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Patent # Description
2017/0305951 HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINS AND CXCR4 CHEMOKINE RECEPTORS
Compounds, compositions, and methods for treatment and/or prevention of cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g.,...
2017/0305950 GLYCAN ANALYSIS AND PROFILING
The invention provides methods and tools, for example, glycan arrays, for the analysis of glycans and anti-glycan antibodies. Embodiments of the invention may...
2017/0305949 A METHOD OF PURIFYING LIGNIN BY SUBJECTING A SLURRY COMPRISING LIGNIN TO AN ELECTRIC FIELD
The present invention relates to a process for purifying, such as salt/ion depletion, and/or ash reduction,and/or sulphur removal, and/or free sugar...
2017/0305948 NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME
The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the...
2017/0305947 DEHYDROGENATION OF NEAT FORMIC ACID
A formic acid decomposition catalyst system includes organometallic complexes having formula 1: ##STR00001## wherein: M is a transition metal; E is P, N, or C...
2017/0305946 COMPOSITIONS AND METHODS COMPRISING RHENIUM FOR THE TREATMENT OF CANCERS
Compositions and methods comprising rhenium are provided. In some embodiments, the rhenium compounds comprise a bidentate ligand. In some embodiments, the...
2017/0305945 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins
N.sup.2-phosphinyl amidine compounds, N.sup.2-phosphinyl amidinates, N.sup.2-phosphinyl amidine metal salt complexes, N.sup.2-phosphinyl amidinate metal salt...
2017/0305944 METHOD OF BIOTRANSFORMATION OF BENZOPYRONE COMPOUNDS INTO THE CORRESPONDING PHOSPHATE-CONJUGATED DERIVATIVES
The present invention is related to a biotransformation process, effected by means of an isolated polypeptide possessing benzopyrone phosphate synthetase...
2017/0305943 COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
Compounds and methods are provided for treating bacterial infections.
2017/0305942 MIXED LIGAND GOLD(I) COMPLEXES AS ANTI-CANCER AGENTS
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g....
2017/0305941 Silylated Pyrimidine Prodrugs And Methods Of Their Use
Silylated-pyrimidine prodrugs, compositions that include the silylated-pyrimidine prodrugs, methods for making the silylated-pyrimidine prodrugs and...
2017/0305940 PROCESS FOR SILANE OLIGOMER COMPOSTITION PREPARATION AND USE THEREOF
Epoxy silane oligomers are prepared from a glycidoxypropyl alkoxysilane in the presence of an alcohol and an esterification and/or transesterification...
2017/0305939 METHOD FOR THE DIRECT SYNTHESIS OF METHYL CHLOROSILANES IN FLUIDIZED-BED REACTORS
Methylchlorosilanes are synthesized by an at least two stage reaction in which contact composition from a first fluidized bed reactor is fed to a second...
2017/0305938 FLUORINE-CONTAINING ALKYLSILANE COMPOUND AND METHOD FOR PRODUCING THE SAME
A fluorine-containing alkylsilane compound represented by the general formula: CF.sub.3(CF.sub.2).sub.n(CH.sub.2CF.sub.2).sub.a(CF.sub.2CF.sub.2).sub.b- ...
2017/0305937 PROCESS FOR THE PREPARATION OF AMINOARYL- AND AMINOHETEROARYL BORONIC ACIDS AND ESTERS
The present invention relates to a process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters thereof of formula (I) in high...
2017/0305936 SOLID STATE FORMS OF CRISABOROLE
Solid state forms of Crisaborole and salts thereof, processes for preparation thereof and pharmaceutical compositions thereof are disclosed.
2017/0305935 Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
2017/0305934 NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS
The invention provides compounds of formula (I): ##STR00001## wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt...
2017/0305933 TYK2 INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated...
2017/0305932 Fused Pentacyclic Imidazole Derivatives
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or...
2017/0305931 N-[2-(2-AMINO-6,6-DISUBSTITUTED-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZ- IN-8a(8H)-YL)-1,3-THIAZOL-4-YL] AMIDES
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds...
2017/0305930 OPTICAL FILM
Provided is an optical film which has a maximum absorption at a wavelength in the range of 600 to 680 nm, has a high dichroic ratio, and is excellent in light...
2017/0305929 QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
There are disclosed a series of quinuclidines having the Formula (I), which bind to the nicotinic .alpha.7 receptor and may be useful for the treatment of...
2017/0305928 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
This invention relates to important intermediates in the preparation of a compound which is an inhibitor of acyl coenzyme A: diacylglycerol acyltransferase 1...
