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Patent # Description
2017/0283507 CAR-EXPRESSING NK-92 CELLS AS CELL THERAPEUTIC AGENTS
The present invention relates to an ErbB2-specific NK-92 cell or cell line containing a lentiviral vector encoding a chimeric antigen receptor and preferably...
2017/0283506 LUNG CANCER DIFFERENTIAL MARKER
An object of the present invention is to develop and provide a lung cancer differential marker with which lung cancer can be diagnosed conveniently and highly...
2017/0283505 PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA
The present invention relates generally to glutamine-free cell culture media supplemented with asparagine. The invention further concerns the production of...
2017/0283504 BCMA BINDING MOLECULES AND METHODS OF USE THEREOF
The invention provides antibodies, antigen binding fragments thereof, chimeric antigen receptors (CARs), and engineered T cell receptors, polynucleotides...
2017/0283503 COMPOSITIONS COMPRISING RANK/RANKL ANTAGONISTS AND RELATED COMPOUNDS FOR TREATING PAIN
Disclosed herein are methods of treating pain using RANK/RANKL antagonists.
2017/0283502 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING INFLAMMATION
The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing...
2017/0283501 Antigen Binding Proteins that Bind c-Met
There is disclosed compositions and methods relating to or derived from anti-c-Met antibodies. More specifically, there is disclosed fully human antibodies...
2017/0283499 ANTIBODY WHICH IS DIRECTED AGAINST GALECTIN-9 AND IS AN INHIBITOR OF THE SUPPRESSOR ACTIVITY OF REGULATORY T...
The invention relates to an antibody which is directed against galectin-9 and is an inhibitor of the suppressor activity of regulatory T lymphocytes, and also...
2017/0283498 THERAPEUTIC CD47 ANTIBODIES
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, CD47, as well as monoclonal antibodies and...
2017/0283497 ROR1 (NTRKR1) SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and...
2017/0283496 OLIGONUCLEOTIDES FOR REDUCTION OF PD-L1 EXPRESSION
The present invention relates to antisense oligonucleotides that are capable of reducing expression of PD-L1 in a target cell. The oligonucleotides hybridize...
2017/0283495 ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF
The present application relates to antibodies that specifically bind to hepcidin and methods of using the antibodies. Another aspect relates to antibodies...
2017/0283494 HUMAN ANTI-IL-33 NEUTRALIZING MONOCLONAL ANTIBODY
An antibody has an antagonistic effect against IL-33. In particular an isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with...
2017/0283493 METHODS FOR ENHANCING PERMEABILITY TO BLOOD-BRAIN BARRIER, AND USES THEREOF
Disclosed herein is a method of facilitating the delivery of an agent across blood-brain barrier (BBB) of a subject. The method includes administering to the...
2017/0283492 Polypeptides With Enhanced Anti-Inflammatory And Decreased Cytotoxic Properties And Relating Methods
The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose...
2017/0283491 METHOD OF PROVIDING DISEASE-SPECIFIC BINDING MOLECULES AND TARGETS
Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes...
2017/0283490 NANOBODIES SUITABLE FOR NEURON REGENERATION THERAPY
The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based...
2017/0283489 Chimeric Antigen Receptor Specific for SSEA4 Antigen
The present invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain specific for SSEA4, a population of engineered cells...
2017/0283488 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS
Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed...
2017/0283487 IMMUNO-BASED BOTULINUM TOXIN SEROTYPE A ACTIVITY ASSAYS
The present specification discloses SNAP-25 compositions, methods of making .alpha.-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at...
2017/0283486 STABLE IMMUNOGEN BASED ON INNER DOMAIN OF HIV-1 GP120 FOR INDUCING IMMUNITY AGAINST HIV
Stable immunogens comprising portions of the inner domain (ID) of the Human Immunodeficiency Virus (HIV-1) gp120 protein are provided. These ID immunogens...
2017/0283485 ANTIBODY CAPABLE OF BINDING TO INFLUENZA VIRUS
The present invention provides a novel antibody capable of binding influenza virus. The antibody directed to the present invention consists of an amino acid...
2017/0283484 ANTI-HEPATITIS C ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF
The invention provides an antibody or antigen binding fragment thereof capable of binding to the antigen binding pocket of the AP33 antibody, wherein said...
2017/0283483 METHODS OF MODIFYING ANTIBODIES FOR PURIFICATION OF BISPECIFIC ANTIBODIES
The present inventors devised methods for efficiently purifying bispecific antibodies using a chromatography column based on the difference in isoelectric...
