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Patent # Description
2017/0306002 A POTENT ANTI-INFLUENZA A NEURAMINIDASE SUBTYPE N1 ANTIBODY
Isolated monoclonal antibodies and antigen binding fragments thereof that specifically bind neuraminidase (NA) of an N1 subtype influenza virus are disclosed...
2017/0306001 CHIMERIZATION AND CHARACTERIZATION OF A MONOCLONAL ANTIBODY WITH POTENT NEUTRALIZING ACTIVITY ACROSS MULTIPLE...
MAb 9F4 provides heterologous protection against multiple influenza A H5N1 clade viruses, including one of the recently designated subclades, namely 2.3.4,...
2017/0306000 METHOD FOR DETERMINING DELETIONS IN HBV PRE-S2 REGION
A method of detecting pre-S.sub.2 deletion mutant LHBS is disclosed herein. The method comprises incubating a biological sample with a first antibody to...
2017/0305999 CELL CULTURE MEDIUM
Provided herein, inter alia, are compositions and methods for culturing mammalian cells. In certain aspects, the composition is a medium containing one or more...
2017/0305998 MODIFIED PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) PEPTIDES AND USES THEREOF FOR TREATING NEOVASCULAR DISEASES,...
Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the...
2017/0305997 EGFR and C-Met Fibronectin Type III Domain Binding Molecules
Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of...
2017/0305996 VASCULAR ENDOTHELIAL GROWTH FACTOR FUSION PROTEIN
The present invention relates to a fusion protein binding to a vascular endothelial growth factor (VEGFR) and/or a placental growth factor (PIGF). The fusion...
2017/0305995 CD44V6-Derived Peptides for Treating Metastasizing Cancer
The present invention relates to compounds, pharmaceutical compositions and methods for treating different forms of pancreatic cancer.
2017/0305994 Antagonistic DR3 Ligands
The present invention relates to treatment of inflammatory diseases. In particular, the present invention relates to antagonistic DR3 ligands useful for...
2017/0305993 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer,...
2017/0305992 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST VARIOUS TUMORS
A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer,...
2017/0305991 Immunotherapy against melanoma and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2017/0305990 TMEM100 PEPTIDES AND VARIANTS THEREOF AND THEIR USE IN TREATING OR PREVENTING DISEASES OR CONDITIONS
The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.
2017/0305989 IL22 IMMUNOCONJUGATES
The application relates to a conjugate comprising interleukin-22 (IL22) and an antibody molecule. The antibody molecule preferably binds an antigen associated...
2017/0305988 METHOD OF USING A PEPTIDE LIBRARY
The present invention provides a peptide selected from the following (i) and (ii): (i) a peptide having the amino acid sequence represented by SEQ ID NO: 1 in...
2017/0305987 A tumor necrosis factor-related apoptosis-inducing ligand variant, as well as a preparation method and use thereof
The present invention discloses a tumor necrosis factor-related apoptosis-inducing ligand variant, which is a fusion protein of a tumor necrosis factor-related...
2017/0305985 Hepatocyte Growth Factor Fragments that Function as Potent Met Receptor Agonists and Antagonists
The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role...
2017/0305984 STATHERIN PEPTIDES
A novel statherin-based fusion peptide is provided. The fusion peptide comprises the statherin peptide, DSSEEKFLR, or a functionally equivalent variant...
2017/0305983 CARDIAC TROPONIN I ULTRA-SENSITIVE DETECTION REAGENT KIT, AND ULTRA-SENSITIVE DETECTION METHOD THEREFOR
A cardiac troponin I ultra-sensitive detection reagent kit, a preparation method, and a detection method. The reagent kit comprises at least one first...
2017/0305982 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST PROSTATE CANCER AND OTHER CANCERS
A method of treating a patient who has prostate cancer includes administering to said patient a composition containing a population of activated T cells that...
2017/0305981 SYNTHETIC PEPTIDES
Provided herein are compositions comprising synthetic lipase-stimulating peptides, and methods of treating hyper-triglyceridemia and other conditions and...
2017/0305980 CA125 GENE AND ITS USE FOR DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS
The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major...
2017/0305979 CONOTOXIN POLYPEPTIDE K-CPTX-BT102, AND METHOD FOR PREPARATION THREOF AND APPLICATION THEREOF
Disclosed are a conotoxin polypeptide .kappa.-CPTx-bt102, a method for preparation thereof, and an application thereof. The conotoxin polypeptide of the...
2017/0305978 BRASSICA NAPUS SEED SPECIFIC PROMOTERS IDENTIFIED BY MICROARRAY ANALYSIS
Provided are constructs and methods for expressing a transgene in plant cells and/or plant tissues using gene regulatory elements obtained from Brassica napus.
