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Patent # Description
2017/0306356 Protein with Recombinase Activity for Site-Specific DNA-Recombination
The invention relates to the use of a protein with recombinase activity to catalyze a site-specific DNA recombination and a method for producing a...
2017/0306355 MODIFIED ADENO-ASSOCIATED VIRUS VECTOR COMPOSITIONS
An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.
2017/0306354 ADENO-ASSOCIATED VIRUS (AAV) SEROTYPE 8 SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR
Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such...
2017/0306353 IMPROVED HVT-VECTORED ND-IBD VACCINE
The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene...
2017/0306352 TRANSGENIC MAMMALS AND METHODS OF USE THEREOF
The present invention relates to transgenic mammals that express canine-based immunoglobulins, including transgenic rodents that express canine-based...
2017/0306351 ENGINEERING A HETEROGENEOUS TISSUE FROM PLURIPOTENT STEM CELLS
Aspects of the present disclosure are directed to methods and compositions for the production of heterogeneous tissue from human induced pluripotent stem...
2017/0306350 PLANTS HAVING INCREASED RESISTANCE TO PLANT PATHOGENS, AND METHOD FOR CREATING INCREASED PATHOGEN RESISTANCE IN...
The invention relates to plants with increased resistance to plant pathogens, wherein the intracellular concentration of inositol pyrophosphate InsP.sub.7...
2017/0306349 COMPOSITIONS AND METHODS FOR PRODUCING PLANTS RESISTANT TO GLYPHOSATE HERBICIDE
The present disclosure includes the production of a mutant plant resistant to an herbicide of the phosphonomethylglycine family, e.g. glyphosate. Compositions...
2017/0306348 POLYPEPTIDE AND USE THEREOF FOR IMPROVING STRESS TOLERANCE IN PLANTS
This disclosure provides a stress-responsive polypeptide sequence for fusion with a polypeptide to specifically induce stability of the fusion polypeptide...
2017/0306347 USE OF JAZ5A FOR IMPROVING DROUGHT-RESISTANCE IN A PLANT
The present invention provides use of a plant gene JAZ5a for improving drought-resistance of a plant. It further provides a method for improving the...
2017/0306346 IMPROVED AGRONOMIC CHARACTERISTICS UNDER WATER LIMITING CONDITIONS FOR PLANTS EXPRESSING PUB10 POLYPEPTIDES
The present invention provides methods and compositions for modulating drought tolerance and/or other agronomic traits in plants. This invention relates to...
2017/0306345 COMPOSITIONS AND METHODS TO ENHANCE MECHANICAL STALK STRENGTH IN PLANTS
Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for enhancing mechanical stalk strength in plants, compositions (such as plants...
2017/0306344 BRASSICA NAPUS SEED SPECIFIC PROMOTERS IDENTIFIED BY MICROARRAY ANALYSIS
Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using gene regulatory elements obtained from Brassica napus.
2017/0306343 METHODS OF INCREASING BIOMASS AND/OR GROWTH RATE OF A PLANT UNDER NON-STRESS CONDITIONS
Provided are methods of increasing yield, biomass, growth rate, vigor, and/or abiotic stress tolerance of a plant by expressing within the plant an exogenous...
2017/0306342 Compositions And Related Methods For Modulating Alkaloid Production By Controlling PMT Promoter Activation...
Compositions and methods for modifying the production levels of alkaloids in plants are provided. Alkaloid production can be genetically controlled by...
2017/0306341 COMPOSITIONS AND RELATED METHODS FOR MODULATING TRANSCRIPTIONAL ACTIVATION BY INCORPORATING GAG MOTIFS UPSTREAM...
Compositions and methods for genetically modifying the production levels of nicotine and other alkaloids in plants are provided.
2017/0306340 BRASSICA NAPUS SEED SPECIFIC PROMOTERS IDENTIFIED BY MICROARRAY ANALYSIS
Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using gene regulatory elements obtained from Brassica napus.
2017/0306339 METHODS FOR TRANSFERRING MOLECULAR SUBSTANCES INTO PLANT CELLS
Provided are methods for introducing a molecule of interest into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise...
2017/0306338 RECOMBINANT BACTERIUM TO DECREASE TUMOR GROWTH
The present invention encompasses a recombinant bacterium capable of reducing tumor growth.
2017/0306337 BIOPRODUCT FORMATION FROM A PLASMID ADDICTION SYSTEM IN THE ABSENCE OF CO-INDUCERS AND ANTIBIOTICS
Described herein are plasmid addiction systems comprising a host cell comprising one or more inactivated host cell essential genes; and a plasmid comprising...
2017/0306336 EXTENSIBLE RECOMBINASE CASCADES
Provided herein are genetic constructs comprising genetic perturbation cassettes and methods of using such to assess the timing and order of gene expression.
2017/0306335 RNA-TARGETING SYSTEM
The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered...
2017/0306334 ANDROGEN RECEPTOR NUCLEIC ACIDS AND USES THEREOF
Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against androgen receptor. Also described herein include methods...
