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Patent # Description
2017/0319723 RADIOIMMUNE COMPLEX, THERANOSTIC AGENT AND KIT
Disclosed herein is a radioimmune complex comprising an epidermal growth factor receptor (EGFR)-targeted antibody and a radioactive isotope of rhenium labeled...
2017/0319722 CD8-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
The present application provides stable peptide-based CD8 capture agents and methods of use as detection agents. The application further provides methods of...
2017/0319721 ALPHA-EMITTING COMPLEXES
The present invention provides a tissue-targeting complex comprising a tissue targeting moiety, an octadentate hydroxypyridinone-containing ligand and the ion...
2017/0319720 METHOD FOR PREPARING ORGANIC FLUORIDE-ALIPHATIC COMPOUND AND METHOD FOR PURIFYING ORGANIC FLUORIDE-ALIPHATIC...
A method for preparing a radiopharmaceutical and, specifically, a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical,...
2017/0319719 J-Aggregate Forming Nanoparticle
There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid...
2017/0319718 METHODS AND DEVICES FOR PREPARATION OF ULTRASOUND CONTRAST AGENTS
Provided herein are methods and devices for identifying and/or distinguishing UCA formulations and specifically activating such formulations to produce UCA...
2017/0319717 PSMA-TARGETED NIR DYES AND THEIR USES
The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their...
2017/0319716 Therapeutic Agent for Tauopathy and Method for Screening Thereof
The present invention provides a tau protein aggregation inhibitor. In addition, a therapeutic agent or a preventive agent for tauopathy, including a tau...
2017/0319715 SYSTEM AND METHOD TO MODULATE PAIN AND ITCH THROUGH CUTANEOUS TRANSFER OF GENETIC INFORMATION
One embodiment is directed to a method for altering the function of the sensory unit that innervates a targeted tissue region in a mammal comprising the steps...
2017/0319714 SYSTEM AND METHOD TO MODULATE PAIN AND ITCH THROUGH CUTANEOUS TRANSFER OF GENETIC INFORMATION
One embodiment is directed to a system for altering the function of a sensory unit that innervates a targeted tissue region in an animal, the sensory unit...
2017/0319713 NOVEL METHOD FOR PRODUCING LIPOPLEX FOR TOPICAL ADMINISTRATION AND ANTITUMOR AGENT USING SUCH LIPOPLEX
An object of this invention is to provide a novel delivery means that enables efficient delivery of an active ingredient to a target cell. Such objective is...
2017/0319712 METHODS AND COMPOSITIONS FOR ENHANCING IMMUNE RESPONSE
Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that...
2017/0319711 ANTIBODY-DRUG CONJUGATES
Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.
2017/0319710 METHODS FOR COUPLING TARGETING PEPTIDES ONTO RECOMBINANT LYSOSOMAL ENZYMES FOR IMPROVED TREATMENTS OF LYSOSOMAL...
Described herein are methods of making targeting peptides conjugated to a recombinant lysosomal enzyme by modifying the amino (N)-terminus and one or more...
2017/0319709 EGFR ANTIBODY CONJUGATES
A maytansinoid is covalently linked through a non-cleavable linker to an EGFR antibody that is a full EGFR antagonist, such as cetuximab or panitumumab. The...
2017/0319708 3-Substituted Piperidine-2, 6-Diones and Non-Covalent Complexes with Albumin
The present disclosure provides derivatives of 3-substituted piperidine-2,6-diones, non-covalently bound complexes with serum albumin, pharmaceutical...
2017/0319707 Combination Of Drugs With Protein-Binding Prodrugs
The present invention relates to a composition and a combination comprising at least one first drug and at least one protein-binding prodrug, wherein the...
2017/0319706 DELIVERING A DRUG TO A MUCOSAL SURFACE
Provided is a method of delivering a drug to a mucosal surface in a living body, said method comprising applying a solution to said mucosal surface, wherein...
2017/0319705 AMPHOTERICIN B DERIVATIVES
Embodiments of the invention provide derivatives of Amphotericin B having increased solubility and reduced toxicity relative to AMB, while retaining antifungal...
2017/0319704 BLOCK COPOLYMERS FOR THERAPEUTIC DRUG DELIVERY
Amphiphilic block copolymers (BCPs) were prepared comprising a poly(ethylene oxide) block and a biodegradable polycarbonate block functionalized with disulfide...
2017/0319703 SHELF-STABLE MOUTH COATING GEL OR LIQUID
The disclosure provides dry, lipid-based mixtures comprising at least 50% by weight lipid molecules. The mixtures may comprise alkalizer molecules, ...
2017/0319702 Injectable, Non-Aqueous Suspension with High Concentration of Therapeutic Agent
An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single...
2017/0319701 DRUG-CONTAINING IMPLANTS AND METHODS OF USE THEREOF
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA)....
2017/0319700 DRUG-CONTAINING IMPLANTS AND METHODS OF USE THEREOF
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA)....
2017/0319699 ACTIVATED MACROPHAGE TARGETABLE DRUG CARRIER FOR TREATMENT OF ATHEROSCLEROSIS AND METHODS OF PREPARING THE SAME
Provided is a drug carrier for treatment of atherosclerosis including a biocompatible amphipathic polymer including a macrophage lignad polymer and a...
