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Patent # Description
2017/0312285 COMPOUNDS FOR THE TREATMENT OF MYOTONIC DYSTROPHY
The present invention relates to a compound of formula (I), provided that this compound is not caffeine, for use in the treatment of myotonic dystrophy type 1...
2017/0312284 ANALOGS OF ADENOSINE MONOPHOSPHATE (AMP) AS INHIBITORS OF UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7
Disclosed are analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activing enzyme ATG7. The AMP analogs may be formulated as...
2017/0312283 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and ...
2017/0312281 METHOTREXATE FORMULATION
A liquid pharmaceutical composition comprises methotrexate free acid and a buffer, wherein the pH of the composition is in the range of 6.5 to 8.2. Processes...
2017/0312280 PYRIMIDINE COMPOUNDS AS JAK KINASE INHIBITORS
The invention provides compounds of formula (I): ##STR00001## wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt...
2017/0312279 1-PYRAZOLYL-3-(4-((2-ANILINOPYRIMIDIN-4 -YL) OXY) NAPTHTHALEN-1 - YL) UREAS AS P38 MAP KNASE INHIBITORS
There are provided compounds of formula (I) which are inhibitors of the family of p38 mitogen-activated protein kinase enzymes, and to their use in therapy,...
2017/0312278 METHODS FOR TREATING CANCER USING TOR KINASE INHIBITOR COMBINATION THERAPY COMPRISING ADMINISTERING SUBSTITUTED...
Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount...
2017/0312277 Compounds for Treatment of Fibrosis Diseases
The present invention relates to compounds as inhibitor of WNT signal transduction pathway, as well as a composition comprising the same. Further, the present...
2017/0312276 COMPOSITIONS AND METHODS FOR TREATING AN INFECTION
The present application relates to compounded compositions, methods of making compounded compositions, kits comprising compounded compositions, containers...
2017/0312275 COMPOSITION AND METHOD FOR TREATMENT OF DEPRESSION AND PSYCHOSIS IN HUMANS
Compositions and methods for the treatment of depression and psychoses in humans are disclosed. More particularly, the invention is directed to formulations...
2017/0312274 METHOD FOR TREATING A BRAIN TUMOUR
A method of treating a brain tumour such as glioblastoma in a mammal is provided comprising administering to the mammal a DRD4 antagonist.
2017/0312273 METHODS OF USING FASN INHIBITORS
The present disclosure relates to methods of treating, preventing or ameliorating a TH17- or CSF1-mediated disease or disorder such as cancer, immunological...
2017/0312272 TEMOZOLOMIDE POWDER FORMULATION
The present invention relates to a solid pharmaceutical composition of temozolomide that has good and consistent flowability as a powder and taste masking and...
2017/0312271 CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS
The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or...
2017/0312270 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS,...
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone...
2017/0312269 COMPOSITIONS AND METHODS FOR REDUCING FOOD CRAVINGS
Disclosed are compositions for reducing food cravings, comprising a first compound and a second compound, where the first compound is an opioid antagonist and...
2017/0312268 METHODS FOR TREATING A NEUROLOGICAL DISORDER IN A SUBJECT USING INHIBITORS OF HYPOXIA-INDUCIBLE FACTOR (HIF)...
The present invention provides methods for treating anemia in a subject having kidney failure by administering a compound that inhibits hypoxia-inducible...
2017/0312267 METHOD OF ISOLATING PHENANTHROINDOLIZIDINE ALKALOIDS FROM TYLOPHORA ATROFOLLICULATA, COMPOSITIONS COMPRISING...
A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used...
2017/0312266 METHOD OF ISOLATING PHENANTHROINDOLIZIDINE ALKALOIDS FROM TYLOPHORA ATROFOLLICULATA WITH HIF-1 INHIBITORY...
A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to...
2017/0312265 METHOD FOR IMPROVING INTERSTITIAL FLOW
Provided is a prophylactic and/or therapeutic drug for mild cognitive impairment, which can improve interstitial flow in cerebral blood vessel and the like to...
2017/0312264 USE OF LAQUINIMOD TO DELAY HUNTINGTON'S DISEASE PROGRESSION
The subject invention provides methods of treating or delaying disease progression in a subject afflicted with Huntington's disease (HD) comprising...
2017/0312263 SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS
The invention provides a chemical entity of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, Y, and n have any of the values described herein and...
2017/0312262 MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
2017/0312261 CHEWING GUM COMPOSITION COMPRISING CANNABINOIDS AND NICOTINE
A chewing gum composition comprising cannabinoids or derivatives thereof and nicotine in the form of nicotine polacrilex is provided. The chewing gum...
2017/0312260 NEW INDICATION OF AZELNIDIPINE PHARMACEUTICAL COMPOSITION FOR TREATING CANCER
A method for treating a cancer includes administering to a subject in need thereof a pharmaceutical composition containing a therapeutically effective amount...
