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Patent # Description
2017/0319571 SOLID PHARMACEUTICAL COMPOSITION
[Problem] To provide a novel pharmaceutical composition which can suppress delayed, release of the compound represented in general formula (1) or a salt...
2017/0319570 Treatment of Multiple Sclerosis With Combination of Laquinimod and Dimethyl Fumarate
This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering...
2017/0319569 COMBINATION OF LAQUINIMOD AND PRIDOPIDINE FOR TREATING NEURODEGENERATIVE DISORDERS, IN PARTICULAR HUNTINGTON'S...
This invention provides a method of treating a patient afflicted with a neurodegenerative disorder, e.g., Huntington's disease (HD), comprising administering...
2017/0319568 QUINOLINE CARBOXAMIDES FOR USE IN THE TREATMENT OF LEUKEMIA
A compound of formula (I) or a pharmaceutically acceptable salt thereof, for use in the treatment of leukemia. ##STR00001##
2017/0319567 Use of CCR3-Inhibitors
The present invention relates to CCR3 inhibitors of formula 1, ##STR00001## wherein R.sup.1 is H, C.sub.1-6-alkyl, C.sub.0-4-alkyl-C.sub.3-6-cycloalkyl,...
2017/0319566 Methylphenidate Extended Release Chewable Tablet
An oral methylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a...
2017/0319565 METHODS AND DRUG PRODUCTS FOR TREATING ALZHEIMER'S DISEASE
Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g., delay of onset) of cognitive impairment of the Alzheimer's type....
2017/0319564 2-Amino-6-(Difluoromethyl)-5,5-Difluoro-6-Phenyl-3,4,5,6-Tetrahydropyridin- es as BACE1 Inhibitors
The present invention is directed to compounds of formula (I) which are inhibitors of the BACE1 enzyme. Separate aspects of the invention are directed to...
2017/0319563 STEROID-FREE DISEASE MANAGEMENT
The present invention relates to the use of the compound 1-(2-(4-fluorophenyl)thiazol-5-yl)-1-(pyridin-4-yl)ethanol ("ASNOO1") in treatments without...
2017/0319562 Compositions and Methods for Extended Therapy with Aminopyridines
Disclosed herein are methods and compositions related to use of aminopyridines, such as 4-aminopyridine, for use in a therapeutically effective manner for...
2017/0319561 DONEPEZIL DERIVATIVE AND USE THEREOF
The present invention relates to a donepezil derivative of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R in the formula is as...
2017/0319560 PYRAZOLE, TRIAZOLE AND TETRAZOLE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to pyrazole, triazole and tetrazole compounds which are antagonists of orexin receptors. The present invention is also...
2017/0319559 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant...
2017/0319558 PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR
This present invention relates to a method of treating a autoimmune, respiratory and/or inflammatory disease or condition (e.g., psoriasis, rheumatoid...
2017/0319557 NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
Provided is a powder inhaler comprising a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicy- clo[2.2.2]octane...
2017/0319556 METHODS OF TREATING DEVELOPMENTAL DISORDERS USING GABOXADOL
Methods of treating a developmental disorder such as Dravet syndrome by administering a pharmaceutical composition of gaboxadol or a pharmaceutically...
2017/0319555 DOSING REGIMEN FOR A SELECTIVE S1P1 RECEPTOR AGONIST
The present invention relates to a dosing regimen for (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]-propylim- ino)-3-o-tolyl-thiazolidin-4-one.
2017/0319554 Methods of Treating Hepatorenal Syndrome and Hepatic Encephalopathy with Thromboxane-A2 Receptor Antagonists
The present invention is directed to methods of treating hepatorenal syndrome by administration of a therapeutically effective amount of a thromboxane A.sub.2...
2017/0319553 NOVEL POLYMORPH OF ITRACONAZOLE WITH IMPROVED PHARMACEUTICAL PROPERTIES
The present invention provides a new crystalline form of itraconazole as well as the method of making same.
2017/0319552 ATROPISOMERS OF TRIAZOLE DERIVATIVE
Atropisomers of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H- 1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions and the uses of...
2017/0319551 NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the...
2017/0319550 CAI-BASED SYSTEMS AND METHODS FOR THE LOCALIZED TREATMENT OF UVEITIS
This invention relates to the treatment of uveitis, in particular posterior infectious uveitis. In specific embodiments, the invention provides for methods of...
2017/0319549 1-CYCLOHEXYL-2-PHENYLAMINOBENZIMIDAZOLES AS MIDH1 INHIBITORS FOR THE TREATMENT OF TUMORS
The present invention relates to benzimidazol-2-amines of general formula (I) in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
2017/0319548 CENICRIVIROC COMBINATION THERAPY FOR THE TREATMENT OF FIBROSIS
Cenicriviroc (CVC) is an orally active antagonist of ligand binding to C-C chemokine receptor type 5 (CCR5) and C-C chemokine receptor type 2 (CCR2). CVC...