2017/0306333 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GLYCOLATE OXIDASE (HAO1) BY DOUBLE-STRANDED RNA
This invention relates to compounds, compositions, and methods useful for reducing Glycolate Oxidase (HAO1) target RNA and protein levels via use of dsRNAs,...
2017/0306332 THERAPEUTIC INHIBITION OF LACTATE DEHYDROGENASE AND AGENTS THEREFOR
This invention relates to compounds, compositions, and methods useful for reducing lactate dehydrogenase target RNA and protein levels via use of dsRNAs, e.g.,...
2017/0306331 ANTI-TNF COMPOUNDS
TNF.alpha. antisense oligonucleotides are provided herein. Methods of treating TNF.alpha. diseases or Initial Screen of Phosphodiester disorders using the...
2017/0306330 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER COMPRISING RNA OLIGONUCLEOTIDE
The present disclosure provides a pharmaceutical composition for treating cancer comprising an RNA oligonucleotide having a particular sequence and structure....
2017/0306329 METHODS FOR TREATING EYE DISORDERS
The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to...
2017/0306328 METHODS FOR CONTROLLING OBESITY USING MINIMALLY INVASIVE MEANS
Methods for controlling obesity using minimally-invasive procedures including introducing embolic crystal particles that are naturally occurring and mostly...
2017/0306327 HIPPO AND DYSTROPHIN COMPLEX SIGNALING IN CARDIOMYOCYTE RENEWAL
Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an...
2017/0306326 MICRORNA INHIBITOR SYSTEM AND METHODS OF USE THEREOF
The present invention relates to plasmid-based miR inhibitory systems (PMIS), miR inhibitors and methods of use of these systems and inhibitors.
2017/0306325 SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR REGULATING EXPRESSION OF GENE HAVING DELIVERING FUNCTION
The invention provides a single-stranded nucleic acid capable of inhibiting expression of a target gene having a delivery function. The nucleic acid contains,...
2017/0306324 NOVEL TETRAGALNAC AND PEPTIDE CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or...
2017/0306323 ANTISENSE ANTIVIRAL COMPOUNDS AND METHODS FOR TREATING A FILOVIRUS INFECTION
The present invention provides antisense antiviral compounds, compositions, and methods of their use and production, mainly for inhibiting the replication of...
2017/0306322 METHODS AND MATERIALS FOR IDENTIFYING COMPOUNDS PROMOTING TRANSLATIONAL READ-THROUGH OF NONSENSE MUTATIONS
Methods and materials for identification of compounds that allow translation read-through of nonsense mutations in recombinant microorganisms and mammalian cells.
2017/0306321 SYSTEMS AND METHODS FOR GENETIC ANALYSIS OF INTRACTABLE MICROBES
Embodiments of the present disclosure relate generally to the genetic analysis of intractable microbes. More particularly, the present disclosure provides...
2017/0306320 METHODS FOR IN VITRO RIBOSOME SYNTHESIS AND EVOLUTION
Disclosed are methods, components, compositions, and kits for preparing and identifying engineered E. coli ribosomes. The E. coli ribosomes may be prepared and...
2017/0306319 VH SCAFFOLD
The invention provides human VH scaffold sequences, libraries derived therefrom and methods of producing. The scaffolds have high expression, solubility and...
2017/0306318 METHOD FOR SELECTING POLYNUCLEOTIDES ENCODING ANTIGEN-SPECIFIC IMMUNOGLOBULIN SUBUNIT
The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a...
2017/0306317 METHOD AND DEVICE FOR UNIFORMLY TREATING ADHERENT CELLS
Disclosed is a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least...
2017/0306316 3-EPIMERASE
A protein comprising a polypeptide sequence having at least 70% sequence identity to SEQ ID NO: 6, SEQ ID NO: 2 or SEQ ID NO: 4. The protein has ketose...
2017/0306315 METHOD FOR RECOMBINANT PRODUCTION OF HORSESHOE CRAB FACTOR C PROTEIN IN PROTOZOA
The present invention provides a novel method for the recombinant production of Factor C protein from horseshoe crab using a parasitic protozoan expressing the...
2017/0306314 Polypeptides Having Serine Protease Activity and Polynucleotides Encoding Same and Their Application in Animal Feed
The present invention relates to animal feed or animal feed additives comprising polypeptides having protease activity and uses thereof. Specifically, the...
2017/0306313 Protease Variants and Polynucleotides Encoding Same
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
2017/0306312 Beta-Glucosidase Variants and Polynucleotides encoding same
The present invention relates to beta-glucosidase variants, e.g., beta-glucosidase variants of a parent Family GH3A beta-glucosidase from Aspergillus...
2017/0306311 Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, and...
2017/0306310 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to glucoamylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2017/0306309 VARIANTS HAVING GLUCOAMYLASE ACTIVITY
The present invention relates to variants having glucoamylase activity with improved properties and to compositions comprising these variants suitable for use...
2017/0306308 AMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and...
2017/0306307 CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS
The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with...
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