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Patent # Description
2017/0305900 HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
2017/0305899 ANTIBIOTIC COMPOUNDS AND COMPOSITIONS, AND METHODS FOR IDENTIFICATION THEREOF
Disclosed herein are compounds and methods for inhibiting bacterial DNA repair enzymes, including AddAB and RecBCD helicase-nucleases. Pharmaceutical...
2017/0305898 Composition and Method for Treating Metabolic Disorders
Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of...
2017/0305897 BENZIMIDAZOLE-PROLINE DERIVATIVES
The present invention relates to compounds of the formula (II) ##STR00001## wherein Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b and (R.sup.5).sub.n...
2017/0305896 PYRIMIDINONE COMPOUND
A pyrimidinone compound represented by formula (1): ##STR00001## wherein: A.sup.1 represents a nitrogen atom or a CR.sup.4; A.sup.2 represents a nitrogen atom...
2017/0305895 SUBSTITUTED AMINOTHIAZOLES FOR THE TREATMENT OF TUBERCULOSIS
Disclosed ore substituted aminothiazoles, which can be used for, among other things, the treatment of tuberculosis, pharmaceutical compositions containing the...
2017/0305894 PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Provided herein are compounds of Formula (I) and compositions useful in increasing PPARS activity. The compounds and compositions provided herein are useful...
2017/0305893 HETEROCYCLIC COMPOUNDS AS DCTPP1 MODULATORS
The invention relates to compounds of formula I, or a pharmaceutically-acceptable salt thereof. The present invention also relates to pharmaceutical...
2017/0305892 NOVEL AMINOPYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN PRENYLATION
A compound for use in the treatment and/or prevention of diseases or disorders wherein an inhibition of protein prenylation is required, which is alternatively...
2017/0305891 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN
The present invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, m, Z, G.sup.1, R.sup.2, and R.sup.3 have any of the values defined in...
2017/0305890 METHODS OF TREATING CANCER
The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need...
2017/0305889 METHODS OF TREATING CANCER
The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need...
2017/0305888 NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic...
2017/0305887 ANTI-ENDOTHELIAL LIPASE COMPOUNDS AND METHODS OF USING THE SAME IN THE TREATMENT AND/OR PREVENTION OF...
Endothelial Lipase (EL) inhibitors and methods of using such inhibitors for treating conditions implicating EL are provided herein. The present invention meets...
2017/0305886 PLANT GROWTH-PROMOTION AGENT AND METHOD FOR PROMOTING PLANT GROWTH
The present invention concerns: a plant growth-promoting agent comprising a compound represented by Formula (I) or a salt thereof: ##STR00001## wherein Ar.sup.1...
2017/0305885 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described...
2017/0305884 PREPARATION METHOD FOR BEMACICLB
Disclosed are an intermediate of bemaciclib or abemaciclib and a preparation method therefor. The preparation method comprises condensation, amidine reaction,...
2017/0305883 Compositions and Methods for Inhibiting BMP
The present invention provides small molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and...
2017/0305882 BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS
Compounds of formula (I) and their use as pharmaceuticals. ##STR00001##
2017/0305881 NON-PLATINUM METAL COMPLEXES FOR EXCIMER BASED SINGLE DOPANT WHITE ORGANIC LIGHT EMITTING DIODES
Complexes and devices, such as organic light emitting devices and full color displays, including a compound of the formula wherein: M is Pd.sup.2+, Ir.sup.+,...
2017/0305880 SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
2017/0305879 PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS
The invention relates to an industrial scale process for the preparation of a compound of general formula (I): (Formula (I)) wherein R.sup.1, R.sup.2 and...
2017/0305878 sGC STIMULATORS
Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be...
2017/0305877 Processes for the Preparation of Rotigotine and Intermediates Thereof
The present invention provides processes for the preparation of a compound of Formula 2 or a salt thereof, wherein R.sup.1 is selected from the group...
2017/0305876 7,8-DIHYDOXYFLAVONE AND 7,8-SUBSTITUTED FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided...
2017/0305875 2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1- ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS...
Compounds of the formula 1 ##STR00001## wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis...
2017/0305874 Diastereoselective Synthesis of (.+-.)-Epianastrephin, (.+-.)-Anastrephin and Analogs Thereof
A process for the synthesis of trans-fused .gamma.-lactones having Formula (IV) from substituted cyclic ketones having Formula (I). A diastereoselective...