2017/0312259 METHOD AND COMPOSITION FOR TREATING ALZHEIMER-TYPE DEMENTIA
There is described a method for increasing the maximal tolerated close and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient...
2017/0312258 TIOTROPIUM DRY POWDERS
The present invention relates to respirable dry powder comprising respirable dry particles that comprise sodium chloride, leucine, and tiotropium bromide,...
2017/0312257 TREATMENT OF ZIKA VIRUS INFECTIONS USING ALPHA-GLUCOSIDASE INHIBITORS
The present invention concerns the use of castanospermine or other alpha-glucosidase inhibitors for the treatment or prevention of Zika virus infections....
2017/0312256 TRANSDERMAL PARASITICIDAL FORMULATIONS
Described herein are transdermal parasiticidal formulations and methods of treatment and use, wherein the formulation is not only able to deliver an agent or...
2017/0312255 IFETROBAN TREATMENT FOR SYSTEMIC SCLEROSIS
The present invention is directed to methods of treating, preventing, and/or ameliorating systemic sclerosis, by administration of a therapeutically effective...
2017/0312254 Low Dose Pharmaceutical Composition
This invention provides a low dose pharmaceutical composition comprising deferasirox or a pharmaceutically acceptable derivative thereof and one or more...
2017/0312253 METHODS OF PREVENTING AND TREATING CEREBRAL AMYLOID ANGIOPATHY (CAA) WITH AN EDARAVONE MEDICAMENT
The present invention belongs to pharmaceutical field, specifically, relates to use of Edaravone in the preparation of a medicament for preventing and treating...
2017/0312252 PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS
The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically...
2017/0312251 NUTRITIONAL SUPPLEMENTS FOR IMPROVING FEMALE FERTILITY
The present invention relates to a fertility-enhancing composition for human male fertility therapy and a method for using the same to improve or enhance human...
2017/0312250 Melanin Compositions and Devices for Protecting Tissues from Radiation Damage
Disclosed are melanin compositions and devices, and methods of use thereof, to protect internal tissues and organs from radiation damage and to prevent or...
2017/0312249 MODULATORS OF 14-3-3 FUNCTIONALITY AND USES THEREOF
The present disclosure relates to modulators of 14-3-3 functionality and their use in methods and compositions for preventing and/or treating various diseases,...
2017/0312248 PHARMACEUTICAL COMPOSITION CONTAINING GINKGOLIDE B AND ADP RECEPTOR ANTAGONIST, PREPARATION METHOD THEREOF AND...
A pharmaceutical composition containing ginkgolide B and an ADP receptor antagonist, a preparation method thereof and use thereof in preparation of...
2017/0312247 HERIPENES WITH PAIN-RELIEVING EFFECT, ACTIVE SUBSTANCES OF Hericium erinaceus MYCELIUM AND THE PREPARATION...
The present invention is related to an active substance of Hericium erinaceus having a pain-relieving effect, and a pharmaceutical composition including the...
2017/0312246 LIPIDIC FURAN, PYRROLE, AND THIOPHENE COMPOUNDS FOR USE IN THE TREATMENT OF ATROPHIC VAGINITIS
Provided herein are lipidic furan, pyrrole, and thiophene compounds, compositions, and methods using such compounds and compositions for the treatment of...
2017/0312245 TARGETED CONJUGATES AND PARTICLES AND FORMULATIONS THEREOF
Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or...
2017/0312244 PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING TAXANE
Provided is a pharmaceutical composition for oral administration, including (a) a taxane, (b) a medium chain triglyceride, (c) an oleoyl glycerol complex...
2017/0312243 SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart...
2017/0312242 SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart...
2017/0312241 SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart...
2017/0312240 COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or...
2017/0312239 COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD
The present invention relates to compounds comprising the general formula (I), in which R.sub.1 and R.sub.2, which may be identical or different, are selected...
2017/0312238 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF
A method of modulating plasma levels of branched chain amino acids and branched chain alpha-keto acids is disclosed, wherein an ammonia scavenger compound or a...
2017/0312237 SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TISSUE SELF-REPAIR AND REGENERATION
Described herein are compounds of Formula I, or pharmaceutically acceptable salts thereof, or combinations thereof, as well as uses thereof. Such uses include...
2017/0312236 PHARMACEUTICAL COMPOSITIONS OF FLURBIPROFEN AND TRAMADOL
The present invention relates to a pharmaceutical composition comprising flurbiprofen and tramadol or pharmaceutically acceptable salts thereof and at least...
2017/0312235 S ISOMERS OF ALPHA-METHYL-HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS
The present intervention generally relates to compositions comprising S-isomer of alpha-methyl-hydrocinnamic acid for the treatment and/or prevention of blood...
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