2017/0305927 ANTIBACTERIAL BASIC BIAROMATIC DERIVATIVES WITH AMINOALKOXY SUBSTITUTION
The invention relates to antibacterial compounds of formula I ##STR00001## wherein R.sup.1a, R.sup.2a, R.sup.2b, R.sup.3a, R.sup.3b, R.sup.4, R.sup.5, U.sup.l,...
2017/0305926 MCL-1 INHIBITORS AND METHODS OF USE THEREOF
Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazah- ...
2017/0305925 PROCESS OF SYNTHESIZING 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1] HEPTANE-2-CARBOXYLIC ACID
The present invention provides a process for producing the compound having the structure: ##STR00001## comprising (a) reacting a compound having the structure: ...
2017/0305924 NARGENICIN COMPOUNDS AND USES THEREOF AS ANTIBACTERIAL AGENTS
The present invention relates to novel nargenicin related compounds which can inhibit DnaE and have antibacterial, particularly antimycobacterial activity...
2017/0305923 FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS
The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, m,...
2017/0305921 FUSED TETRA OR PENTA-CYCLIC DIHYDRODIAZEPINOCARBAZOLONES AS PARP INHIBITORS
Provided are certain fused tetra or penta-cyclic compounds and salts thereof, compositions thereof, and methods of use thereof.
2017/0305920 3-ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USES THEREOF
The present invention relates to the field of chemical and medicine, more particularly, 3-ethynylpyrazolopyrimidine derivatives and their preparation methods...
2017/0305919 CRYSTALLINE FORMS OF A BRUTON'S TYROSINE KINASE INHIBITOR
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- ...
2017/0305918 DUAL-WARHEAD COVALENT INHIBITORS OF FGFR-4
The disclosure includes compounds of Formula (I) ##STR00001## wherein Warhead1, Warhead2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, Q, A, B, p, q,...
2017/0305917 COMPOUNDS
The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as...
2017/0305916 METHYL DIAZEPANE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to methyl diazepane compounds which are antagonists of orexin receptors. The present invention is also directed to uses of...
2017/0305915 INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATES ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR...
The present invention provides compounds of formula (I), wherein A.sup.1, A.sup.2, Z.sup.1, Z.sup.2, Z.sup.3, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5,...
2017/0305914 ACID ADDITION SALT OF IBRUTINIB
The present invention relates to acid addition salts of ibrutinib, a pharmaceutical composition comprising the same as well as a method of preparing the same.
2017/0305913 SUBSTITUTED PYRAZOLOQUINAZOLINONES AND PYRROLOQUINAZOLINONES AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC...
The present invention provides pyrazoloquinazolinone and pyrroloquinazolinone derivatives of the general formula (I) and pharmaceutical compositions containing...
2017/0305912 PROCESS FOR THE PREPARATION OF 3-PHENYL/HETEROARYL-6-PHENOXY-8-ALKYLAMINO-IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES
A process for the preparation of 3-phenyl/heteroaryl-6-phenoxy-8-alkylamino-imidazo[1,2-b]pyridazine derivatives and intermediates of this process. A...
2017/0305911 DEUTERATED QUINAZOLINONE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Deuterated quinazolinone compounds and pharmaceutical compositions containing such compounds are provided. In particular, deuterated quinazolinone compounds of...
2017/0305910 Substituted Xanthines and Methods of Use Thereof
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
2017/0305909 CHEMICAL COMPOUNDS
The specification relates to compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof. The specification also relates to processes...
2017/0305908 SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV)
Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, C.sub.1-3 alkylene,...
2017/0305907 METHODS OF PRODUCING HETEROPOLYCYCLES VIA BIS-EPOXIDATION
A method of synthesizing a heteropolycycle, the method involving: reacting a bisepoxide with a first heteroatom nucleophile, to obtain a mixture comprising a...
2017/0305906 Pro-Neurogenic Compounds
Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or...
2017/0305905 CRYSTALLINE FORM OF AN ANXIOLYTIC COMPOUND
The present invention provides a crystalline Form B of compound 1, and pharmaceutically compositions thereof. The present invention also provides methods of...
2017/0305904 COMPOUNDS FOR INHIBITING DRUG-RESISTANT STRAINS OF HIV-1 INTEGRASE
A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of...
2017/0305903 DIAZEPINONE DERIVATIVES
The invention relates to compound of the formula I ##STR00001## or a salt thereof, wherein the substituents are as defined in the specification; to its...
2017/0305902 TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein...
2017/0305901 THERAPEUTIC TARGETING OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (IRAK4) IN CANCERS CHARACTERIZED BY...
Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (MLL-r), including MLL-r leukemia. The methods...
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