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Patent # Description
2017/0306052 Antibody Molecules Which Bind IL-17A and IL-17F
The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules...
2017/0306051 TREATMENT WITH ANTI-PCSK9 ANTIBODIES
The present invention relates to therapeutic dosing regimens utilizing a dose reduction strategy for treating disorders characterized by marked elevations of...
2017/0306050 COMPOSITIONS AND METHODS FOR TREATING CANCER, INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES
The present disclosure provides compositions and methods of use comprising a matrix metalloproteinase-9 (MMP9) binding protein, alone or in combination with...
2017/0306049 ANTI-HER3 ANTIBODIES AND USES OF SAME
An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain specifically binding human HER-3 with a K.sub.D value of...
2017/0306048 ANTIBODY THERAPEUTICS THAT BIND STAT3
The present disclosure provides anti-STAT3 antibodies, and antigen-binding portions thereof. In certain embodiments, the antibodies or fragments thereof, are...
2017/0306047 PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION AND TREATMENT, CONTAINING NDRG3 EXPRESSION OR ACTIVITY...
The present invention relates to a pharmaceutical composition for preventing and treating cancer or inflammatory disease, containing an NDRG3 expression or...
2017/0306046 GLYCAN-INTERACTING COMPOUNDS AND METHODS OF USE
The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of...
2017/0306045 PROSTATE-SPECIFIC MEMBRANE ANTIGEN BINDING PROTEINS AND RELATED COMPOSITIONS AND METHODS
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane...
2017/0306044 BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND ROR1 FOR USE IN THE TREATMENT OF OVARIAN CANCER
Bispecific antibodies against CD3epsilon and ROR1 are useful for use in the treatmentof ovarian cancer.
2017/0306043 Monoclonal Antibody Which Specifically Recognizes B Cell Lymphoma and Use Thereof
Provided is a monoclonal antibody which specifically recognizes B cell lymphoma cells and a use thereof. More specifically, provided are the monoclonal...
2017/0306042 IMMUNOGENIC MODULATION BY ENDOCRINE DEPRIVATION THERAPY IMPROVES SENSITIVITY OF TUMOR CELLS TO IMMUNE MEDIATED...
The invention is directed to methods of reducing growth of prostate cancer cells and breast cancer cells, which comprises treating such cancer cells with a...
2017/0306041 ANTIBODIES AND ASSAYS FOR DETECTION OF FOLATE RECEPTOR 1
The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using...
2017/0306040 COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A CD22 ANTIBODY-DRUG CONJUGATE
The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with a CD22 antibody-drug conjugate for the treatment of...
2017/0306039 HUMAN VH DOMAIN SCAFFOLDS
The invention provides human VH scaffold sequences, libraries derived therefrom and methods of producing. The scaffolds have high expression, solubility and...
2017/0306038 COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER THERAPY
The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis...
2017/0306037 COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER THERAPY
The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis...
2017/0306036 BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND BCMA
A bispecific bi- or trivalent antibody specifically binding to the two targets which are extracellular domain of human B cell maturation antigen (BCMA) and...
2017/0306035 ANTIBODIES AGAINST OX40 AND USES THEREOF
Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications,...
2017/0306034 METHODS OF TREATING AUTOIMMUNE DISEASE USING A DOMAIN ANTIBODY DIRECTED AGAINST CD40L
Methods of treating autoimmune diseases, such as primary immune thrombocytopenia (ITP), solid organ transplant rejection, graft-related disease, pemphigus...
2017/0306033 BI-SPECIFIC ANTI-CGRP RECEPTOR/PAC1 RECEPTOR ANTIGEN BINDING PROTEINS AND USES THEREOF
The present invention relates to bispecific antigen binding proteins that are capable of binding to both the human CGRP receptor and the human PAC1 receptor....
2017/0306032 SMALL ANTIBODY-LIKE POLYPEPTIDES THAT BIND TO EPHA2 RECEPTOR
The present disclosure is directed to a modified isolated immunoglobulin CH2 domain that specifically binds to an extracellular region of an EphA2 receptor,...
2017/0306031 BINDING PROTEINS AND METHODS OF USE THEREOF
The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha Like (GFRAL) protein, including human GFRAL...