2017/0319547 ANESTHETIC COMPRISING TETRACAINE AND A VASOCONSTRICTOR FOR ADMINISTRATION TO A SUBJECT
The present invention relates to tetracaine based anesthetic formulations and methods of use thereof The invention further relates to topical formulations of...
2017/0319546 SALINOSPORAMIDES AND METHODS OF USE THEREOF
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective...
2017/0319545 METHOD FOR CONTROLLING SKIN PENETRATION
An object of the present invention is to provide a method for controlling skin permeability of an anionic compound and having superior safety. An ionic liquid...
2017/0319544 SOLID COMPOSITION OF PYRROLE CARBOXAMIDE
An object is to provide a solid composition of stabilized pyrrole carboxamide. A means for achieving the object is a solid composition for medical use...
2017/0319543 DNA DAMAGE REPAIR INHIBITORS FOR TREATMENT OF CANCER
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR...
2017/0319542 PHARMACEUTICAL COMPOSITION CONTAINING GINKGOLIDE B AND XA FACTOR INHIBITOR, PREPARATION METHOD THEREOF AND USE...
A pharmaceutical composition containing ginkgolide B and an Xa factor inhibitor xaban, a preparation method and use of the pharmaceutical composition, wherein...
2017/0319541 METHODS OF STIMULATING CELLULAR GROWTH, SYNAPTIC REMODELING AND CONSOLIDATION OF LONG-TERM MEMORY
The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC...
2017/0319540 Methods and Compositions for the Treatment of Non-Alcoholic Steatohepatitis
The present disclosure relates to methods of preventing, treating, delaying the onset of, and delaying the progression of liver disease by administering...
2017/0319539 Amorphous Empagliflozin
The present disclosure relates to solid dispersion of amorphous empagliflozin and its process thereof.
2017/0319538 SOLID PHARMACEUTICAL COMPOSITIONS CONTAINING BENZOFURAN DERIVATIVES
The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with...
2017/0319537 NOVEL METHODS FOR TARGETING CANCER STEM CELLS
The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that...
2017/0319536 Arginase Inhibitors and Their Therapeutic Applications
Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical...
2017/0319535 COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF CANCER
The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to...
2017/0319534 EUTECTIC ANESTHETIC TOPICAL COMPOSITIONS
A eutectic anesthetic composition used to deliver pharmaceutical products topically as well as a method for producing the eutectic anesthetic composition,...
2017/0319533 COMPOSITIONS AND METHODS OF USE OF PHORBOL ESTERS
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such...
2017/0319532 METHODS AND FORMULATIONS FOR TREATMENT AND/OR PREVENTION OF BLOOD-ASSOCIATED DISORDERS
A method of treating and/or preventing blood-associated disorders is provided. Also provided is a method of treating and/or preventing hemophilic arthropathy...
2017/0319531 Composition and Method for Treating Neuronal Ceroid Lipofuscinosis
Provided herein are methods for treatment of a neurodegenerative disease, such as neuronal ceroid lipofuscinosis including administering to a subject in need...
2017/0319530 PREPARATION CONTAINING CHLOROGENIC ACID CRYSTAL FORM AND USE THEREOF
A preparation containing a chlorogenic acid crystal form. The crystal form is an orthorhombic crystal system, a space group is P2.sub.12.sub.12.sub.1, cell...
2017/0319529 Compounds and Methods for Modulating Vascular Injury
Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the...
2017/0319528 TREATMENT FOR CHRONIC KIDNEY DISEASE
A method of treating chronic kidney disease in a mammalian subject by administering a composition that includes L-arginine, glycine, L-glutamine, L-histidine,...
2017/0319527 Carbidopa for the Treatment of Cancer
The present invention includes a method of inhibiting or reducing mTOR signaling or inhibition of indoleamine dioxygenase-1 (IDO1) in a subject with a...
2017/0319526 COMPOSITIONS AND METHODS OF PROVIDING THYROID HORMONE OR ANALOGS THEREOF
The present invention includes a pharmaceutical composition, and methods of making and using, a pharmaceutical composition comprising one or more thyroid...
2017/0319525 TREATMENT AND DIAGNOSIS OF MELANOMA
The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.
2017/0319524 ENTERICALLY COATED CYSTEAMINE, CYSTAMINE AND DERIVATIVES THEREOF
The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The ...
2017/0319523 ENTERICALLY COATED CYSTEAMINE, CYSTAMINE AND DERIVATIVES THEREOF
The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The ...
2017/0319522 ENTERICALLY COATED CYSTEAMINE, CYSTAMINE AND DERIVATIVES THEREOF
The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The ...
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