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Patent # Description
2017/0313757 OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL
Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates...
2017/0313756 PEPTIDE ANALOGS OF ALPHA-MELANOCYTE STIMULATING HORMONE
Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (.alpha.-MSH) having selectivity for the melanocortin 1 receptor...
2017/0313755 INSULIN RECEPTOR PARTIAL AGONISTS
Disclosed herein are insulin analog conjugates comprising an insulin agonist covalently linked to an insulin antagonist peptide. The conjugates are high...
2017/0313754 HEPCIDIN AND MINI-HEPCIDIN ANALOGUES AND USES THEREOF
The present invention provides novel hepcidin analogues, and related methods of using these hepcidin analogues to treat or prevent a variety of diseases and...
2017/0313753 METHODS OF TREATING GRAFT VERSUS HOST DISEASE USING IL-2 MUTEINS
Described herein are immunosuppressive molecules including immunosuppressive variants of IL-2, and use of such molecules to treat inflammatory and autoimmune...
2017/0313751 Methods and Pharmaceutical Composition for the Preservation of Vascular Endothelial Cell Barrier Integrity
The invention relates to an ANGPTL4 polypeptide for use in the preservation of vascular endothelial cell barrier integrity and reduction in no-reflow...
2017/0313750 SELECTIVE PYY COMPOUNDS AND USES THEREOF
The invention relates to PYY compounds with the amino acid modifications 7Lys, 30Trp, and 31Leu, and in addition to these, 22Ile and/or 28Tyr, and derivatives...
2017/0313749 COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile...
2017/0313748 CAPPING MODULES FOR DESIGNED ANKYRIN REPEAT PROTEINS
Improved N-terminal capping modules for designed Ankyrin repeat proteins (DARPins) conferring improved thermal stability to the DARPins are described, as well...
2017/0313747 SELF-ASSEMBLED NANOSTRUCTURES
The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit...
2017/0313746 Peptides Useful For Treating Cancer
Provided is a class of peptides which are useful for modulating the activity of poly (ADP-ribose) polymerase (PARP) and in particular for the treatment of...
2017/0313745 INHIBITORS OF HEPATITIS C VIRUS
Compounds of formula I: ##STR00001## or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said...
2017/0313744 NOVEL D-ENANTIOMERIC PEPTIDES DERIVED FROM D3 AND USE THEREOF
The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.
2017/0313743 NPR-B Agonists
Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or...
2017/0313742 USE OF CAPRYLIC ACID PRECIPITATION FOR PROTEIN PURIFICATION
In certain embodiments, the invention provides a method of purifying a protein of interest from a mixture which comprises the protein of interest and one or...
2017/0313741 ACTIVATED CARBON FOR THE REMOVAL OF LEACHABLES AND/OR EXTRACTABLES
The present invention relates to the purification of target molecules like recombinant and/or biotherapeutic proteins. Activated carbon can be used to remove...
2017/0313740 METHODS OF PREPARING PEPTIDES
The present invention provides methods of preparing a peptide having an N-terminal histidine, and compositions comprising a plurality of peptides prepared by...
2017/0313739 TACCALONOLIDE MICROTUBULE STABILIZERS
The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.
2017/0313738 RAMAN TAG
The present invention provides novel Raman tags for exploring membrane interactions in cells. The tags comprise a phenyl diyne probe where in the dyine is...
2017/0313737 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide...
2017/0313736 MUTAGENIC NUCLEOSIDE ANALOGS AND USES THEREOF
The present disclosure provides nucleoside analogs of Formula (I) or (II). The nucleoside analogs are expected to show multiple tautomerism and may increase...
2017/0313735 Improved Fluorination Process
A process comprising (i) providing a mixture comprising a compound of formula (I) or isomers, stereoisomers, diastereomers, enantiomers or salts thereof; (ii)...
2017/0313734 METHOD FOR PREPARING D-PSICOSE CRYSTAL
A method for producing high purity D-psicose crystals having a purity of 98% (w/w) or more and a grain size of MA200 or more. The method includes: removing...
2017/0313733 COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
2017/0313732 NOVEL ANNELATED PHENOXYACETAMIDES
The present invention relates to compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, and Z have one of the meanings as indicated in the...
2017/0313731 PROCESS FOR PRODUCING METHYLDICHLOROPHOSPHANE
The present invention primarily relates to a process for producing methyldichlorophosphane (MDP) by reaction of methane with PCl.sub.3 (phosphorus trichloride)...
2017/0313730 PROCESS FOR PREPARING PHOSPHORUS CONTAINING CYANOHYDRINS
The present invention relates primarily to a process for preparing certain phosphorus-containing cyanohydrins of the formula (I), and also to certain...