2017/0306030 CHIMERIC ACTIVATORS: QUANTITATIVELY DESIGNED PROTEIN THERAPEUTICS AND USES THEREOF
Aspects of the invention provide methods for harnessing the potential of proteins that occur naturally (e.g., in humans) and that have serious but finite...
2017/0306029 WNT SIGNALING AGONIST MOLECULES
Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is...
2017/0306028 ALK7 Binding Proteins and Uses Thereof
This disclosure provides ALK7-binding proteins such as anti-ALK7 antibodies, and compositions and methods for making the ALK7-binding proteins. In certain...
2017/0306027 ALK7 ANTAGONISTS AND USES THEREOF
In certain aspects, the disclosure provides ALK7 antagonists. In certain aspects, these ALK7 antagonists are can be used to improve metabolic parameters in a...
2017/0306026 ADMINISTRATION OF AGENTS FOR THE TREATMENT OF INFLAMMATION
A method of chronically reducing a patient's pathological inflammation via the administration of an agent that specifically binds to an alpha-4 integrin or a...
2017/0306025 COMPOSITIONS COMPRISING COFORMULATION OF ANTI-PD-L1 AND ANTI-CTLA-4 ANTIBODIES
Provided herein are compositions comprising coformulation of anti-PD-L1 and anti-CTLA-4 antibodies, or antigen-binding fragments thereof, and methods of making...
2017/0306024 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate...
2017/0306023 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate...
2017/0306022 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate...
2017/0306021 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate...
2017/0306020 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate...
2017/0306019 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate...
2017/0306018 BISPECIFIC ANTIBODIES AGAINST CD3EPSILON AND ROR1
The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.
2017/0306017 ANTI-CD100 ANTIBODIES AND METHODS FOR USING THE SAME
Compositions and methods are provided for treating diseases associated with CD100, including certain autoimmune diseases, inflammatory diseases, and cancers....
2017/0306016 Anti-TIM-3 Antibodies
Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the...
2017/0306015 BINDING MOLECULES, ESPECIALLY ANTIBODIES, BINDING TO L1CAM (CD171)
The present disclosure relates to a binding molecule binding to L1, which is capable of binding to the same L1 epitope recognized by the monoclonal antibody...
2017/0306014 CROSS REACTIVE SIGLEC ANTIBODIES
This invention relates to agents that bind multiple Siglecs, including antibodies that neutralize the inhibitory activity of multiple Siglec-7 and Siglec-9 in...
2017/0306013 SELECTIVE NAV PROTEIN BINDERS
The invention provides antibodies and fragments thereof which bind to human Nav1.7, as well as nucleic acids, vectors, host cells and hybridomas for making the...
2017/0306012 MONOCLONAL ANTIBODIES TO PROGASTRIN AND THEIR USES
The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and...
2017/0306011 MONOCLONAL ANTIBODIES TO PROGASTRIN AND THEIR USES
The present disclosure is directed to progastrin monoclonal antibodies, fragments thereof, compositions comprising progastrin monoclonal antibodies, and...
2017/0306010 GLYCOENGINEERED BINDING PROTEIN COMPOSITIONS
Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of...
2017/0306009 METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING DISSOLVED OXYGEN
The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant...
2017/0306008 METHODS OF REVERSING CACHEXIA AND PROLONGING SURVIVAL COMPRISING ADMINISTERING A GDF15 MODULATOR AND AN...
Methods are provided for improved treatment of subjects with cancer anorexia-cachexia syndrome, comprising treatment with a combination of at least one...
2017/0306007 COMPLEMENT COMPONENT C5 ANTIBODIES
The present disclosure relates to antibodies and polynucleotides encoding the same, that may be used to prevent, control, or reduce the activity of the...
2017/0306006 HUMAN NOTCH1 DECOYS
Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the...
2017/0306005 ANTI-TENASCIN C ANTIBODIES AND USES THEREOF
There is provided antibodies or antigen-binding fragments, derivatives or variants thereof which are capable of binding to the FBG domain of tenascin-C. There...
2017/0306004 COMPOSITIONS AND METHODS RELATED TO ANTIBODIES THAT NEUTRALIZE COAGULASE ACTIVITY DURING STAPHYLOCOCCUS AUREUS...
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects...
2017/0306003 AGENTS FOR INFLUENZA NEUTRALIZATION
The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza...
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