2017/0305873 FORMATION OF 2,5-FURAN DICARBOXYLIC ACID FROM ALDARIC ACIDS
The disclosure relates to a method for forming 2,5-furan dicarboxylic acid (FDCA) from aldaric acids. The aldaric acids are dehydrating and cyclizing via acid...
2017/0305872 IMPROVED 5-HYDROXYMETHYLFURFURAL PRODUCTION USING A MULTI-FLUORINATED ALCOHOL COMPOUND
The present invention relates to a process for producing a water cleavage product, a water cleavage product thus produced, a process for producing at least one...
2017/0305871 LONG-CHAINED MONO AND DI-ESTERS OF 2,5-DI(HYDROXYMETHYL)TETRAHYDROFURAN, USE AND PRODUCTION THEREOF
The present invention relates to novel mono- and diesters of 2,5-di(hydroxymethyl)tetrahydrofuran, processes for their preparation by esterification in the...
2017/0305870 METHOD FOR PRODUCING 3-CHLORO-2-HYDROXYPROPYL (METH)ACRYLATE AND METHOD FOR PRODUCING GLYCIDYL (METH)ACRYLATE
To reduce formation of side products and to enhance a selectivity rate in a method for producing 3-chloro-2-hydroxypropyl (meth)acrylate and in a method for...
2017/0305869 HETEROCYCLIC IONIC LIQUIDS
An ionic liquid compound includes an azepanium-functionalized cation. An electrochemical cell electrolyte for an electrical energy storage device includes the...
2017/0305868 ARYLALKYL-AND ARYLOXYALKYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS
The present invention relates to the compound of the formula: ##STR00001## or pharmaceutically acceptable salts thereof, as well as compositions containing the...
2017/0305867 ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF
An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively...
2017/0305866 Histone Deacetylase 6 Selective Inhibitors for the Treatment of Bone Disease
This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule...
2017/0305865 PROCESS FOR SYNTHESIZING ERGOTHIONEINE AND RELATED COMPOUNDS
The invention provides a process for synthesising a compound of formula V ##STR00001## wherein: n is 0, 1 or 2; and R is H or ##STR00002## or a physiologically...
2017/0305864 HETEROCYCLIC COMPOUNDS AS PESTICIDES
The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel...
2017/0305863 N-((HET) ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS
The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the...
2017/0305862 METHYL-1H-PYRAZOLE ALKYLAMINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
2017/0305861 HETEROARYL COMPOUNDS COMPRISING NITROGEN AND USE THEREOF
The present invention relates to heteroaryl compounds comprising nitrogen and use thereof, and more specifically to compounds which exhibit a remarkable effect...
2017/0305860 PROCESS FOR THE PREPARATION OF ESLICARBAZEPINE AND ESLICARBAZEPINE ACETATE
An improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts is provided.
2017/0305858 AMORPHOUS FORM OF LOMITAPIDE MESYLATE
Provided is novel amorphous form of lomitapide mesylate salt and process for preparation thereof.
2017/0305857 N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS
The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in...
2017/0305856 Novel diacylated and mono-acylated alkylated imino sugars exhibiting glucosidase inhibition and their method of use
Described herein are alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity...
2017/0305855 STERICALLY HINDERED AMINE AND OXYALKYL AMINE LIGHT STABILIZERS
Compounds having hindered amine and oxyalkyl amine light stabilizers can mitigate the adverse effects of actinic radiation, such as visible and ultraviolet...
2017/0305854 NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND AN ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
The present disclosure relates to novel organic electroluminescent compounds and an organic electroluminescent device comprising the same. By using the organic...
2017/0305853 THERMOSETTING RING-OPENING METATHESIS POLYMERIZATION MATERIALS WITH THERMALLY DEGRADABLE LINKAGES
The present invention provides a new class of thermosetting ring-opening metathesis polymerization materials based on norbornene and oxanorbornene ...
2017/0305852 Tetracyline Compounds
The present invention is directed to a compound represented by Structural Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. The variables...
2017/0305851 PHOTOIRRADIATION DEVICE, PHOTOREACTION METHOD USING THE SAME, AND METHOD FOR PRODUCING LACTAM
Provided are a photoirradiation device equipped with: a first optically transparent container for covering a light-emitting body provided with light-emitting...
2017/0305850 PROCESS FOR PURIFYING ASTAXANTHIN AND CANTHAXANTHIN
The present invention relates to a process for purifying the xanthophylls astaxanthin and canthaxanthin. The process comprises suspending the xanthophyll in an...
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