2017/0313729 METHOD OF HYDROSILYLATION IMPLEMENTING AN ORGANIC CATALYST DERIVED FROM GERMYLENE
The present invention concerns a method for the hydrosilylation of an unsaturated compound comprising at least one ketone function, one aldehyde function, one...
2017/0313728 TRANSPARENT FILM
The object of the present invention is to attain water repellency as well as the heat resistance and the light resistance. the transparent film of the present...
2017/0313727 SUBSTITUTED DIHYDROPYRROLOPYRAZOLE COMPOUND
Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof: ##STR00001## wherein L.sup.1 is an optionally substituted...
2017/0313726 BIODEGRADABLE HYBRID POLYMERS USABLE IN MEDICAL TECHNOLOGY OR IN BIOLOGY, STARTING SILANES THEREFOR, AND...
The invention relates to a silane or silane mixture obtainable by reacting a hydrolysable silane of the formula (A): SiR4 in which R is a hydrolytically...
2017/0313725 Process For Producing Tetrakis(F aryl)Borate Salts
This invention provides processes for forming halomagnesium tetrakis(.sup.Faryl)borates, which processes comprise bringing together, in an anhydrous liquid...
2017/0313724 CRYSTALLINE FORMS OF A THERAPEUTIC COMPOUND AND USES THEREOF
Disclosed herein are certain crystalline forms of Compound 5, N-(5-((2-(4-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butanamido)imidazo[1,2-0]pyr- ...
2017/0313723 Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
2017/0313722 TETRAHYDRONAPHTHYRIDINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF...
The invention provides tetrahydronaphthyridine and related compounds, pharmaceutical compositions, methods of inhibiting ROR.gamma. activity, reducing the...
2017/0313721 SUBSTITUTED 1,2,3-TRIAZOL-1-YL-METHYL-2,3-DIHYDRO-2-METHYL-6-NITROIMIDAZO[2,1-B]OXAZO- LES AS...
The present invention relates to new generation of triazole functionality containing 6-nitro-2,3-dihydroimidazooxazole agents for general formula I, their...
2017/0313720 METHODS FOR TREATMENT OF RESISTANT CANCER
The present disclosure describes a method to treat conditions, including cancer, using compounds that can target resistant cancer cells. The compounds of the...
2017/0313719 Thieno[2,3-D]pyrimidin-4-one Derivatives as NMDAR Modulators and Uses Related Thereto
The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the...
2017/0313718 INHIBITORS OF HIF PROLYL HYDROXYLASE
The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for...
2017/0313717 NOVEL GLP-1 RECEPTOR MODULATORS
Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic...
2017/0313716 ORIDONIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO
Certain embodiments are directed to oridonin analogs or derivatives. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents.
2017/0313715 SIX-MEMBERED RING BENZO DERIVATIVES AS DPP-4 INHIBITOR AND USE THEREOF
The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a...
2017/0313714 EGFR INHIBITOR, PREPARATION METHOD AND USE THEREOF
Epidermal growth factor receptor (EGFR) inhibitors are provided. In particular, 4-substituted-2-(N-(5-substituted allyl amide)phenyl)amino)pyrimidine...
2017/0313713 AMINOINDANE-, AMINOTETRAHYDRONAPHTHALENE- AND AMINOBENZOCYCLOBUTANE-DERIVED PRMT5-INHIBITORS
A compound of formula (1a), (1b) or (1c) wherein: n is 1 or 2; R.sup.N is H or Me; R.sup.1 is optionally one or more halo or methyl groups; R.sup.1 and...
2017/0313712 DIHETEROARYL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY
The present invention is a compound having the following formula: (Formula (I)) or a pharmaceutically acceptable salt thereof, wherein e.g. X is C or N; n is 1...
2017/0313711 1,5-DISUBSTITUTED 1,2,3-TRIAZOLES ARE INHIBITORS OF RAC/CDC42 GTPASES
Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit...
2017/0313710 TRICYCLIC TRIAZOLIC COMPOUNDS
The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the...
2017/0313709 CRYSTALLINE FORM OF JAK KINASE INHIBITOR BISULFATE AND A PREPARATION METHOD THEREOF
A crystal form of JAK kinase inhibitor bisulfate and a preparation method thereof are provided. In particular, a type II crystal of ...
2017/0313708 NONANOIC AND DECANOIC ACID DERIVATIVES AND USES THEREOF
The present disclosure relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present disclosure also relates to...
2017/0313707 SOLID FORMS OF A TOLL-LIKE RECEPTOR MODULATOR
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropterid- in-6(5H)-one,...
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