2017/0283482 Chimeric Receptors with 4-1BB Stimulatory Signaling Domain
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the...
2017/0283481 Engineered Invariant Natural Killer T (iNKT) Cells and Methods of Making and Using Thereof
Disclosed are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof....
2017/0283480 PEPTIDES HAVING REDUCED TOXICITY THAT STIMULATE CHOLESTEROL EFFLUX
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length...
2017/0283479 LIPIDATED AMIDE-BASED INSULIN PRODRUGS
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug...
2017/0283478 PROCESS FOR PREPARATION OF LIRAGLUTIDE
The present application relates to improved processes for the preparation of Liraglutide.
2017/0283477 ANIMAL MODEL OF LONGEVITY AND RELATED METHODS FOR INCREASING LONGEVITY AND INHIBITING TUMORIGENESIS
The present invention includes a genetically-modified non-human animal model of longevity and increased health span, which is associated with reduced...
2017/0283476 MYC NUCLEIC ACIDS AND USES THEREOF
Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against MYC. Also described herein include methods for treating a...
2017/0283475 CANCER VACCINE COMPOSITIONS AND METHODS OF USE THEREOF
The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The...
2017/0283474 PRODUCTION OF PROTEINS AND POLYPEPTIDES
A method of producing a desired non-spidroin protein or polypeptide is comprising the steps of expressing in a suitable host a fusion protein, obtaining a...
2017/0283473 GENETICALLY MODIFIED HIGHER PLANTS WITH INCREASED PHOTOSYNTHESIS AND/OR BIOMASS PRODUCTION, METHODS AND USES...
The technology provided herein generally relates relates to genetically modified higher plants, for example C3 and C4 plants, and subsequent generations...
2017/0283472 COMPOSITIONS COMPRISING RECOMBINANT BACILLUS CELLS AND ANOTHER BIOLOGICAL CONTROL AGENT
The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at...
2017/0283471 MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS
We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell...
2017/0283470 MUTANT CSGG PORES
The invention relates to mutant forms of the outer membrane located lipoprotein CsgG, in particular, modifications at one or more of positions Tyr51; Asn55;...
2017/0283469 PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION
The present disclosure provides modified proteins that are capable of being cleaved by the protease OmpT1. The proteins can be modified in an exposed surface...
2017/0283468 PEPTIDES FOR DIAGNOSIS AND TREATMENT OF CANCER
The present invention provides a method of peptide histochemical diagnosis to detect the peptide binding protein in the cancer tissue. This peptide binding...
2017/0283467 PROGRAMMABLE POLYPEPTIDE AND NUCLEIC ACID NANOPARTICLES
Provided herein are polypeptides that self-assemble into nanoparticles upon binding to nucleic acids. The nanoparticles find use, for example in the delivery...
2017/0283466 METHOD FOR PREPARING MULTIPLE ANTIGEN GLYCOPEPTIDE CARBOHYDRATE CONJUGATES
The present invention relates to a method for preparing carbohydrate T cell epitope conjugates of formula (I): M(T-B).sub.n (I) wherein M, T, B and n ore as...
2017/0283465 NOVEL ANGIOTENSIN TYPE 2 (AT2) RECEPTOR AGONISTS AND USES THEREOF
The invention relates to novel pharmaceutically-useful peptides, in particular cyclic peptides that are agonists of the AngII type 2 receptor (AT2 receptor)....
2017/0283464 Crystalline And Amorphous Forms Of A Beta-Arrestin Effector
The present disclosure provides novel crystalline forms of a compound that acts as a .beta.-arrestin effector, processes for preparing novel crystalline and...
2017/0283463 IMMUNOMODULATORS
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
2017/0283462 IMMUNOMODULATORS
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
2017/0283461 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS
In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects,...
2017/0283460 Immune System Modulation for Prophylaxis and Treatment of Diseases and Disorders
The invention is directed to biological response modifiers (BRM) which may contain one or more compounds, and to methods for enhancement of an immune system...
2017/0283459 PEPTIDE INHIBITORS OF CALCIUM OXALATE MONOHYDRATE CRYSTALLIZATION AND USES THEREOF
In an embodiment, the present disclosure pertains to a composition for inhibiting calcium oxalate monohydrate crystal growth comprising at least one isolated...
2017/0283458 COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR WOUND HEALING
Methods and compositions for promoting wound healing in a patient by administering a collagen-binding synthetic peptidoglycan to the patient are described....
2017/0283457 USE OF INHIBITORY PEPTIDES FOR THE TREATMENT OF INFLAMMATORY DISEASES
An isolated peptide is disclosed which comprises an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1...
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