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Patent # Description
2017/0275287 NOVEL N2, N4, N7, 6-TETRASUBSTITUTED PTERIDINE-2,4,7-TRIAMINE AND 2, 4, 6, 7-TETRASUBSTITUTED PTERIDINE...
Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and...
2017/0275286 Novel Sulfonimidoylpurinone Compounds and Derivatives for the Treatment and Prophylaxis of Virus Infection
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or...
2017/0275285 INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL
The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of...
2017/0275284 Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
2017/0275283 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The...
2017/0275282 FACTOR XIA-INHIBITING PYRIDOBENZAZEPINE AND PYRIDOBENZAZOCINE DERIVATIVES
The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and to processes for preparation thereof, and also to the use thereof...
2017/0275281 IMIDAZO[4,5-C]PYRIDINE DERIVED SSAO INHIBITORS
A compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof and the use of the same in therapy: wherein Z, Y, R.sup.1, W, V, and...
2017/0275280 NOVEL CAPSAZEPINE ANALOGS FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES
The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using...
2017/0275279 SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE
The present disclosure is generally directed to compositions useful in the inhibition of MetRS and methods for treating diseases that are ameliorated by the...
2017/0275278 Mammalian and Bacterial Nitric Oxide Synthase Inhibitors
Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions...
2017/0275277 NEW BICYCLIC DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES
The present invention relates to novel compounds having .beta.2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions...
2017/0275276 N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALING PATHWAY
Disclosed are compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In...
2017/0275275 BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS
The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to...
2017/0275274 ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors...
2017/0275273 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds...
2017/0275272 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS
The present invention provides compounds of Formula (I): ##STR00001## wherein all variables are as defined in the specification, and compositions comprising any...
2017/0275271 6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE INHIBITORS OF PHD
The present invention provides compounds of the formula: ##STR00001## which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for...
2017/0275270 BENZYL SUBSTITUTED INDAZOLES
Compounds of formula (I) and their use as pharmaceuticals. ##STR00001##
2017/0275269 BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS
Compounds of formula (I) and their use as pharmaceuticals. ##STR00001##
2017/0275268 HETEROARYL SUBSTITUTED INDAZOLES
Compounds of formula (I), which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
2017/0275267 SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER
Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or...
2017/0275266 HISTONE DEMETHYLASE INHIBITORS
Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising...
2017/0275265 4-(3-CYANOPHENYL)-6-PYRIDINYLPYRIMIDINE MGLU5 MODULATORS
The disclosures herein relate to novel compounds of formula wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and n are defined herein, and their use in treating,...
2017/0275264 CARBAMATE/UREA DERIVATIVES
The invention relates to compound of the formula I ##STR00001## or a salt thereof, wherein the substituents are as defined in the specification; to its...
2017/0275263 Compounds for the treatment of HPV-induced carcinoma
A compound of Formula 1 ##STR00001## wherein, X represents an alkyl, alkylene, alkenyl, alkenylene, alkynyl or alkynylene group, optionally having at least...
2017/0275262 CYCLOPROPANE DERIVATIVES IN FLAVOR AND FRAGRANCE COMPOSITIONS
The present invention relates to novel cyclopropane derivatives represented by Formula I: ##STR00001## wherein R represents a hydrocarbon group containing 1-20...
2017/0275261 1,3,4-THIADIAZOLES HAVING A HERBICIDAL ACTIVITY, THEIR AGRONOMICAL COMPOSITIONS AND RELATIVE USE
The present invention relates to new thiadiazoles having general formula (I): ##STR00001## and their use as herbicides.
2017/0275260 ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
The present disclosure relates to compounds of formula I that are useful as modulators of .alpha.7 nAChR, compositions comprising such compounds, and the use...
2017/0275259 CRYSTALLINE(2S,4R)-5-(5'-CHLORO-2'-FLUORO-[1,1'-BIPHENY]-4-YL)-2-(ETHOXYME- ...
In one aspect, the invention relates to a crystalline form of the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, having neprilysin ...
