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Patent # Description
2017/0320887 URETHANE ACRYLATES BASED ON 2,4,8,10-TETRAOXOSPIRO[5.5]-UNDECANE-3,9-DIALKANOLS
Disclosed is a novel urethane acrylate being a reaction product of a raw material composition comprising at least (A) a diol component, (B) a component having...
2017/0320886 CORTISTATIN ANALOGUES AND SYNTHESES THEREOF
The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: ##STR00001## and salts thereof, wherein R.sub.1, R.sub.2,...
2017/0320885 PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN THE PREPARATION OF HEPATITIS C VIRUS (HCV) INHIBITORS
The present invention generally relates to a process for preparation of 9-halo-3-(2-haloacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one of Formula I,...
2017/0320884 HYDROXMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to hydroxymethyl piperidine compounds which are antagonists of orexin receptors. The present invention is also directed to...
2017/0320883 CARM1 INHIBITORS AND USES THEREOF
Provided herein are compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X,...
2017/0320882 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS
Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the...
2017/0320881 PYRAZOLOPYRIMIDINE COMPOUNDS
The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also...
2017/0320880 INDANE INHIBITORS OF EED AND METHODS OF THEIR USE
Compounds having a structure of Formula (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A.sup.1, A.sup.2,...
2017/0320879 A PROCESS FOR THE PREPARATION OF IBRUTINIB
The present invention provides processes for the preparation of ibrutinib, intermediate compounds of Formula VI and Formula VIII, and salts thereof. The...
2017/0320878 METHOD FOR PREPARATION OF FLUORO, CHLORO AND FLUOROCHLORO ALKYLATED COMPOUNDS BY HOMOGENEOUS CATALYSIS
The invention discloses a method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous Pd catalyzed fluoro, chloro and...
2017/0320877 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in...
2017/0320876 BRIDGED DIAZEPANE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to bridged diazepane compounds which are antagonists of orexin receptors. The present invention is also directed to uses of...
2017/0320875 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2017/0320874 6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to 6,5-bicyclic octahydropyrrolopyridine compounds which are antagonists of orexin receptors. The present invention is also...
2017/0320873 Method For The Production of Praziquantel and Precursors Thereof
The present invention relates to methods for the production of enantiopure or enantioenriched Praziquantel precursors and to methods for the production of...
2017/0320872 SUBSTANTIALLY PURE VEMURAFENIB AND ITS SALTS
The present invention relates to a process for the preparation substantially pure propane-1-sulfonicacid-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3- ...
2017/0320871 TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
Described herein are tetrahydroisoquinoline compounds with estrogen receptor modulation activity or function having the Formula I structure: ##STR00001## and...
2017/0320870 COMPOUNDS
A compound of formula I, or a pharmaceutically acceptable salt or ester thereof, ##STR00001## wherein R.sup.1 is selected from: aryl; heteroaryl; ...
2017/0320869 DERIVATIVES OF 2-(1,2,4-TRIAZOL-3-YLSULFANYL)-N-1,3,4-THIADIAZOL-2-YL ACETAMIDE WHICH ARE USEFUL FOR THE...
Disclosed are compounds, pharmaceutical compositions and methods for modulating aquaporin 9.
2017/0320868 NOVEL (CYANO-DIMETHYL-METHYL)-ISOXAZOLES AND -[1,3,4]THIADIAZOLES
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical...
2017/0320867 HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS
The present invention encompasses compounds of the formula (I) ##STR00001## wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the...
2017/0320866 SUBSTITUTED PYRIDINONES AS BROMODOMAIN INHIBITORS
The present disclosure relates to substituted pyridinones, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in...
2017/0320865 OXAZOLE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole...
2017/0320864 Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders
The invention relates to novel heterocyclic compounds of the formula ##STR00001## in which all of the variables are as defined in the specification, ...
2017/0320863 HERBICIDAL COMPOUNDS
The present invention relates to a compound of formula (I) wherein: wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9,...
2017/0320862 PROCESS FOR THE PREPARATION OF BREXPIPRAZOLE AND INTERMEDIATES THEREOF
The present invention relates to Brexpiprazole having a purity of about 99.5% or more by area percentage of HPLC, having total impurities not more than 0.5%...
2017/0320861 BENZIMIDAZOL-2-AMINES AS MIDH1 INHIBITORS
The present invention relates to benzim-idazol-2-amines of general formula (I) in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
2017/0320860 HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of...
