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Patent # Description
2017/0273968 MAO-B INHIBITORS AND REHABILITATION
Methods of rehabilitation of neurological disorders, including neurological deficits associated with neurotraumas, such as stroke and traumatic brain injury,...
2017/0273966 TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
The present invention relates to a compound represented by formula I:and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors...
2017/0273965 TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2
The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof. The compounds of formula (I) are...
2017/0273964 FATTY ACID SYNTHASE INHIBITOR FOR USE IN THE TREATMENT OF DRUG RESISTANT CANCER
Compounds that are fatty acid synthesis modulators are provided. The compounds may be used in pharmaceutical compositions to treat taxane-resistant cancers....
2017/0273963 PHARMACEUTICAL COMPOUNDS AND USE OF SAME IN CANCER AND TAUOPATHIES
Disclosed are compounds of formula (I)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation,...
2017/0273962 Inhibitors of Hepatitis C Virus Polymerase
The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X,...
2017/0273961 NOVEL IMINONITRILE DERIVATIVES
The invention relates to a compound of formula (I) wherein X.sup.1 to X.sup.4 and R.sup.C to R.sup.G are defined as in the description and in the claims. The...
2017/0273960 METHODS OF USING SUSTAINED RELEASE AMINOPYRIDINE COMPOSITIONS
A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a...
2017/0273959 Methods Of Treating Fabry Disease In Patients Having The G9331A Mutation In The GLA Gene
Provided are methods of treating a patient diagnosed with Fabry disease and methods of enhancing .alpha.-galactosidase A in a patient diagnosed with or...
2017/0273958 INCREASING EXPRESSION LEVEL OF APOPTOSIS-RELATED GENES BY TREATING A HUMAN SUBJECT WITH A NITROXIDE
Disclosed herein are methods for counteracting age-related decrease in gene expression or treating age-related diseases, for example cancers and autoimmune...
2017/0273957 ANTITUSSIVE COMPOSITIONS AND METHODS
Disclosed herein are compositions which include nicotinic receptor agonists, specifically of the .alpha.7 nAChR subtype, and methods for suppressing cough.
2017/0273956 METHODS OF INCREASING TONIC INHIBITION AND TREATING SECONDARY INSOMNIA
Methods of increasing tonic inhibition in a subject in need thereof, for example a subject with Fragile X syndrome or Angelman syndrome are disclosed. Methods...
2017/0273955 AZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: ##STR00001## or its pharmaceutically acceptable salt,...
2017/0273954 METHODS AND COMPOSITIONS FOR BACTERIA INFECTIONS
Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the...
2017/0273953 CRYSTALLINE SOLID FORMS OF 6-CARBOXY-2-(3,5-DICHLOROPHENYL)-BENZOXAZOLE
The present invention relates to solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also...
2017/0273952 METHODS OF TREATING LIVER DISEASE
The present disclosure relates to a method of preventing and/or treating liver disease comprising administering an ASK1 inhibitor in combination with a FXR...
2017/0273951 ANESTHETIC COMPOUNDS AND RELATED METHODS OF USE
Provided herein are compounds according to formula (I): ##STR00001## Provided herein is also a pharmaceutical composition comprising a compound according to...
2017/0273950 SYNTHESIS OF CYCLOCREATINE AND ANALOGS THEREOF
Provided herein is a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, using cynamide in the reaction. ...
2017/0273949 AGENT FOR PREVENTING AND/OR TREATING OPHTHALMOLOGIC DISEASES
It is an object of the present invention to provide a novel medicament for preventing and/or treating ophthalmologic diseases caused by ocular angiogenesis....
2017/0273948 USE OF SIGMA RECEPTOR LIGANDS IN OSTEOARTHRITIS
The invention relates to compounds of formula (I) or formula (II) ##STR00001## having pharmacological activity towards the sigma receptor, for use in the...
2017/0273947 N-(5-ARYLAMIDO-2-METHYLPHENYL)-5-METHYLISOOXAZOLE-4-CARBOXAMIDE DERAVATIVE, PHARMACEUTICAL ACCEPTABLE SALT...
The present invention relates to N-(5-arylamido-2-methylphenyl)-5-methylisoquoxazole-4-carboxamide derivative, or a pharmaceutically acceptable salt thereof...
2017/0273946 EXTENDED RELEASE PHARMACEUTICAL FORMULATIONS
The present invention relates to coated extended release pharmaceutical formulations of valsartan comprising a core comprising valsartan and at least one...
2017/0273945 PHARMACEUTICAL COMPOSITION FOR TOPICAL ADMINISTRATION
The present invention relates to a pharmaceutical composition for topical administration comprising a compound of formula I, ...
2017/0273944 ACTIVE METABOLITE OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-- 1H-INDOLE...
The present invention is directed to active metabolite of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-- 1H-indole dimesylate...
2017/0273943 SUBSTITUTED PHENYLPYRROLECARBOXAMIDES WITH THERAPEUTIC ACTIVITY IN HIV
Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
2017/0273942 Taxane Analogs for the Treatment of Brain Cancer
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a...
2017/0273941 MAST CELL STABILIZERS TREATMENT FOR SYSTEMIC DISORDERS
Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders, are provided.