2017/0275258 METHOD FOR PRODUCING EPOXY COMPOUND CONTAINING HYDROGEN PEROXIDE STABILIZER
The present invention provides a method for producing an epoxy compound by a reaction of an olefin compound with hydrogen peroxide, wherein the epoxy compound...
2017/0275257 2-THIOPYRIMIDINONES
Myeloperoxidase inhibitor, pharmaceutical compositions containing the inhibitor and the use of the inhibitor to treat, for example, cardiovascular conditions.
2017/0275256 COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS
The present invention relates to compounds of Formula I, ##STR00001## a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate...
2017/0275255 CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID
The present invention relates to crystalline form of Eltrombopag free acid and its process for preparation. ##STR00001##
2017/0275254 PYRAZOLES
The invention relates to pyrazole derivatives which are NMDA NR2B receptor inhibitors, useful in treating central nervous system diseases. ##STR00001##
2017/0275253 BENZAZEPINE SULFONAMIDE COMPOUNDS
This invention relates to novel benzazepine sulfonamide compounds of the formula ##STR00001## wherein R.sup.4 or R.sup.5 is --SO.sub.2--NR.sup.7R.sup.8...
2017/0275252 ASYMMETRIC BISAMINOQUINOLINES AND BISAMINOQUINOLINES WITH VARIED LINKERS AS AUTOPHAGY INHIBITORS FOR CANCER AND...
The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit...
2017/0275251 Malate salt of N-(4-phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms...
Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cy- clo-propane-1,1-dicarboxamide, including a (L)-malate...
2017/0275250 PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE
Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically...
2017/0275249 SMALL LIPOPEPTIDOMIMETIC INHIBITORS OF GHRELIN O-ACYL TRANSFERASE
Compositions and methods are disclosed that relate to small molecule lipopeptidomimetic inhibitors of mammalian ghrelin O-acyl transferase (GOAT). Compounds of...
2017/0275248 Carbondisulfide Derived Zwitterions
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be...
2017/0275247 METHOD FOR PRODUCING METHIONINE
A method for producing methionine involves contacting 2-amino-4-(methylthio)butanenitrile with water in the presence of an oxide catalyst containing cerium....
2017/0275246 NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR
The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor...
2017/0275245 Modularized System and Method for Urea Production Using Stranded Natural Gas
A modular system and method for producing urea from stranded natural gas includes removal of foreign particulate matter to obtain a substantially homogeneous...
2017/0275244 C7-Fluoro Substituted Tetracycline Compounds
The present invention is directed to a compound represented by Structural Formula (A): ##STR00001## or a pharmaceutically acceptable salt thereof. The variables...
2017/0275243 Lipids and Lipid Compositions for the Delivery of Active Agents
This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R.sup.A, R.sup.B, R.sub.2 and R.sub.4 are defined...
2017/0275241 TRANSESTERIFICATION REACTION BY MEANS OF IRON CATALYST
Provided is a catalyst for transesterification reactions, which contains an iron salen complex. Also provided is a method for producing an ester compound,...
2017/0275240 METHOD FOR PREPARING CHIRAL gamma-SECONDARY AMINO ALCOHOL
A method for preparing chiral .gamma.-secondary amino alcohol includes: adding into a solvent an acid addition salt of .beta.-secondary amino ketone...
2017/0275239 COMPOUNDS AND MIXTURES WITH ANTIDEGRADANT AND ANTIFATIGUE EFFICACY AND COMPOSITIONS INLUDING SUCH COMPOUNDS
Antidegradant compounds are disclosed, and methods of making them, that are represented by the formula I: ##STR00001## wherein each X is independently selected...
2017/0275238 METHODS OF MAKING COMPOUNDS AND MIXTURES HAVING ANTIDEGRADANT AND ANTIFATIGUE EFFICACY
Methods of making antidegradant compounds are disclosed in which a p-phenylenediamine is reacted with a diol to obtain mixtures comprising the antidegradant...
2017/0275237 COMPOUNDS AND MIXTURES WITH ANTIDEGRADANT AND ANTIFATIGUE EFFICACY AND COMPOSITIONS INCLUDING SAID COMPOUNDS
A compound represented by the formula: ##STR00001## wherein each R is independently selected from the group consisting of (i) substituted or unsubstituted...
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