2017/0320859 4-AMINOQUINAZOLIN COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS
Aminoquinazolinyl compounds of formula (I) are described, ##STR00001## which are useful as prolyl hydroxylase inhibitors. Such compounds may be used in...
2017/0320858 COMPOUND
This invention relates to compounds, as defined in the specification, useful in the treatment of mycoses, compositions containing them and their use in therapy.
2017/0320857 COMPOUNDS AND METHODS FOR INHIBITING JAK
Disclosed are compounds of formula (I), pharmaceutical compositions comprising such compounds and methods/uses of using the same, for example, for treating a...
2017/0320856 AMIDOETHYL AZOLE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to amidoethyl azole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of...
2017/0320855 Spiroacridine-Triazine Hybrids and Applications for Electroluminescent Devices
The present invention relates to compounds of the formula (1), to the use thereof in electroluminescent devices, and particularly organic electroluminescence...
2017/0320854 AMIDE-SUBSTITUTED PYRIDINYLTRIAZOLE DERIVATIVES AND USES THEREOF
The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to...
2017/0320853 URACIL DERIVATIVES AS AXL AND C-MET KINASE INHIBITORS
The present invention provides compounds of Formula I ##STR00001## or pharmaceutically acceptable salt forms thereof, wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d,...
2017/0320852 MALEATE SALTS OF (E)-N--4-(DIMETHYLAMINO)-2-BUTENAMIDE AND CRYSTALLINE FORMS THEREOF
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quin- ...
2017/0320851 CRYSTALLINE FORMS OF C21H22Cl2N4O2
The present invention provides crystalline forms of a compound of formula (I): ##STR00001## Also provided are pharmaceutical compositions that include the...
2017/0320850 CRYSTALLINE C21H22Cl2N4O2 MALONATE
The present invention provides a malonate salt of a compound of formula (I): ##STR00001## which is a crystalline salt. Also provided are pharmaceutical ...
2017/0320849 MODULATORS OF RESISTANT ANDROGEN RECEPTOR
The present invention provides compounds useful as modulators, agonists or antagonists of androgen receptor (AR), compositions thereof, and methods of making...
2017/0320848 COMPOUNDS FOR USE IN ANTHELMINTHIC TREATMENT
Disclosed are compounds of formula (I) which possess anthelminthic properties wherein the structural elements have the meaning as indicated in the description....
2017/0320847 METHOD FOR PRODUCING GLYCERIC ACID CARBONATE
The present invention relates to a method for preparing a compound of the formula (I) with a specific definition of the substituent R.sub.3 ##STR00001## a...
2017/0320846 PHOTOINDUCED ELECTRON TRANSFER VOLTAGE-SENSITIVE COMPOUNDS
The disclosure provides methods to synthesize photoinduced electron transfer voltage-sensitive compounds, the compounds made therefrom, and uses of the...
2017/0320845 PREPARATION OF DIALKYL ESTERS OF 2,5-FURANDICARBOXYLIC ACID
Dialkyil esters of 2,5-furandicarboxylic acid are prepared in a process including: contacting an acid starting composition having 2,5-furandicarboxylic acid...
2017/0320844 METHOD FOR PREPARING 2,5-DISUBSTITUTED FURAN COMPOUND
Disclosed is a method for preparing a 2,5-disubstituted furan compound. The 2,5-disubstituted furan compound is prepared in a simple, convenient and highly...
2017/0320843 PRODUCTION OF FURANS
The invention relates to obtaining furans from biomass. In particular, the invention relates to obtaining furans from polyols, such as tetrahydroxybutane. In...
2017/0320842 PROCESS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND TETRAHYDROFURAN FROM FURAN
The present invention provides a process for the preparation of 1,4-butanediol and tetrahydrofuran said process comprising contacting furan with hydrogen and...
2017/0320841 14-HYDROXY-DOCOSAHEXAENOIC ACID COMPOUNDS
The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.
2017/0320840 METHOD FOR PREPARATION OF 2-METHYL-1,2-BENZISOTHIAZOLIN-3-ONE
A method for preparation of 2-methyl-1,2-benzisothiazolin-3-one from 1,2-benzisothiazolin-3-one by contacting 1,2-benzisothiazolin-3-one with an alkali metal...
2017/0320839 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods...
2017/0320838 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS
The invention relates to morpholine and 1,4-oxazepane amide derivatives of general formula (I), which are agonists of somatostatin receptor subtype 4 (SSTR4),...
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