2017/0305977 Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2017/0305976 PEPTIDE COMPOSITION AND USES THEREOF
Subject of the invention is a composition comprising at least one fragment of the peptide ESAT-6 and at least one fragment of the peptide CFP-10. Preferably,...
2017/0305975 FUSION PROTEINS COMPRISING P3 OF BACTERIOPHAGE
The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid...
2017/0305974 AGENT FOR CONTROLLING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME
An object of the present invention is to optimize, and to increase the accumulation amount of, GP5 antigen, in order to enhance the performance of a PRRS...
2017/0305973 Rhinovirus C Immunogenic Peptides
A peptide comprising the rhinovirus immunogen peptide of the rhinovirus structural protein 1 (VP1) of rhinovirus C and related vaccines and therapeutic...
2017/0305972 Scalable Fermentation Process
This invention provides a robust fermentation process for the expression of a capsid protein of a bacteriophage which is forming a VLP by self-assembly,...
2017/0305971 POTENT COMPSTATIN ANALOGS
Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display...
2017/0305970 CONOTOXIN POLYPEPTIDE K-CPTX-BT101, AND METHOD FOR PREPARATION THREOF AND APPLICATION THEREOF
Disclosed are a conotoxin polypeptide .kappa.-CPTx-bt101, a method for preparation thereof, and an application thereof. The conotoxin polypeptide of the...
2017/0305969 B-Lamella Blocking Peptide Used for Preventing and/or Treating Alzheimer's Disease
Provided in the present invention are a .beta.-sheet breaker peptide used for preventing and/or treating Alzheimer's disease, and the use thereof for...
2017/0305968 PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE
Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport...
2017/0305967 METHODS FOR REDUCING CD36 EXPRESSION
The invention provides a method for treating one or more complications of diabetes in a mammal. The method comprises administering to a mammal in need thereof...
2017/0305966 METHOD FOR PRODUCING A STABLE PRECIPITATE ENRICHED IN PHYCOBILIPROTEINS.
The invention relates to a novel method for producing a stable precipitate enriched in phycobiliproteins by means of salicylic acid precipitation. The...
2017/0305965 Fab REGION-BINDING PEPTIDE
The objective of the present invention is to provide a Fab region-binding peptide which is excellent in a binding capability to a Fab region of IgG, an...
2017/0305964 IMMUNOGLOBULIN AGGREGATE REMOVAL
For the removal of high molecular weight compounds from recombinantly produced polypeptides generally chromatographic methods are employed. It has been found...
2017/0305963 PEPTIDE FRAGMENT CONDENSATION AND CYCLISATION USING A SUBTILISIN VARIANT WITH IMPROVED SYNTHESIS OVER...
The invention relates to a method for enzymatically synthesizing an (oligo)peptide, comprising coupling (a) an (oligo)peptide C-terminal ester or thioester and...
2017/0305962 C17-ARYL SUBSTITUTED BETULINIC ACID ANALOGS
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid...
2017/0305961 Steroids as Agonists for FXR
The invention relates to compounds of formula (I): ##STR00001## wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino...
2017/0305960 NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF
Compounds are provided according to Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein...
2017/0305959 ANTILEISHMANIAL COMPOSITIONS AND METHODS OF USE
In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds...
2017/0305958 CRYSTALLINE FORMS OF 5alpha-ANDROSTANE-3beta,5,6beta-TRIOL AND PREPARATION METHODS THEREFOR
The present invention relates to four crystalline forms (crystalline forms A, B, C and D) of 5.alpha.-androstane-3.beta.,5,6.beta.-triol (YC-6) and preparation...
2017/0305957 CRYSTALLINE FORMS OF 5alpha-ANDROSTANE-3beta,5,6beta-TRIOL AND PREPARATION METHODS THEREFOR
The present invention relates to four crystalline forms (crystalline forms A, B, C and D) of 5.alpha.-androstane-3.beta.,5,6.beta.-triol (YC-6) and preparation...
2017/0305956 Ligand-Modified Double-Stranded Nucleic Acids
The invention provides for double stranded nucleic acid molecules comprising a 5' extension of the sense or antisense strand and further comprising a plurality...
2017/0305955 Reprogramming of Cellular Adhesion
Disclosed are membrane-anchored polynucleotides, and compositions comprising the membrane-anchored polynucleotides. Also disclosed are the processes for the...
2017/0305954 SYNTHESIS OF 2', 3'-DIDEOXYNUCLEOSIDES FOR AUTOMATED DNA SYNTHESIS AND PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION
Methods for preparation of 2',3'-dideoxynucleotides support structures, such as 2',3'-dideoxyguanosine, 2',3'-dideoxyadenosine, and 3'-deoxythymidine support...
2017/0305953 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE
Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macro-cyclization, and...
2017/0305952 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF
The invention relates to a pharmaceutical composition according to the claim 1 comprising an SGLT2 inhibitor and a GLP-1 receptor agonist which is suitable in...
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