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Patent # Description
2017/0298384 STEM CELL GENE TARGETING
The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing...
2017/0298383 WHEAT MS1 POLYNUCLEOTIDES, POLYPEPTIDES, AND METHODS OF USE
Compositions and methods are capable of modulating male fertility in a plant. Compositions comprise polynucleotides and polypeptides, and fragments and...
2017/0298382 GENETIC REDUCTION OF MALE FERTILITY IN PLANTS
Genetic male sterile plants are provided in which complementing constructs result in suppression of a parental phenotype in the progeny. Methods to generate...
2017/0298381 COMBINATION OF FOUR VIP AND CRY PROTEIN TOXINS FOR MANAGEMENT OF INSECT PESTS IN PLANTS
The subject invention includes methods and plants for controlling lepidopteran pests, especially soybean looper (Pseudoplusia includens) and velvet bean...
2017/0298380 IMIDAZOLINONE HERBICIDE RESISTANT BORAGE
The present disclosure provides borage plants having increased resistance to imidazolinone herbicides. More particularly, provided herein are methods for...
2017/0298379 FUNCTIONAL MUTANT ALLELES OF EIN5 FOR YIELD INCREASE
This disclosure relates to novel mutant alleles for increasing biomass in plants and provides mutant plants comprising alleles and chimeric genes encoding the...
2017/0298378 GENES TO PROVIDE ENVIRONMENTAL STRESS TOLERANCE AND THE USE THEREOF
It is intended to provide a gene capable of conferring more practical environmental stress tolerances to a plant and the use thereof. The present invention...
2017/0298377 METHODS OF CONTROLLING SEED SIZE IN PLANTS
This invention relates to the identification of a regulator protein (termed CYP78A6, or EOD3) which controls the size of plant seeds and organs in Arabidopsis...
2017/0298376 TOBACCO PLANTS EXHIBITING ALTERED PHOTOSYNTHESIS AND METHODS OF MAKING AND USING
This disclosure provides tobacco plants that exhibit altered photosynthesis as well as methods of making and using such plants.
2017/0298375 CONTROL OF CELLULOSE BIOSYNTHESIS BY OVEREXPRESSION OF A TRANSCRIPTION FACTOR
The invention relates to nucleic acids, proteins and methods for modulating the cellulose content of plants.
2017/0298374 COMPOSITIONS AND METHODS OF DELIVERING MOLECULES TO PLANTS
Compositions and method of delivering a molecule to a plant are provided. In an embodiment, an avenic acid transporter is introduced into a plant. The plant...
2017/0298373 PLANT PROMOTER AND 3'UTR FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a Zea mays...
2017/0298372 SOYBEAN IF5A PROMOTER AND ITS USE IN CONSTITUTIVE EXPRESSION OF TRANSGENIC GENES IN PLANTS
The disclosure relates to gene expression regulatory sequences from soybean, specifically to the promoter of a soybean eukaryotic translation initiation factor...
2017/0298371 Method for Transforming a Plant Cell or Plant Tissue Using Agrobacterium, Transgenic Plant, Transgenic Cell or...
There are provided compositions and methods for transforming plants, preferably monocot, and even more preferably, sugarcane. The transformation methods...
2017/0298370 Viral Based Transient-Expression Vector System That Allows Multiple Applications
Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes. Specifically...
2017/0298369 FUSION PROTEINS COMPRISING IMMUNOGLOBULIN CONSTANT DOMAIN-DERIVED SCAFFOLDS
This disclosure features fusion proteins comprising a base protein linked to or incorporated in a CH2 scaffold of IgG. The CH2 scaffold can derive from the...
2017/0298368 UREOHYDROLASES AS DOMINANT SELECTABLE MARKERS IN YEAST
The invention relates to a nucleic acid molecule encoding a novel selection marker. Said marker is a guanidinobutyrase from Kluyveromyces lactis, which, when...
2017/0298367 AUTO-INDUCIBLE EXPRESSION SYSTEM
A method for the expression of a protein of interest by a bacterium, notable in that it comprises the culturing of a bacterium temporarily or continuously...
2017/0298366 EXPRESSION CASSETTE INCLUDING AN rrnA PROMOTER DERIVED FROM VIBRIO NATRIEGENS FOR ENHANCING THE GROWTH RATE OF...
The present disclosure relates to an expression cassette including an rrnA promoter derived from Vibrio natriegens for enhancing the growth rate of Escherichia...
2017/0298365 PROTEIN MUNS THAT CAN FORM INCLUSIONS IN THE ENDOPLASMIC RETICULUM, METHODS FOR THE USE THEREOF AND USES OF SAME
The invention relates to a polynucleotide encoding a polypeptide based on the minimum region of the Orthoreovirus muNS protein that can form inclusions in the...
2017/0298364 FUSION PROTEIN, NANOPARTICLE COMPOSED OF A PLURALITY OF MONOMERS OF SAID FUSION PROTEIN, AND USES THEREOF
A fusion protein based on the heavy chain of human ferritin is described, which includes at the N terminus of the protein at least one metalloproteinase...
2017/0298363 NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGETIC EFFICIENCY
The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through...
2017/0298362 ANTI-TUMOR THERAPY
Panels, compositions, and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders...
2017/0298361 USE OF AGENTS FOR TREATING FAT-RELATED DISORDERS
Use of agents that down-regulates an amount and/or activity of Abelson murine leukemia viral oncogene homolog 1 (c-Abl) or checkpoint kinase 1 (Chk1) in the...
