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| Patent # | Description |
|---|---|
| 2017/0306052 |
Antibody Molecules Which Bind IL-17A and IL-17F The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules... |
| 2017/0306051 |
TREATMENT WITH ANTI-PCSK9 ANTIBODIES The present invention relates to therapeutic dosing regimens utilizing a dose reduction strategy for treating disorders characterized by marked elevations of... |
| 2017/0306050 |
COMPOSITIONS AND METHODS FOR TREATING CANCER, INFLAMMATORY DISEASES AND
AUTOIMMUNE DISEASES The present disclosure provides compositions and methods of use comprising a matrix metalloproteinase-9 (MMP9) binding protein, alone or in combination with... |
| 2017/0306049 |
ANTI-HER3 ANTIBODIES AND USES OF SAME An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain specifically binding human HER-3 with a K.sub.D value of... |
| 2017/0306048 |
ANTIBODY THERAPEUTICS THAT BIND STAT3 The present disclosure provides anti-STAT3 antibodies, and antigen-binding portions thereof. In certain embodiments, the antibodies or fragments thereof, are... |
| 2017/0306047 |
PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION AND TREATMENT, CONTAINING
NDRG3 EXPRESSION OR ACTIVITY... The present invention relates to a pharmaceutical composition for preventing and treating cancer or inflammatory disease, containing an NDRG3 expression or... |
| 2017/0306046 |
GLYCAN-INTERACTING COMPOUNDS AND METHODS OF USE The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of... |
| 2017/0306045 |
PROSTATE-SPECIFIC MEMBRANE ANTIGEN BINDING PROTEINS AND RELATED
COMPOSITIONS AND METHODS The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane... |
| 2017/0306044 |
BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND ROR1 FOR USE IN THE TREATMENT
OF OVARIAN CANCER Bispecific antibodies against CD3epsilon and ROR1 are useful for use in the treatmentof ovarian cancer. |
| 2017/0306043 |
Monoclonal Antibody Which Specifically Recognizes B Cell Lymphoma and Use
Thereof Provided is a monoclonal antibody which specifically recognizes B cell lymphoma cells and a use thereof. More specifically, provided are the monoclonal... |
| 2017/0306042 |
IMMUNOGENIC MODULATION BY ENDOCRINE DEPRIVATION THERAPY IMPROVES
SENSITIVITY OF TUMOR CELLS TO IMMUNE MEDIATED... The invention is directed to methods of reducing growth of prostate cancer cells and breast cancer cells, which comprises treating such cancer cells with a... |
| 2017/0306041 |
ANTIBODIES AND ASSAYS FOR DETECTION OF FOLATE RECEPTOR 1 The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using... |
| 2017/0306040 |
COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A CD22
ANTIBODY-DRUG CONJUGATE The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD22 antibody-drug conjugate for the treatment of... |
| 2017/0306039 |
HUMAN VH DOMAIN SCAFFOLDS The invention provides human VH scaffold sequences, libraries derived therefrom and methods of producing. The scaffolds have high expression, solubility and... |
| 2017/0306038 |
COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER
THERAPY The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis... |
| 2017/0306037 |
COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER
THERAPY The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis... |
| 2017/0306036 |
BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND BCMA A bispecific bi- or trivalent antibody specifically binding to the two targets which are extracellular domain of human B cell maturation antigen (BCMA) and... |
| 2017/0306035 |
ANTIBODIES AGAINST OX40 AND USES THEREOF Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications,... |
| 2017/0306034 |
METHODS OF TREATING AUTOIMMUNE DISEASE USING A DOMAIN ANTIBODY DIRECTED
AGAINST CD40L Methods of treating autoimmune diseases, such as primary immune thrombocytopenia (ITP), solid organ transplant rejection, graft-related disease, pemphigus... |
| 2017/0306033 |
BI-SPECIFIC ANTI-CGRP RECEPTOR/PAC1 RECEPTOR ANTIGEN BINDING PROTEINS AND
USES THEREOF The present invention relates to bispecific antigen binding proteins that are capable of binding to both the human CGRP receptor and the human PAC1 receptor.... |
| 2017/0306032 |
SMALL ANTIBODY-LIKE POLYPEPTIDES THAT BIND TO EPHA2 RECEPTOR The present disclosure is directed to a modified isolated immunoglobulin CH2 domain that specifically binds to an extracellular region of an EphA2 receptor,... |
