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Patent # Description
2017/0304429 VACCINATION OF IMMUNOCOMPROMISED SUBJECTS
Disclosed herein are methods for enhancing immune responses to a vaccine in immunocompromised individuals, including those receiving a statin therapy. Related...
2017/0304428 Compositions and Methods for Increasing Immunogenicity of Glycoprotein Vaccines
The present invention relates to the microbial immunogens engineered to bear .alpha.-gal epitope(s) for induction of potent humoral and cellular immune...
2017/0304427 RECOMBINANT MODIFIED VACCINIA VIRUS ANKARA (MVA) FILOVIRUS VACCINE
The present invention relates to an improved filovirus vaccine comprising a recombinant modified vaccinia virus Ankara-based (MVA-based) vaccine against...
2017/0304426 VACCINE COMPOSITIONS AGAINST DENGUE VIRUS DISEASES
The present invention relates to vaccine compositions that are useful in a method of protecting a human subject against dengue disease.
2017/0304425 NOVEL TARGETS OF ACINETOBACTER BAUMANNII
The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising...
2017/0304424 ATTENUATED MANNHEIMIA HAEMOLYTICA STRAINS
The present invention provides attenuated M haemolitica strains that elicit an immune response in animal against M haemolitica, compositions comprising said...
2017/0304423 Compositions and Methods for Immunizing Against C. Difficile
This disclosure relates to methods for eliciting an immune response against C. difficile toxin A and toxin B in an adult human subject. The subject may be at...
2017/0304422 COMPOSITIONS AND METHODS FOR COMBINATION THERAPY WITH DENGUE VIRUS AND DENDRITIC CELLS
Described herein are compositions and methods for treating cancer through the combination of tumor antigen-pulsed dendritic cells and Dengue Virus. The...
2017/0304421 ANTI-MUTATED KRAS T CELL RECEPTORS
Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for an HLA-A11-restricted epitope of mutated Kirsten rat sarcoma viral...
2017/0304420 POLYMER ADJUVANT
The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing...
2017/0304419 CANCER IMMUNOTHERAPY BY IMMUNE ACTIVATION OR IMMUNE MODULATION VIA GLOBO SERIES ANTIGENS
The disclosure provides a method of immunotherapy for a cancer patient, comprises administering vaccines against Globo series antigens (i.e., Globo H,...
2017/0304418 UNIVERSAL DONOR CHECKPOINT INHIBITOR SILENCED/GENE EDITED CORD BLOOD KILLER CELLS
Disclosed are compositions of matters, cells, and treatment protocols useful for induction of anticancer responses in a patient suffering from cancer. In one...
2017/0304417 METHOD FOR ESTABLISHING PLURIPOTENT STEM CELLS BEARING GENES ENCODING ANTIGEN SPECIFIC T CELL RECEPTOR
Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of: (1) providing human pluripotent stem cells bearing genes...
2017/0304416 GENETICALLY MODIFIED BABESIA PARASITES EXPRESSING PROTECTIVE TICK ANTIGENS AND USES THEREOF
The present invention relates to methods for stable transfection of Babesia parasites, and for vaccines conferring immunity against parasitic arthropods.
2017/0304415 Anti-Cancer Combination Treatment and Kit-of-Parts
In one aspect the present invention relates to pharmaceutical kits of parts suitable for treating neoplastic diseases such as cancer comprising an anti-cancer...
2017/0304414 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PHENYLKETONURIA (PKU)
The present invention provides compositions for the treatment of phenylketonuria in mammals, as well as methods of preparing said compositions. The present...
2017/0304413 IMPLANTABLE MATRIX HAVING OPTIMUM LIGAND CONCENTRATIONS
Implantable matrices and methods are provided. The matrices are configured to fit at or near a target tissue site, the matrices comprise biodegradable...
2017/0304412 VARIANTS OF TACE PRO-DOMAIN AS TNF-A INHIBITOR AND THEIR MEDICAL USE
A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a...
2017/0304411 TOPICAL FORMULATION FOR TREATING SKIN OR MUCOSAL INFECTIONS, PREPARATION METHOD AND USES THEREOF
The present disclosure relates to the field of therapeutics for skin and mucosal infections and refers to the use of bromelain either alone or with...
2017/0304410 TREATMENT OF CANCER AND INHIBITION OF METASTASIS USING HEMOGLOBIN BETA SUBUNIT
The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against...
2017/0304409 COMPOSITIONS USEFUL FOR THE PREVENTION AND/OR TREATMENT OF INFECTIONS AND INFLAMMATIONS
Disclosed are compositions containing a lactoferrin hydrolysate, glycerophosphorylinositol or salts thereof and/or verbascoside which are useful for the...
2017/0304408 Metallic Gold Cluster Molecules As Therapeutic Agents for Arthritic Animals
A therapeutic method for attenuating symptoms of inflammation and autoimmune diseases. This method includes preparing and administering to animals...
2017/0304407 IMPROVED CLOTTING COMPOSITION
The present invention relates to improved clotting compositions for producing high quality blood serum samples for analyte testing, such as for pathology...
2017/0304406 NEW INDICATION FOR ALPHA-MSH ANALOGUES
The present invention is directed to alpha-MSH analogues for treatment of neurodegenerative disorders.
2017/0304405 TREATMENT OF HORMONAL DISORDERS OF GROWTH
The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of...