2017/0319698 GASTRORETENTIVE GEL FORMULATIONS
The present invention provides a gastric retentive gel composition comprising: (a) a hydrophobic or amphiphilic liquid gelled with an organogelator; (b) an...
2017/0319697 Valerian Composition and Related Methods
A valerian composition includes a therapeutically effective pharmaceutical dosage form having a solid core including a polymer in which valerian and a valerian...
2017/0319696 Derivatized Hyperbranched Polyglycerols
Herein are provided derivatized hyperbranched polyglycerols ("dHPGs"). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with...
2017/0319695 COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS
Described herein are neuroactive steroids of the Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof; wherein , A, R.sup.1, R.sup.2, and...
2017/0319694 DIHYDROXYPHENYL NEUROTRANSMITTER COMPOUNDS, COMPOSITIONS AND METHODS
The present invention relates to new dihydoxyphenyl modulators of neurotransmitter levels, pharmaceutical compositions thereof, and methods of use thereof. ...
2017/0319693 NOVEL TREATMENT OF CORNEA USING LAMININ
The present invention provides a technique for treating the cornea. More specifically, the present invention is an agent for the treatment or prevention of a...
2017/0319692 ANTI-AR AGENT AND RADIATION THERAPY FOR ANDROGEN RECEPTOR POSITIVE CANCER
Provided herein are compositions, systems, kits, and methods for treating cancer in a subject with androgen receptor positive cancer cells by sensitizing such...
2017/0319691 COMBINATION THERAPY FOR TREATING BREAST CANCER
The invention provides compositions and methods for treating breast cancer. Specifically, the invention relates to administering a Transforming Growth Factor...
2017/0319690 Anti-PD-L1 Antibodies
Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
2017/0319688 ANTI-RSPO3 ANTIBODIES AND METHODS OF USE
Provided herein are anti-RSPO3 antibodies and methods of using the same.
2017/0319687 RANKL-SPECIFIC AGENT FOR TREATING METASTATIC DISEASE
The invention provides for a RANKL-specific antagonistic agent recognizing human platelet-expressed receptor activator of nuclear factor kappa-B ligand...
2017/0319686 VACCINE AND PRIME-BOOST VACCINE
A vaccine for activating CD8 T cells including Bacillus Calmette-Guerin (BCG bacteria) which express a protein derived from a pathogenic microorganism as an...
2017/0319685 COMPOSITIONS AND METHODS FOR SELF-ADJUVANTING VACCINES AGAINST MICROBES AND TUMORS
The present invention is drawn to compositions and methods to enhance an immune response in order to prevent or treat infections or hyperproliferative diseases...
2017/0319684 Novel Artificial Antigen Presenting Cells and Uses Thereof
The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory...
2017/0319683 Methods of Selecting T cell Line and Donor Thereof for Adoptive Cellular Therapy
Disclosed herein are methods of selecting an allogeneic T cell line for therapeutic administration to a patient having or suspected of having a pathogen or...
2017/0319682 RECOMBINANT NANOPARTICLE RSV F VACCINE FOR RESPIRATORY SYNCYTIAL VIRUS
The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them,...
2017/0319681 LENTIVIRAL VECTOR-BASED JAPANESE ENCEPHALITIS IMMUNOGENIC COMPOSITION
The present invention relates to a lentiviral vector-based Japanese encephalitis (JE) immunogenic composition. The present invention is directed to a...
2017/0319680 NOVEL TH1-INDUCING ADJUVANT COMPRISING COMBINATION OF DIFFERENT NUCLEIC ACID ADJUVANTS, AND USE OF SAME
The present invention provides the induction of novel Th1 response, the induction of cytotoxic T cells and anti-cancer/anti-allergic activity techniques....
2017/0319679 HIV Vaccines Comprising One or More Population Episensus Antigens
Provided herein are HIV-1 vaccines comprising a carrier and a population episensus antigen determined using the EpiGraph approach. Also provided are HIV-1...
2017/0319678 ATTENUATED PASTEURELLA MULTOCIDA STRAINS
This disclosure provides attenuated P. multocida strains which can be used to prepare vaccine compositions useful for protection against P. multocida.
2017/0319677 TEMPERATURE SENSITIVE MULTIVALENT BORDETELLA AVIUM VACCINES
The present invention is related to various vaccine compositions against Bordetella avium and methods for preparing and administering the various vaccine...
2017/0319676 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF CANCERS
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides...
2017/0319675 IMMUNOTHERAPY AGAINST SEVERAL TUMORS, SUCH AS LUNG CANCER, INCLUDING NSCLC
A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer, gastric cancer, and/or glioblastoma includes administering to said...
2017/0319674 USE OF ANTIBODIES FOR ENRICHMENT OF ENGINEERED T CELLS WITH EXOGENOUS IMMUNE RECEPTORS AND ANTIBODIES FOR USE...
The current application provides for exogenous immune receptors that do not require any additional selection marker genes and/or any additional silicide genes....
2017/0319673 TRI-SEGMENTED ARENAVIRUSES AS VACCINE VECTORS
The present application relates to arenaviruses with rearrangements of their open reading frames ("ORF") in their genomes. In particular, described herein is a...
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