| 2017/0306031 |
BINDING PROTEINS AND METHODS OF USE THEREOF The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha Like (GFRAL) protein, including human GFRAL... |
| 2017/0306030 |
CHIMERIC ACTIVATORS: QUANTITATIVELY DESIGNED PROTEIN THERAPEUTICS AND USES
THEREOF Aspects of the invention provide methods for harnessing the potential of proteins that occur naturally (e.g., in humans) and that have serious but finite... |
| 2017/0306029 |
WNT SIGNALING AGONIST MOLECULES Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is... |
| 2017/0306028 |
ALK7 Binding Proteins and Uses Thereof This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins. In certain... |
| 2017/0306027 |
ALK7 ANTAGONISTS AND USES THEREOF In certain aspects, the disclosure provides ALK7 antagonists. In certain aspects, these ALK7 antagonists are can be used to improve metabolic parameters in a... |
| 2017/0306026 |
ADMINISTRATION OF AGENTS FOR THE TREATMENT OF INFLAMMATION A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a... |
| 2017/0306025 |
COMPOSITIONS COMPRISING COFORMULATION OF ANTI-PD-L1 AND ANTI-CTLA-4
ANTIBODIES Provided herein are compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making... |
| 2017/0306024 |
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate... |
| 2017/0306023 |
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate... |
| 2017/0306022 |
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate... |
| 2017/0306021 |
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate... |
| 2017/0306020 |
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate... |
| 2017/0306019 |
ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate... |
| 2017/0306018 |
BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND ROR1 The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use. |
| 2017/0306017 |
ANTI-CD100 ANTIBODIES AND METHODS FOR USING THE SAME Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers.... |
| 2017/0306016 |
Anti-TIM-3 Antibodies Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the... |
| 2017/0306015 |
BINDING MOLECULES, ESPECIALLY ANTIBODIES, BINDING TO L1CAM (CD171) The present disclosure relates to a binding molecule binding to L1, which is capable of binding to the same L1 epitope recognized by the monoclonal antibody... |
| 2017/0306014 |
CROSS REACTIVE SIGLEC ANTIBODIES This invention relates to agents that bind multiple Siglecs, including antibodies that neutralize the inhibitory activity of multiple Siglec-7 and Siglec-9 in... |
| 2017/0306013 |
SELECTIVE NAV PROTEIN BINDERS The invention provides antibodies and fragments thereof which bind to human Nav1.7, as well as nucleic acids, vectors, host cells and hybridomas for making the... |
| 2017/0306012 |
MONOCLONAL ANTIBODIES TO PROGASTRIN AND THEIR USES The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and... |
| 2017/0306011 |
MONOCLONAL ANTIBODIES TO PROGASTRIN AND THEIR USES The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and... |
| 2017/0306010 |
GLYCOENGINEERED BINDING PROTEIN COMPOSITIONS Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of... |
| 2017/0306009 |
METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS
USING DISSOLVED OXYGEN The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant... |
| 2017/0306008 |
METHODS OF REVERSING CACHEXIA AND PROLONGING SURVIVAL COMPRISING
ADMINISTERING A GDF15 MODULATOR AND AN... Methods are provided for improved treatment of subjects with cancer anorexia-cachexia syndrome, comprising treatment with a combination of at least one... |
| 2017/0306007 |
COMPLEMENT COMPONENT C5 ANTIBODIES The present disclosure relates to antibodies and polynucleotides encoding the same, that may be used to prevent, control, or reduce the activity of the... |
| 2017/0306006 |
HUMAN NOTCH1 DECOYS Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the... |
| 2017/0306005 |
ANTI-TENASCIN C ANTIBODIES AND USES THEREOF There is provided antibodies or antigen-binding fragments, derivatives or variants thereof which are capable of binding to the FBG domain of tenascin-C. There... |
| 2017/0306004 |
COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE
ACTIVITY DURING STAPHYLOCOCCUS AUREUS... Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects... |
| 2017/0306003 |
AGENTS FOR INFLUENZA NEUTRALIZATION The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza... |
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