2017/0304404 METHOD FOR TREATING HYPERGLYCEMIA WITH GLP-1
A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2...
2017/0304403 METHOD FOR INHIBITING INFLAMMATION and PRO-INFLAMMATORY CYTOKINE/CHEMOKINE EXPRESSION USING A GHRELIN ANALOGUE
The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various...
2017/0304402 USE OF LOW DOSE IL-2 FOR TREATING AUTOIMMUNE RELATED OR INFLAMMATORY DISORDERS
The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use...
2017/0304401 PEPTIDE INHIBITION OF CCR3-MEDIATED DISEASES OR CONDITIONS
A C--C chemokine receptor 3 (CCR3) peptide analog that exhibits biased antagonism by binding to and inhibiting ligand-mediated signaling and chemotaxis while...
2017/0304400 METHODS FOR PREVENTING FIBROSIS USING CXCR4 AND/OR CXCR7 BINDING AGENTS
This disclosure is directed to methods of treating a subject with a fibrotic or fibroproliferative disease, comprising administering to the subject a...
2017/0304399 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING GASTROINTESTINAL AND GASTRIC CANCER
A pharmaceutical composition contains an antibody or a fragment thereof specific for COL6A3 for the treatment of a cancer. A method of treating a cancer...
2017/0304398 POLYMER CONJUGATES OF BOX-A OF HMGB1 AND BOX-A VARIANTS OF HMGB1
The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a...
2017/0304397 TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS
Provided herein are methods of treating diseases associated with vascular calcification and/or cardiovascular disease in a subject by using the level of a...
2017/0304396 AQUEOUS SOLUTION FORMULATIONS OF VANCOMYCIN
This invention relates to aqueous solution compositions of vancomycin that are stable, ready for use and do not require reconstitution.
2017/0304395 TREATMENT OF ENTERAL FEEDING INTOLERANCE
Enteral Feeding Intolerance (EFI) can be efficaciously treated by administration of therapeutically effective doses of ulimorelin every 8 hours (three times a...
2017/0304394 ORALLY DISINTEGRATING SOLID PHARMACEUTICAL DOSAGE UNIT CONTAINING A PARTUS CONTROL SUBSTANCE
An orally disintegrating solid pharmaceutical dosage unit having a weight between 50 and 1,000 mg is disclosed. The dosage unit consists of: (a) 5-100 wt. % of...
2017/0304393 ORALLY DISINTEGRATING SOLID PHARMACEUTICAL DOSAGE UNIT CONTAINING A PARTUS CONTROL SUBSTANCE
The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight between 50 and 1,000 mg, said dosage unit consisting...
2017/0304392 DAB2 INHIBITORS FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS
Compositions and kits including an agent that inhibits the interaction between Disabled-2 and mutant CFTR proteins, optionally in combination with a CFTR...
2017/0304391 ANG-(1-7) Derivative Oligopeptides for the Treatment of Pain and Other Indications
The present invention provides oligopeptides, in particular, Ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment,...
2017/0304390 COMPOSITIONS AND METHODS FOR MODULATING AT2R ACTIVITY
New polypeptide agonists of AT2R are disclosed, as well as pharmaceutical compositions comprising the agonists, methods of their use in the treatment of...
2017/0304389 Methods for Increasing the Selective Efficacy of Gene Therapy Using CAR Peptide and Heparan Sulfate Mediated...
Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a...
2017/0304388 NEW INDICATION OF CARDIOVASCULAR DRUGS FOR PREPARATION OF CANCER INHIBITION PHARMACEUTICAL COMPOSITION
A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount...
2017/0304387 NEW INDICATION OF ANTIBIOTIC DRUGS FOR PREPARATION OF CANCER INHIBITION PHARMACEUTICAL COMPOSITION
A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount...
2017/0304386 METHOD FOR INHIBITING SURVIVAL, TUMORIGENESIS AND METASTASIS OF CANCER CELLS AND/OR CANCER STEM CELLS
A new method for preventing tumorigenicity or treating a cancer in a subject includes administering to the subject a Collagen XVII (Col XVII) inhibitor in an...
2017/0304385 METHODS OF TREATING CERVICAL CANCER
This invention relates to the treatment of cervical tumor caused by human papillomavirus (HPV) infection. In particular, the invention provides methods for...
2017/0304384 SUBSTANCES AND METHODS FOR THE USE IN PREVENTION AND/OR TREATMENT IN HUNTINGTON'S DISEASE
Disclosed are immunogenic peptides of the HTT protein and HTT specific antibodies for use in the prevention and/or treatment of Huntington's disease.
2017/0304383 SMALL MOLECULE RAS INHIBITORS
Disclosed herein are novel compounds that are Ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in...
2017/0304382 TREATING ERECTILE DYSFUNCTION BY ORCHIS ANATOLICA EXTRACT
A composition for treating erectile dysfunction in a male mammal comprising an Orchis anatolica root bulb extract. A method of treating erectile dysfunction in...
2017/0304381 PHARMACEUTICAL COMPOSITION AND THE USE THEREOF
A pharmaceutical composition, as well as the use of composition in medical applications, are described.
2017/0304380 USE OF ALPHAVIRUS IN PREPARATION OF ANTITUMOR DRUGS
Disclosed is use of alphavirus in preparation of antitumor drugs. The alphavirus is M1 virus or Getah virus. In addition, the specific tumor types sensitive to...
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