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Patent # Description
2017/0296660 METHODS AND MATERIALS FOR MODULATING RESISTANCE TO APOPTOSIS
This document provides methods and materials involved in modulating a cell's ability to be resistant to apoptosis. For example, methods and materials for...
2017/0296659 COMBINATION THERAPIES
Disclosed is a combination comprising an immunomodulator and a second therapeutic agent for use in treating cancer, wherein the immunomodulator is an inhibitor...
2017/0296658 Compositions and Methods for Treating and Diagnosing Cancer
The present invention relates to compositions and methods for characterizing, diagnosing and treating cancer. In particular, the present invention identifies...
2017/0296657 Methods for Treating Hypercholesterolemia and Reducing LDL-C Using Antibodies to PCSK9
The present invention provides methods for treating hypercholesterolemia and reducing LDL-C. The methods of the present invention comprise administering to a...
2017/0296656 ALUMINUM COMPOUNDS FOR USE IN THERAPEUTICS AND VACCINES
The invention relates to means and methods for preparing aqueous composition comprising aluminium and a protein said composition comprising less than 700 ppm...
2017/0296655 Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway
Cyclic-GMP-AMP (cGAMP), including 2',3'-cGAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.
2017/0296654 6-ACETYLMORPHINE ANALOGS, AND METHODS FOR THEIR SYNTHESIS AND USE
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient...
2017/0296653 Methods of Lowering Serum Cholesterol
Methods of treating subjects having diseases, disorders, or conditions, including disorders associated with cholesterol homeostasis, responsive to agents...
2017/0296652 METHODS AND COMPOSITIONS INVOLVING RECOMBINANT HYPOALLERGENS
This disclosure describes recombinant hypoallergens and methods of treating allergy that involve administering a recombinant hypoallergen to a subject....
2017/0296651 EPITOPES RELATED TO COELIAC DISEASE
The invention herein disclosed is related to epitopes useful in methods of diagnosing, treating, and preventing coeliac disease. Therapeutic compositions which...
2017/0296650 COMBINATION OF HUMAN CYTOMEGALOVIRUS NEUTRALIZING ANTIBODIES
The disclosure relates to the use of a combination of antibodies or antigen binding fragments thereof to hCMV; and to dosages, ratios and minimum trough serum...
2017/0296649 METHOD FOR INDUCING T CELLS FOR CELL-BASED IMMUNOTHERAPY
Provided is a method for inducing T cells for a cell-based immunotherapy, which comprises the steps of: (1) providing human pluripotent stem cells bearing a T...
2017/0296648 Vaccine for Use in Protecting Offspring of a Sow Against Porcine Endemic Diarrhea Virus
The present invention pertains to a vaccine for use in protecting offspring of a sow against an infection with porcine endemic diarrhea virus (PEDV), the...
2017/0296646 ATTENUATED ZIKA VIRUS CONSTRUCTS AND USES THEREOF
Novel attenuating deletions of Zika virus E2 polypeptides are provided as are attenuated viruses comprising the deletions. Also provided are immunogenic...
2017/0296645 Immunogenic Proteins and Compositions
The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS)
2017/0296644 METHODS FOR TREATING PLAGUE
Provided herein are methods for using compositions that include a fusion protein having a YscF protein domain, a mature F1 protein domain, and a LcrV protein...
2017/0296643 ESCHERICHIA COLI VACCINE COMBINATION
The invention provides an immunogenic composition comprising a combination of (i) bacterial Ig-like domain protein fragment (orf405B) having the amino acid...
2017/0296642 XENOGENIC NORMAL TISSUE-DERIVED VACCINES FOR BREAKING THE IMMUNE TOLERANCE TO TUMOR-ASSOCIATED, ANTIGENS
Disclosed is an antitumor vaccine including testicular and fetal tissue-derived components. Cell preparations are prepared from normal tissues harvested...
2017/0296641 PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST NON-SMALL CELL LUNG CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0296640 Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0296639 METHOD FOR PREPARING DENDRITIC CELL LOADED WITH ANTIGEN
The present invention provides a method for preparing dendritic cell loaded with antigen, the method comprising the steps of adding serum-free cell culture...
2017/0296638 SYNERGISTIC COMPOSITIONS OF IMMUNOSTIMULATING RECONSTITUTED INFLUENZA VIROSOMES WITH IMMUNOPOTENTIATORS AND...
The present invention is directed to a preparation of an adjuvant system to achieve required level of humoral and cellular immune response against antigen of...
2017/0296637 Chagas Antigens and Antibodies and Compositions, Methods and Uses Thereof
The present specification discloses Trypanosoma antigens, immunogenic compositions and medicaments comprising such Trypanosoma antigens, methods and uses for...
2017/0296636 GLYCOTARGETING THERAPEUTICS
Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic...
2017/0296635 COMPOSITIONS AND METHODS COMPRISING GLYCYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods...
2017/0296634 SINGLE-DOSE ADMINISTRATION OF FACTOR VIIa
The present invention provides methods for preventing and/or treating bleeding episodes by administering a single dose of a Factor VIIa equivalent. Preferably,...
2017/0296633 Compositions and Methods for Treating Celiac Sprue Disease
The invention provides compositions and methods for treating celiac sprue.
