COMPOSITIONS, AND METHODS OF USE
The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or...
2017/0275336 NOVEL PEPTIDE AND USE THEREOF
An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The...
2017/0275335 IMPROVED PROCESS FOR PREPARATION OF AMORPHOUS LINACLOTIDE
The present application relates to an improved process for the formation of disulfide bonds in linaclotide. The present application also relates to an improved...
2017/0275334 LINEAR PEPTIDE ANTIBIOTICS
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in...
2017/0275333 NOVEL PEPTIDE COMPOSITIONS
The present invention provides, among other things, novel peptides and compositions for treating disease.
2017/0275332 POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS
The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies...
2017/0275331 SITE-SELECTIVE FUNCTIONALIZATION OF PROTEINS USING TRACELESS AFFINITY LABELS
The present disclosure relates to site-selective labeling compounds, and methods of using such compounds.
2017/0275330 POLYMORPHIC FORMS OF AN OXYSTEROL AND METHODS OF MAKING THEM
Compositions and methods for preparing an OXY133 polymorph are provided. This compositions and methods include subjecting a slurry of OXY133 to conditions...
2017/0275329 ALKYNYL NUCLEOSIDE ANALOGS AS INHIBITORS OF HUMAN RHINOVIRUS
The present invention provides a compound of Formula (I) or a salt thereof; ##STR00001## and therapeutic uses of these compounds. The invention further provides ...
2017/0275328 DI- AND TRIPHOSPHATE PRODRUGS
Compounds which can be used as prodrugs, in particular nucleoside diphosphate and triphosphate prodrugs, and a method for producing these compounds. The aim is...
2017/0275327 SUBSTITUTED PHOSPHORAMIDATE COMPOUNDS AND USES THEREOF
The present invention is directed to Compounds of Formula (I) and salts thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined above herein. The...
2017/0275326 IDIOPATHIC PULMONARY FIBROSIS-DETECTION, MONITORING, PREDICTION METHODS
Provided is a compound of the general formula (I): ##STR00001## The compound of formula (I) is suitable for treating pulmonary fibrosis, such as Idiopathic...
2017/0275325 Novel Diterpene Glycosides, Compositions and Purification Methods
Novel diterpene glycosides and methods for purifying the same are provided herein. In addition, compositions comprising the novel diterpene glycosides, as well...
2017/0275324 Novel Diterpene Glycosides, Compositions and Purification Methods
A novel diterpene glycoside and methods for preparing and purifying the same are provided herein. In addition, compositions comprising the novel diterpene...
2017/0275323 GLYCOLIPIDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR USE IN THERAPY
A compound of Formula I: R1-L1-C(A)(A')-CH.sub.2, -L2-R2 or a pharmaceutically acceptable salt thereof, for use in medicine, for example in the treatment of a...
2017/0275322 METHODS FOR THE PREPARATION OF DIASTEREOMERICALLY PURE PHOSPHORAMIDATE PRODRUGS
Methods for the preparation of diastereomerically pure phosphoramidate prodrugs of nucleosides, and intermediates useful for the preparation are provided. The...
2017/0275321 First-Row Transition Metal Hydrogenation and Hydrosilylation Catalysts
Transition metal compounds, and specifically transition metal compounds having a tetradentate and/or pentadentate supporting ligand are described, together...
2017/0275320 First Row Transition Metal Amino Borohydrides
A transition metal amino borohydride material includes a first row transition metal in conjunction with an amine ligand and borohydride, in a condition of...
2017/0275319 PLATINUM DERIVATIVES FOR HYDROPHOBIC FORMULATIONS
New derivatives of a Pt (II) complex provided which are liposoluble and useful as anticancer agents. Also disclosed are platinum II complexes in delivery...
2017/0275318 SOLID-SUPPORTED PALLADIUM (II) COMPLEX AS A HETEROGENEOUS CATALYST FOR CROSS COUPLING REACTIONS AND METHODS THEREOF
A solid-supported catalyst ligand which chelates palladium (II) species to form a complex that functions as a heterogeneous catalyst that is stable and can be...
2017/0275317 COMPLEXES AND METHODS FOR THEIR PREPARATION
Disclosed are methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the...
2017/0275316 BISPHOSPHITES HAVING AN UNSYMMETRIC OUTER BIPHENOL UNIT
Bisphosphites having at least one unsymmetric outer biphenol unit are useful for the hydroformylation of an olefin.
2017/0275315 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5- -HYDROXYMETHYL OXAZOLIDIN-2-ONE...
A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydro- xymethyl oxazolidin-2-one dihydrogen phosphate,...
2017/0275314 ALKYLIDENE PHOSPHONATE ESTERS AS P-GLYCOPROTEIN INDUCERS
The present invention relates to the alkylidene phosphonate esters of formula I wherein, R.sub.1 is selected from a group consisting of hydrogen or alkyl...
2017/0275313 MODIFIED MITO-METFORMIN COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the...