2017/0298360 LATS AND BREAST CANCER
The present invention relates to a method for treating breast cancer in a subject having a breast cancer of the estrogen receptor (ER.alpha.) negative type,...
2017/0298359 OLIGONUCLEOTIDE TARGETED TO THE A20-THREE PRIME UNTRANSLATED REGION
An antisense oligonucleotide comprising a sequence targeted to the 3' untranslated region (3' UTR) of the TNFAIP3 (A20) transcript and its use as a medicament,...
2017/0298357 Treatment of HIV
Described herein are silencing nucleic acids, compositions comprising silencing nucleic acids, and methods of utilizing the silencing nucleic acids to to...
2017/0298356 Binding and Catalytic Molecules Built from L-DNA with Added Nucleotides
This invention provides for processes for binding to and/or chemically transforming a preselected target, where the process involves contacting said target to...
2017/0298355 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC...
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic,...
2017/0298354 ORGANIC COMPOSITIONS TO TREAT HSF1-RELATED DISEASES
The present disclosure relates to methods of treating heat stock factor 1 (HSF1)-related diseases such as cancer, autoimmune and viral diseases, using a...
2017/0298353 ENHANCING DERMAL WOUND HEALING BY DOWNREGULATING MICRORNA-26A
Methods for enhancing wound healing, e.g., in diabetic subjects, by administering an antagonist of miR-26a, e.g., an inhibitory nucleic acid that targets miR-26a.
2017/0298352 COMPOSITIONS AND METHODS FOR TREATING HEPATIC FIBROSIS
This disclosure provides pharmaceutical compositions and purified or isolated naturally occurring exosome products that have therapeutic use for treating an...
2017/0298351 Method For Screening Interfering Molecules
A method for screening interfering nucleic acids enhancing the expression or the activity of expressed gene sequences is described. The method includes a step...
2017/0298350 METHODS AND COMPOSITIONS FOR USE OF NON-CODING RNA IN CELL CULTURING AND SELECTION
Described herein are methods and compositions for producing a gene of interest (GOD, which, in certain embodiments, can reduce the metabolic burden on cells...
2017/0298349 INTERGENIC RNAS AND METHODS FOR MODULATING GENE EXPRESSION AND PATHOGENESIS IN CANDIDA
Intergenic non-coding RNA molecules that regulate the expression of HWP1 and ALS3 of Candida are provided as are methods of using the non-coding RNA molecules...
2017/0298348 GENOME EDITING OF HUMAN NEURAL STEM CELLS USING NUCLEASES
The invention provides methods for generating a genetically modified human neural stem cell, genetically modified human neural stem cells, and pharmaceutical...
2017/0298347 NOVEL FUSION-CIRCULAR RNAs AND USES THEREOF
Novel fusion-circular RNAs (f-circRNAs) and complements thereof are provided. Diagnostic and treatment methods using f-circRNA inhibitors are provided....
2017/0298346 Dnazyme-nanoparticle conjugates and methods of use thereof
The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to...
2017/0298345 COMPOSITIONS AND METHODS FOR TARGETED NUCLEIC ACID SEQUENCE ENRICHMENT AND HIGH EFFICIENCY LIBRARY GENERATION
The present invention provides methods, compositions and kits for targeted nucleic acid sequence enrichment in a nucleic acid sample and for high efficiency...
2017/0298344 De Novo Design of Allosteric Proteins
Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change...
2017/0298343 METHOD OF IDENTIFYING OR PRODUCING AN APTAMER
The invention relates to a method of identifying or producing an aptamer, and a reagent comprising a nucleic acid ligand capable of binding a target sample,...
2017/0298342 SYSTEMS AND METHODS FOR AMPLIFICATION AND PHAGE DISPLAY
The present invention generally relates to amplification of biological entities, for example, for phage display. In one aspect, members of a library of...
2017/0298341 Methods for Culturing Cells in an Alternating Ionic Magnetic Resonance (AIMR) Multiple-Chambered Culture Apparatus
Provided herein are models comprising a tissue-like assembly of cells tissues or organoid bodies cultured in the presence of a pulsating alternating ionic...
2017/0298340 Alternating Ionic Magnetic Resonance (AIMR) Multiple-Chambered Culture Apparatus
Provided herein are a culture apparatus, culture systems and an alternating ionic magnetic resonance electromagnetic chamber for culturing cells, tissues or...
2017/0298339 Engineered Stable Microorganism/Cell Communities
Engineered stable multi-organism (or multi-cell type) communities encapsulated in a media that slows or prohibits certain metabolic functions such as cell...
2017/0298338 THERMOSTABLE BLUNT-END LIGASE AND METHODS OF USE
Fusion proteins having thermostable blunt-end ligase activity are provided. Blunt-end ligases are useful for DNA amplification, sequencing, production of...
2017/0298337 METHODS FOR EXTRACTING AND PURIFYING NON-DENATURED PROTEINS
Materials and methods for extracting and purifying proteins are provided. For example, the materials and methods provided herein can be used for extracting and...
2017/0298336 Polypeptides Having Xylanase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to...
2017/0298335 Highly Potent Acid Alpha-Glucosidase With Enhanced Carbohydrates
Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount...
2017/0298334 STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA
The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of...
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