2017/0296632 BEVERAGE, AND METHOD OF PRODUCING THE SAME
The invention relates to a drink includes angiogenin and/or angiogenin hydrolysate in an amount of more than 0.8 mg/100 ml and not more than 150 mg/100 ml, and...
2017/0296631 LIPID HYDROLYSIS THERAPY FOR ATHEROSCLEROSIS AND RELATED DISEASES
The present invention comprises a method to diminish and/or eliminate atherosclerotic plaques, in mammals, through direct and indirect treatment of these...
2017/0296630 LENTIVIRAL VECTOR FOR TREATING HEMOGLOBIN DISORDERS
The invention is directed to a more efficient lentiviral vector comprising a nucleic acid sequence encoding a human .beta.-globin protein or a human...
2017/0296629 INHIBITOR OF EXTRACELLULAR TRAP FORMATION IN LEUKOCYTE
An object of the present invention is to provide a novel drug inhibiting extracellular trap formation in leukocytes. The present invention provides an...
2017/0296628 PEGYLATED BIOACTIVE PEPTIDES AND USES THEREOF
Described herein are bioactive peptides that are modified at one or more positions with a PEG moiety. An example of such a PEGylated bioactive peptide is a...
2017/0296627 EXERSOMES, METHODS OF PRODUCING AND METHOD OF USING
An exosome pellet or physiological solution comprising resuspended exosomes is provided. The exosomes are essentially free from undesirable particles having a...
2017/0296626 EXOSOME ISOLATION
Methods of isolating exosomes from a biological sample is provided. In one embodiment, the method may include a series of optional centrifugation steps, and...
2017/0296625 THERAPEUTIC ANGIOGENESIS FOR WOUND HEALING
Methods for detecting, imaging, analyzing, diagnosing and/or treating cutaneous conditions and dermatoses such as disorders of the skin, subcutaneous tissues,...
2017/0296624 GLA DOMAINS AS TARGETING AGENTS
The disclosure relates to the recombinant Gla domain proteins and their use targeting phosphatidylserine (PtdS) moieties on the surface of cells, particularly...
2017/0296623 INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR OR N-CAR) EXPRESSING NON-T CELL TRANSDUCTION DOMAIN
The invention relates to negative T-cell signal inducing chimeric antigen receptor (N-CAR or i-CAR) and to T-cells comprising such N-CAR as well as a positive...
2017/0296622 Method of Treatment
The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and...
2017/0296621 NOD2-DEPENDENT PATHWAY OF CYTOPROTECTION OF STEM CELLS
The present invention is directed to an agonist of NOD2 for use in therapy for increasing the autonomous capacity of survival of vertebrate adult stem cells,...
2017/0296620 BIS-SULFHYDRYL MACROCYCLIZATION SYSTEMS
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming...
2017/0296619 MODULATION OF HEPATITIS B VIRUS CCCDNA TRANSCRIPTION
The present invention provides small molecule inhibitors of hepatitis B virus (HBV) covalently closed circular (ccc) DNA, which are useful as therapeutics in...
2017/0296618 BRAIN PERMEANT PEPTIDOMIMETIC BETA-SECRETASE 1 INHIBITORS FOR THE TREATMENT OR PROPHYLAXIS OF NEUROLOGICAL...
The present application presents novel peptidomimetic substituted hydroxyethylene compounds, which are inhibitors of beta amyloid cleavage enzyme, capable to...
2017/0296617 RHO ASSOCIATED KINASE (ROCK) INHIBITORS AND THEIR USE IN TREATING DISEASE
The present disclosure describes peptide inhibitors of Rho-associtated-kinase (ROCK) and their use in treating disorders including heart failure, the leading...
2017/0296616 METHODS OF TREATING DEPRESSION USING NMDA MODULATORS
This disclosure provides methods and regimens for treating depression (e.g., treatment-resistant depression) in a patient (e.g., a patient n need of such...
2017/0296615 METHOD AND COMPOSITION FOR A PROTEIN TRANSDUCTION TECHNOLOGY AND ITS APPLICATIONS
A protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different...
2017/0296614 Herbal Extract Composition
The present invention relates to the field of herbal compositions. In particular, the present invention is directed to an Improved Herbal Extract Composition...
2017/0296613 DERMATOLOGICAL KIT COMPRISING COMPOSITIONS BASED ON HIBISCUS FLOWER AND BURITI OIL
The invention provides a dermatological kit comprising a first container comprising a first composition and a second container comprising a second composition,...
2017/0296612 COMBINATION OF VALERIAN ROOT EXTRACT AND LAVENDER OIL FOR USE IN THE TREATMENT OF SLEEP DISORDERS
The present invention relates to a combination of valerian root extract and lavender oil for treating of sleep disorders, as well as to a combination of...
2017/0296611 Pharmaceutical Compositions Comprising Extracts of Sarcopoterium Spinosum, Components Thereof, and Uses Thereof
Disclosed are pharmaceutical compositions comprising extracts of Sarcopoterium spinosum, components of the extracts and uses of the pharmaceutical compositions...
2017/0296610 COMPOSITIONS AND METHODS FOR MAINTAINING OR ENHANCING HOMEOSTASIS OR FUNCTION OF FEMALE LOWER REPRODUCTIVE TRACT
The present disclosure provides compositions and methods for making and using topical compositions comprised of an isotonic, biome-friendly solution containing...
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