2017/0275312 PHOSPHINIC VANADIUM COMPLEX, CATALYTIC SYSTEM COMPRISING SAID PHOSPHINIC VANADIUM COMPLEX AND PROCESS FOR THE...
Vanadium phosphinic complex having general formula (I) or (II): V(X)M3P WFys-nMO V(X)3[(R3)2P(R4)P(R3)2] (ID wherein: X represents an anion selected from...
2017/0275311 NON-AQUEOUS LIQUID ELECTROLYTE, ELECTRICITY STORAGE DEVICE USING SAME, AND PHOSPHORUS COMPOUND USED THEREIN
The present invention is concerned with a nonaqueous electrolytic solution having an electrolyte salt dissolved in a nonaqueous solvent, the nonaqueous...
2017/0275310 ELECTROLYTIC SOLUTION AND NOVEL FLUORINATED PHOSPHORIC ACID ESTER
The present invention provides a novel electrolyte solution capable of providing electrochemical devices having a high storage capacity retention. The...
2017/0275309 NOVEL ORGANIC TITANIUM COMPOUND, METHOD FOR PRODUCING SAME, AND ROOM TEMPERATURE-CURABLE RESIN COMPOSITION
The present invention provides: a novel organic titanium compound having an effect as an adhesion promoter by itself; a production method of such organic...
2017/0275308 Process For Production of Halosilanes From Silicon-Containing Ternary Intermetallic Compounds
A process for preparing a reaction product including a halosilane includes: contacting an unsaturated hydrocarbyl halide and a ternary intermetallic compound...
2017/0275307 PREPARATION OF FLUOROSILICON COMPOUNDS
Methods of synthesizing fluorosilanes containing cyano-substituted alkyl groups are provided. For example, 3-cyano-propyldimethylfluorosilane may be produced...
2017/0275306 Method For Producing Aryl-Functional Silanes
A method for preparing a reaction product including an aryl-functional silane includes sequential steps (1) and (2). Step (1) is contacting, under silicon...
2017/0275304 HIGHLY DISPERSIBLE ANTIMICROBIAL AND ADHESION AGENTS
Compositions of matter that have antimicrobial properties and adhesion properties and are highly dispersible in aqueous solutions. The presence of a large...
2017/0275303 CHIRAL BINUCLEAR METAL COMPLEXES FOR STEREOSELECTIVE GLYCOSIDE HYDROLYSIS OF SACCHARIDES
Disclosed herein is a class of chiral binuclear metal complexes for stereoselective glycoside hydrolysis of saccharides, and more particular chiral binuclear...
2017/0275302 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel....
2017/0275301 Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof
Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.
2017/0275300 SYNTHESIS OF CEPHALOSPORIN COMPOUNDS
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are...
2017/0275299 PREPARATION METHOD FOR BENZOXAZOLEOXAZINE KETONE COMPOUND AND INTERMEDIATE AND CRYSTAL FORM THEREOF
A preparation method for a high-purity benzoxazoleoxazine ketone compound, a crystal form thereof, and an intermediate compound for preparing a compound of...
2017/0275298 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The...
2017/0275297 INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for...
2017/0275296 THERAPEUTIC AGENT FOR MOTOR DISORDERS
Provided are an agent for the treatment and/or prophylaxis of a movement disorder, the agent for the treatment and/or prophylaxis wherein the movement disorder...
2017/0275295 METHOD FOR CONDITIONING A DIANHYDROHEXITOL, AQUEOUS SOLUTION OF CONDITIONED DIANHYDROHEXITOL, AND USES THEREOF
The invention relates to a method for conditioning a dianhydrohexitol in the form of an aqueous solution in a container comprising a polyolefin-based layer....
2017/0275294 Nalmefene Salts as Medicaments for Reducing Alcohol Consumption or for Preventing Excessive Alcohol Consumption
The present invention relates to new nalmefene salts which salts fall within at least one of the two following categories: non-hydrate forming salts and...
2017/0275293 Novel Alpha-Hydroxy Carboxylic Acid and Derivatives and Other GRAS Based Prodrugs of Oxycodone and Uses thereof
The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxycodone, in a manner that substantially...
2017/0275292 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula I: (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1)...
2017/0275291 INDAZOLE COMPOUNDS AS FGFR KINASE INHIBITOR, PREPARATION AND USE THEREOF
The present invention provides an indazole compound as a FGFR kinase inhibitor, preparation and use thereof. Specifically, the present invention provides a...
2017/0275290 PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS
This application relates to compounds of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are...
2017/0275289 THERAPEUTIC COMPOUNDS AND USES THEREOF
The present invention relates to methods for treating PCAF and GCN5 mediated disorders using a compound of formula (I) or a pharmaceutically acceptable salt...
2017/0275288 PTERIDINES USEFUL AS HCV INHIBITORS AND METHODS FOR THE PREPARATION THEREOF
The present invention relates to the use of pteridines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or...
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