2017/0273940 MANGIFERIN-6-O-BERBERINE SALT AND PREPARATION METHOD AND USE THEREOF
The present invention provides a mangiferin-6-O-berberine salt and a preparation method thereof, and further provides a use of the mangiferin-6-O-berberine...
2017/0273939 A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MULTI-DRUG RESISTANT INFECTIONS
A pharmaceutical composition for the treatment of multi-drug resistant infections includes an antimicrobial agent in combination the ...
2017/0273938 USE OF FLAVONOIDS IN MANUFACTURING COMPOSITIONS FOR WOUND HEALING
Disclosed is a method for wound healing comprising administering a subject in need thereof a therapeutically effective amount of a flavonoid compound, wherein...
2017/0273937 ENKEPHALIN-INFLUENCING COMPOSITION AND METHOD
A composition which includes Phenylalanine, Serine, Glutamine and GABA (.gamma.-aminobutyric acid). The composition contains the essential amino acids...
2017/0273936 USE OF DRONEDARONE FOR THE PREPARATION OF A MEDICAMENT FOR USE IN THE PREVENTION OF CARDIOVASCULAR...
Methods of using dronedarone or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in the prevention of cardiovascular...
2017/0273935 CINEOLE-CONTAINING COMPOSITION FOR NASAL APPLICATION
The invention relates to a pharmaceutical composition containing cineole for topical, in particular nasal, preferably intranasal application, to the use...
2017/0273934 Treatment of Triple Receptor Negative Breast Cancer
The present invention relates to the use of a liposomal preparation for the manufacture of a pharmaceutical composition and the use of such a composition for...
2017/0273933 ANTI-TUMOR COMPOUND AND THE MEDICAL USE THEREOF
The invention disclose a compound of formula (I), wherein, R.sub.1 is selected from --H or C1-C6 hydrocarbon group, --NH.sub.2, --OH, ...
2017/0273932 LYOPHILIZED COMPOSITIONS CONTAINING A METAP-2 INHIBITOR
This disclosure features compositions (e.g., re-constitutable solids, such as lyophilized cakes; or liquid compositions, such as solutions or suspensions,...
2017/0273931 COMPOSITION COMPRISING A COMPOUND FROM THE FAMILY OF AVERMECTINS AND DOXYCYCLINE FOR THE TREATMENT OF ROSACEA
The use of a composition comprising a compound from the family of avermectins, preferably ivermectin, and doxycycline or one of the salts thereof that is...
2017/0273930 METHODS TO TREAT NEURODEGENERATIVE DISEASES
The specification provides compositions and methods to treat neurodegenerative diseases.
2017/0273929 CARDIOVASCULAR DISEASE PRIMARY PREVENTION AGENT FOR PATIENTS HAVING HIGH BLOOD LEVELS OF HIGH-SENSITIVITY...
The present invention provides the following: a cardiovascular disease primary prevention agent, which comprises as the active ingredient at least one selected...
2017/0273928 COMPOSITION FOR PREVENTING THE OCCURRENCE OF CARDIOVASCULAR EVENT IN MULTIPLE RISK PATIENT
Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a...
2017/0273927 METHODS OF TREATING AUTOIMMUNITY
Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic...
2017/0273926 COMPOSITIONS AND METHODS FOR USE OF EFLORNITHINE AND DERIVATIVES AND ANALOGS THEREOF TO TREAT CANCERS,...
Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress...
2017/0273925 CO-ADMINISTRATION OF INTRAVENOUS IBUPROFEN AND ACETAMINOPHEN FOR TREATMENT OF PAIN
An effective dose of intravenous ibuprofen administered co-adminstered with intravenous acetaminophen in surgery patients is a safe and effective way to reduce...
2017/0273924 VALPROATE AS A TOPICAL ANTI-FUNGAL TREATMENT
Valproate is useful as an antifungal agent. The valproate compositions can be used to treat fungal infections. The valproate compositions can be formulated as...
2017/0273923 METHOD OF ADMINISTERING DIVALPROEX
A compact sustained release tablet comprising divalproex or its pharmaceutically acceptable salts as a sole active ingredient is present in an amount...
2017/0273922 UREA AND BIS-UREA BASED COMPOUNDS AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF ANDROGEN RECEPTOR MEDIATED...
Urea-based and bis-urea based compounds and analogues thereof are disclosed. These compounds are useful in the treatment of androgen-dependent diseases or...
2017/0273921 3,5,N-TRIHYDROXY-ALKANAMIDE OR 3,5,N-TRIHYDROXY-6-ALKENAMIDE DERIVATIVE ALONE OR IN COMBINATION WITH...
The present invention provides a novel method for treating cancer that comprises administering a compound represented by formula (I) and/or a chemotherapeutic...
2017/0273920 PARTICULATE MATERIALS
The present invention relates to active substances in particulate form, to methods for preparing them and to their uses. The present invention provides...
2017/0273919 NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE
The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present...
2017/0273918 PHARMACEUTICAL COMPOSITIONS FOR N-PROPARGYLAMINE DERIVATIVE
The present application relates to a method of treating Parkinson's disease by administering a mouth-dissolving composition of N-propargylamine derivative,...
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